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Entry version 121 (03 Jul 2019)
Sequence version 4 (10 Aug 2010)
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Protein

Ankyrin repeat domain-containing protein 36B

Gene

ANKRD36B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 36B
Alternative name(s):
CLL-associated antigen KW-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:29333 ANKRD36B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N2N9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57730

Open Targets

More...
OpenTargetsi
ENSG00000196912

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANKRD36B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
302393831

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002439121 – 1353Ankyrin repeat domain-containing protein 36BAdd BLAST1353

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N2N9

PeptideAtlas

More...
PeptideAtlasi
Q8N2N9

PRoteomics IDEntifications database

More...
PRIDEi
Q8N2N9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71719
71720 [Q8N2N9-2]
71721 [Q8N2N9-3]
71722 [Q8N2N9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N2N9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N2N9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196912 Expressed in 95 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N2N9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N2N9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051757
HPA057661

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-2876112,EBI-10175124

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121750, 36 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N2N9, 27 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000481149

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N2N9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati19 – 48ANK 1Add BLAST30
Repeati52 – 81ANK 2Add BLAST30
Repeati85 – 114ANK 3Add BLAST30
Repeati118 – 147ANK 4Add BLAST30
Repeati151 – 180ANK 5Add BLAST30
Repeati184 – 213ANK 6Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili731 – 762Sequence analysisAdd BLAST32
Coiled coili821 – 908Sequence analysisAdd BLAST88
Coiled coili937 – 1055Sequence analysisAdd BLAST119
Coiled coili1119 – 1344Sequence analysisAdd BLAST226

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ANKRD36 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163264

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N2N9

Identification of Orthologs from Complete Genome Data

More...
OMAi
RESTPAY

Database of Orthologous Groups

More...
OrthoDBi
305292at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039497 CC144C-like_CC_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF14915 CCDC144C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N2N9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERLCSDGFA FPHYYIKPYH LKRIHRAVLR GNLEKLKYLL LTYYDANKRD
60 70 80 90 100
RKERTALHLA CATGQPEMVH LLVSRRCELN LCDREDRTPL IKAVQLRQEA
110 120 130 140 150
CATLLLQNGA DPNITDVFGR TALHYAVYNE DTSMIEKLLS HGTNIEECSK
160 170 180 190 200
NEYQPLLLAV SRRKVKMVEF LLKKKANVNA IDYLGRSALI LAVTLGEKDI
210 220 230 240 250
VILLLQHNID VFSRDVYGKL AEDYASEAEN RVIFDLIYEY KRKRYEDLPI
260 270 280 290 300
NSNPVSPQKQ RAEKATSDDK DSVSNIATEI KEGPISGTVS SQKQPAEKAT
310 320 330 340 350
SDEKDSVSNI ATEIKEGQQS GTVSPQKQSA QKVIFKKKVS LLNIATRIMG
360 370 380 390 400
GGKSGTVSSQ KQPASKTASD KTDSALNTAT EIKDGLQCGT VSSQKQQALK
410 420 430 440 450
ATTDEEGSVS NIATEIKDGE KSGTVSSQKK PALKATSDEK DSFSNITREK
460 470 480 490 500
KDGEISRTVS SQKPPALKAT SVKEDSVLNI AREKKDGEKS RTVSFEQPPG
510 520 530 540 550
LKATRDEKDS LLNIARGKKD GEKTRRVSSH KQPSLKATSD KEDSVPNMAT
560 570 580 590 600
ETKDEQISGT VSCQKQPALK ATSDKKDSVS NIPTEIKDGQ QSGTVSSQKQ
610 620 630 640 650
PAWKATSVKK DSVSNIATEI KDGQIRGTVS SQRRPALKTT GDEKDSVSNI
660 670 680 690 700
AREIKDGEKS GTVSPQKQSA QKVIFKKKVS LLNIATRITG GGKSGTEYPE
710 720 730 740 750
NLRTLKATIE NKDSVLNTAT KMKEVQTSTP AEQDLEMASE GEQKRLEEYE
760 770 780 790 800
NNQPQVKNQI HSRDDLDDII QSSQTVSEDG DSLCCNCKNV ILLIDQHEMK
810 820 830 840 850
CKDCVHLLKI KNTFCLWKRL IKLKDNHCEQ LRVKIRKLKN KASVLQKRIS
860 870 880 890 900
EKEEIKSQLK HEILELEKEL CSLRFAIQQE KKKRRNVEEL HQKVREKLRI
910 920 930 940 950
TEEQYRIEAD VTKPIKPALK SAEVELKTGG NNSNQVSETD EKEDLLHENR
960 970 980 990 1000
LMQDEIARLR LEKDTIKNQN LEKKYLKDFE IVKRKHEDLQ KALKRNGETL
1010 1020 1030 1040 1050
AKTIACYSGQ LAALTDENTT LRSKLEKQRE SRQRLETEMQ SYRCRLNAAR
1060 1070 1080 1090 1100
CDHDQSHSSK RDQELAFQGT VDKCRHLQEN LNSHVLILSL QLSKAESKSR
1110 1120 1130 1140 1150
VLKTELHYTG EALKEKALVF EHVQSELKQK QSQMKDIEKM YKSGYNTMEK
1160 1170 1180 1190 1200
CIEKQERFCQ LKKQNMLLQQ QLDDARNKAD NQEKAILNIQ ARCDARVQNL
1210 1220 1230 1240 1250
QAECRKHRLL LEEDNKMLVN ELNHSKEKEC QYEKEKAERE VAVRQLQQKR
1260 1270 1280 1290 1300
DDVLNKGSAT KALLDASSRH CTYLENGMQD SRKKLDQMRS QFQEIQDQLT
1310 1320 1330 1340 1350
ATIRCTKEME GDTQKLEVEH VMMRKIIKKQ DDQIERLEKI LQHSSLMLQV

