UniProtKB - Q8N2Q7 (NLGN1_HUMAN)
Neuroligin-1
NLGN1
Functioni
GO - Molecular functioni
- amyloid-beta binding Source: ARUK-UCL
- cell adhesion molecule binding Source: BHF-UCL
- identical protein binding Source: BHF-UCL
- neurexin family protein binding Source: UniProtKB
- PDZ domain binding Source: UniProtKB
- protein-containing complex binding Source: Ensembl
- scaffold protein binding Source: BHF-UCL
- signaling receptor activity Source: BHF-UCL
GO - Biological processi
- AMPA glutamate receptor clustering Source: BHF-UCL
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
- cellular response to calcium ion Source: ARUK-UCL
- chemical synaptic transmission Source: GO_Central
- cytoskeletal matrix organization at active zone Source: BHF-UCL
- establishment of protein localization Source: BHF-UCL
- excitatory synapse assembly Source: ARUK-UCL
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
- long-term synaptic potentiation Source: Ensembl
- modulation of chemical synaptic transmission Source: ARUK-UCL
- negative regulation of dendritic spine morphogenesis Source: BHF-UCL
- nervous system development Source: UniProtKB
- neurexin clustering involved in presynaptic membrane assembly Source: BHF-UCL
- neuronal signal transduction Source: BHF-UCL
- neuron cell-cell adhesion Source: BHF-UCL
- neuron projection arborization Source: ARUK-UCL
- neuron projection development Source: CACAO
- NMDA glutamate receptor clustering Source: BHF-UCL
- positive regulation of circadian sleep/wake cycle, wakefulness Source: UniProtKB
- positive regulation of dendritic spine development Source: BHF-UCL
- positive regulation of excitatory postsynaptic potential Source: BHF-UCL
- positive regulation of filopodium assembly Source: BHF-UCL
- positive regulation of intracellular signal transduction Source: BHF-UCL
- positive regulation of presynaptic active zone assembly Source: Ensembl
- positive regulation of protein localization to synapse Source: Ensembl
- positive regulation of ruffle assembly Source: BHF-UCL
- positive regulation of synapse assembly Source: MGI
- positive regulation of synaptic transmission, GABAergic Source: BHF-UCL
- positive regulation of synaptic transmission, glutamatergic Source: BHF-UCL
- positive regulation of synaptic vesicle clustering Source: Ensembl
- positive regulation of synaptic vesicle endocytosis Source: BHF-UCL
- positive regulation of synaptic vesicle exocytosis Source: BHF-UCL
- postsynaptic density protein 95 clustering Source: BHF-UCL
- postsynaptic membrane assembly Source: BHF-UCL
- postsynaptic specialization assembly Source: Ensembl
- presynapse assembly Source: ARUK-UCL
- presynaptic membrane assembly Source: BHF-UCL
- protein localization to synapse Source: BHF-UCL
- protein targeting Source: UniProtKB
- receptor localization to synapse Source: BHF-UCL
- regulation of AMPA receptor activity Source: BHF-UCL
- regulation of neuron differentiation Source: UniProtKB
- regulation of NMDA receptor activity Source: BHF-UCL
- regulation of respiratory gaseous exchange by nervous system process Source: Ensembl
- retrograde trans-synaptic signaling by trans-synaptic protein complex Source: Ensembl
- rhythmic process Source: UniProtKB-KW
- synapse assembly Source: UniProtKB
- synaptic membrane adhesion Source: Ensembl
- synaptic vesicle clustering Source: BHF-UCL
- synaptic vesicle endocytosis Source: GO_Central
- synaptic vesicle targeting Source: UniProtKB
- synaptic vesicle transport Source: Ensembl
- terminal button organization Source: BHF-UCL
Keywordsi
Biological process | Biological rhythms, Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | Q8N2Q7 |
Reactomei | R-HSA-6794361, Neurexins and neuroligins |
Protein family/group databases
ESTHERi | human-NLGN1, Neuroligin |
MEROPSi | S09.994 |
TCDBi | 8.A.117.1.2, the neuroligin (nlg) family |
Names & Taxonomyi
