Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuroligin-1

Gene

NLGN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processBiological rhythms, Cell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Protein family/group databases

ESTHERihuman-NLGN1 Neuroligin
MEROPSiS09.994

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroligin-1
Gene namesi
Name:NLGN1
Synonyms:KIAA1070
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000169760.17
HGNCiHGNC:14291 NLGN1
MIMi600568 gene
neXtProtiNX_Q8N2Q7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini46 – 694ExtracellularSequence analysisAdd BLAST649
Transmembranei695 – 715HelicalSequence analysisAdd BLAST21
Topological domaini716 – 840CytoplasmicSequence analysisAdd BLAST125

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi22871
OpenTargetsiENSG00000169760
PharmGKBiPA31647

Polymorphism and mutation databases

DMDMi31076822

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 45Sequence analysisAdd BLAST45
ChainiPRO_000000864046 – 840Neuroligin-1Add BLAST795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109N-linked (GlcNAc...) (complex) asparagineBy similarity1
Disulfide bondi117 ↔ 153By similarity
Glycosylationi300N-linked (GlcNAc...) (complex) asparagineBy similarity1
Disulfide bondi339 ↔ 350By similarity
Glycosylationi340N-linked (GlcNAc...) (complex) asparagineBy similarity1
Disulfide bondi509 ↔ 543By similarity
Glycosylationi544N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi680O-linked (GalNAc...) serineBy similarity1
Glycosylationi683O-linked (GalNAc...) serineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8N2Q7
PaxDbiQ8N2Q7
PeptideAtlasiQ8N2Q7
PRIDEiQ8N2Q7
ProteomicsDBi71725
71726 [Q8N2Q7-2]

PTM databases

iPTMnetiQ8N2Q7
PhosphoSitePlusiQ8N2Q7

Expressioni

Tissue specificityi

Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.2 Publications

Gene expression databases

BgeeiENSG00000169760 Expressed in 159 organ(s), highest expression level in stomach
CleanExiHS_NLGN1
ExpressionAtlasiQ8N2Q7 baseline and differential
GenevisibleiQ8N2Q7 HS

Organism-specific databases

HPAiHPA006572
HPA006680

Interactioni

Subunit structurei

Interacts with NRXN1, NRXN2 and NRXN3. Interacts with NLGN3. Interacts with AIP1 and PDZRN3 (By similarity). Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with GOPC.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116538, 12 interactors
IntActiQ8N2Q7, 5 interactors
MINTiQ8N2Q7
STRINGi9606.ENSP00000354541

Structurei

Secondary structure

1840
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8N2Q7
SMRiQ8N2Q7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00760000118946
HOGENOMiHOG000231424
HOVERGENiHBG008839
InParanoidiQ8N2Q7
KOiK07378
OMAiANDFDYA
OrthoDBiEOG091G0CHW
PhylomeDBiQ8N2Q7
TreeFamiTF326187

