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Protein

Neuroligin-1

Gene

NLGN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBiological rhythms, Cell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6794361 Neurexins and neuroligins

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

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ESTHERi
human-NLGN1 Neuroligin

MEROPS protease database

More...
MEROPSi
S09.994

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuroligin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NLGN1
Synonyms:KIAA1070
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000169760.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14291 NLGN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600568 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N2Q7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini46 – 694ExtracellularSequence analysisAdd BLAST649
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei695 – 715HelicalSequence analysisAdd BLAST21
Topological domaini716 – 840CytoplasmicSequence analysisAdd BLAST125

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22871

Open Targets

More...
OpenTargetsi
ENSG00000169760

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31647

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NLGN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
31076822

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 45Sequence analysisAdd BLAST45
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000864046 – 840Neuroligin-1Add BLAST795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi109N-linked (GlcNAc...) (complex) asparagineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi117 ↔ 153By similarity
Glycosylationi300N-linked (GlcNAc...) (complex) asparagineBy similarity1
Disulfide bondi339 ↔ 350By similarity
Glycosylationi340N-linked (GlcNAc...) (complex) asparagineBy similarity1
Disulfide bondi509 ↔ 543By similarity
Glycosylationi544N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi680O-linked (GalNAc...) serineBy similarity1
Glycosylationi683O-linked (GalNAc...) serineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N2Q7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N2Q7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N2Q7

PeptideAtlas

More...
PeptideAtlasi
Q8N2Q7

PRoteomics IDEntifications database

More...
PRIDEi
Q8N2Q7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71725
71726 [Q8N2Q7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N2Q7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N2Q7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000169760 Expressed in 159 organ(s), highest expression level in stomach

CleanEx database of gene expression profiles

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CleanExi
HS_NLGN1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N2Q7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8N2Q7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006572
HPA006680

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NRXN1, NRXN2 and NRXN3. Interacts with NLGN3. Interacts with AIP1 and PDZRN3 (By similarity). Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with GOPC.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116538, 12 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q8N2Q7

Protein interaction database and analysis system

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IntActi
Q8N2Q7, 6 interactors

Molecular INTeraction database

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MINTi
Q8N2Q7

STRING: functional protein association networks

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STRINGi
9606.ENSP00000354541

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1840
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5OJ6X-ray3.30A46-635[»]
5OJKX-ray2.55A/B46-635[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8N2Q7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N2Q7

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1516 Eukaryota
COG2272 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155789

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231424

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG008839

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N2Q7

KEGG Orthology (KO)

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KOi
K07378

Identification of Orthologs from Complete Genome Data

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OMAi
ANDFDYA

Database of Orthologous Groups

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OrthoDBi
754103at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8N2Q7

TreeFam database of animal gene trees

More...
TreeFami
TF326187

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS
IPR000460 Nlgn
IPR030022 NLGN1

The PANTHER Classification System

More...
PANTHERi
PTHR43903:SF2 PTHR43903:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00135 COesterase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01090 NEUROLIGIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N2Q7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALPRCTWPN YVWRAVMACL VHRGLGAPLT LCMLGCLLQA GHVLSQKLDD
60 70 80 90 100
VDPLVATNFG KIRGIKKELN NEILGPVIQF LGVPYAAPPT GERRFQPPEP
110 120 130 140 150
PSPWSDIRNA TQFAPVCPQN IIDGRLPEVM LPVWFTNNLD VVSSYVQDQS
160 170 180 190 200
EDCLYLNIYV PTEDGPLTKK RDEATLNPPD TDIRDSGGPK PVMVYIHGGS
210 220 230 240 250
YMEGTGNLYD GSVLASYGNV IVITVNYRLG VLGFLSTGDQ AAKGNYGLLD
260 270 280 290 300
LIQALRWTSE NIGFFGGDPL RITVFGSGAG GSCVNLLTLS HYSEGNRWSN
310 320 330 340 350
STKGLFQRAI AQSGTALSSW AVSFQPAKYA RMLATKVGCN VSDTVELVEC
360 370 380 390 400
LQKKPYKELV DQDIQPARYH IAFGPVIDGD VIPDDPQILM EQGEFLNYDI
410 420 430 440 450
MLGVNQGEGL KFVENIVDSD DGISASDFDF AVSNFVDNLY GYPEGKDVLR
460 470 480 490 500
ETIKFMYTDW ADRHNPETRR KTLLALFTDH QWVAPAVATA DLHSNFGSPT
510 520 530 540 550
YFYAFYHHCQ TDQVPAWADA AHGDEVPYVL GIPMIGPTEL FPCNFSKNDV
560 570 580 590 600
MLSAVVMTYW TNFAKTGDPN QPVPQDTKFI HTKPNRFEEV AWTRYSQKDQ
610 620 630 640 650
LYLHIGLKPR VKEHYRANKV NLWLELVPHL HNLNDISQYT STTTKVPSTD
660 670 680 690 700
ITFRPTRKNS VPVTSAFPTA KQDDPKQQPS PFSVDQRDYS TELSVTIAVG
710 720 730 740 750
ASLLFLNILA FAALYYKKDK RRHDVHRRCS PQRTTTNDLT HAQEEEIMSL
760 770 780 790 800
QMKHTDLDHE CESIHPHEVV LRTACPPDYT LAMRRSPDDV PLMTPNTITM
810 820 830 840
IPNTIPGIQP LHTFNTFTGG QNNTLPHPHP HPHSHSTTRV
Note: No experimental confirmation available.
Length:840
Mass (Da):93,835
Last modified:May 23, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3FB21716F62DE29
GO
Isoform 2 (identifier: Q8N2Q7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-181: Missing.