FES
Length:1,353
Mass (Da):153,582
Last modified:August 10, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB5EEB358EBBC0BE4
GO
Isoform 2 (identifier: Q8N2N9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1292-1304: FQEIQDQLTATIR → VCMQLCTPTTVNL
     1305-1353: Missing.

Show »
Length:1,304
Mass (Da):147,586
Checksum:i734ECD8A794C395A
GO
Isoform 3 (identifier: Q8N2N9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1292-1292: F → A
     1293-1353: Missing.

Show »
Length:1,292
Mass (Da):146,252
Checksum:i44C7633F2DA1C333
GO
Isoform 4 (identifier: Q8N2N9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-239: IFDLIYE → VSSETTS
     240-1353: Missing.

Show »
Length:239
Mass (Da):27,341
Checksum:iB2484A3265820AE1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1R3A0A087X1R3_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD36B
1,032Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WX87A0A087WX87_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD36B
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGX0A0A0C4DGX0_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD36B
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI25133 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI25134 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAL99915 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB15039 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB71081 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3R → C in BAC11066 (PubMed:14702039).Curated1
Sequence conflicti117V → F in BAC11066 (PubMed:14702039).Curated1
Sequence conflicti884R → K in AAH31883 (PubMed:15489334).Curated1
Sequence conflicti884R → K in AAH44844 (PubMed:15489334).Curated1
Sequence conflicti1223N → T in BAB71081 (PubMed:14702039).Curated1
Sequence conflicti1310E → D in BAB15039 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060687483E → G. Corresponds to variant dbSNP:rs1839230Ensembl.1
Natural variantiVAR_057818496E → D. Corresponds to variant dbSNP:rs13001728Ensembl.1
Natural variantiVAR_060688534S → A. Corresponds to variant dbSNP:rs6761299Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039666233 – 239IFDLIYE → VSSETTS in isoform 4. 2 Publications7
Alternative sequenceiVSP_039667240 – 1353Missing in isoform 4. 2 PublicationsAdd BLAST1114
Alternative sequenceiVSP_0396681292 – 1304FQEIQ…TATIR → VCMQLCTPTTVNL in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_0396691292F → A in isoform 3. 1 Publication1
Alternative sequenceiVSP_0396701293 – 1353Missing in isoform 3. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_0396711305 – 1353Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC017099 Genomic DNA No translation available.
BC031883 mRNA Translation: AAH31883.1
BC044844 mRNA Translation: AAH44844.1
BC071771 mRNA No translation available.
BC125132 mRNA Translation: AAI25133.1 Different initiation.
BC125133 mRNA Translation: AAI25134.1 Different initiation.
AK024934 mRNA Translation: BAB15039.1 Different initiation.
AK056042 mRNA Translation: BAB71081.1 Different initiation.
AK074570 mRNA Translation: BAC11066.1
AF432208 mRNA Translation: AAL99915.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS74543.1 [Q8N2N9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_079466.3, NM_025190.3 [Q8N2N9-1]
XP_005264052.1, XM_005263995.4 [Q8N2N9-1]
XP_006712724.1, XM_006712661.1 [Q8N2N9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000258459; ENSP00000481149; ENSG00000196912 [Q8N2N9-1]
ENST00000359901; ENSP00000477778; ENSG00000196912 [Q8N2N9-1]
ENST00000443455; ENSP00000482644; ENSG00000196912 [Q8N2N9-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57730