Protein namesi | Recommended name: Neuroligin-1 |
Gene namesi | Name:NLGN1 Synonyms:KIAA1070 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14291, NLGN1 |
MIMi | 600568, gene |
neXtProti | NX_Q8N2Q7 |
VEuPathDBi | HostDB:ENSG00000169760.17 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
- synaptic cell membrane By similarity
Extracellular region or secreted
- synaptic cleft By similarity
Other locations
- postsynaptic density By similarity
Note: Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1.By similarity
Extracellular region or secreted
- synaptic cleft Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: BHF-UCL
Plasma Membrane
- external side of plasma membrane Source: Ensembl
- integral component of plasma membrane Source: UniProtKB
- integral component of postsynaptic membrane Source: BHF-UCL
- integral component of postsynaptic specialization membrane Source: Ensembl
- NMDA selective glutamate receptor complex Source: Ensembl
- plasma membrane Source: BHF-UCL
Other locations
- asymmetric, glutamatergic, excitatory synapse Source: ARUK-UCL
- cell surface Source: BHF-UCL
- dendrite Source: BHF-UCL
- dendritic shaft Source: Ensembl
- dendritic spine Source: BHF-UCL
- excitatory synapse Source: ARUK-UCL
- filopodium tip Source: BHF-UCL
- postsynapse Source: ARUK-UCL
- postsynaptic density Source: BHF-UCL
- presynapse Source: GOC
- receptor complex Source: BHF-UCL
- spanning component of membrane Source: ARUK-UCL
- synapse Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 46 – 717 | ExtracellularSequence analysisAdd BLAST | 672 | |
Transmembranei | 718 – 738 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 739 – 863 | CytoplasmicSequence analysisAdd BLAST | 125 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Secreted, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 22871 |
MalaCardsi | NLGN1 |
OpenTargetsi | ENSG00000169760 |
PharmGKBi | PA31647 |
Miscellaneous databases
Pharosi | Q8N2Q7, Tbio |
Genetic variation databases
BioMutai | NLGN1 |
DMDMi | 31076822 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 45 | Sequence analysisAdd BLAST | 45 | |
ChainiPRO_0000008640 | 46 – 863 | Neuroligin-1Add BLAST | 818 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 109 | N-linked (GlcNAc...) (complex) asparagineBy similarity | 1 | |
Disulfide bondi | 117 ↔ 153 | By similarity | ||
Glycosylationi | 323 | N-linked (GlcNAc...) (complex) asparagineBy similarity | 1 | |
Disulfide bondi | 362 ↔ 373 | By similarity | ||
Glycosylationi | 363 | N-linked (GlcNAc...) (complex) asparagineBy similarity | 1 | |
Disulfide bondi | 532 ↔ 566 | By similarity | ||
Glycosylationi | 567 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Glycosylationi | 703 | O-linked (GalNAc...) serineBy similarity | 1 | |
Glycosylationi | 706 | O-linked (GalNAc...) serineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q8N2Q7 |
MassIVEi | Q8N2Q7 |
PaxDbi | Q8N2Q7 |
PeptideAtlasi | Q8N2Q7 |
PRIDEi | Q8N2Q7 |
ProteomicsDBi | 71726 [Q8N2Q7-2] |
PTM databases
GlyGeni | Q8N2Q7, 6 sites |
iPTMneti | Q8N2Q7 |
PhosphoSitePlusi | Q8N2Q7 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000169760, Expressed in stomach and 179 other tissues |
ExpressionAtlasi | Q8N2Q7, baseline and differential |
Genevisiblei | Q8N2Q7, HS |
Organism-specific databases
HPAi | ENSG00000169760, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts with NRXN1, NRXN2 and NRXN3.
Interacts with NLGN3.
Interacts with AIP1 and PDZRN3 (By similarity).
Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3).
Interacts with GOPC.
By similarity2 PublicationsGO - Molecular functioni
- cell adhesion molecule binding Source: BHF-UCL
- identical protein binding Source: BHF-UCL
- neurexin family protein binding Source: UniProtKB
- PDZ domain binding Source: UniProtKB
