UniProtKB - Q8N2Q7 (NLGN1_HUMAN)

BLAST

>sp|Q8N2Q7|NLGN1_HUMAN Neuroligin-1 OS=Homo sapiens OX=9606 GN=NLGN1 PE=1 SV=2
MALPRCTWPNYVWRAVMACLVHRGLGAPLTLCMLGCLLQAGHVLSQKLDDVDPLVATNFG
KIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQN
IIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKRDEATLNPPD
TDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQ
AAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSN
STKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKELV
DQDIQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSD
DGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDH
QWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTEL
FPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQ
LYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDITFRPTRKNS
VPVTSAFPTAKQDDPKQQPSPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDK
RRHDVHRRCSPQRTTTNDLTHAQEEEIMSLQMKHTDLDHECESIHPHEVVLRTACPPDYT
LAMRRSPDDVPLMTPNTITMIPNTIPGIQPLHTFNTFTGGQNNTLPHPHPHPHSHSTTRV

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History
Entry version 156 (07 Nov 2018)
Sequence version 2 (23 May 2003)
Previous versions | rss
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Protein

Neuroligin-1

Gene

NLGN1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep.By similarity

GO - Molecular functionⁱ

amyloid-beta binding
Source: ARUK-UCL
Non-traceable author statementⁱ
- 21838267
cell adhesion molecule binding Source: BHF-UCL
neurexin family protein binding Source: UniProtKB
PDZ domain binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17474715
protein dimerization activity Source: BHF-UCL
scaffold protein binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 17474715
signaling receptor activity Source: BHF-UCL

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

AMPA glutamate receptor clustering Source: BHF-UCL
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
cellular response to calcium ion Source: ARUK-UCL
cytoskeletal matrix organization at active zone Source: BHF-UCL
establishment of protein localization Source: BHF-UCL
excitatory synapse assembly
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 26440732
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
long-term synaptic potentiation Source: Ensembl
modulation of chemical synaptic transmission Source: ARUK-UCL
negative regulation of dendritic spine morphogenesis
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 23143522
nervous system development Source: UniProtKB
neurexin clustering involved in presynaptic membrane assembly Source: BHF-UCL
neuronal signal transduction
Source: BHF-UCL
Traceable author statementⁱ
- 15797875
neuron cell-cell adhesion Source: BHF-UCL
neuron projection arborization Source: ARUK-UCL
neuron projection development
Source: CACAO
Inferred from direct assayⁱ
- 22750515
NMDA glutamate receptor clustering Source: BHF-UCL
positive regulation of circadian sleep/wake cycle, wakefulness Source: UniProtKB
positive regulation of dendritic spine development
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 23143522
positive regulation of excitatory postsynaptic potential
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 23143522
positive regulation of filopodium assembly Source: BHF-UCL
positive regulation of intracellular signal transduction Source: BHF-UCL
positive regulation of presynaptic active zone assembly Source: Ensembl
positive regulation of protein localization to synapse Source: Ensembl
positive regulation of ruffle assembly Source: BHF-UCL
positive regulation of synapse assembly
Source: MGI
Inferred from direct assayⁱ
- 24613359
positive regulation of synaptic transmission, GABAergic Source: BHF-UCL
positive regulation of synaptic transmission, glutamatergic Source: BHF-UCL
positive regulation of synaptic vesicle clustering Source: Ensembl
positive regulation of synaptic vesicle endocytosis Source: BHF-UCL
positive regulation of synaptic vesicle exocytosis Source: BHF-UCL
postsynaptic density protein 95 clustering Source: BHF-UCL
postsynaptic membrane assembly Source: BHF-UCL
postsynaptic specialization assembly Source: Ensembl
presynapse assembly
Source: ARUK-UCL
Traceable author statementⁱ
- 21838267
presynaptic membrane assembly Source: BHF-UCL
protein heterotetramerization Source: Ensembl
protein homooligomerization Source: BHF-UCL
protein localization to synapse Source: BHF-UCL
protein targeting Source: UniProtKB
receptor localization to synapse Source: BHF-UCL
regulation of AMPA receptor activity Source: BHF-UCL
regulation of neuron differentiation Source: UniProtKB
regulation of NMDA receptor activity
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 23143522
regulation of respiratory gaseous exchange by neurological system process Source: Ensembl
retrograde trans-synaptic signaling by trans-synaptic protein complex Source: Ensembl
rhythmic process Source: UniProtKB-KW
synapse assembly Source: UniProtKB
synaptic membrane adhesion Source: Ensembl
synaptic vesicle clustering Source: BHF-UCL
synaptic vesicle endocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
synaptic vesicle targeting Source: UniProtKB
terminal button organization Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Biological rhythms, Cell adhesion

