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UniProtKB - Q8N2Q7 (NLGN1_HUMAN)

Entry version 179 (23 Feb 2022)
Sequence version 3 (31 Jul 2019)
Previous versions | rss
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Protein

Neuroligin-1

Gene

NLGN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (By similarity).

The protein is involved in nervous system development.

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBiological rhythms, Cell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N2Q7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6794361, Neurexins and neuroligins

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8N2Q7

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8N2Q7

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...ESTHERi		human-NLGN1, Neuroligin

MEROPS protease database

More...MEROPSi		S09.994

Transport Classification Database

More...TCDBi		8.A.117.1.2, the neuroligin (nlg) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuroligin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NLGN1
Synonyms:KIAA1070
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14291, NLGN1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600568, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N2Q7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000169760

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini46 – 717ExtracellularSequence analysisAdd BLAST672
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei718 – 738HelicalSequence analysisAdd BLAST21
Topological domaini739 – 863CytoplasmicSequence analysisAdd BLAST125

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Secreted, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Autism 20 (AUTS20)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. The transmission pattern of AUTS20 is consistent with autosomal dominant inheritance.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08419525 – 863Missing in AUTS20; unknown pathological significance. 1 PublicationAdd BLAST839
Natural variantiVAR_08419689P → L in AUTS20; risk factor for disease development; decreased function in dendritic spine formation; decreased protein abundance; does not localize to the plasma membrane but is retained in the endoplasmic reticulum. 1 Publication1
Natural variantiVAR_08419790T → I in AUTS20; unknown pathological significance; does not affect dendritic spine formation; no effect on protein abundance; no effect on subcellular localization. 1 Publication1
Natural variantiVAR_084198309L → P in AUTS20; risk factor for disease development; decreased function in dendritic spine formation; decreased protein abundance; does not localize to the plasma membrane but is retained in the endoplasmic reticulum. 1 Publication1
Natural variantiVAR_084199337G → E in AUTS20; risk factor for disease development; decreased function in dendritic spine formation; decreased protein abundance; does not localize to the plasma membrane but is retained in the endoplasmic reticulum. 1 Publication1
Natural variantiVAR_084201835H → Y in AUTS20; risk factor for disease development; decreased function in dendritic spine formation; decreased protein abundance; does not affect subcellular location. 1 Publication1

Keywords - Diseasei

Autism, Autism spectrum disorder, Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		22871

MalaCards human disease database

More...MalaCardsi		NLGN1
MIMi618830, phenotype

Open Targets

More...OpenTargetsi		ENSG00000169760

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31647

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N2Q7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NLGN1

Domain mapping of disease mutations (DMDM)

More...DMDMi		31076822

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 45Sequence analysisAdd BLAST45
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000864046 – 863Neuroligin-1Add BLAST818

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi109N-linked (GlcNAc...) (complex) asparagineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi117 ↔ 153By similarity
Glycosylationi323N-linked (GlcNAc...) (complex) asparagineBy similarity1
Disulfide bondi362 ↔ 373By similarity
Glycosylationi363N-linked (GlcNAc...) (complex) asparagineBy similarity1
Disulfide bondi532 ↔ 566By similarity
Glycosylationi567N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi703O-linked (GalNAc...) serineBy similarity1
Glycosylationi706O-linked (GalNAc...) serineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N2Q7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N2Q7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N2Q7

PeptideAtlas

More...PeptideAtlasi		Q8N2Q7

PRoteomics IDEntifications database

More...PRIDEi		Q8N2Q7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71726 [Q8N2Q7-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8N2Q7, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N2Q7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N2Q7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the blood vessel walls (at protein level). Highly expressed in brain through prenatal stages, and at lower levels in pancreas islet beta cells.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000169760, Expressed in stomach and 180 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N2Q7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N2Q7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000169760, Tissue enhanced (brain, retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NRXN1, NRXN2 and NRXN3.

Interacts with NLGN3.

Interacts with AIP1 and PDZRN3 (By similarity).

Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3).

Interacts with GOPC.

By similarity2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116538, 19 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-4101, NLGN1(+SSA+SSB) - NRXN1-beta(-SS4) complex
CPX-909, NLGN1(-SSA-SSB) - NRXN1-beta(-SS4) complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8N2Q7

Protein interaction database and analysis system

More...IntActi		Q8N2Q7, 8 interactors

Molecular INTeraction database

More...MINTi		Q8N2Q7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000392500

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N2Q7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1863
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N2Q7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni183 – 212DisorderedSequence analysisAdd BLAST30
Regioni670 – 708DisorderedSequence analysisAdd BLAST39
Regioni842 – 863DisorderedSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1516, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155789

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N2Q7

Identification of Orthologs from Complete Genome Data

More...OMAi		HDMVLRT

Database of Orthologous Groups

More...OrthoDBi		754103at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N2Q7

TreeFam database of animal gene trees

More...TreeFami		TF326187

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029058, AB_hydrolase
IPR002018, CarbesteraseB
IPR019819, Carboxylesterase_B_CS
IPR000460, Nlgn
IPR030022, NLGN1

The PANTHER Classification System

More...PANTHERi		PTHR43903:SF2, PTHR43903:SF2, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00135, COesterase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01090, NEUROLIGIN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53474, SSF53474, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00941, CARBOXYLESTERASE_B_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N2Q7-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALPRCTWPN YVWRAVMACL VHRGLGAPLT LCMLGCLLQA GHVLSQKLDD 
        60         70         80         90        100
VDPLVATNFG KIRGIKKELN NEILGPVIQF LGVPYAAPPT GERRFQPPEP 
       110        120        130        140        150
PSPWSDIRNA TQFAPVCPQN IIDGRLPEVM LPVWFTNNLD VVSSYVQDQS 
       160        170        180        190        200
EDCLYLNIYV PTEDVKRISK ECARKPGKKI CRKGGPLTKK QTDDLGDNDG 
       210        220        230        240        250
AEDEDIRDSG GPKPVMVYIH GGSYMEGTGN LYDGSVLASY GNVIVITVNY 
       260        270        280        290        300
RLGVLGFLST GDQAAKGNYG LLDLIQALRW TSENIGFFGG DPLRITVFGS 
       310        320        330        340        350
GAGGSCVNLL TLSHYSEGNR WSNSTKGLFQ RAIAQSGTAL SSWAVSFQPA 
       360        370        380        390        400
KYARMLATKV GCNVSDTVEL VECLQKKPYK ELVDQDIQPA RYHIAFGPVI 
       410        420        430        440        450
DGDVIPDDPQ ILMEQGEFLN YDIMLGVNQG EGLKFVENIV DSDDGISASD 
       460        470        480        490        500
FDFAVSNFVD NLYGYPEGKD VLRETIKFMY TDWADRHNPE TRRKTLLALF 
       510        520        530        540        550
TDHQWVAPAV ATADLHSNFG SPTYFYAFYH HCQTDQVPAW ADAAHGDEVP 
       560        570        580        590        600
YVLGIPMIGP TELFPCNFSK NDVMLSAVVM TYWTNFAKTG DPNQPVPQDT 
       610        620        630        640        650
KFIHTKPNRF EEVAWTRYSQ KDQLYLHIGL KPRVKEHYRA NKVNLWLELV 
       660        670        680        690        700
PHLHNLNDIS QYTSTTTKVP STDITFRPTR KNSVPVTSAF PTAKQDDPKQ 
       710        720        730        740        750
QPSPFSVDQR DYSTELSVTI AVGASLLFLN ILAFAALYYK KDKRRHDVHR 
       760        770        780        790        800
RCSPQRTTTN DLTHAQEEEI MSLQMKHTDL DHECESIHPH EVVLRTACPP 
       810        820        830        840        850
DYTLAMRRSP DDVPLMTPNT ITMIPNTIPG IQPLHTFNTF TGGQNNTLPH 
       860 
PHPHPHSHST TRV
Length:863
Mass (Da):96,368
Last modified:July 31, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFDF64A8325A075E2
GO
Isoform 2 (identifier: Q8N2Q7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-204: Missing.