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS
IPR000460 Nlgn
IPR030022 NLGN1
PANTHERiPTHR43903:SF2 PTHR43903:SF2, 1 hit
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
PRINTSiPR01090 NEUROLIGIN
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N2Q7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALPRCTWPN YVWRAVMACL VHRGLGAPLT LCMLGCLLQA GHVLSQKLDD
60 70 80 90 100
VDPLVATNFG KIRGIKKELN NEILGPVIQF LGVPYAAPPT GERRFQPPEP
110 120 130 140 150
PSPWSDIRNA TQFAPVCPQN IIDGRLPEVM LPVWFTNNLD VVSSYVQDQS
160 170 180 190 200
EDCLYLNIYV PTEDGPLTKK RDEATLNPPD TDIRDSGGPK PVMVYIHGGS
210 220 230 240 250
YMEGTGNLYD GSVLASYGNV IVITVNYRLG VLGFLSTGDQ AAKGNYGLLD
260 270 280 290 300
LIQALRWTSE NIGFFGGDPL RITVFGSGAG GSCVNLLTLS HYSEGNRWSN
310 320 330 340 350
STKGLFQRAI AQSGTALSSW AVSFQPAKYA RMLATKVGCN VSDTVELVEC
360 370 380 390 400
LQKKPYKELV DQDIQPARYH IAFGPVIDGD VIPDDPQILM EQGEFLNYDI
410 420 430 440 450
MLGVNQGEGL KFVENIVDSD DGISASDFDF AVSNFVDNLY GYPEGKDVLR
460 470 480 490 500
ETIKFMYTDW ADRHNPETRR KTLLALFTDH QWVAPAVATA DLHSNFGSPT
510 520 530 540 550
YFYAFYHHCQ TDQVPAWADA AHGDEVPYVL GIPMIGPTEL FPCNFSKNDV
560 570 580 590 600
MLSAVVMTYW TNFAKTGDPN QPVPQDTKFI HTKPNRFEEV AWTRYSQKDQ
610 620 630 640 650
LYLHIGLKPR VKEHYRANKV NLWLELVPHL HNLNDISQYT STTTKVPSTD
660 670 680 690 700
ITFRPTRKNS VPVTSAFPTA KQDDPKQQPS PFSVDQRDYS TELSVTIAVG
710 720 730 740 750
ASLLFLNILA FAALYYKKDK RRHDVHRRCS PQRTTTNDLT HAQEEEIMSL
760 770 780 790 800
QMKHTDLDHE CESIHPHEVV LRTACPPDYT LAMRRSPDDV PLMTPNTITM
810 820 830 840
IPNTIPGIQP LHTFNTFTGG QNNTLPHPHP HPHSHSTTRV
Note: No experimental confirmation available.
Length:840
Mass (Da):93,835
Last modified:May 23, 2003 - v2
Checksum:iA3FB21716F62DE29
GO
Isoform 2 (identifier: Q8N2Q7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-181: Missing.

Show »
Length:823
Mass (Da):92,000
Checksum:iEA93E8F9801CB8A8
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQ19J3KQ19_HUMAN
Neuroligin-1
NLGN1
608Annotation score:
C9J4D3C9J4D3_HUMAN
Neuroligin-1
NLGN1
367Annotation score:
C9JWG7C9JWG7_HUMAN
Neuroligin-1
NLGN1
13Annotation score:
A0A1D5RMP7A0A1D5RMP7_HUMAN
Neuroligin-1
NLGN1
10Annotation score:

Sequence cautioni

The sequence BAA83022 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC11039 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti711F → L in BAC11039 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007527165 – 181Missing in isoform 2. 2 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028993 mRNA Translation: BAA83022.2 Different initiation.
AC008082 Genomic DNA No translation available.
AC008120 Genomic DNA No translation available.
AC092923 Genomic DNA No translation available.
AC092967 Genomic DNA No translation available.
AC110871 Genomic DNA No translation available.
AC131158 Genomic DNA No translation available.
BC032555 mRNA Translation: AAH32555.1
AK074522 mRNA Translation: BAC11039.1 Different initiation.
CCDSiCCDS3222.1 [Q8N2Q7-2]
RefSeqiNP_055747.1, NM_014932.3 [Q8N2Q7-2]
XP_005247291.1, XM_005247234.2 [Q8N2Q7-2]
XP_005247292.1, XM_005247235.3 [Q8N2Q7-2]
XP_016861387.1, XM_017005898.1 [Q8N2Q7-2]
XP_016861388.1, XM_017005899.1 [Q8N2Q7-2]
XP_016861389.1, XM_017005900.1 [Q8N2Q7-2]
XP_016861390.1, XM_017005901.1 [Q8N2Q7-2]
UniGeneiHs.478289
Hs.732502

