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Entry version 142 (17 Jun 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Zinc finger protein 619

Gene

ZNF619

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri188 – 210C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 266C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri300 – 322C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 350C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 619
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF619
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000177873.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26910 ZNF619

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N2I2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000177873

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134889198

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N2I2 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF619

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762517

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002346011 – 560Zinc finger protein 619Add BLAST560

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N2I2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N2I2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N2I2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N2I2

PeptideAtlas

More...
PeptideAtlasi
Q8N2I2

PRoteomics IDEntifications database

More...
PRIDEi
Q8N2I2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
11385
19430
71705 [Q8N2I2-1]
71706 [Q8N2I2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N2I2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N2I2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000177873 Expressed in leukocyte and 93 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N2I2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N2I2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000177873 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
130063, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8N2I2, 2 interactors

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N2I2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N2I2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri188 – 210C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 266C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri300 – 322C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 350C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163750

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N2I2

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
RYFSQHS

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N2I2

TreeFam database of animal gene trees

More...
TreeFami
TF350844

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N2I2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGQPAPYAEG PIQGGDAGEL CKCDFLVSIS IPQTRSDIPA GARRSSMGPR
60 70 80 90 100
SLDTCWGRGP ERHVHRLECN GVIFTHRNLC LPGGKTKTEN EEKTAQLNIS
110 120 130 140 150
KESESHRLIV EGLLMDVPQH PDFKDRLEKS QLHDTGNKTK IGDCTDLTVQ
160 170 180 190 200
DHESSTTERE EIARKLEESS VSTHLITKQG FAKEQVFYKC GECGSYYNPH
210 220 230 240 250
SDFHLHQRVH TNEKPYTCKE CGKTFRYNSK LSRHQKIHTG EKPYSCEECG
260 270 280 290 300
QAFSQNSHLL QHQKLHGGQR PYECTDCGKT FSYNSKLIRH QRIHTGEKPF
310 320 330 340 350
KCKECGKAFS CSYDCIIHER IHNGEKPYEC KECGKSLSSN SVLIQHQRIH
360 370 380 390 400
TGEKPYECKE CGKAFHRSSV FLQHQRFHTG EQLYKCNECW KTFSCSSRFI
410 420 430 440 450
VHQRIHNGEK PYECQECGKT FSQKITLVQH QRVHTGEKPY ECKECGKAFR
460 470 480 490 500
WNASFIQHQK WHTRKKLING TGLSAVKPYC PCAILSPLPP QHTCSALAPP
510 520 530 540 550
GPPLSSSHAV VLPPSVPFFL LLPSSEKANP SPVQIAHFFQ DLAFPGKSSL
560
QSPNPLSHSL
Length:560
Mass (Da):63,322
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA65162901A812767
GO
Isoform 2 (identifier: Q8N2I2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: MGQPAPYAEG...IFTHRNLCLP → MKPGVISHAP...GGEALRGMCT

Show »
Length:532
Mass (Da):60,138
Checksum:iBEB317A07AC9A93A
GO
Isoform 3 (identifier: Q8N2I2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: MGQPAPYAEG...IFTHRNLCLP → MLQTVWFQGL...GGEALRGMCT

Show »
Length:576
Mass (Da):65,587
Checksum:i840970DA2F210408
GO
Isoform 4 (identifier: Q8N2I2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: MGQPAPYAEG...IFTHRNLCLP → MLQTVWFQGL...GGEALRGMCT

Show »
Length:616
Mass (Da):69,776
Checksum:iE8C80759E007D28E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJF3E5RJF3_HUMAN
Zinc finger protein 619
ZNF619
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q17RW3Q17RW3_HUMAN
ZNF619 protein
ZNF619
567Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0430801 – 82MGQPA…NLCLP → MKPGVISHAPDSVVPAAFPF PKPDLIFQLEQGEAAWGPDP WTLAGGEALRGMCT in isoform 2. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_0557151 – 82MGQPA…NLCLP → MLQTVWFQGLGRNLLFQEPV TFEDVAVYFTQNEWASLHPT QRALYREVMLENYANVTSLS AFPFPKPDLIFQLEQGEAAW GPDPWTLAGGEALRGMCT in isoform 3. CuratedAdd BLAST82
Alternative sequenceiVSP_0557161 – 82MGQPA…NLCLP → MLQTVWFQGLGRNLLFQEPV TFEDVAVYFTQNEWASLHPT QRALYREVMLENYANVTSLY PTAGGFPLDTERTEKVPGAL SSFLPSSSSLELILALLPMS AFPFPKPDLIFQLEQGEAAW GPDPWTLAGGEALRGMCT in isoform 4. CuratedAdd BLAST82

