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UniProtKB - Q8N2R0 (OSR2_HUMAN)
Protein
Protein odd-skipped-related 2
Gene
OSR2
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 172 – 194 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 200 – 222 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 228 – 250 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 256 – 278 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 284 – 306 | C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: ARUK-UCL
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: ARUK-UCL
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- bone morphogenesis Source: UniProtKB
- cell differentiation Source: BHF-UCL
- chondrocyte differentiation Source: BHF-UCL
- embryo development ending in birth or egg hatching Source: UniProtKB
- embryonic digit morphogenesis Source: BHF-UCL
- embryonic forelimb morphogenesis Source: BHF-UCL
- embryonic hindlimb morphogenesis Source: BHF-UCL
- embryonic skeletal joint development Source: BHF-UCL
- embryonic skeletal joint morphogenesis Source: BHF-UCL
- embryonic skeletal limb joint morphogenesis Source: BHF-UCL
- embryonic skeletal system morphogenesis Source: UniProtKB
- eyelid development in camera-type eye Source: UniProtKB
- head development Source: BHF-UCL
- mesonephros development Source: UniProtKB
- metanephros development Source: UniProtKB
- middle ear morphogenesis Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- odontogenesis Source: UniProtKB
- osteoblast proliferation Source: UniProtKB
- positive regulation of bone mineralization Source: BHF-UCL
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of epithelial cell proliferation Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of transcription by RNA polymerase II Source: GO_Central
- roof of mouth development Source: UniProtKB
- urogenital system development Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8N2R0 |
SignaLinki | Q8N2R0 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein odd-skipped-related 2 |
Gene namesi | Name:OSR2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15830, OSR2 |
MIMi | 611297, gene |
neXtProti | NX_Q8N2R0 |
VEuPathDBi | HostDB:ENSG00000164920 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 116039 |
OpenTargetsi | ENSG00000164920 |
PharmGKBi | PA134924513 |
Miscellaneous databases
Pharosi | Q8N2R0, Tbio |
Genetic variation databases
BioMutai | OSR2 |
DMDMi | 146345473 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047007 | 1 – 312 | Protein odd-skipped-related 2Add BLAST | 312 |
Proteomic databases
MassIVEi | Q8N2R0 |
MaxQBi | Q8N2R0 |
PaxDbi | Q8N2R0 |
PeptideAtlasi | Q8N2R0 |
PRIDEi | Q8N2R0 |
ProteomicsDBi | 71727 [Q8N2R0-1] 71728 [Q8N2R0-2] |
PTM databases
iPTMneti | Q8N2R0 |
PhosphoSitePlusi | Q8N2R0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000164920, Expressed in ectocervix and 188 other tissues |
ExpressionAtlasi | Q8N2R0, baseline and differential |
Genevisiblei | Q8N2R0, HS |
Organism-specific databases
HPAi | ENSG00000164920, Tissue enhanced (cervix, endometrium, fallopian tube) |
Interactioni
Binary interactionsi
Q8N2R0
With | #Exp. | IntAct |
---|---|---|
PSMA3 [P25788] | 3 | EBI-5660512,EBI-348380 |
Isoform 2 [Q8N2R0-2]
With | #Exp. | IntAct |
