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Entry version 145 (26 Feb 2020)
Sequence version 4 (14 Apr 2009)
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Protein

CLK4-associating serine/arginine rich protein

Gene

CLASRP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CLK4-associating serine/arginine rich protein
Alternative name(s):
Splicing factor, arginine/serine-rich 16
Suppressor of white-apricot homolog 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLASRP
Synonyms:SFRS16, SWAP2
ORF Names:UNQ2428/PRO4988
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17731 CLASRP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618532 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N2M8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11129

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134961731

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N2M8 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CLASRP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
226694202

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000819451 – 674CLK4-associating serine/arginine rich proteinAdd BLAST674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei101PhosphoserineCombined sources1
Modified residuei285PhosphoserineCombined sources1
Modified residuei294PhosphoserineCombined sources1
Modified residuei327PhosphothreonineCombined sources1
Modified residuei331PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei547PhosphoserineCombined sources1
Modified residuei573PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in vitro by CLK4.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N2M8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N2M8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N2M8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N2M8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N2M8

PeptideAtlas

More...
PeptideAtlasi
Q8N2M8

PRoteomics IDEntifications database

More...
PRIDEi
Q8N2M8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
30495
71717 [Q8N2M8-1]
71718 [Q8N2M8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N2M8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N2M8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104859 Expressed in left lobe of thyroid gland and 221 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N2M8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N2M8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA060469
HPA062455

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probably interacts with CLK4.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9Y6A43EBI-751069,EBI-1046872

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116302, 39 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N2M8, 28 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000221455

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N2M8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N2M8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili585 – 647Sequence analysisAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi369 – 673Arg-richAdd BLAST305
Compositional biasi377 – 535Ser-richAdd BLAST159

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2548 Eukaryota
COG0303 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N2M8

KEGG Orthology (KO)

More...
KOi
K13168

Database of Orthologous Groups

More...
OrthoDBi
1620115at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N2M8

TreeFam database of animal gene trees

More...
TreeFami
TF351621

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040397 SWAP
IPR019147 SWAP_N_domain

The PANTHER Classification System

More...
PANTHERi
PTHR13161 PTHR13161, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09750 DRY_EERY, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01141 DRY_EERY, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N2M8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWHEARKHER KLRGMMVDYK KRAERRREYY EKIKKDPAQF LQVHGRACKV
60 70 80 90 100
HLDSAVALAA ESPVNMMPWQ GDTNNMIDRF DVRAHLDHIP DYTPPLLTTI
110 120 130 140 150
SPEQESDERK CNYERYRGLV QNDFAGISEE QCLYQIYIDE LYGGLQRPSE
160 170 180 190 200
DEKKKLAEKK ASIGYTYEDS TVAKVEKAAE KPEEEESAAE EESNSDEDEV
210 220 230 240 250
IPDIDVEVDV DELNQEQVAD LNKQATTYGM ADGDFVRMLR KDKEEAEAIK
260 270 280 290 300
HAKALEEEKA MYSGRRSRRQ RREFREKRLR GRKISPPSYA RRDSPTYDPY
310 320 330 340 350
KRSPSESSSE SRSRSRSPTP GREEKITFIT SFGGSDEEAA AAAAAAAASG
360 370 380 390 400
VTTGKPPAPP QPGGPAPGRN ASARRRSSSS SSSSSASRTS SSRSSSRSSS
410 420 430 440 450
RSRRGGGYYR SGRHARSRSR SWSRSRSRSR RYSRSRSRGR RHSGGGSRDG
460 470 480 490 500
HRYSRSPARR GGYGPRRRSR SRSHSGDRYR RGGRGLRHHS SSRSRSSWSL
510 520 530 540 550
SPSRSRSLTR SRSHSPSPSQ SRSRSRSRSQ SPSPSPAREK LTRPAASPAV
560 570 580 590 600
GEKLKKTEPA AGKETGAAKP KLTPQEKLKL RMQKALNRQF KADKKAAQEK
610 620 630 640 650
MIQQEHERQE REDELRAMAR KIRMKERERR EKEREEWERQ YSRQSRSPSP
660 670
RYSREYSSSR RRSRSRSRSP HYRH
Length:674
Mass (Da):77,161
Last modified:April 14, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i454F935EBDD96541
GO
Isoform 2 (identifier: Q8N2M8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     570-594: PKLTPQEKLKLRMQKALNRQFKADK → VTQADASGEAETEDAEGAEQAVQGG
     595-674: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:594
Mass (Da):66,355
Checksum:i0886C8D42E4F88C1
GO
Isoform 3 (identifier: Q8N2M8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-103: Missing.

