Neuroligin-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• amyloid-beta binding Source: ARUK-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "The synaptic protein neuroligin-1 interacts with the amyloid beta-peptide. Is there a role in Alzheimer's disease?"
    Dinamarca M.C., Weinstein D., Monasterio O., Inestrosa N.C.
    Biochemistry 50:8127-8137(2011) [PubMed] [Europe PMC] [Abstract]
• cell adhesion molecule binding Source: BHF-UCL
• identical protein binding Source: BHF-UCL
• neurexin family protein binding Source: UniProtKB
• PDZ domain binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95."
    Saro D., Li T., Rupasinghe C., Paredes A., Caspers N., Spaller M.R.
    Biochemistry 46:6340-6352(2007) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: Ensembl
• scaffold protein binding Source: BHF-UCLInferred from direct assayⁱ
  • "A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95."
    Saro D., Li T., Rupasinghe C., Paredes A., Caspers N., Spaller M.R.
    Biochemistry 46:6340-6352(2007) [PubMed] [Europe PMC] [Abstract]
• signaling receptor activity Source: BHF-UCL

GO - Biological processⁱ

• AMPA glutamate receptor clustering Source: BHF-UCL
• calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
• cellular response to calcium ion Source: ARUK-UCL
• chemical synaptic transmission Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cytoskeletal matrix organization at active zone Source: BHF-UCL
• establishment of protein localization Source: BHF-UCL
• excitatory synapse assembly Source: ARUK-UCL <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "A truncating mutation in Alzheimer's disease inactivates neuroligin-1 synaptic function."
    Tristan-Clavijo E., Camacho-Garcia R.J., Robles-Lanuza E., Ruiz A., van der Zee J., Van Broeckhoven C., Hernandez I., Martinez-Mir A., Scholl F.G.
    Neurobiol Aging 36:3171-3175(2015) [PubMed] [Europe PMC] [Abstract]
• heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
• long-term synaptic potentiation Source: Ensembl
• modulation of chemical synaptic transmission Source: ARUK-UCL
• negative regulation of dendritic spine morphogenesis Source: BHF-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number."
    Kwon H.B., Kozorovitskiy Y., Oh W.J., Peixoto R.T., Akhtar N., Saulnier J.L., Gu C., Sabatini B.L.
    Nat Neurosci 15:1667-1674(2012) [PubMed] [Europe PMC] [Abstract]
• nervous system development Source: UniProtKB
• neurexin clustering involved in presynaptic membrane assembly Source: BHF-UCL
• neuronal signal transduction Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism."
    Chubykin A.A., Liu X., Comoletti D., Tsigelny I., Taylor P., Sudhof T.C.
    J Biol Chem 280:22365-22374(2005) [PubMed] [Europe PMC] [Abstract]
• neuron cell-cell adhesion Source: BHF-UCL
• neuron projection arborization Source: ARUK-UCL
• neuron projection development Source: CACAOInferred from direct assayⁱ
  • "Neuroligin-1 induces neurite outgrowth through interaction with neurexin-1beta and activation of fibroblast growth factor receptor-1."
    Gjorlund M.D., Nielsen J., Pankratova S., Li S., Korshunova I., Bock E., Berezin V.
    FASEB J 26:4174-4186(2012) [PubMed] [Europe PMC] [Abstract]
• NMDA glutamate receptor clustering Source: BHF-UCL
• positive regulation of circadian sleep/wake cycle, wakefulness Source: UniProtKB
• positive regulation of dendritic spine development Source: BHF-UCLInferred from genetic interactionⁱ
  • "Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number."
    Kwon H.B., Kozorovitskiy Y., Oh W.J., Peixoto R.T., Akhtar N., Saulnier J.L., Gu C., Sabatini B.L.
    Nat Neurosci 15:1667-1674(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of excitatory postsynaptic potential Source: BHF-UCLInferred from genetic interactionⁱ
  • "Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number."
    Kwon H.B., Kozorovitskiy Y., Oh W.J., Peixoto R.T., Akhtar N., Saulnier J.L., Gu C., Sabatini B.L.
    Nat Neurosci 15:1667-1674(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of filopodium assembly Source: BHF-UCL
• positive regulation of intracellular signal transduction Source: BHF-UCL
• positive regulation of presynaptic active zone assembly Source: Ensembl
• positive regulation of protein localization to synapse Source: Ensembl
• positive regulation of ruffle assembly Source: BHF-UCL
• positive regulation of synapse assembly Source: MGIInferred from direct assayⁱ
  • "Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins."
    Um J.W., Pramanik G., Ko J.S., Song M.Y., Lee D., Kim H., Park K.S., Sudhof T.C., Tabuchi K., Ko J.
    Cell Rep 6:1096-1109(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of synaptic transmission, GABAergic Source: BHF-UCL
• positive regulation of synaptic transmission, glutamatergic Source: BHF-UCL
• positive regulation of synaptic vesicle clustering Source: Ensembl
• positive regulation of synaptic vesicle endocytosis Source: BHF-UCL
• positive regulation of synaptic vesicle exocytosis Source: BHF-UCL
• postsynaptic density protein 95 clustering Source: BHF-UCL
• postsynaptic membrane assembly Source: BHF-UCL
• postsynaptic specialization assembly Source: Ensembl
• presynapse assembly Source: ARUK-UCLTraceable author statementⁱ
  • "The synaptic protein neuroligin-1 interacts with the amyloid beta-peptide. Is there a role in Alzheimer's disease?"
    Dinamarca M.C., Weinstein D., Monasterio O., Inestrosa N.C.
    Biochemistry 50:8127-8137(2011) [PubMed] [Europe PMC] [Abstract]
• presynaptic membrane assembly Source: BHF-UCL
• protein localization to synapse Source: BHF-UCL
• protein targeting Source: UniProtKB
• receptor localization to synapse Source: BHF-UCL
• regulation of AMPA receptor activity Source: BHF-UCL
• regulation of neuron differentiation Source: UniProtKB
• regulation of NMDA receptor activity Source: BHF-UCLInferred from genetic interactionⁱ
  • "Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number."
    Kwon H.B., Kozorovitskiy Y., Oh W.J., Peixoto R.T., Akhtar N., Saulnier J.L., Gu C., Sabatini B.L.
    Nat Neurosci 15:1667-1674(2012) [PubMed] [Europe PMC] [Abstract]
• regulation of respiratory gaseous exchange by nervous system process Source: Ensembl
• retrograde trans-synaptic signaling by trans-synaptic protein complex Source: Ensembl
• rhythmic process Source: UniProtKB-KW
• synapse assembly Source: UniProtKB
• synaptic membrane adhesion Source: Ensembl
• synaptic vesicle clustering Source: BHF-UCL
• synaptic vesicle endocytosis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• synaptic vesicle targeting Source: UniProtKB
• synaptic vesicle transport Source: Ensembl
• terminal button organization Source: BHF-UCL