Show »
Length:823
Mass (Da):92,000
Checksum:iEA93E8F9801CB8A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQ19J3KQ19_HUMAN
Neuroligin-1
NLGN1
608Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J4D3C9J4D3_HUMAN
Neuroligin-1
NLGN1
367Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWG7C9JWG7_HUMAN
Neuroligin-1
NLGN1
13Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMP7A0A1D5RMP7_HUMAN
Neuroligin-1
NLGN1
10Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83022 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC11039 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti711F → L in BAC11039 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007527165 – 181Missing in isoform 2. 2 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB028993 mRNA Translation: BAA83022.2 Different initiation.
AC008082 Genomic DNA No translation available.
AC008120 Genomic DNA No translation available.
AC092923 Genomic DNA No translation available.
AC092967 Genomic DNA No translation available.
AC110871 Genomic DNA No translation available.
AC131158 Genomic DNA No translation available.
BC032555 mRNA Translation: AAH32555.1
AK074522 mRNA Translation: BAC11039.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3222.1 [Q8N2Q7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_055747.1, NM_014932.3 [Q8N2Q7-2]
XP_005247291.1, XM_005247234.2 [Q8N2Q7-2]
XP_005247292.1, XM_005247235.3 [Q8N2Q7-2]
XP_016861387.1, XM_017005898.1 [Q8N2Q7-2]
XP_016861388.1, XM_017005899.1 [Q8N2Q7-2]
XP_016861389.1, XM_017005900.1 [Q8N2Q7-2]
XP_016861390.1, XM_017005901.1 [Q8N2Q7-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.478289
Hs.732502

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000361589; ENSP00000354541; ENSG00000169760 [Q8N2Q7-2]
ENST00000457714; ENSP00000392500; ENSG00000169760 [Q8N2Q7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22871

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:22871

UCSC genome browser

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UCSCi
uc003fio.3 human [Q8N2Q7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028993 mRNA Translation: BAA83022.2 Different initiation.
AC008082 Genomic DNA No translation available.
AC008120 Genomic DNA No translation available.
AC092923 Genomic DNA No translation available.
AC092967 Genomic DNA No translation available.
AC110871 Genomic DNA No translation available.
AC131158 Genomic DNA No translation available.
BC032555 mRNA Translation: AAH32555.1
AK074522 mRNA Translation: BAC11039.1 Different initiation.
CCDSiCCDS3222.1 [Q8N2Q7-2]
RefSeqiNP_055747.1, NM_014932.3 [Q8N2Q7-2]
XP_005247291.1, XM_005247234.2 [Q8N2Q7-2]
XP_005247292.1, XM_005247235.3 [Q8N2Q7-2]
XP_016861387.1, XM_017005898.1 [Q8N2Q7-2]
XP_016861388.1, XM_017005899.1 [Q8N2Q7-2]
XP_016861389.1, XM_017005900.1 [Q8N2Q7-2]
XP_016861390.1, XM_017005901.1 [Q8N2Q7-2]
UniGeneiHs.478289
Hs.732502

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5OJ6X-ray3.30A46-635[»]
5OJKX-ray2.55A/B46-635[»]
ProteinModelPortaliQ8N2Q7
SMRiQ8N2Q7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116538, 12 interactors
CORUMiQ8N2Q7
IntActiQ8N2Q7, 6 interactors
MINTiQ8N2Q7
STRINGi9606.ENSP00000354541

Protein family/group databases

ESTHERihuman-NLGN1 Neuroligin
MEROPSiS09.994

PTM databases

iPTMnetiQ8N2Q7
PhosphoSitePlusiQ8N2Q7

Polymorphism and mutation databases

BioMutaiNLGN1
DMDMi31076822

Proteomic databases

EPDiQ8N2Q7
jPOSTiQ8N2Q7
PaxDbiQ8N2Q7
PeptideAtlasiQ8N2Q7
PRIDEiQ8N2Q7
ProteomicsDBi71725
71726 [Q8N2Q7-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
22871
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361589; ENSP00000354541; ENSG00000169760 [Q8N2Q7-2]
ENST00000457714; ENSP00000392500; ENSG00000169760 [Q8N2Q7-2]
GeneIDi22871
KEGGihsa:22871
UCSCiuc003fio.3 human [Q8N2Q7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22871
DisGeNETi22871
EuPathDBiHostDB:ENSG00000169760.17

GeneCards: human genes, protein and diseases

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GeneCardsi
NLGN1
HGNCiHGNC:14291 NLGN1
HPAiHPA006572
HPA006680
MIMi600568 gene
neXtProtiNX_Q8N2Q7
OpenTargetsiENSG00000169760
PharmGKBiPA31647

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00940000155789
HOGENOMiHOG000231424
HOVERGENiHBG008839
InParanoidiQ8N2Q7
KOiK07378
OMAiANDFDYA
OrthoDBi754103at2759
PhylomeDBiQ8N2Q7
TreeFamiTF326187

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NLGN1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NLGN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22871

Protein Ontology

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PROi
PR:Q8N2Q7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169760 Expressed in 159 organ(s), highest expression level in stomach
CleanExiHS_NLGN1
ExpressionAtlasiQ8N2Q7 baseline and differential
GenevisibleiQ8N2Q7 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS
IPR000460 Nlgn
IPR030022 NLGN1
PANTHERiPTHR43903:SF2 PTHR43903:SF2, 1 hit
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
PRINTSiPR01090 NEUROLIGIN
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNLGN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N2Q7
Secondary accession number(s): Q9UPT2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: May 23, 2003
Last modified: January 16, 2019
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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