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Protein

Protein SYS1 homolog

Gene

SYS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in protein trafficking. May serve as a receptor for ARFRP1.

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SYS1 homolog
Gene namesi
Name:SYS1
Synonyms:C20orf169
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000204070.9
HGNCiHGNC:16162 SYS1
MIMi612979 gene
neXtProtiNX_Q8N2H4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204070
PharmGKBiPA162405119

Polymorphism and mutation databases

BioMutaiSYS1
DMDMi51316873

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139401 – 156Protein SYS1 homologAdd BLAST156

Proteomic databases

EPDiQ8N2H4
MaxQBiQ8N2H4
PaxDbiQ8N2H4
PeptideAtlasiQ8N2H4
PRIDEiQ8N2H4
ProteomicsDBi71700
TopDownProteomicsiQ8N2H4-1 [Q8N2H4-1]

PTM databases

iPTMnetiQ8N2H4
PhosphoSitePlusiQ8N2H4

Expressioni

Gene expression databases

BgeeiENSG00000204070 Expressed in 196 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiQ8N2H4 baseline and differential
GenevisibleiQ8N2H4 HS

Organism-specific databases

HPAiHPA046716

Interactioni

Subunit structurei

Interacts with ARFRP1.1 Publication

Protein-protein interaction databases

IntActiQ8N2H4, 18 interactors
STRINGi9606.ENSP00000243918

Structurei

3D structure databases

ProteinModelPortaliQ8N2H4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SYS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4697 Eukaryota
ENOG4111H59 LUCA
GeneTreeiENSGT00390000004826
HOGENOMiHOG000185908
HOVERGENiHBG056907
InParanoidiQ8N2H4
KOiK20318
OMAiRSKLAWD
OrthoDBiEOG091G0RM8
PhylomeDBiQ8N2H4
TreeFamiTF105875

Family and domain databases

InterProiView protein in InterPro
IPR016973 Integral_membrane_SYS1
IPR019185 Integral_membrane_SYS1-rel
PANTHERiPTHR12952 PTHR12952, 1 hit
PfamiView protein in Pfam
PF09801 SYS1, 1 hit
PIRSFiPIRSF031402 SYS1_homologue, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q8N2H4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGQFRSYVW DPLLILSQIV LMQTVYYGSL GLWLALVDGL VRSSPSLDQM
60 70 80 90 100
FDAEILGFST PPGRLSMMSF ILNALTCALG LLYFIRRGKQ CLDFTVTVHF
110 120 130 140 150
FHLLGCWFYS SRFPSALTWW LVQAVCIALM AVIGEYLCMR TELKEIPLNS

APKSNV
Length:156
Mass (Da):17,615
Last modified:October 1, 2002 - v1
Checksum:i541FBB6326C9C0BB
GO
Isoform 2 (identifier: Q8N2H4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-156: Missing.

Note: No experimental confirmation available.
Show »
Length:76
Mass (Da):8,444
Checksum:iCDBBC2666CAC8B78
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ETM6E7ETM6_HUMAN
Protein SYS1 homolog
SYS1
135Annotation score:
Q5QPU8Q5QPU8_HUMAN
Protein SYS1 homolog
SYS1
118Annotation score:
F8WB21F8WB21_HUMAN
Protein SYS1 homolog
SYS1
57Annotation score:

Sequence cautioni

The sequence CAC39448 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04454077 – 156Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591714 mRNA Translation: CAC39448.1 Different initiation.
AK075264 mRNA Translation: BAC11506.1
AK172738 mRNA No translation available.
AL021578 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75847.1
CH471077 Genomic DNA Translation: EAW75857.1
BC048286 mRNA Translation: AAH48286.1
CCDSiCCDS13351.1 [Q8N2H4-1]
CCDS56192.1 [Q8N2H4-2]
RefSeqiNP_001093261.1, NM_001099791.2 [Q8N2H4-2]
NP_001184058.1, NM_001197129.1 [Q8N2H4-1]
NP_291020.1, NM_033542.3 [Q8N2H4-1]
UniGeneiHs.655055
Hs.733183

Genome annotation databases

EnsembliENST00000243918; ENSP00000243918; ENSG00000204070 [Q8N2H4-1]
ENST00000372727; ENSP00000361812; ENSG00000204070 [Q8N2H4-1]
ENST00000426004; ENSP00000416506; ENSG00000204070 [Q8N2H4-2]
GeneIDi90196
KEGGihsa:90196
UCSCiuc002xnv.4 human [Q8N2H4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSYS1_HUMAN
AccessioniPrimary (citable) accession number: Q8N2H4
Secondary accession number(s): C9JFB3
, E1P620, Q5QPU7, Q96SD8, Q9BQZ2, Q9BQZ4, Q9H1F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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