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Protein

CLK4-associating serine/arginine rich protein

Gene

CLASRP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
CLK4-associating serine/arginine rich protein
Alternative name(s):
Splicing factor, arginine/serine-rich 16
Suppressor of white-apricot homolog 2
Gene namesi
Name:CLASRP
Synonyms:SFRS16, SWAP2
ORF Names:UNQ2428/PRO4988
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104859.14
HGNCiHGNC:17731 CLASRP
neXtProtiNX_Q8N2M8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134961731

Polymorphism and mutation databases

BioMutaiCLASRP
DMDMi226694202

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000819451 – 674CLK4-associating serine/arginine rich proteinAdd BLAST674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei101PhosphoserineCombined sources1
Modified residuei285PhosphoserineCombined sources1
Modified residuei294PhosphoserineCombined sources1
Modified residuei327PhosphothreonineCombined sources1
Modified residuei331PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei547PhosphoserineCombined sources1
Modified residuei573PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated in vitro by CLK4.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N2M8
MaxQBiQ8N2M8
PaxDbiQ8N2M8
PeptideAtlasiQ8N2M8
PRIDEiQ8N2M8
ProteomicsDBi71717
71718 [Q8N2M8-3]

PTM databases

iPTMnetiQ8N2M8
PhosphoSitePlusiQ8N2M8

Expressioni

Gene expression databases

BgeeiENSG00000104859 Expressed in 222 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_SFRS16
ExpressionAtlasiQ8N2M8 baseline and differential
GenevisibleiQ8N2M8 HS

Organism-specific databases

HPAiHPA060469
HPA062455

Interactioni

Subunit structurei

Probably interacts with CLK4.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CFAP20Q9Y6A43EBI-751069,EBI-1046872

Protein-protein interaction databases

BioGridi116302, 36 interactors
IntActiQ8N2M8, 10 interactors
STRINGi9606.ENSP00000221455

Structurei

3D structure databases

ProteinModelPortaliQ8N2M8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili585 – 647Sequence analysisAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi369 – 673Arg-richAdd BLAST305
Compositional biasi377 – 535Ser-richAdd BLAST159

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2548 Eukaryota
COG0303 LUCA
HOGENOMiHOG000067785
HOVERGENiHBG065901
InParanoidiQ8N2M8
KOiK13168
PhylomeDBiQ8N2M8
TreeFamiTF351621

Family and domain databases

InterProiView protein in InterPro
IPR019147 SWAP_N_domain
PfamiView protein in Pfam
PF09750 DRY_EERY, 1 hit
SMARTiView protein in SMART
SM01141 DRY_EERY, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N2M8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWHEARKHER KLRGMMVDYK KRAERRREYY EKIKKDPAQF LQVHGRACKV
60 70 80 90 100
HLDSAVALAA ESPVNMMPWQ GDTNNMIDRF DVRAHLDHIP DYTPPLLTTI
110 120 130 140 150
SPEQESDERK CNYERYRGLV QNDFAGISEE QCLYQIYIDE LYGGLQRPSE
160 170 180 190 200
DEKKKLAEKK ASIGYTYEDS TVAKVEKAAE KPEEEESAAE EESNSDEDEV
210 220 230 240 250
IPDIDVEVDV DELNQEQVAD LNKQATTYGM ADGDFVRMLR KDKEEAEAIK
260 270 280 290 300
HAKALEEEKA MYSGRRSRRQ RREFREKRLR GRKISPPSYA RRDSPTYDPY
310 320 330 340 350
KRSPSESSSE SRSRSRSPTP GREEKITFIT SFGGSDEEAA AAAAAAAASG
360 370 380 390 400
VTTGKPPAPP QPGGPAPGRN ASARRRSSSS SSSSSASRTS SSRSSSRSSS
410 420 430 440 450
RSRRGGGYYR SGRHARSRSR SWSRSRSRSR RYSRSRSRGR RHSGGGSRDG
460 470 480 490 500
HRYSRSPARR GGYGPRRRSR SRSHSGDRYR RGGRGLRHHS SSRSRSSWSL
510 520 530 540 550
SPSRSRSLTR SRSHSPSPSQ SRSRSRSRSQ SPSPSPAREK LTRPAASPAV
560 570 580 590 600
GEKLKKTEPA AGKETGAAKP KLTPQEKLKL RMQKALNRQF KADKKAAQEK
610 620 630 640 650
MIQQEHERQE REDELRAMAR KIRMKERERR EKEREEWERQ YSRQSRSPSP
660 670
RYSREYSSSR RRSRSRSRSP HYRH
Length:674
Mass (Da):77,161
Last modified:April 14, 2009 - v4
Checksum:i454F935EBDD96541
GO
Isoform 2 (identifier: Q8N2M8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     570-594: PKLTPQEKLKLRMQKALNRQFKADK → VTQADASGEAETEDAEGAEQAVQGG
     595-674: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:594
Mass (Da):66,355
Checksum:i0886C8D42E4F88C1
GO
Isoform 3 (identifier: Q8N2M8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-103: Missing.