- scaffold protein binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 116538, 14 interactors |
ComplexPortali | CPX-4101, NLGN1(+SSA+SSB) - NRXN1-beta(-SS4) complex CPX-909, NLGN1(-SSA-SSB) - NRXN1-beta(-SS4) complex |
CORUMi | Q8N2Q7 |
IntActi | Q8N2Q7, 8 interactors |
MINTi | Q8N2Q7 |
STRINGi | 9606.ENSP00000392500 |
Miscellaneous databases
RNActi | Q8N2Q7, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8N2Q7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1516, Eukaryota |
GeneTreei | ENSGT00940000155789 |
InParanoidi | Q8N2Q7 |
OMAi | NACPPDY |
OrthoDBi | 754103at2759 |
PhylomeDBi | Q8N2Q7 |
TreeFami | TF326187 |
Family and domain databases
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002018, CarbesteraseB IPR019819, Carboxylesterase_B_CS IPR000460, Nlgn IPR030022, NLGN1 |
PANTHERi | PTHR43903:SF2, PTHR43903:SF2, 1 hit |
Pfami | View protein in Pfam PF00135, COesterase, 1 hit |
PRINTSi | PR01090, NEUROLIGIN |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00941, CARBOXYLESTERASE_B_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALPRCTWPN YVWRAVMACL VHRGLGAPLT LCMLGCLLQA GHVLSQKLDD
60 70 80 90 100
VDPLVATNFG KIRGIKKELN NEILGPVIQF LGVPYAAPPT GERRFQPPEP
110 120 130 140 150
PSPWSDIRNA TQFAPVCPQN IIDGRLPEVM LPVWFTNNLD VVSSYVQDQS
160 170 180 190 200
EDCLYLNIYV PTEDVKRISK ECARKPGKKI CRKGGPLTKK QTDDLGDNDG
210 220 230 240 250
AEDEDIRDSG GPKPVMVYIH GGSYMEGTGN LYDGSVLASY GNVIVITVNY
260 270 280 290 300
RLGVLGFLST GDQAAKGNYG LLDLIQALRW TSENIGFFGG DPLRITVFGS
310 320 330 340 350
GAGGSCVNLL TLSHYSEGNR WSNSTKGLFQ RAIAQSGTAL SSWAVSFQPA
360 370 380 390 400
KYARMLATKV GCNVSDTVEL VECLQKKPYK ELVDQDIQPA RYHIAFGPVI
410 420 430 440 450
DGDVIPDDPQ ILMEQGEFLN YDIMLGVNQG EGLKFVENIV DSDDGISASD
460 470 480 490 500
FDFAVSNFVD NLYGYPEGKD VLRETIKFMY TDWADRHNPE TRRKTLLALF
510 520 530 540 550
TDHQWVAPAV ATADLHSNFG SPTYFYAFYH HCQTDQVPAW ADAAHGDEVP
560 570 580 590 600
YVLGIPMIGP TELFPCNFSK NDVMLSAVVM TYWTNFAKTG DPNQPVPQDT
610 620 630 640 650
KFIHTKPNRF EEVAWTRYSQ KDQLYLHIGL KPRVKEHYRA NKVNLWLELV
660 670 680 690 700
PHLHNLNDIS QYTSTTTKVP STDITFRPTR KNSVPVTSAF PTAKQDDPKQ
710 720 730 740 750
QPSPFSVDQR DYSTELSVTI AVGASLLFLN ILAFAALYYK KDKRRHDVHR
760 770 780 790 800
RCSPQRTTTN DLTHAQEEEI MSLQMKHTDL DHECESIHPH EVVLRTACPP
810 820 830 840 850
DYTLAMRRSP DDVPLMTPNT ITMIPNTIPG IQPLHTFNTF TGGQNNTLPH
860
PHPHPHSHST TRV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KQ19 | J3KQ19_HUMAN | Neuroligin-1 | NLGN1 | 608 | Annotation score: | ||
C9J4D3 | C9J4D3_HUMAN | Neuroligin-1 | NLGN1 | 367 | Annotation score: | ||
C9JWG7 | C9JWG7_HUMAN | Neuroligin-1 | NLGN1 | 13 | Annotation score: | ||
A0A1D5RMP7 | A0A1D5RMP7_HUMAN | Neuroligin-1 | NLGN1 | 10 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 734 | F → L in BAC11039 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_060231 | 165 – 204 | Missing in isoform 2. Add BLAST | 40 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ489206 mRNA Translation: ADB12633.1 AB028993 mRNA Translation: BAA83022.2 Different initiation. AC008082 Genomic DNA No translation available. AC008120 Genomic DNA No translation available. AC092923 Genomic DNA No translation available. AC092967 Genomic DNA No translation available. AC110871 Genomic DNA No translation available. AC131158 Genomic DNA No translation available. BC032555 mRNA Translation: AAH32555.1 AK074522 mRNA Translation: BAC11039.1 Different initiation. |
CCDSi | CCDS3222.1 [Q8N2Q7-2] |
RefSeqi | NP_055747.1, NM_014932.3 [Q8N2Q7-2] XP_005247291.1, XM_005247234.2 XP_005247292.1, XM_005247235.3 XP_016861387.1, XM_017005898.1 XP_016861388.1, XM_017005899.1 XP_016861389.1, XM_017005900.1 [Q8N2Q7-2] XP_016861390.1, XM_017005901.1 |
Genome annotation databases
Ensembli | ENST00000361589; ENSP00000354541; ENSG00000169760 [Q8N2Q7-2] ENST00000457714; ENSP00000392500; ENSG00000169760 [Q8N2Q7-2] |
GeneIDi | 22871 |
KEGGi | hsa:22871 |