Show »
Length:823
Mass (Da):92,000
Checksum:iEA93E8F9801CB8A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQ19J3KQ19_HUMAN
Neuroligin-1
NLGN1
608Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J4D3C9J4D3_HUMAN
Neuroligin-1
NLGN1
367Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWG7C9JWG7_HUMAN
Neuroligin-1
NLGN1
13Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMP7A0A1D5RMP7_HUMAN
Neuroligin-1
NLGN1
10Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83022 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC11039 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti734F → L in BAC11039 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08419525 – 863Missing in AUTS20; unknown pathological significance. 1 PublicationAdd BLAST839
Natural variantiVAR_08419689P → L in AUTS20; risk factor for disease development; decreased function in dendritic spine formation; decreased protein abundance; does not localize to the plasma membrane but is retained in the endoplasmic reticulum. 1 Publication1
Natural variantiVAR_08419790T → I in AUTS20; unknown pathological significance; does not affect dendritic spine formation; no effect on protein abundance; no effect on subcellular localization. 1 Publication1
Natural variantiVAR_084198309L → P in AUTS20; risk factor for disease development; decreased function in dendritic spine formation; decreased protein abundance; does not localize to the plasma membrane but is retained in the endoplasmic reticulum. 1 Publication1
Natural variantiVAR_084199337G → E in AUTS20; risk factor for disease development; decreased function in dendritic spine formation; decreased protein abundance; does not localize to the plasma membrane but is retained in the endoplasmic reticulum. 1 Publication1
Natural variantiVAR_084200756R → H Likely benign variant; does not affect dendritic spine formation; does not affect localization to plasma membrane. 1 Publication1
Natural variantiVAR_084201835H → Y in AUTS20; risk factor for disease development; decreased function in dendritic spine formation; decreased protein abundance; does not affect subcellular location. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_060231165 – 204Missing in isoform 2. Add BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
GQ489206 mRNA Translation: ADB12633.1
AB028993 mRNA Translation: BAA83022.2 Different initiation.
AC008082 Genomic DNA No translation available.
AC008120 Genomic DNA No translation available.
AC092923 Genomic DNA No translation available.
AC092967 Genomic DNA No translation available.
AC110871 Genomic DNA No translation available.
AC131158 Genomic DNA No translation available.
BC032555 mRNA Translation: AAH32555.1
AK074522 mRNA Translation: BAC11039.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3222.1 [Q8N2Q7-2]

NCBI Reference Sequences

More...RefSeqi		NP_055747.1, NM_014932.3 [Q8N2Q7-2]
XP_005247291.1, XM_005247234.2
XP_005247292.1, XM_005247235.3
XP_016861387.1, XM_017005898.1
XP_016861388.1, XM_017005899.1
XP_016861389.1, XM_017005900.1 [Q8N2Q7-2]
XP_016861390.1, XM_017005901.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361589; ENSP00000354541; ENSG00000169760 [Q8N2Q7-2]
ENST00000457714; ENSP00000392500; ENSG00000169760 [Q8N2Q7-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		22871

