UniProtKB - Q8N2N9 (AN36B_HUMAN)
Protein
Ankyrin repeat domain-containing protein 36B
Gene
ANKRD36B
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- identical protein binding Source: IntAct
Enzyme and pathway databases
PathwayCommonsi | Q8N2N9 |
Names & Taxonomyi
Protein namesi | Recommended name: Ankyrin repeat domain-containing protein 36BAlternative name(s): CLL-associated antigen KW-1 |
Gene namesi | Name:ANKRD36B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000196912.12 |
HGNCi | HGNC:29333, ANKRD36B |
neXtProti | NX_Q8N2N9 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 57730 |
OpenTargetsi | ENSG00000196912 |
Miscellaneous databases
Pharosi | Q8N2N9, Tdark |
Polymorphism and mutation databases
BioMutai | ANKRD36B |
DMDMi | 302393831 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000243912 | 1 – 1353 | Ankyrin repeat domain-containing protein 36BAdd BLAST | 1353 |
Proteomic databases
EPDi | Q8N2N9 |
MassIVEi | Q8N2N9 |
PeptideAtlasi | Q8N2N9 |
PRIDEi | Q8N2N9 |
ProteomicsDBi | 71719 [Q8N2N9-1] 71720 [Q8N2N9-2] 71721 [Q8N2N9-3] 71722 [Q8N2N9-4] |
PTM databases
iPTMneti | Q8N2N9 |
PhosphoSitePlusi | Q8N2N9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000196912, Expressed in sural nerve and 116 other tissues |
ExpressionAtlasi | Q8N2N9, baseline and differential |
Genevisiblei | Q8N2N9, HS |
Organism-specific databases
HPAi | ENSG00000196912, Tissue enhanced (bone) |
Interactioni
Binary interactionsi
Hide detailsQ8N2N9
With | #Exp. | IntAct |
---|---|---|
FAM9B [Q8IZU0] | 3 | EBI-2876112,EBI-10175124 |
ANKRD36B - isoform 4 [Q8N2N9-4]
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 121750, 53 interactors |
IntActi | Q8N2N9, 26 interactors |
STRINGi | 9606.ENSP00000481149 |
Miscellaneous databases
RNActi | Q8N2N9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 19 – 48 | ANK 1Add BLAST | 30 | |
Repeati | 52 – 81 | ANK 2Add BLAST | 30 | |
Repeati | 85 – 114 | ANK 3Add BLAST | 30 | |
Repeati | 118 – 147 | ANK 4Add BLAST | 30 | |
Repeati | 151 – 180 | ANK 5Add BLAST | 30 | |
Repeati | 184 – 213 | ANK 6Add BLAST | 30 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 731 – 762 | Sequence analysisAdd BLAST | 32 | |
Coiled coili | 821 – 908 | Sequence analysisAdd BLAST | 88 | |
Coiled coili | 937 – 1055 | Sequence analysisAdd BLAST | 119 | |
Coiled coili | 1119 – 1344 | Sequence analysisAdd BLAST | 226 |
Sequence similaritiesi
Belongs to the ANKRD36 family.Curated
Keywords - Domaini
ANK repeat, Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0504, Eukaryota |
GeneTreei | ENSGT00940000163264 |
HOGENOMi | CLU_001111_2_2_1 |
InParanoidi | Q8N2N9 |
OMAi | RESTPAY |
OrthoDBi | 305292at2759 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR039497, CC144C-like_CC_dom |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF14915, CCDC144C, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 6 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N2N9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERLCSDGFA FPHYYIKPYH LKRIHRAVLR GNLEKLKYLL LTYYDANKRD
60 70 80 90 100
RKERTALHLA CATGQPEMVH LLVSRRCELN LCDREDRTPL IKAVQLRQEA
110 120 130 140 150
CATLLLQNGA DPNITDVFGR TALHYAVYNE DTSMIEKLLS HGTNIEECSK
160 170 180 190 200
NEYQPLLLAV SRRKVKMVEF LLKKKANVNA IDYLGRSALI LAVTLGEKDI
210 220 230 240 250
VILLLQHNID VFSRDVYGKL AEDYASEAEN RVIFDLIYEY KRKRYEDLPI
260 270 280 290 300
NSNPVSPQKQ RAEKATSDDK DSVSNIATEI KEGPISGTVS SQKQPAEKAT
310 320 330 340 350
SDEKDSVSNI ATEIKEGQQS GTVSPQKQSA QKVIFKKKVS LLNIATRIMG
360 370 380 390 400
GGKSGTVSSQ KQPASKTASD KTDSALNTAT EIKDGLQCGT VSSQKQQALK
410 420 430 440 450
ATTDEEGSVS NIATEIKDGE KSGTVSSQKK PALKATSDEK DSFSNITREK
460 470 480 490 500
KDGEISRTVS SQKPPALKAT SVKEDSVLNI AREKKDGEKS RTVSFEQPPG
510 520 530 540 550