Genome annotation databases

EnsembliENST00000361589; ENSP00000354541; ENSG00000169760 [Q8N2Q7-2]
ENST00000457714; ENSP00000392500; ENSG00000169760 [Q8N2Q7-2]
GeneIDi22871
KEGGihsa:22871
UCSCiuc003fio.3 human [Q8N2Q7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028993 mRNA Translation: BAA83022.2 Different initiation.
AC008082 Genomic DNA No translation available.
AC008120 Genomic DNA No translation available.
AC092923 Genomic DNA No translation available.
AC092967 Genomic DNA No translation available.
AC110871 Genomic DNA No translation available.
AC131158 Genomic DNA No translation available.
BC032555 mRNA Translation: AAH32555.1
AK074522 mRNA Translation: BAC11039.1 Different initiation.
CCDSiCCDS3222.1 [Q8N2Q7-2]
RefSeqiNP_055747.1, NM_014932.3 [Q8N2Q7-2]
XP_005247291.1, XM_005247234.2 [Q8N2Q7-2]
XP_005247292.1, XM_005247235.3 [Q8N2Q7-2]
XP_016861387.1, XM_017005898.1 [Q8N2Q7-2]
XP_016861388.1, XM_017005899.1 [Q8N2Q7-2]
XP_016861389.1, XM_017005900.1 [Q8N2Q7-2]
XP_016861390.1, XM_017005901.1 [Q8N2Q7-2]
UniGeneiHs.478289
Hs.732502

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5OJ6X-ray3.30A46-635[»]
5OJKX-ray2.55A/B46-635[»]
ProteinModelPortaliQ8N2Q7
SMRiQ8N2Q7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116538, 12 interactors
IntActiQ8N2Q7, 5 interactors
MINTiQ8N2Q7
STRINGi9606.ENSP00000354541

Protein family/group databases

ESTHERihuman-NLGN1 Neuroligin
MEROPSiS09.994

PTM databases

iPTMnetiQ8N2Q7
PhosphoSitePlusiQ8N2Q7

Polymorphism and mutation databases

DMDMi31076822

Proteomic databases

EPDiQ8N2Q7
PaxDbiQ8N2Q7
PeptideAtlasiQ8N2Q7
PRIDEiQ8N2Q7
ProteomicsDBi71725
71726 [Q8N2Q7-2]

Protocols and materials databases

DNASUi22871
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361589; ENSP00000354541; ENSG00000169760 [Q8N2Q7-2]
ENST00000457714; ENSP00000392500; ENSG00000169760 [Q8N2Q7-2]
GeneIDi22871
KEGGihsa:22871
UCSCiuc003fio.3 human [Q8N2Q7-1]

Organism-specific databases

CTDi22871
DisGeNETi22871
EuPathDBiHostDB:ENSG00000169760.17
GeneCardsiNLGN1
HGNCiHGNC:14291 NLGN1
HPAiHPA006572
HPA006680
MIMi600568 gene
neXtProtiNX_Q8N2Q7
OpenTargetsiENSG00000169760
PharmGKBiPA31647
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00760000118946
HOGENOMiHOG000231424
HOVERGENiHBG008839
InParanoidiQ8N2Q7
KOiK07378
OMAiANDFDYA
OrthoDBiEOG091G0CHW
PhylomeDBiQ8N2Q7
TreeFamiTF326187

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSiNLGN1 human
GeneWikiiNLGN1
GenomeRNAii22871
PROiPR:Q8N2Q7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169760 Expressed in 159 organ(s), highest expression level in stomach
CleanExiHS_NLGN1
ExpressionAtlasiQ8N2Q7 baseline and differential
GenevisibleiQ8N2Q7 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS
IPR000460 Nlgn
IPR030022 NLGN1
PANTHERiPTHR43903:SF2 PTHR43903:SF2, 1 hit
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
PRINTSiPR01090 NEUROLIGIN
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNLGN1_HUMAN
AccessioniPrimary (citable) accession number: Q8N2Q7
Secondary accession number(s): Q9UPT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: May 23, 2003
Last modified: November 7, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again