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• cell adhesion molecule binding Source: BHF-UCL
• identical protein binding Source: BHF-UCL
• neurexin family protein binding Source: UniProtKB
• PDZ domain binding Source: UniProtKBInferred from direct assayⁱ
  • "A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95."
    Saro D., Li T., Rupasinghe C., Paredes A., Caspers N., Spaller M.R.
    Biochemistry 46:6340-6352(2007) [PubMed] [Europe PMC] [Abstract]
• scaffold protein binding Source: BHF-UCLInferred from direct assayⁱ
  • "A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95."
    Saro D., Li T., Rupasinghe C., Paredes A., Caspers N., Spaller M.R.
    Biochemistry 46:6340-6352(2007) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MALPRCTWPN YVWRAVMACL VHRGLGAPLT LCMLGCLLQA GHVLSQKLDD 
        60         70         80         90        100
VDPLVATNFG KIRGIKKELN NEILGPVIQF LGVPYAAPPT GERRFQPPEP 
       110        120        130        140        150
PSPWSDIRNA TQFAPVCPQN IIDGRLPEVM LPVWFTNNLD VVSSYVQDQS 
       160        170        180        190        200
EDCLYLNIYV PTEDVKRISK ECARKPGKKI CRKGGPLTKK QTDDLGDNDG 
       210        220        230        240        250
AEDEDIRDSG GPKPVMVYIH GGSYMEGTGN LYDGSVLASY GNVIVITVNY 
       260        270        280        290        300
RLGVLGFLST GDQAAKGNYG LLDLIQALRW TSENIGFFGG DPLRITVFGS 
       310        320        330        340        350
GAGGSCVNLL TLSHYSEGNR WSNSTKGLFQ RAIAQSGTAL SSWAVSFQPA 
       360        370        380        390        400
KYARMLATKV GCNVSDTVEL VECLQKKPYK ELVDQDIQPA RYHIAFGPVI 
       410        420        430        440        450
DGDVIPDDPQ ILMEQGEFLN YDIMLGVNQG EGLKFVENIV DSDDGISASD 
       460        470        480        490        500
FDFAVSNFVD NLYGYPEGKD VLRETIKFMY TDWADRHNPE TRRKTLLALF 
       510        520        530        540        550
TDHQWVAPAV ATADLHSNFG SPTYFYAFYH HCQTDQVPAW ADAAHGDEVP 
       560        570        580        590        600
YVLGIPMIGP TELFPCNFSK NDVMLSAVVM TYWTNFAKTG DPNQPVPQDT 
       610        620        630        640        650
KFIHTKPNRF EEVAWTRYSQ KDQLYLHIGL KPRVKEHYRA NKVNLWLELV 
       660        670        680        690        700
PHLHNLNDIS QYTSTTTKVP STDITFRPTR KNSVPVTSAF PTAKQDDPKQ 
       710        720        730        740        750
QPSPFSVDQR DYSTELSVTI AVGASLLFLN ILAFAALYYK KDKRRHDVHR 
       760        770        780        790        800
RCSPQRTTTN DLTHAQEEEI MSLQMKHTDL DHECESIHPH EVVLRTACPP 
       810        820        830        840        850
DYTLAMRRSP DDVPLMTPNT ITMIPNTIPG IQPLHTFNTF TGGQNNTLPH 
       860 
PHPHPHSHST TRV                                         