LKATRDEKDS LLNIARGKKD GEKTRRVSSH KQPSLKATSD KEDSVPNMAT
560 570 580 590 600
ETKDEQISGT VSCQKQPALK ATSDKKDSVS NIPTEIKDGQ QSGTVSSQKQ
610 620 630 640 650
PAWKATSVKK DSVSNIATEI KDGQIRGTVS SQRRPALKTT GDEKDSVSNI
660 670 680 690 700
AREIKDGEKS GTVSPQKQSA QKVIFKKKVS LLNIATRITG GGKSGTEYPE
710 720 730 740 750
NLRTLKATIE NKDSVLNTAT KMKEVQTSTP AEQDLEMASE GEQKRLEEYE
760 770 780 790 800
NNQPQVKNQI HSRDDLDDII QSSQTVSEDG DSLCCNCKNV ILLIDQHEMK
810 820 830 840 850
CKDCVHLLKI KNTFCLWKRL IKLKDNHCEQ LRVKIRKLKN KASVLQKRIS
860 870 880 890 900
EKEEIKSQLK HEILELEKEL CSLRFAIQQE KKKRRNVEEL HQKVREKLRI
910 920 930 940 950
TEEQYRIEAD VTKPIKPALK SAEVELKTGG NNSNQVSETD EKEDLLHENR
960 970 980 990 1000
LMQDEIARLR LEKDTIKNQN LEKKYLKDFE IVKRKHEDLQ KALKRNGETL
1010 1020 1030 1040 1050
AKTIACYSGQ LAALTDENTT LRSKLEKQRE SRQRLETEMQ SYRCRLNAAR
1060 1070 1080 1090 1100
CDHDQSHSSK RDQELAFQGT VDKCRHLQEN LNSHVLILSL QLSKAESKSR
1110 1120 1130 1140 1150
VLKTELHYTG EALKEKALVF EHVQSELKQK QSQMKDIEKM YKSGYNTMEK
1160 1170 1180 1190 1200
CIEKQERFCQ LKKQNMLLQQ QLDDARNKAD NQEKAILNIQ ARCDARVQNL
1210 1220 1230 1240 1250
QAECRKHRLL LEEDNKMLVN ELNHSKEKEC QYEKEKAERE VAVRQLQQKR
1260 1270 1280 1290 1300
DDVLNKGSAT KALLDASSRH CTYLENGMQD SRKKLDQMRS QFQEIQDQLT
1310 1320 1330 1340 1350
ATIRCTKEME GDTQKLEVEH VMMRKIIKKQ DDQIERLEKI LQHSSLMLQV
FES
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087X1R3 | A0A087X1R3_HUMAN | Ankyrin repeat domain-containing pr... | ANKRD36B | 1,032 | Annotation score: | ||
A0A087WX87 | A0A087WX87_HUMAN | Ankyrin repeat domain-containing pr... | ANKRD36B | 171 | Annotation score: | ||
A0A0C4DGX0 | A0A0C4DGX0_HUMAN | Ankyrin repeat domain-containing pr... | ANKRD36B | 137 | Annotation score: |
Sequence cautioni
The sequence AAI25133 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI25134 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAL99915 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB15039 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB71081 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | R → C in BAC11066 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 117 | V → F in BAC11066 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 884 | R → K in AAH31883 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 884 | R → K in AAH44844 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1223 | N → T in BAB71081 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1310 | E → D in BAB15039 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060687 | 483 | E → G. Corresponds to variant dbSNP:rs1839230Ensembl. | 1 | |
Natural variantiVAR_057818 | 496 | E → D. Corresponds to variant dbSNP:rs13001728Ensembl. | 1 | |
Natural variantiVAR_060688 | 534 | S → A. Corresponds to variant dbSNP:rs6761299Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039666 | 233 – 239 | IFDLIYE → VSSETTS in isoform 4. 2 Publications | 7 | |
Alternative sequenceiVSP_039667 | 240 – 1353 | Missing in isoform 4. 2 PublicationsAdd BLAST | 1114 | |
Alternative sequenceiVSP_039668 | 1292 – 1304 | FQEIQ…TATIR → VCMQLCTPTTVNL in isoform 2. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_039669 | 1292 | F → A in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_039670 | 1293 – 1353 | Missing in isoform 3. 1 PublicationAdd BLAST | 61 | |
Alternative sequenceiVSP_039671 | 1305 – 1353 | Missing in isoform 2. 1 PublicationAdd BLAST | 49 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC017099 Genomic DNA No translation available. BC031883 mRNA Translation: AAH31883.1 BC044844 mRNA Translation: AAH44844.1 BC071771 mRNA No translation available. BC125132 mRNA Translation: AAI25133.1 Different initiation. BC125133 mRNA Translation: AAI25134.1 Different initiation. AK024934 mRNA Translation: BAB15039.1 Different initiation. AK056042 mRNA Translation: BAB71081.1 Different initiation. AK074570 mRNA Translation: BAC11066.1 AF432208 mRNA Translation: AAL99915.1 Different initiation. |
