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UniProtKB - Q8N2M4 (TM86A_HUMAN)
Protein
Lysoplasmalogenase-like protein TMEM86A
Gene
TMEM86A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- alkenylglycerophosphocholine hydrolase activity Source: GO_Central
- alkenylglycerophosphoethanolamine hydrolase activity Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q8N2M4 |
SignaLinki | Q8N2M4 |
Names & Taxonomyi
Protein namesi | Recommended name: Lysoplasmalogenase-like protein TMEM86AAlternative name(s): Transmembrane protein 86A |
Gene namesi | Name:TMEM86A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26890, TMEM86A |
neXtProti | NX_Q8N2M4 |
VEuPathDBi | HostDB:ENSG00000151117 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 22 – 42 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 44 – 64 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 71 – 91 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 93 – 113 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 139 – 159 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 175 – 195 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 207 – 227 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000151117 |
PharmGKBi | PA142670737 |
Miscellaneous databases
Pharosi | Q8N2M4, Tdark |
Genetic variation databases
BioMutai | TMEM86A |
DMDMi | 74728715 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000201838 | 1 – 240 | Lysoplasmalogenase-like protein TMEM86AAdd BLAST | 240 |
Proteomic databases
MassIVEi | Q8N2M4 |
PaxDbi | Q8N2M4 |
PeptideAtlasi | Q8N2M4 |
PRIDEi | Q8N2M4 |
ProteomicsDBi | 71716 |
Expressioni
Gene expression databases
Bgeei | ENSG00000151117, Expressed in adrenal tissue and 153 other tissues |
Genevisiblei | Q8N2M4, HS |
Organism-specific databases
HPAi | ENSG00000151117, Tissue enhanced (skin) |
Interactioni
Binary interactionsi
Q8N2M4
Protein-protein interaction databases
BioGRIDi | 126831, 49 interactors |
IntActi | Q8N2M4, 46 interactors |
MINTi | Q8N2M4 |
STRINGi | 9606.ENSP00000280734 |
Miscellaneous databases
RNActi | Q8N2M4, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q8N2M4 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM86 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4804, Eukaryota |
GeneTreei | ENSGT00390000007101 |
HOGENOMi | CLU_079086_1_1_1 |
InParanoidi | Q8N2M4 |
OMAi | ACFKCLP |
OrthoDBi | 1516092at2759 |
PhylomeDBi | Q8N2M4 |
TreeFami | TF324663 |
Family and domain databases
InterProi | View protein in InterPro IPR012506, YhhN |
PANTHERi | PTHR31885, PTHR31885, 1 hit |
Pfami | View protein in Pfam PF07947, YhhN, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8N2M4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSPVTVVKS EGPKLVPFFK ATCVYFVLWL PSSSPSWVST LIKCLPIFCL
60 70 80 90 100
WLFLLAHGLG FLLAHPSATR IFVGLVFSAV GDAFLIWQDQ GYFVHGLLMF
110 120 130 140 150
AVTHMFYASA FGMQPLALRT GLVMAALSGL CYALLYPCLS GAFTYLVGVY
160 170 180 190 200
VALIGFMGWR AMAGLRLAGA DWRWTELAAG SGALFFIISD LTIALNKFCF
210 220 230 240
PVPYSRALIM STYYVAQMLV ALSAVESREP VEHYRLTKAN
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034564 | 215 | V → A. Corresponds to variant dbSNP:rs7945285Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074600 mRNA Translation: BAC11084.1 BC017073 mRNA Translation: AAH17073.2 BC035692 mRNA Translation: AAH35692.1 |
CCDSi | CCDS7844.1 |
RefSeqi | NP_699178.1, NM_153347.2 |
Genome annotation databases
Ensembli | ENST00000280734.3; ENSP00000280734.2; ENSG00000151117.9 |
GeneIDi | 144110 |
KEGGi | hsa:144110 |
MANE-Selecti | ENST00000280734.3; ENSP00000280734.2; NM_153347.3; NP_699178.1 |
UCSCi | uc001moz.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074600 mRNA Translation: BAC11084.1 BC017073 mRNA Translation: AAH17073.2 BC035692 mRNA Translation: AAH35692.1 |
CCDSi | CCDS7844.1 |
RefSeqi | NP_699178.1, NM_153347.2 |
3D structure databases
AlphaFoldDBi | Q8N2M4 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 126831, 49 interactors |
IntActi | Q8N2M4, 46 interactors |
MINTi | Q8N2M4 |
STRINGi | 9606.ENSP00000280734 |
Genetic variation databases
BioMutai | TMEM86A |
DMDMi | 74728715 |
Proteomic databases
MassIVEi | Q8N2M4 |
PaxDbi | Q8N2M4 |
PeptideAtlasi | Q8N2M4 |
PRIDEi | Q8N2M4 |
ProteomicsDBi | 71716 |
Protocols and materials databases
Antibodypediai | 71292, 17 antibodies from 9 providers |
DNASUi | 144110 |
Genome annotation databases
Ensembli | ENST00000280734.3; ENSP00000280734.2; ENSG00000151117.9 |
GeneIDi | 144110 |
KEGGi | hsa:144110 |
MANE-Selecti | ENST00000280734.3; ENSP00000280734.2; NM_153347.3; NP_699178.1 |
UCSCi | uc001moz.2, human |
Organism-specific databases
CTDi | 144110 |
GeneCardsi | TMEM86A |
HGNCi | HGNC:26890, TMEM86A |
HPAi | ENSG00000151117, Tissue enhanced (skin) |
neXtProti | NX_Q8N2M4 |
OpenTargetsi | ENSG00000151117 |
PharmGKBi | PA142670737 |
VEuPathDBi | HostDB:ENSG00000151117 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4804, Eukaryota |
GeneTreei | ENSGT00390000007101 |
HOGENOMi | CLU_079086_1_1_1 |
InParanoidi | Q8N2M4 |
OMAi | ACFKCLP |
OrthoDBi | 1516092at2759 |
PhylomeDBi | Q8N2M4 |
TreeFami | TF324663 |
Enzyme and pathway databases
PathwayCommonsi | Q8N2M4 |
SignaLinki | Q8N2M4 |
Miscellaneous databases
BioGRID-ORCSi | 144110, 15 hits in 1074 CRISPR screens |
GenomeRNAii | 144110 |
Pharosi | Q8N2M4, Tdark |
PROi | PR:Q8N2M4 |
RNActi | Q8N2M4, protein |
Gene expression databases
Bgeei | ENSG00000151117, Expressed in adrenal tissue and 153 other tissues |
Genevisiblei | Q8N2M4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR012506, YhhN |
PANTHERi | PTHR31885, PTHR31885, 1 hit |
Pfami | View protein in Pfam PF07947, YhhN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TM86A_HUMAN | |
Accessioni | Q8N2M4Primary (citable) accession number: Q8N2M4 Secondary accession number(s): Q96AJ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | October 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families