---|---|---|
KRTAP6-1 [Q3LI64] | 3 | EBI-12850348,EBI-12111050 |
Protein-protein interaction databases
BioGRIDi | 125467, 9 interactors |
IntActi | Q8N2R0, 3 interactors |
STRINGi | 9606.ENSP00000414657 |
Miscellaneous databases
RNActi | Q8N2R0, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 129 – 165 | DisorderedSequence analysisAdd BLAST | 37 |
Sequence similaritiesi
Belongs to the Odd C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 172 – 194 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 200 – 222 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 228 – 250 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 256 – 278 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 284 – 306 | C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160530 |
HOGENOMi | CLU_051854_0_0_1 |
InParanoidi | Q8N2R0 |
OMAi | HTPHQDY |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8N2R0 |
TreeFami | TF350876 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N2R0-1) [UniParc]FASTAAdd to basket
Also known as: OSR2A
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PATVDHLQGL YGLSAVQTMH
60 70 80 90 100
MNHWTLGYPN VHEITRSTIT EMAAAQGLVD ARFPFPALPF TTHLFHPKQG
110 120 130 140 150
AIAHVLPALH KDRPRFDFAN LAVAATQEDP PKMGDLSKLS PGLGSPISGL
160 170 180 190 200
SKLTPDRKPS RGRLPSKTKK EFICKFCGRH FTKSYNLLIH ERTHTDERPY
210 220 230 240 250
TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS RTLAVHKTLH
260 270 280 290 300
MQESPHKCPT CGRTFNQRSN LKTHLLTHTD IKPYSCEQCG KVFRRNCDLR
310
RHSLTHTPRQ DF
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RGY8 | E5RGY8_HUMAN | Protein odd-skipped-related 2 | OSR2 | 270 | Annotation score: | ||
E5RH04 | E5RH04_HUMAN | Protein odd-skipped-related 2 | OSR2 | 288 | Annotation score: | ||
E5RH47 | E5RH47_HUMAN | Protein odd-skipped-related 2 | OSR2 | 213 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 132 | K → G in AAK74066 (Ref. 1) Curated | 1 | |
Sequence conflicti | 286 | C → R in BAC11035 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054849 | 1 | M → MGLRAEEGKRKPPRSVRGEV SPSQGPLAQEDEARRLRSCT PACHPGKRGKGGHRARRQRS AWDLTTHPLTHRSQELRGAA ATEGFLYVLLSHWVFVGAPR PPASDSWKKGLVPSAPPASR KM in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_017121 | 253 – 312 | ESPHK…PRQDF → TSSPTAASSAAKCSGETVIC GGTA in isoform 2. 3 PublicationsAdd BLAST | 60 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY038072 mRNA Translation: AAK74066.1 AY038073 mRNA Translation: AAK74067.1 AK074518 mRNA Translation: BAC11035.1 AK291491 mRNA Translation: BAF84180.1 AK304654 mRNA Translation: BAG65429.1 AC016877 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW91785.1 BC016936 mRNA Translation: AAH16936.1 |
CCDSi | CCDS47901.1 [Q8N2R0-1] CCDS47902.1 [Q8N2R0-2] CCDS69520.1 [Q8N2R0-3] |
RefSeqi | NP_001135934.1, NM_001142462.2 [Q8N2R0-1] NP_001273770.1, NM_001286841.1 [Q8N2R0-3] NP_443727.2, NM_053001.3 [Q8N2R0-2] XP_011515129.1, XM_011516827.2 [Q8N2R0-1] XP_016868507.1, XM_017013018.1 [Q8N2R0-1] |
Genome annotation databases
Ensembli | ENST00000297565.9; ENSP00000297565.4; ENSG00000164920.10 ENST00000435298.6; ENSP00000402862.2; ENSG00000164920.10 [Q8N2R0-2] ENST00000457907.3; ENSP00000414657.2; ENSG00000164920.10 [Q8N2R0-3] ENST00000522510.5; ENSP00000430780.1; ENSG00000164920.10 |