CCDSi | CCDS74543.1 [Q8N2N9-1] |
RefSeqi | NP_079466.3, NM_025190.3 [Q8N2N9-1] XP_005264052.1, XM_005263995.4 [Q8N2N9-1] XP_006712724.1, XM_006712661.1 [Q8N2N9-1] |
Genome annotation databases
Ensembli | ENST00000258459; ENSP00000481149; ENSG00000196912 [Q8N2N9-1] ENST00000359901; ENSP00000477778; ENSG00000196912 [Q8N2N9-1] ENST00000443455; ENSP00000482644; ENSG00000196912 [Q8N2N9-4] |
GeneIDi | 57730 |
KEGGi | hsa:57730 |
UCSCi | uc010fid.2, human [Q8N2N9-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC017099 Genomic DNA No translation available. BC031883 mRNA Translation: AAH31883.1 BC044844 mRNA Translation: AAH44844.1 BC071771 mRNA No translation available. BC125132 mRNA Translation: AAI25133.1 Different initiation. BC125133 mRNA Translation: AAI25134.1 Different initiation. AK024934 mRNA Translation: BAB15039.1 Different initiation. AK056042 mRNA Translation: BAB71081.1 Different initiation. AK074570 mRNA Translation: BAC11066.1 AF432208 mRNA Translation: AAL99915.1 Different initiation. |
CCDSi | CCDS74543.1 [Q8N2N9-1] |
RefSeqi | NP_079466.3, NM_025190.3 [Q8N2N9-1] XP_005264052.1, XM_005263995.4 [Q8N2N9-1] XP_006712724.1, XM_006712661.1 [Q8N2N9-1] |
3D structure databases
SMRi | Q8N2N9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121750, 53 interactors |
IntActi | Q8N2N9, 26 interactors |
STRINGi | 9606.ENSP00000481149 |
PTM databases
iPTMneti | Q8N2N9 |
PhosphoSitePlusi | Q8N2N9 |
Polymorphism and mutation databases
BioMutai | ANKRD36B |
DMDMi | 302393831 |
Proteomic databases
EPDi | Q8N2N9 |
MassIVEi | Q8N2N9 |
PeptideAtlasi | Q8N2N9 |
PRIDEi | Q8N2N9 |
ProteomicsDBi | 71719 [Q8N2N9-1] 71720 [Q8N2N9-2] 71721 [Q8N2N9-3] 71722 [Q8N2N9-4] |
Protocols and materials databases
Antibodypediai | 73249, 46 antibodies |
Genome annotation databases
Ensembli | ENST00000258459; ENSP00000481149; ENSG00000196912 [Q8N2N9-1] ENST00000359901; ENSP00000477778; ENSG00000196912 [Q8N2N9-1] ENST00000443455; ENSP00000482644; ENSG00000196912 [Q8N2N9-4] |
GeneIDi | 57730 |
KEGGi | hsa:57730 |
UCSCi | uc010fid.2, human [Q8N2N9-1] |
Organism-specific databases
CTDi | 57730 |
DisGeNETi | 57730 |
EuPathDBi | HostDB:ENSG00000196912.12 |
GeneCardsi | ANKRD36B |
HGNCi | HGNC:29333, ANKRD36B |
HPAi | ENSG00000196912, Tissue enhanced (bone) |
neXtProti | NX_Q8N2N9 |
OpenTargetsi | ENSG00000196912 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0504, Eukaryota |
GeneTreei | ENSGT00940000163264 |
HOGENOMi | CLU_001111_2_2_1 |
InParanoidi | Q8N2N9 |
OMAi | RESTPAY |
OrthoDBi | 305292at2759 |
Enzyme and pathway databases
PathwayCommonsi | Q8N2N9 |
Miscellaneous databases
BioGRID-ORCSi | 57730, 0 hits in 36 CRISPR screens |
ChiTaRSi | ANKRD36B, human |
GenomeRNAii | 57730 |
Pharosi | Q8N2N9, Tdark |
PROi | PR:Q8N2N9 |
RNActi | Q8N2N9, protein |
Gene expression databases
Bgeei | ENSG00000196912, Expressed in sural nerve and 116 other tissues |
ExpressionAtlasi | Q8N2N9, baseline and differential |
Genevisiblei | Q8N2N9, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR039497, CC144C-like_CC_dom |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF14915, CCDC144C, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 6 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AN36B_HUMAN | |
Accessioni | Q8N2N9Primary (citable) accession number: Q8N2N9 Secondary accession number(s): Q08AK5 Q9H759 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | August 10, 2010 | |
Last modified: | October 7, 2020 | |
This is version 130 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations