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Entry version 101 (13 Feb 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Lysoplasmalogenase-like protein TMEM86A

Gene

TMEM86A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysoplasmalogenase-like protein TMEM86A
Alternative name(s):
Transmembrane protein 86A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM86A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000151117.8

Human Gene Nomenclature Database

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HGNCi
HGNC:26890 TMEM86A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N2M4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000151117

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670737

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM86A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74728715

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002018381 – 240Lysoplasmalogenase-like protein TMEM86AAdd BLAST240

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N2M4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N2M4

PRoteomics IDEntifications database

More...
PRIDEi
Q8N2M4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71716

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000151117 Expressed in 129 organ(s), highest expression level in adrenal tissue

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N2M4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA057119

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
126831, 1 interactor

Protein interaction database and analysis system

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IntActi
Q8N2M4, 40 interactors

Molecular INTeraction database

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MINTi
Q8N2M4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000280734

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8N2M4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM86 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4804 Eukaryota
ENOG410ZQJ5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007101

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000204433

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG055092

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N2M4

Identification of Orthologs from Complete Genome Data

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OMAi
ANDLWTW

Database of Orthologous Groups

More...
OrthoDBi
1516092at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N2M4

TreeFam database of animal gene trees

More...
TreeFami
TF324663

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012506 YhhN

The PANTHER Classification System

More...
PANTHERi
PTHR31885 PTHR31885, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07947 YhhN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N2M4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSPVTVVKS EGPKLVPFFK ATCVYFVLWL PSSSPSWVST LIKCLPIFCL
60 70 80 90 100
WLFLLAHGLG FLLAHPSATR IFVGLVFSAV GDAFLIWQDQ GYFVHGLLMF
110 120 130 140 150
AVTHMFYASA FGMQPLALRT GLVMAALSGL CYALLYPCLS GAFTYLVGVY
160 170 180 190 200
VALIGFMGWR AMAGLRLAGA DWRWTELAAG SGALFFIISD LTIALNKFCF
210 220 230 240
PVPYSRALIM STYYVAQMLV ALSAVESREP VEHYRLTKAN
Length:240
Mass (Da):26,398
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FABCC64A964BAA9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034564215V → A. Corresponds to variant dbSNP:rs7945285Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK074600 mRNA Translation: BAC11084.1
BC017073 mRNA Translation: AAH17073.2
BC035692 mRNA Translation: AAH35692.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7844.1

NCBI Reference Sequences

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RefSeqi
NP_699178.1, NM_153347.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.502100

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000280734; ENSP00000280734; ENSG00000151117

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
144110

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:144110

UCSC genome browser

More...
UCSCi
uc001moz.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074600 mRNA Translation: BAC11084.1
BC017073 mRNA Translation: AAH17073.2
BC035692 mRNA Translation: AAH35692.1
CCDSiCCDS7844.1
RefSeqiNP_699178.1, NM_153347.2
UniGeneiHs.502100

3D structure databases

ProteinModelPortaliQ8N2M4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126831, 1 interactor
IntActiQ8N2M4, 40 interactors
MINTiQ8N2M4
STRINGi9606.ENSP00000280734

Polymorphism and mutation databases

BioMutaiTMEM86A
DMDMi74728715

Proteomic databases

jPOSTiQ8N2M4
PaxDbiQ8N2M4
PRIDEiQ8N2M4
ProteomicsDBi71716

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
144110
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280734; ENSP00000280734; ENSG00000151117
GeneIDi144110
KEGGihsa:144110
UCSCiuc001moz.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
144110
EuPathDBiHostDB:ENSG00000151117.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM86A
HGNCiHGNC:26890 TMEM86A
HPAiHPA057119
neXtProtiNX_Q8N2M4
OpenTargetsiENSG00000151117
PharmGKBiPA142670737

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4804 Eukaryota
ENOG410ZQJ5 LUCA
GeneTreeiENSGT00390000007101
HOGENOMiHOG000204433
HOVERGENiHBG055092
InParanoidiQ8N2M4
OMAiANDLWTW
OrthoDBi1516092at2759
PhylomeDBiQ8N2M4
TreeFamiTF324663

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
144110

Protein Ontology

More...
PROi
PR:Q8N2M4

Gene expression databases

BgeeiENSG00000151117 Expressed in 129 organ(s), highest expression level in adrenal tissue
GenevisibleiQ8N2M4 HS

Family and domain databases

InterProiView protein in InterPro
IPR012506 YhhN
PANTHERiPTHR31885 PTHR31885, 1 hit
PfamiView protein in Pfam
PF07947 YhhN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM86A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N2M4
Secondary accession number(s): Q96AJ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2002
Last modified: February 13, 2019
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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