Show »
Length:612
Mass (Da):70,286
Checksum:i1D876098123C08C5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQS2A0A0A0MQS2_HUMAN
CLK4-associating serine/arginine-ri...
CLASRP SFRS16, hCG_22138
674Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H0Q6F5H0Q6_HUMAN
CLK4-associating serine/arginine-ri...
CLASRP SFRS16, hCG_22138
655Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EP11K7EP11_HUMAN
CLK4-associating serine/arginine-ri...
CLASRP
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM61K7EM61_HUMAN
CLK4-associating serine/arginine-ri...
CLASRP
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKR8K7EKR8_HUMAN
CLK4-associating serine/arginine-ri...
CLASRP
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKC9K7EKC9_HUMAN
CLK4-associating serine/arginine-ri...
CLASRP
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC82339 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAC82340 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH80554 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_016809174K → E4 PublicationsCorresponds to variant dbSNP:rs4803794Ensembl.1
Natural variantiVAR_035490213L → S in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05571742 – 103Missing in isoform 3. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_013894570 – 594PKLTP…FKADK → VTQADASGEAETEDAEGAEQ AVQGG in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_013895595 – 674Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF042800 mRNA Translation: AAC82339.1 Different initiation.
AF042810 AF042809 Genomic DNA Translation: AAC82340.1 Different initiation.
AY358944 mRNA Translation: AAQ89303.1
AK293333 mRNA Translation: BAG56849.1
AC011489 Genomic DNA No translation available.
BC080554 mRNA Translation: AAH80554.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12652.2 [Q8N2M8-1]
CCDS62710.1 [Q8N2M8-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001265368.1, NM_001278439.1
NP_008987.2, NM_007056.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000391953; ENSP00000375815; ENSG00000104859
ENST00000391952; ENSP00000375814; ENSG00000104859

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11129

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11129

UCSC genome browser

More...
UCSCi
uc010xxh.3 human [Q8N2M8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042800 mRNA Translation: AAC82339.1 Different initiation.
AF042810 AF042809 Genomic DNA Translation: AAC82340.1 Different initiation.
AY358944 mRNA Translation: AAQ89303.1
AK293333 mRNA Translation: BAG56849.1
AC011489 Genomic DNA No translation available.
BC080554 mRNA Translation: AAH80554.1 Different initiation.
CCDSiCCDS12652.2 [Q8N2M8-1]
CCDS62710.1 [Q8N2M8-4]
RefSeqiNP_001265368.1, NM_001278439.1
NP_008987.2, NM_007056.2

3D structure databases

SMRiQ8N2M8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116302, 39 interactors
IntActiQ8N2M8, 28 interactors
STRINGi9606.ENSP00000221455

PTM databases

iPTMnetiQ8N2M8
PhosphoSitePlusiQ8N2M8

Polymorphism and mutation databases

BioMutaiCLASRP
DMDMi226694202

Proteomic databases

EPDiQ8N2M8
jPOSTiQ8N2M8
MassIVEiQ8N2M8
MaxQBiQ8N2M8
PaxDbiQ8N2M8
PeptideAtlasiQ8N2M8
PRIDEiQ8N2M8
ProteomicsDBi30495
71717 [Q8N2M8-1]
71718 [Q8N2M8-3]

Genome annotation databases

EnsembliENST00000391953; ENSP00000375815; ENSG00000104859
ENST00000391952; ENSP00000375814; ENSG00000104859
GeneIDi11129
KEGGihsa:11129
UCSCiuc010xxh.3 human [Q8N2M8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11129
DisGeNETi11129

GeneCards: human genes, protein and diseases

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GeneCardsi
CLASRP
HGNCiHGNC:17731 CLASRP
HPAiHPA060469
HPA062455
MIMi618532 gene
neXtProtiNX_Q8N2M8
PharmGKBiPA134961731

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2548 Eukaryota
COG0303 LUCA
InParanoidiQ8N2M8
KOiK13168
OrthoDBi1620115at2759
PhylomeDBiQ8N2M8
TreeFamiTF351621

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CLASRP human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SFRS16

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
11129
PharosiQ8N2M8 Tbio

Protein Ontology

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PROi
PR:Q8N2M8
RNActiQ8N2M8 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000104859 Expressed in left lobe of thyroid gland and 221 other tissues
ExpressionAtlasiQ8N2M8 baseline and differential
GenevisibleiQ8N2M8 HS

Family and domain databases

InterProiView protein in InterPro
IPR040397 SWAP
IPR019147 SWAP_N_domain
PANTHERiPTHR13161 PTHR13161, 2 hits
PfamiView protein in Pfam
PF09750 DRY_EERY, 1 hit
SMARTiView protein in SMART
SM01141 DRY_EERY, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLASR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N2M8
Secondary accession number(s): B4DDT8
, F8WAG9, O96026, Q6UW71, Q96DX2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: April 14, 2009
Last modified: February 26, 2020
This is version 145 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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