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:22871

UCSC genome browser

More...UCSCi		uc003fio.3, human [Q8N2Q7-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ489206 mRNA Translation: ADB12633.1
AB028993 mRNA Translation: BAA83022.2 Different initiation.
AC008082 Genomic DNA No translation available.
AC008120 Genomic DNA No translation available.
AC092923 Genomic DNA No translation available.
AC092967 Genomic DNA No translation available.
AC110871 Genomic DNA No translation available.
AC131158 Genomic DNA No translation available.
BC032555 mRNA Translation: AAH32555.1
AK074522 mRNA Translation: BAC11039.1 Different initiation.
CCDSiCCDS3222.1 [Q8N2Q7-2]
RefSeqiNP_055747.1, NM_014932.3 [Q8N2Q7-2]
XP_005247291.1, XM_005247234.2
XP_005247292.1, XM_005247235.3
XP_016861387.1, XM_017005898.1
XP_016861388.1, XM_017005899.1
XP_016861389.1, XM_017005900.1 [Q8N2Q7-2]
XP_016861390.1, XM_017005901.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5OJ6X-ray3.30A51-656[»]
5OJKX-ray2.55A/B51-654[»]
SMRiQ8N2Q7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116538, 19 interactors
ComplexPortaliCPX-4101, NLGN1(+SSA+SSB) - NRXN1-beta(-SS4) complex
CPX-909, NLGN1(-SSA-SSB) - NRXN1-beta(-SS4) complex
CORUMiQ8N2Q7
IntActiQ8N2Q7, 8 interactors
MINTiQ8N2Q7
STRINGi9606.ENSP00000392500

Protein family/group databases

ESTHERihuman-NLGN1, Neuroligin
MEROPSiS09.994
TCDBi8.A.117.1.2, the neuroligin (nlg) family

PTM databases

GlyGeniQ8N2Q7, 6 sites
iPTMnetiQ8N2Q7
PhosphoSitePlusiQ8N2Q7

Genetic variation databases

BioMutaiNLGN1
DMDMi31076822

Proteomic databases

jPOSTiQ8N2Q7
MassIVEiQ8N2Q7
PaxDbiQ8N2Q7
PeptideAtlasiQ8N2Q7
PRIDEiQ8N2Q7
ProteomicsDBi71726 [Q8N2Q7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1513, 293 antibodies from 35 providers

The DNASU plasmid repository

More...DNASUi		22871

Genome annotation databases

EnsembliENST00000361589; ENSP00000354541; ENSG00000169760 [Q8N2Q7-2]
ENST00000457714; ENSP00000392500; ENSG00000169760 [Q8N2Q7-2]
GeneIDi22871
KEGGihsa:22871
UCSCiuc003fio.3, human [Q8N2Q7-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22871
DisGeNETi22871

GeneCards: human genes, protein and diseases

More...GeneCardsi		NLGN1
HGNCiHGNC:14291, NLGN1
HPAiENSG00000169760, Tissue enhanced (brain, retina)
MalaCardsiNLGN1
MIMi600568, gene
618830, phenotype
neXtProtiNX_Q8N2Q7
OpenTargetsiENSG00000169760
PharmGKBiPA31647
VEuPathDBiHostDB:ENSG00000169760

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1516, Eukaryota
GeneTreeiENSGT00940000155789
InParanoidiQ8N2Q7
OMAiHDMVLRT
OrthoDBi754103at2759
PhylomeDBiQ8N2Q7
TreeFamiTF326187

Enzyme and pathway databases

PathwayCommonsiQ8N2Q7
ReactomeiR-HSA-6794361, Neurexins and neuroligins
SignaLinkiQ8N2Q7
SIGNORiQ8N2Q7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		22871, 3 hits in 1040 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NLGN1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NLGN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		22871
PharosiQ8N2Q7, Tbio

Protein Ontology

More...PROi		PR:Q8N2Q7
RNActiQ8N2Q7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000169760, Expressed in stomach and 180 other tissues
ExpressionAtlasiQ8N2Q7, baseline and differential
GenevisibleiQ8N2Q7, HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR002018, CarbesteraseB
IPR019819, Carboxylesterase_B_CS
IPR000460, Nlgn
IPR030022, NLGN1
PANTHERiPTHR43903:SF2, PTHR43903:SF2, 1 hit
PfamiView protein in Pfam
PF00135, COesterase, 1 hit
PRINTSiPR01090, NEUROLIGIN
SUPFAMiSSF53474, SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00941, CARBOXYLESTERASE_B_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNLGN1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N2Q7
Secondary accession number(s): D2X2H5, Q9UPT2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: July 31, 2019
Last modified: February 23, 2022
This is version 179 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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