        10         20         30         40         50
MALPRCTWPN YVWRAVMACL VHRGLGAPLT LCMLGCLLQA GHVLSQKLDD 
        60         70         80         90        100
VDPLVATNFG KIRGIKKELN NEILGPVIQF LGVPYAAPPT GERRFQPPEP 
       110        120        130        140        150
PSPWSDIRNA TQFAPVCPQN IIDGRLPEVM LPVWFTNNLD VVSSYVQDQS 
       160        170        180        190        200
EDCLYLNIYV PTEDDIRDSG GPKPVMVYIH GGSYMEGTGN LYDGSVLASY 
       210        220        230        240        250
GNVIVITVNY RLGVLGFLST GDQAAKGNYG LLDLIQALRW TSENIGFFGG 
       260        270        280        290        300
DPLRITVFGS GAGGSCVNLL TLSHYSEGNR WSNSTKGLFQ RAIAQSGTAL 
       310        320        330        340        350
SSWAVSFQPA KYARMLATKV GCNVSDTVEL VECLQKKPYK ELVDQDIQPA 
       360        370        380        390        400
RYHIAFGPVI DGDVIPDDPQ ILMEQGEFLN YDIMLGVNQG EGLKFVENIV 
       410        420        430        440        450
DSDDGISASD FDFAVSNFVD NLYGYPEGKD VLRETIKFMY TDWADRHNPE 
       460        470        480        490        500
TRRKTLLALF TDHQWVAPAV ATADLHSNFG SPTYFYAFYH HCQTDQVPAW 
       510        520        530        540        550
ADAAHGDEVP YVLGIPMIGP TELFPCNFSK NDVMLSAVVM TYWTNFAKTG 
       560        570        580        590        600
DPNQPVPQDT KFIHTKPNRF EEVAWTRYSQ KDQLYLHIGL KPRVKEHYRA 
       610        620        630        640        650
NKVNLWLELV PHLHNLNDIS QYTSTTTKVP STDITFRPTR KNSVPVTSAF 
       660        670        680        690        700
PTAKQDDPKQ QPSPFSVDQR DYSTELSVTI AVGASLLFLN ILAFAALYYK 
       710        720        730        740        750
KDKRRHDVHR RCSPQRTTTN DLTHAQEEEI MSLQMKHTDL DHECESIHPH 
       760        770        780        790        800
EVVLRTACPP DYTLAMRRSP DDVPLMTPNT ITMIPNTIPG IQPLHTFNTF 
       810        820 
TGGQNNTLPH PHPHPHSHST TRV                              

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 3
   Human chromosome 3: entries, gene names and cross-references to MIM
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
4. SIMILARITY comments
   Index of protein domains and families