UCSCi | uc003fio.3, human [Q8N2Q7-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ489206 mRNA Translation: ADB12633.1 AB028993 mRNA Translation: BAA83022.2 Different initiation. AC008082 Genomic DNA No translation available. AC008120 Genomic DNA No translation available. AC092923 Genomic DNA No translation available. AC092967 Genomic DNA No translation available. AC110871 Genomic DNA No translation available. AC131158 Genomic DNA No translation available. BC032555 mRNA Translation: AAH32555.1 AK074522 mRNA Translation: BAC11039.1 Different initiation. |
CCDSi | CCDS3222.1 [Q8N2Q7-2] |
RefSeqi | NP_055747.1, NM_014932.3 [Q8N2Q7-2] XP_005247291.1, XM_005247234.2 XP_005247292.1, XM_005247235.3 XP_016861387.1, XM_017005898.1 XP_016861388.1, XM_017005899.1 XP_016861389.1, XM_017005900.1 [Q8N2Q7-2] XP_016861390.1, XM_017005901.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5OJ6 | X-ray | 3.30 | A | 51-656 | [»] | |
5OJK | X-ray | 2.55 | A/B | 51-654 | [»] | |
SMRi | Q8N2Q7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116538, 14 interactors |
ComplexPortali | CPX-4101, NLGN1(+SSA+SSB) - NRXN1-beta(-SS4) complex CPX-909, NLGN1(-SSA-SSB) - NRXN1-beta(-SS4) complex |
CORUMi | Q8N2Q7 |
IntActi | Q8N2Q7, 8 interactors |
MINTi | Q8N2Q7 |
STRINGi | 9606.ENSP00000392500 |
Protein family/group databases
ESTHERi | human-NLGN1, Neuroligin |
MEROPSi | S09.994 |
TCDBi | 8.A.117.1.2, the neuroligin (nlg) family |
PTM databases
GlyGeni | Q8N2Q7, 6 sites |
iPTMneti | Q8N2Q7 |
PhosphoSitePlusi | Q8N2Q7 |
Genetic variation databases
BioMutai | NLGN1 |
DMDMi | 31076822 |
Proteomic databases
jPOSTi | Q8N2Q7 |
MassIVEi | Q8N2Q7 |
PaxDbi | Q8N2Q7 |
PeptideAtlasi | Q8N2Q7 |
PRIDEi | Q8N2Q7 |
ProteomicsDBi | 71726 [Q8N2Q7-2] |
Protocols and materials databases
Antibodypediai | 1513, 284 antibodies |
DNASUi | 22871 |
Genome annotation databases
Ensembli | ENST00000361589; ENSP00000354541; ENSG00000169760 [Q8N2Q7-2] ENST00000457714; ENSP00000392500; ENSG00000169760 [Q8N2Q7-2] |
GeneIDi | 22871 |
KEGGi | hsa:22871 |
UCSCi | uc003fio.3, human [Q8N2Q7-3] |
Organism-specific databases
CTDi | 22871 |
DisGeNETi | 22871 |
GeneCardsi | NLGN1 |
HGNCi | HGNC:14291, NLGN1 |
HPAi | ENSG00000169760, Tissue enhanced (brain) |
MalaCardsi | NLGN1 |
MIMi | 600568, gene |
neXtProti | NX_Q8N2Q7 |
OpenTargetsi | ENSG00000169760 |
PharmGKBi | PA31647 |
VEuPathDBi | HostDB:ENSG00000169760.17 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1516, Eukaryota |
GeneTreei | ENSGT00940000155789 |
InParanoidi | Q8N2Q7 |
OMAi | NACPPDY |
OrthoDBi | 754103at2759 |
PhylomeDBi | Q8N2Q7 |
TreeFami | TF326187 |
Enzyme and pathway databases
PathwayCommonsi | Q8N2Q7 |
Reactomei | R-HSA-6794361, Neurexins and neuroligins |
Miscellaneous databases
BioGRID-ORCSi | 22871, 2 hits in 876 CRISPR screens |
ChiTaRSi | NLGN1, human |
GeneWikii | NLGN1 |
GenomeRNAii | 22871 |
Pharosi | Q8N2Q7, Tbio |
PROi | PR:Q8N2Q7 |
RNActi | Q8N2Q7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169760, Expressed in stomach and 179 other tissues |
ExpressionAtlasi | Q8N2Q7, baseline and differential |
Genevisiblei | Q8N2Q7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002018, CarbesteraseB IPR019819, Carboxylesterase_B_CS IPR000460, Nlgn IPR030022, NLGN1 |
PANTHERi | PTHR43903:SF2, PTHR43903:SF2, 1 hit |
Pfami | View protein in Pfam PF00135, COesterase, 1 hit |
PRINTSi | PR01090, NEUROLIGIN |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00941, CARBOXYLESTERASE_B_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NLGN1_HUMAN | |
Accessioni | Q8N2Q7Primary (citable) accession number: Q8N2Q7 Secondary accession number(s): D2X2H5, Q9UPT2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 23, 2003 |
Last sequence update: | July 31, 2019 | |
Last modified: | February 10, 2021 | |
This is version 175 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families