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Protein

Protein FAM43A

Gene

FAM43A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM43A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM43A
ORF Names:PP7298
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000185112.5

Human Gene Nomenclature Database

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HGNCi
HGNC:26888 FAM43A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N2R8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
131583

Open Targets

More...
OpenTargetsi
ENSG00000185112

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134950686

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
FAM43A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51316022

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001870241 – 423Protein FAM43AAdd BLAST423

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8N2R8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8N2R8

PeptideAtlas

More...
PeptideAtlasi
Q8N2R8

PRoteomics IDEntifications database

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PRIDEi
Q8N2R8

ProteomicsDB human proteome resource

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ProteomicsDBi
71730

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8N2R8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N2R8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000185112 Expressed in 186 organ(s), highest expression level in placenta

CleanEx database of gene expression profiles

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CleanExi
HS_FAM43A

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8N2R8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048345

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
126288, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N2R8, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8N2R8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N2R8

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM43 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4448 Eukaryota
ENOG410YZ8H LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161593

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231650

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051535

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N2R8

Identification of Orthologs from Complete Genome Data

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OMAi
SQGIRMV

Database of Orthologous Groups

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OrthoDBi
EOG091G0OEI

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8N2R8

TreeFam database of animal gene trees

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TreeFami
TF314159

Family and domain databases

Conserved Domains Database

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CDDi
cd01214 PTB_FAM43A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR033930 FAM43A/B_PTB
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14719 PID_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00462 PTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N2R8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPWKKHKFE LLAEAPPRQA SKPKGYAVSL HYSALSSLAR ACPEGALSRV
60 70 80 90 100
GSMFRSKRKK LHITSEDPTY TVLYLGNATT IQARGDGCTD LAVGKIWSKS
110 120 130 140 150
EAGRQGTKMK LTVSAQGIRM VHAEERALRR PGHLYLLHRV TYCVADARLP
160 170 180 190 200
KVFAWVYRHE LKHKAVMLRC HAVLVSKPEK AQAMALLLYQ TSANALAEFK
210 220 230 240 250
RLKRRDDARH QQQELVGAHT IPLVPLRKLL LHGPCCYKPP VERSRSAPKL
260 270 280 290 300
GSITEDLLGE QLEQELQEEE EEEQPEGCPE EEENRAAEGD PAEEEAEAQR
310 320 330 340 350
ALVVAMHFEC GDLLDTLENG RGEALGGGGG SLGPGAGPPP LLLGSASDMK
360 370 380 390 400
AELSQLISDL GELSFGNDVR TLQADLRVTR LLSGDSTGSE SSIEGGGPDA
410 420
TSATAGDSSR QADGASADEP HSG
Length:423
Mass (Da):45,776
Last modified:August 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA70223F96B2729A
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL55769 differs from that shown. Reason: Frameshift at position 246.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti305A → V in BAC11027 (PubMed:14702039).Curated1
Sequence conflicti351A → V in AAL55769 (PubMed:15498874).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF289585 mRNA Translation: AAL55769.1 Frameshift.
AK074503 mRNA Translation: BAC11027.1
CH471052 Genomic DNA Translation: EAW78033.1
BC039689 mRNA Translation: AAH39689.1
BC064989 mRNA Translation: AAH64989.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33923.1

NCBI Reference Sequences

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RefSeqi
NP_710157.2, NM_153690.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.435080

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329759; ENSP00000371397; ENSG00000185112

Database of genes from NCBI RefSeq genomes

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GeneIDi
131583

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:131583

UCSC genome browser

More...
UCSCi
uc003fuj.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289585 mRNA Translation: AAL55769.1 Frameshift.
AK074503 mRNA Translation: BAC11027.1
CH471052 Genomic DNA Translation: EAW78033.1
BC039689 mRNA Translation: AAH39689.1
BC064989 mRNA Translation: AAH64989.1
CCDSiCCDS33923.1
RefSeqiNP_710157.2, NM_153690.4
UniGeneiHs.435080

3D structure databases

ProteinModelPortaliQ8N2R8
SMRiQ8N2R8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126288, 15 interactors
IntActiQ8N2R8, 1 interactor

PTM databases

iPTMnetiQ8N2R8
PhosphoSitePlusiQ8N2R8

Polymorphism and mutation databases

BioMutaiFAM43A
DMDMi51316022

Proteomic databases

EPDiQ8N2R8
PaxDbiQ8N2R8
PeptideAtlasiQ8N2R8
PRIDEiQ8N2R8
ProteomicsDBi71730

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329759; ENSP00000371397; ENSG00000185112
GeneIDi131583
KEGGihsa:131583
UCSCiuc003fuj.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
131583
DisGeNETi131583
EuPathDBiHostDB:ENSG00000185112.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM43A

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0024294
HGNCiHGNC:26888 FAM43A
HPAiHPA048345
neXtProtiNX_Q8N2R8
OpenTargetsiENSG00000185112
PharmGKBiPA134950686

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4448 Eukaryota
ENOG410YZ8H LUCA
GeneTreeiENSGT00940000161593
HOGENOMiHOG000231650
HOVERGENiHBG051535
InParanoidiQ8N2R8
OMAiSQGIRMV
OrthoDBiEOG091G0OEI
PhylomeDBiQ8N2R8
TreeFamiTF314159

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM43A human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FAM43A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
131583

Protein Ontology

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PROi
PR:Q8N2R8

Gene expression databases

BgeeiENSG00000185112 Expressed in 186 organ(s), highest expression level in placenta
CleanExiHS_FAM43A
GenevisibleiQ8N2R8 HS

Family and domain databases

CDDicd01214 PTB_FAM43A, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR033930 FAM43A/B_PTB
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
PfamiView protein in Pfam
PF14719 PID_2, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA43A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N2R8
Secondary accession number(s): A3KME2, Q8IXP4, Q8WZ07
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: December 5, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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