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK075245 mRNA Translation: BAC11495.1
AK304139 mRNA Translation: BAG65033.1
AC121754 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46801.1 [Q8N2I2-2]
CCDS46802.1 [Q8N2I2-4]
CCDS46803.1 [Q8N2I2-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001138554.1, NM_001145082.2 [Q8N2I2-4]
NP_001138555.1, NM_001145083.1 [Q8N2I2-2]
NP_001138565.1, NM_001145093.2 [Q8N2I2-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314686; ENSP00000322529; ENSG00000177873 [Q8N2I2-1]
ENST00000432264; ENSP00000388710; ENSG00000177873 [Q8N2I2-3]
ENST00000447116; ENSP00000411132; ENSG00000177873 [Q8N2I2-4]
ENST00000456778; ENSP00000397232; ENSG00000177873 [Q8N2I2-2]
ENST00000521353; ENSP00000430705; ENSG00000177873 [Q8N2I2-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
285267

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:285267

UCSC genome browser

More...
UCSCi
uc003ckj.4 human [Q8N2I2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075245 mRNA Translation: BAC11495.1
AK304139 mRNA Translation: BAG65033.1
AC121754 Genomic DNA No translation available.
CCDSiCCDS46801.1 [Q8N2I2-2]
CCDS46802.1 [Q8N2I2-4]
CCDS46803.1 [Q8N2I2-3]
RefSeqiNP_001138554.1, NM_001145082.2 [Q8N2I2-4]
NP_001138555.1, NM_001145083.1 [Q8N2I2-2]
NP_001138565.1, NM_001145093.2 [Q8N2I2-3]

3D structure databases

SMRiQ8N2I2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi130063, 1 interactor
IntActiQ8N2I2, 2 interactors

PTM databases

iPTMnetiQ8N2I2
PhosphoSitePlusiQ8N2I2

Polymorphism and mutation databases

BioMutaiZNF619
DMDMi74762517

Proteomic databases

jPOSTiQ8N2I2
MassIVEiQ8N2I2
MaxQBiQ8N2I2
PaxDbiQ8N2I2
PeptideAtlasiQ8N2I2
PRIDEiQ8N2I2
ProteomicsDBi11385
19430
71705 [Q8N2I2-1]
71706 [Q8N2I2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
29047 124 antibodies

The DNASU plasmid repository

More...
DNASUi
285267

Genome annotation databases

EnsembliENST00000314686; ENSP00000322529; ENSG00000177873 [Q8N2I2-1]
ENST00000432264; ENSP00000388710; ENSG00000177873 [Q8N2I2-3]
ENST00000447116; ENSP00000411132; ENSG00000177873 [Q8N2I2-4]
ENST00000456778; ENSP00000397232; ENSG00000177873 [Q8N2I2-2]
ENST00000521353; ENSP00000430705; ENSG00000177873 [Q8N2I2-4]
GeneIDi285267
KEGGihsa:285267
UCSCiuc003ckj.4 human [Q8N2I2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
285267
EuPathDBiHostDB:ENSG00000177873.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF619
HGNCiHGNC:26910 ZNF619
HPAiENSG00000177873 Low tissue specificity
neXtProtiNX_Q8N2I2
OpenTargetsiENSG00000177873
PharmGKBiPA134889198

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000163750
HOGENOMiCLU_002678_44_5_1
InParanoidiQ8N2I2
KOiK09228
OMAiRYFSQHS
OrthoDBi1318335at2759
PhylomeDBiQ8N2I2
TreeFamiTF350844

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
285267 3 hits in 812 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF619 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
285267
PharosiQ8N2I2 Tdark

Protein Ontology

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PROi
PR:Q8N2I2
RNActiQ8N2I2 protein

Gene expression databases

BgeeiENSG00000177873 Expressed in leukocyte and 93 other tissues
ExpressionAtlasiQ8N2I2 baseline and differential
GenevisibleiQ8N2I2 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN619_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N2I2
Secondary accession number(s): B4E271
, C9JRN5, D4PHA2, E9PCD9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 1, 2002
Last modified: June 17, 2020
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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