GeneIDi | 116039 |
KEGGi | hsa:116039 |
MANE-Selecti | ENST00000297565.9; ENSP00000297565.4; NM_001142462.3; NP_001135934.1 |
UCSCi | uc003yiq.5, human [Q8N2R0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY038072 mRNA Translation: AAK74066.1 AY038073 mRNA Translation: AAK74067.1 AK074518 mRNA Translation: BAC11035.1 AK291491 mRNA Translation: BAF84180.1 AK304654 mRNA Translation: BAG65429.1 AC016877 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW91785.1 BC016936 mRNA Translation: AAH16936.1 |
CCDSi | CCDS47901.1 [Q8N2R0-1] CCDS47902.1 [Q8N2R0-2] CCDS69520.1 [Q8N2R0-3] |
RefSeqi | NP_001135934.1, NM_001142462.2 [Q8N2R0-1] NP_001273770.1, NM_001286841.1 [Q8N2R0-3] NP_443727.2, NM_053001.3 [Q8N2R0-2] XP_011515129.1, XM_011516827.2 [Q8N2R0-1] XP_016868507.1, XM_017013018.1 [Q8N2R0-1] |
3D structure databases
AlphaFoldDBi | Q8N2R0 |
SMRi | Q8N2R0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125467, 9 interactors |
IntActi | Q8N2R0, 3 interactors |
STRINGi | 9606.ENSP00000414657 |
PTM databases
iPTMneti | Q8N2R0 |
PhosphoSitePlusi | Q8N2R0 |
Genetic variation databases
BioMutai | OSR2 |
DMDMi | 146345473 |
Proteomic databases
MassIVEi | Q8N2R0 |
MaxQBi | Q8N2R0 |
PaxDbi | Q8N2R0 |
PeptideAtlasi | Q8N2R0 |
PRIDEi | Q8N2R0 |
ProteomicsDBi | 71727 [Q8N2R0-1] 71728 [Q8N2R0-2] |
Protocols and materials databases
Antibodypediai | 26083, 141 antibodies from 29 providers |
DNASUi | 116039 |
Genome annotation databases
Ensembli | ENST00000297565.9; ENSP00000297565.4; ENSG00000164920.10 ENST00000435298.6; ENSP00000402862.2; ENSG00000164920.10 [Q8N2R0-2] ENST00000457907.3; ENSP00000414657.2; ENSG00000164920.10 [Q8N2R0-3] ENST00000522510.5; ENSP00000430780.1; ENSG00000164920.10 |
GeneIDi | 116039 |
KEGGi | hsa:116039 |
MANE-Selecti | ENST00000297565.9; ENSP00000297565.4; NM_001142462.3; NP_001135934.1 |
UCSCi | uc003yiq.5, human [Q8N2R0-1] |
Organism-specific databases
CTDi | 116039 |
DisGeNETi | 116039 |
GeneCardsi | OSR2 |
HGNCi | HGNC:15830, OSR2 |
HPAi | ENSG00000164920, Tissue enhanced (cervix, endometrium, fallopian tube) |
MIMi | 611297, gene |
neXtProti | NX_Q8N2R0 |
OpenTargetsi | ENSG00000164920 |
PharmGKBi | PA134924513 |
VEuPathDBi | HostDB:ENSG00000164920 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160530 |
HOGENOMi | CLU_051854_0_0_1 |
InParanoidi | Q8N2R0 |
OMAi | HTPHQDY |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8N2R0 |
TreeFami | TF350876 |
Enzyme and pathway databases
PathwayCommonsi | Q8N2R0 |
SignaLinki | Q8N2R0 |
Miscellaneous databases
BioGRID-ORCSi | 116039, 16 hits in 1107 CRISPR screens |
ChiTaRSi | OSR2, human |
GeneWikii | OSR2_(gene) |
GenomeRNAii | 116039 |
Pharosi | Q8N2R0, Tbio |
PROi | PR:Q8N2R0 |
RNActi | Q8N2R0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164920, Expressed in ectocervix and 188 other tissues |
ExpressionAtlasi | Q8N2R0, baseline and differential |
Genevisiblei | Q8N2R0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | OSR2_HUMAN | |
Accessioni | Q8N2R0Primary (citable) accession number: Q8N2R0 Secondary accession number(s): A8K626 Q96LB7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2006 |
Last sequence update: | May 1, 2007 | |
Last modified: | May 25, 2022 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families