Show »
Length:612
Mass (Da):70,286
Checksum:i1D876098123C08C5
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQS2A0A0A0MQS2_HUMAN
CLK4-associating serine/arginine-ri...
CLASRP SFRS16, hCG_22138
674Annotation score:
F5H0Q6F5H0Q6_HUMAN
CLK4-associating serine/arginine-ri...
CLASRP SFRS16, hCG_22138
655Annotation score:
K7EP11K7EP11_HUMAN
CLK4-associating serine/arginine-ri...
CLASRP
131Annotation score:
K7EKC9K7EKC9_HUMAN
CLK4-associating serine/arginine-ri...
CLASRP
86Annotation score:
K7EM61K7EM61_HUMAN
CLK4-associating serine/arginine-ri...
CLASRP
188Annotation score:
K7EKR8K7EKR8_HUMAN
CLK4-associating serine/arginine-ri...
CLASRP
81Annotation score:

Sequence cautioni

The sequence AAC82339 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAC82340 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH80554 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016809174K → E4 PublicationsCorresponds to variant dbSNP:rs4803794Ensembl.1
Natural variantiVAR_035490213L → S in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05571742 – 103Missing in isoform 3. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_013894570 – 594PKLTP…FKADK → VTQADASGEAETEDAEGAEQ AVQGG in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_013895595 – 674Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042800 mRNA Translation: AAC82339.1 Different initiation.
AF042810
, AF042802, AF042803, AF042804, AF042805, AF042806, AF042807, AF042808, AF042809 Genomic DNA Translation: AAC82340.1 Different initiation.
AY358944 mRNA Translation: AAQ89303.1
AK293333 mRNA Translation: BAG56849.1
AC011489 Genomic DNA No translation available.
BC080554 mRNA Translation: AAH80554.1 Different initiation.
CCDSiCCDS12652.2 [Q8N2M8-1]
CCDS62710.1 [Q8N2M8-4]
RefSeqiNP_001265368.1, NM_001278439.1
NP_008987.2, NM_007056.2
UniGeneiHs.466917

Genome annotation databases

EnsembliENST00000391952; ENSP00000375814; ENSG00000104859
ENST00000391953; ENSP00000375815; ENSG00000104859
GeneIDi11129
KEGGihsa:11129
UCSCiuc010xxh.3 human [Q8N2M8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042800 mRNA Translation: AAC82339.1 Different initiation.
AF042810
, AF042802, AF042803, AF042804, AF042805, AF042806, AF042807, AF042808, AF042809 Genomic DNA Translation: AAC82340.1 Different initiation.
AY358944 mRNA Translation: AAQ89303.1
AK293333 mRNA Translation: BAG56849.1
AC011489 Genomic DNA No translation available.
BC080554 mRNA Translation: AAH80554.1 Different initiation.
CCDSiCCDS12652.2 [Q8N2M8-1]
CCDS62710.1 [Q8N2M8-4]
RefSeqiNP_001265368.1, NM_001278439.1
NP_008987.2, NM_007056.2
UniGeneiHs.466917

3D structure databases

ProteinModelPortaliQ8N2M8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116302, 36 interactors
IntActiQ8N2M8, 10 interactors
STRINGi9606.ENSP00000221455

PTM databases

iPTMnetiQ8N2M8
PhosphoSitePlusiQ8N2M8

Polymorphism and mutation databases

BioMutaiCLASRP
DMDMi226694202

Proteomic databases

EPDiQ8N2M8
MaxQBiQ8N2M8
PaxDbiQ8N2M8
PeptideAtlasiQ8N2M8
PRIDEiQ8N2M8
ProteomicsDBi71717
71718 [Q8N2M8-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391952; ENSP00000375814; ENSG00000104859
ENST00000391953; ENSP00000375815; ENSG00000104859
GeneIDi11129
KEGGihsa:11129
UCSCiuc010xxh.3 human [Q8N2M8-1]

Organism-specific databases

CTDi11129
EuPathDBiHostDB:ENSG00000104859.14
GeneCardsiCLASRP
H-InvDBiHIX0015221
HGNCiHGNC:17731 CLASRP
HPAiHPA060469
HPA062455
neXtProtiNX_Q8N2M8
PharmGKBiPA134961731
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2548 Eukaryota
COG0303 LUCA
HOGENOMiHOG000067785
HOVERGENiHBG065901
InParanoidiQ8N2M8
KOiK13168
PhylomeDBiQ8N2M8
TreeFamiTF351621

Miscellaneous databases

ChiTaRSiCLASRP human
GeneWikiiSFRS16
GenomeRNAii11129
PROiPR:Q8N2M8

Gene expression databases

BgeeiENSG00000104859 Expressed in 222 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_SFRS16
ExpressionAtlasiQ8N2M8 baseline and differential
GenevisibleiQ8N2M8 HS

Family and domain databases

InterProiView protein in InterPro
IPR019147 SWAP_N_domain
PfamiView protein in Pfam
PF09750 DRY_EERY, 1 hit
SMARTiView protein in SMART
SM01141 DRY_EERY, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLASR_HUMAN
AccessioniPrimary (citable) accession number: Q8N2M8
Secondary accession number(s): B4DDT8
, F8WAG9, O96026, Q6UW71, Q96DX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: April 14, 2009
Last modified: September 12, 2018
This is version 136 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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