Biological process

Biological rhythms, Cell adhesion

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6794361 Neurexins and neuroligins

Reactomeⁱ

R-HSA-6794361 Neurexins and neuroligins

Protein family/group databases

ESTHERⁱ	human-NLGN1 Neuroligin
MEROPS protease database More...MEROPSⁱ	S09.994

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neuroligin-1
Gene namesⁱ	Name:NLGN1 Synonyms:KIAA1070
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000169760.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14291 NLGN1
MIMⁱ	600568 gene
neXtProtⁱ	NX_Q8N2Q7

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	46 – 694	ExtracellularSequence analysisAdd BLAST	649
Transmembraneⁱ	695 – 715	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	716 – 840	CytoplasmicSequence analysisAdd BLAST	125

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	22871
Open Targets More...OpenTargetsⁱ	ENSG00000169760
PharmGKBⁱ	PA31647

Polymorphism and mutation databases

DMDMⁱ	31076822

DMDMⁱ

31076822

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 45	Sequence analysisAdd BLAST		45
ChainⁱPRO_0000008640	46 – 840	Neuroligin-1Add BLAST		795

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	109	N-linked (GlcNAc...) (complex) asparagineBy similarity	1
Disulfide bondⁱ	117 ↔ 153	By similarity
Glycosylationⁱ	300	N-linked (GlcNAc...) (complex) asparagineBy similarity	1
Disulfide bondⁱ	339 ↔ 350	By similarity
Glycosylationⁱ	340	N-linked (GlcNAc...) (complex) asparagineBy similarity	1
Disulfide bondⁱ	509 ↔ 543	By similarity
Glycosylationⁱ	544	N-linked (GlcNAc...) asparagineBy similarity	1
Glycosylationⁱ	680	O-linked (GalNAc...) serineBy similarity	1
Glycosylationⁱ	683	O-linked (GalNAc...) serineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	Q8N2Q7
PaxDbⁱ	Q8N2Q7
PeptideAtlas More...PeptideAtlasⁱ	Q8N2Q7
PRIDEⁱ	Q8N2Q7
ProteomicsDBⁱ	71725 71726 [Q8N2Q7-2]

PTM databases

iPTMnetⁱ	Q8N2Q7
PhosphoSitePlusⁱ	Q8N2Q7

Expressionⁱ

Tissue specificityⁱ

Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000169760 Expressed in 159 organ(s), highest expression level in stomach
CleanExⁱ	HS_NLGN1
ExpressionAtlasⁱ	Q8N2Q7 baseline and differential
Genevisibleⁱ	Q8N2Q7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA006572 HPA006680

HPAⁱ

HPA006572
HPA006680

Interactionⁱ

Subunit structureⁱ

GO - Molecular functionⁱ

cell adhesion molecule binding Source: BHF-UCL
neurexin family protein binding Source: UniProtKB
PDZ domain binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17474715
protein dimerization activity Source: BHF-UCL
scaffold protein binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 17474715

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116538, 12 interactors
IntActⁱ	Q8N2Q7, 5 interactors
Molecular INTeraction database More...MINTⁱ	Q8N2Q7
STRINGⁱ	9606.ENSP00000354541

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	54 – 57	Combined sources	4
Beta strandⁱ	60 – 63	Combined sources	4
Beta strandⁱ	65 – 67	Combined sources	3
Beta strandⁱ	72 – 74	Combined sources	3
Beta strandⁱ	77 – 84	Combined sources	8
Helixⁱ	91 – 93	Combined sources	3
Beta strandⁱ	105 – 109	Combined sources	5
Beta strandⁱ	122 – 125	Combined sources	4
Turnⁱ	128 – 130	Combined sources	3
Helixⁱ	133 – 137	Combined sources	5
Helixⁱ	139 – 144	Combined sources	6
Beta strandⁱ	147 – 149	Combined sources	3
Beta strandⁱ	155 – 160	Combined sources	6
Beta strandⁱ	190 – 195	Combined sources	6
Beta strandⁱ	199 – 203	Combined sources	5
Helixⁱ	206 – 208	Combined sources	3
Helixⁱ	212 – 218	Combined sources	7
Beta strandⁱ	220 – 225	Combined sources	6
Helixⁱ	230 – 234	Combined sources	5
Beta strandⁱ	238 – 241	Combined sources	4
Helixⁱ	246 – 261	Combined sources	16
Helixⁱ	262 – 265	Combined sources	4
Beta strandⁱ	267 – 277	Combined sources	11
Helixⁱ	279 – 288	Combined sources	10
Helixⁱ	291 – 293	Combined sources	3
Beta strandⁱ	304 – 313	Combined sources	10
Beta strandⁱ	316 – 318	Combined sources	3
Helixⁱ	326 – 336	Combined sources	11
Helixⁱ	344 – 351	Combined sources	8
Helixⁱ	356 – 360	Combined sources	5
Beta strandⁱ	372 – 374	Combined sources	3
Beta strandⁱ	379 – 382	Combined sources	4
Helixⁱ	386 – 391	Combined sources	6
Beta strandⁱ	399 – 405	Combined sources	7
Turnⁱ	406 – 409	Combined sources	4
Helixⁱ	410 – 413	Combined sources	4
Turnⁱ	414 – 416	Combined sources	3
Beta strandⁱ	419 – 421	Combined sources	3
Helixⁱ	425 – 439	Combined sources	15
Beta strandⁱ	443 – 445	Combined sources	3
Helixⁱ	446 – 456	Combined sources	11
Helixⁱ	460 – 462	Combined sources	3
Helixⁱ	466 – 481	Combined sources	16
Helixⁱ	483 – 495	Combined sources	13
Beta strandⁱ	500 – 505	Combined sources	6
Turnⁱ	522 – 525	Combined sources	4
Helixⁱ	526 – 530	Combined sources	5
Helixⁱ	532 – 535	Combined sources	4
Beta strandⁱ	539 – 541	Combined sources	3
Helixⁱ	547 – 566	Combined sources	20
Beta strandⁱ	571 – 573	Combined sources	3
Turnⁱ	586 – 589	Combined sources	4
Turnⁱ	597 – 599	Combined sources	3
Beta strandⁱ	601 – 608	Combined sources	8
Beta strandⁱ	610 – 614	Combined sources	5
Helixⁱ	617 – 624	Combined sources	8
Helixⁱ	626 – 629	Combined sources	4
Turnⁱ	630 – 632	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8N2Q7
SMRⁱ	Q8N2Q7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the type-B carboxylesterase/lipase family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1516 Eukaryota COG2272 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118946
HOGENOMⁱ	HOG000231424
HOVERGENⁱ	HBG008839
InParanoidⁱ	Q8N2Q7
KEGG Orthology (KO) More...KOⁱ	K07378
OMAⁱ	ANDFDYA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CHW
PhylomeDBⁱ	Q8N2Q7
TreeFamⁱ	TF326187

Family and domain databases

Gene3Dⁱ	3.40.50.1820, 1 hit
InterProⁱ	View protein in InterPro IPR029058 AB_hydrolase IPR002018 CarbesteraseB IPR019819 Carboxylesterase_B_CS IPR000460 Nlgn IPR030022 NLGN1
PANTHERⁱ	PTHR43903:SF2 PTHR43903:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00135 COesterase, 1 hit
PRINTSⁱ	PR01090 NEUROLIGIN
SUPFAMⁱ	SSF53474 SSF53474, 1 hit
PROSITEⁱ	View protein in PROSITE PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8N2Q7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPRCTWPN YVWRAVMACL VHRGLGAPLT LCMLGCLLQA GHVLSQKLDD 
        60         70         80         90        100
VDPLVATNFG KIRGIKKELN NEILGPVIQF LGVPYAAPPT GERRFQPPEP 
       110        120        130        140        150
PSPWSDIRNA TQFAPVCPQN IIDGRLPEVM LPVWFTNNLD VVSSYVQDQS 
       160        170        180        190        200
EDCLYLNIYV PTEDGPLTKK RDEATLNPPD TDIRDSGGPK PVMVYIHGGS 
       210        220        230        240        250
YMEGTGNLYD GSVLASYGNV IVITVNYRLG VLGFLSTGDQ AAKGNYGLLD 
       260        270        280        290        300
LIQALRWTSE NIGFFGGDPL RITVFGSGAG GSCVNLLTLS HYSEGNRWSN 
       310        320        330        340        350
STKGLFQRAI AQSGTALSSW AVSFQPAKYA RMLATKVGCN VSDTVELVEC 
       360        370        380        390        400
LQKKPYKELV DQDIQPARYH IAFGPVIDGD VIPDDPQILM EQGEFLNYDI 
       410        420        430        440        450
MLGVNQGEGL KFVENIVDSD DGISASDFDF AVSNFVDNLY GYPEGKDVLR 
       460        470        480        490        500
ETIKFMYTDW ADRHNPETRR KTLLALFTDH QWVAPAVATA DLHSNFGSPT 
       510        520        530        540        550
YFYAFYHHCQ TDQVPAWADA AHGDEVPYVL GIPMIGPTEL FPCNFSKNDV 
       560        570        580        590        600
MLSAVVMTYW TNFAKTGDPN QPVPQDTKFI HTKPNRFEEV AWTRYSQKDQ 
       610        620        630        640        650
LYLHIGLKPR VKEHYRANKV NLWLELVPHL HNLNDISQYT STTTKVPSTD 
       660        670        680        690        700
ITFRPTRKNS VPVTSAFPTA KQDDPKQQPS PFSVDQRDYS TELSVTIAVG 
       710        720        730        740        750
ASLLFLNILA FAALYYKKDK RRHDVHRRCS PQRTTTNDLT HAQEEEIMSL 
       760        770        780        790        800
QMKHTDLDHE CESIHPHEVV LRTACPPDYT LAMRRSPDDV PLMTPNTITM 
       810        820        830        840
IPNTIPGIQP LHTFNTFTGG QNNTLPHPHP HPHSHSTTRV

Note: No experimental confirmation available.

Length:840

Mass (Da):93,835

Last modified:May 23, 2003 - v2

Checksum:ⁱA3FB21716F62DE29

Isoform 2 (identifier: Q8N2Q7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
165-181: Missing.

« Hide

        10         20         30         40         50
MALPRCTWPN YVWRAVMACL VHRGLGAPLT LCMLGCLLQA GHVLSQKLDD 
        60         70         80         90        100
VDPLVATNFG KIRGIKKELN NEILGPVIQF LGVPYAAPPT GERRFQPPEP 
       110        120        130        140        150
PSPWSDIRNA TQFAPVCPQN IIDGRLPEVM LPVWFTNNLD VVSSYVQDQS 
       160        170        180        190        200
EDCLYLNIYV PTEDDIRDSG GPKPVMVYIH GGSYMEGTGN LYDGSVLASY 
       210        220        230        240        250
GNVIVITVNY RLGVLGFLST GDQAAKGNYG LLDLIQALRW TSENIGFFGG 
       260        270        280        290        300
DPLRITVFGS GAGGSCVNLL TLSHYSEGNR WSNSTKGLFQ RAIAQSGTAL 
       310        320        330        340        350
SSWAVSFQPA KYARMLATKV GCNVSDTVEL VECLQKKPYK ELVDQDIQPA 
       360        370        380        390        400
RYHIAFGPVI DGDVIPDDPQ ILMEQGEFLN YDIMLGVNQG EGLKFVENIV 
       410        420        430        440        450
DSDDGISASD FDFAVSNFVD NLYGYPEGKD VLRETIKFMY TDWADRHNPE 
       460        470        480        490        500
TRRKTLLALF TDHQWVAPAV ATADLHSNFG SPTYFYAFYH HCQTDQVPAW 
       510        520        530        540        550
ADAAHGDEVP YVLGIPMIGP TELFPCNFSK NDVMLSAVVM TYWTNFAKTG 
       560        570        580        590        600
DPNQPVPQDT KFIHTKPNRF EEVAWTRYSQ KDQLYLHIGL KPRVKEHYRA 
       610        620        630        640        650
NKVNLWLELV PHLHNLNDIS QYTSTTTKVP STDITFRPTR KNSVPVTSAF 
       660        670        680        690        700
PTAKQDDPKQ QPSPFSVDQR DYSTELSVTI AVGASLLFLN ILAFAALYYK 
       710        720        730        740        750
KDKRRHDVHR RCSPQRTTTN DLTHAQEEEI MSLQMKHTDL DHECESIHPH 
       760        770        780        790        800
EVVLRTACPP DYTLAMRRSP DDVPLMTPNT ITMIPNTIPG IQPLHTFNTF 
       810        820 
TGGQNNTLPH PHPHPHSHST TRV

Show »

Length:823

Mass (Da):92,000

Checksum:ⁱEA93E8F9801CB8A8

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3KQ19	J3KQ19_HUMAN	Neuroligin-1 Neuroligin-1	NLGN1	608	Annotation score:
C9J4D3	C9J4D3_HUMAN	Neuroligin-1 Neuroligin-1	NLGN1	367	Annotation score:
C9JWG7	C9JWG7_HUMAN	Neuroligin-1 Neuroligin-1	NLGN1	13	Annotation score:
A0A1D5RMP7	A0A1D5RMP7_HUMAN	Neuroligin-1 Neuroligin-1	NLGN1	10	Annotation score:

Sequence cautionⁱ

The sequence BAA83022 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence BAC11039 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	711	F → L in BAC11039 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_007527	165 – 181	Missing in isoform 2. 2 PublicationsAdd BLAST		17

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB028993 mRNA Translation: BAA83022.2 Different initiation. AC008082 Genomic DNA No translation available. AC008120 Genomic DNA No translation available. AC092923 Genomic DNA No translation available. AC092967 Genomic DNA No translation available. AC110871 Genomic DNA No translation available. AC131158 Genomic DNA No translation available. BC032555 mRNA Translation: AAH32555.1 AK074522 mRNA Translation: BAC11039.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3222.1 [Q8N2Q7-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_055747.1, NM_014932.3 [Q8N2Q7-2] XP_005247291.1, XM_005247234.2 [Q8N2Q7-2] XP_005247292.1, XM_005247235.3 [Q8N2Q7-2] XP_016861387.1, XM_017005898.1 [Q8N2Q7-2] XP_016861388.1, XM_017005899.1 [Q8N2Q7-2] XP_016861389.1, XM_017005900.1 [Q8N2Q7-2] XP_016861390.1, XM_017005901.1 [Q8N2Q7-2]
UniGeneⁱ	Hs.478289 Hs.732502

Genome annotation databases

Ensemblⁱ	ENST00000361589; ENSP00000354541; ENSG00000169760 [Q8N2Q7-2] ENST00000457714; ENSP00000392500; ENSG00000169760 [Q8N2Q7-2]
GeneIDⁱ	22871
KEGGⁱ	hsa:22871
UCSC genome browser More...UCSCⁱ	uc003fio.3 human [Q8N2Q7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N2Q7	Neuroligin-1	)	RAT		843	UniRef90_Q62765
Neuroligin-1	)	MOUSE		843
neuroligin-1 isoform X1		DELLE		843
neuroligin-1 isoform X1		NEOSC		843
Neuroligin-1 (Fragment)		NEOVI		835
+185
Q8N2Q7-2	Isoform 4 of Neuroligin-1		RAT		823	UniRef90_Q62765-4
neuroligin-1 isoform X1		URSMA		828
neuroligin-1 isoform X2		DELLE		823
Neuroligin-1		MACMU		823
Neuroligin-1		CALJA		823
+194

Protein	Similar proteins		Species	Score	Length	Source
Q8N2Q7	Neuroligin-1	)	RAT		843	UniRef50_Q62765
Neuroligin-1	)	MOUSE		843
Neuroligin-4, X-linked	)	HUMAN		816
neuroligin-1 isoform X2		MESAU		843
neuroligin-1		PHYCD		843
+1288

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB028993 mRNA Translation: BAA83022.2 Different initiation. AC008082 Genomic DNA No translation available. AC008120 Genomic DNA No translation available. AC092923 Genomic DNA No translation available. AC092967 Genomic DNA No translation available. AC110871 Genomic DNA No translation available. AC131158 Genomic DNA No translation available. BC032555 mRNA Translation: AAH32555.1 AK074522 mRNA Translation: BAC11039.1 Different initiation.
CCDSⁱ	CCDS3222.1 [Q8N2Q7-2]
RefSeqⁱ	NP_055747.1, NM_014932.3 [Q8N2Q7-2] XP_005247291.1, XM_005247234.2 [Q8N2Q7-2] XP_005247292.1, XM_005247235.3 [Q8N2Q7-2] XP_016861387.1, XM_017005898.1 [Q8N2Q7-2] XP_016861388.1, XM_017005899.1 [Q8N2Q7-2] XP_016861389.1, XM_017005900.1 [Q8N2Q7-2] XP_016861390.1, XM_017005901.1 [Q8N2Q7-2]
UniGeneⁱ	Hs.478289 Hs.732502

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5OJ6	X-ray	3.30	A	46-635	[»]
	5OJK	X-ray	2.55	A/B	46-635	[»]
ProteinModelPortalⁱ	Q8N2Q7
SMRⁱ	Q8N2Q7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116538, 12 interactors
IntActⁱ	Q8N2Q7, 5 interactors
MINTⁱ	Q8N2Q7
STRINGⁱ	9606.ENSP00000354541

Protein family/group databases

ESTHERⁱ	human-NLGN1 Neuroligin
MEROPSⁱ	S09.994

PTM databases

iPTMnetⁱ	Q8N2Q7
PhosphoSitePlusⁱ	Q8N2Q7

Polymorphism and mutation databases

DMDMⁱ	31076822

DMDMⁱ

31076822

Proteomic databases

EPDⁱ	Q8N2Q7
PaxDbⁱ	Q8N2Q7
PeptideAtlasⁱ	Q8N2Q7
PRIDEⁱ	Q8N2Q7
ProteomicsDBⁱ	71725 71726 [Q8N2Q7-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	22871
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000361589; ENSP00000354541; ENSG00000169760 [Q8N2Q7-2] ENST00000457714; ENSP00000392500; ENSG00000169760 [Q8N2Q7-2]
GeneIDⁱ	22871
KEGGⁱ	hsa:22871
UCSCⁱ	uc003fio.3 human [Q8N2Q7-1]

Organism-specific databases

CTDⁱ	22871
DisGeNETⁱ	22871
EuPathDBⁱ	HostDB:ENSG00000169760.17
GeneCardsⁱ	NLGN1
HGNCⁱ	HGNC:14291 NLGN1
HPAⁱ	HPA006572 HPA006680
MIMⁱ	600568 gene
neXtProtⁱ	NX_Q8N2Q7
OpenTargetsⁱ	ENSG00000169760
PharmGKBⁱ	PA31647
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1516 Eukaryota COG2272 LUCA
GeneTreeⁱ	ENSGT00760000118946
HOGENOMⁱ	HOG000231424
HOVERGENⁱ	HBG008839
InParanoidⁱ	Q8N2Q7
KOⁱ	K07378
OMAⁱ	ANDFDYA
OrthoDBⁱ	EOG091G0CHW
PhylomeDBⁱ	Q8N2Q7
TreeFamⁱ	TF326187

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6794361 Neurexins and neuroligins

Reactomeⁱ

R-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSⁱ	NLGN1 human
GeneWikiⁱ	NLGN1
GenomeRNAiⁱ	22871
Protein Ontology More...PROⁱ	PR:Q8N2Q7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000169760 Expressed in 159 organ(s), highest expression level in stomach
CleanExⁱ	HS_NLGN1
ExpressionAtlasⁱ	Q8N2Q7 baseline and differential
Genevisibleⁱ	Q8N2Q7 HS

Family and domain databases

Gene3Dⁱ	3.40.50.1820, 1 hit
InterProⁱ	View protein in InterPro IPR029058 AB_hydrolase IPR002018 CarbesteraseB IPR019819 Carboxylesterase_B_CS IPR000460 Nlgn IPR030022 NLGN1
PANTHERⁱ	PTHR43903:SF2 PTHR43903:SF2, 1 hit
Pfamⁱ	View protein in Pfam PF00135 COesterase, 1 hit
PRINTSⁱ	PR01090 NEUROLIGIN
SUPFAMⁱ	SSF53474 SSF53474, 1 hit
PROSITEⁱ	View protein in PROSITE PS00941 CARBOXYLESTERASE_B_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NLGN1_HUMAN
Accessionⁱ	Q8N2Q7Primary (citable) accession number: Q8N2Q7 Secondary accession number(s): Q9UPT2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 23, 2003
	Last sequence update:	May 23, 2003
	Last modified:	November 7, 2018
	This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q8N2Q7 (NLGN1_HUMAN)

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Neuroligin-1

NLGN1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Keywords - PTMi

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Gene expression databases

Organism-specific databases

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Protein-protein interaction databases

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Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Phylogenomic databases

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Experimental Info

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Genome annotation databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