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57730

UCSC genome browser

More...
UCSCi
uc010fid.2 human [Q8N2N9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC017099 Genomic DNA No translation available.
BC031883 mRNA Translation: AAH31883.1
BC044844 mRNA Translation: AAH44844.1
BC071771 mRNA No translation available.
BC125132 mRNA Translation: AAI25133.1 Different initiation.
BC125133 mRNA Translation: AAI25134.1 Different initiation.
AK024934 mRNA Translation: BAB15039.1 Different initiation.
AK056042 mRNA Translation: BAB71081.1 Different initiation.
AK074570 mRNA Translation: BAC11066.1
AF432208 mRNA Translation: AAL99915.1 Different initiation.
CCDSiCCDS74543.1 [Q8N2N9-1]
RefSeqiNP_079466.3, NM_025190.3 [Q8N2N9-1]
XP_005264052.1, XM_005263995.4 [Q8N2N9-1]
XP_006712724.1, XM_006712661.1 [Q8N2N9-1]

3D structure databases

SMRiQ8N2N9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121750, 36 interactors
IntActiQ8N2N9, 27 interactors
STRINGi9606.ENSP00000481149

PTM databases

iPTMnetiQ8N2N9
PhosphoSitePlusiQ8N2N9

Polymorphism and mutation databases

BioMutaiANKRD36B
DMDMi302393831

Proteomic databases

EPDiQ8N2N9
PeptideAtlasiQ8N2N9
PRIDEiQ8N2N9
ProteomicsDBi71719
71720 [Q8N2N9-2]
71721 [Q8N2N9-3]
71722 [Q8N2N9-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258459; ENSP00000481149; ENSG00000196912 [Q8N2N9-1]
ENST00000359901; ENSP00000477778; ENSG00000196912 [Q8N2N9-1]
ENST00000443455; ENSP00000482644; ENSG00000196912 [Q8N2N9-4]
GeneIDi57730
KEGGihsa:57730
UCSCiuc010fid.2 human [Q8N2N9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57730
DisGeNETi57730

GeneCards: human genes, protein and diseases

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GeneCardsi
ANKRD36B
HGNCiHGNC:29333 ANKRD36B
HPAiHPA051757
HPA057661
neXtProtiNX_Q8N2N9
OpenTargetsiENSG00000196912

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

GeneTreeiENSGT00940000163264
InParanoidiQ8N2N9
OMAiRESTPAY
OrthoDBi305292at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ANKRD36B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57730

Protein Ontology

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PROi
PR:Q8N2N9

Gene expression databases

BgeeiENSG00000196912 Expressed in 95 organ(s), highest expression level in intestine
ExpressionAtlasiQ8N2N9 baseline and differential
GenevisibleiQ8N2N9 HS

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039497 CC144C-like_CC_dom
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF14915 CCDC144C, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAN36B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N2N9
Secondary accession number(s): Q08AK5
, Q6IPR0, Q6PI49, Q8IZM7, Q8TDH6, Q96N30, Q9H759
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: August 10, 2010
Last modified: July 3, 2019
This is version 121 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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