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Entry version 137 (08 May 2019)
Sequence version 2 (27 Jun 2006)
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Protein

Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2

Gene

PYROXD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable oxidoreductase.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi38 – 71FADSequence analysisAdd BLAST34

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (EC:1.-.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PYROXD2
Synonyms:C10orf33
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23517 PYROXD2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617889 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N2H3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84795

Open Targets

More...
OpenTargetsi
ENSG00000119943

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165549043

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PYROXD2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
109820933

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002440711 – 581Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2Add BLAST581

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N2H3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N2H3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N2H3

PeptideAtlas

More...
PeptideAtlasi
Q8N2H3

PRoteomics IDEntifications database

More...
PRIDEi
Q8N2H3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71699

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N2H3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N2H3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119943 Expressed in 192 organ(s), highest expression level in right uterine tube

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N2H3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037566
HPA037567
HPA067394

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-3919450,EBI-743771

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124263, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N2H3, 3 interactors

Molecular INTeraction database

More...
MINTi
Q8N2H3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359607

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4254 Eukaryota
COG1233 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011684

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000238954

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N2H3

Identification of Orthologs from Complete Genome Data

More...
OMAi
NIFHCAM

Database of Orthologous Groups

More...
OrthoDBi
392025at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N2H3

TreeFam database of animal gene trees

More...
TreeFami
TF315188

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.50.50.60, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01593 Amino_oxidase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51905 SSF51905, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N2H3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASGRGLCK AVAASPFPAW RRDNTEARGG LKPEYDAVVI GAGHNGLVAA
60 70 80 90 100
AYLQRLGVNT AVFERRHVIG GAAVTEEIIP GFKFSRASYL LSLLRPQIYT
110 120 130 140 150
DLELKKHGLR LHLRNPYSFT PMLEEGAGSK VPRCLLLGTD MAENQKQIAQ
160 170 180 190 200
FSQKDAQVFP KYEEFMHRLA LAIDPLLDAA PVDMAAFQHG SLLQRMRSLS
210 220 230 240 250
TLKPLLKAGR ILGAQLPRYY EVLTAPITKV LDQWFESEPL KATLATDAVI
260 270 280 290 300
GAMTSPHTPG SGYVLLHHVM GGLEGMQGAW GYVQGGMGAL SDAIASSATT
310 320 330 340 350
HGASIFTEKT VAKVQVNSEG CVQGVVLEDG TEVRSKMVLS NTSPQITFLK
360 370 380 390 400
LTPQEWLPEE FLERISQLDT RSPVTKINVA VDRLPSFLAA PNAPRGQPLP
410 420 430 440 450
HHQCSIHLNC EDTLLLHQAF EDAMDGLPSH RPVIELCIPS SLDPTLAPPG
460 470 480 490 500
CHVVSLFTQY MPYTLAGGKA WDEQERDAYA DRVFDCIEVY APGFKDSVVG
510 520 530 540 550
RDILTPPDLE RIFGLPGGNI FHCAMSLDQL YFARPVPLHS GYRCPLQGLY
560 570 580
LCGSGAHPGG GVMGAAGRNA AHVAFRDLKS M
Length:581
Mass (Da):63,068
Last modified:June 27, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i64A9FB0B283939EE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026877428P → S1 PublicationCorresponds to variant dbSNP:rs17856170Ensembl.1
Natural variantiVAR_026878461M → T2 PublicationsCorresponds to variant dbSNP:rs2147896Ensembl.1
Natural variantiVAR_026879533A → T1 PublicationCorresponds to variant dbSNP:rs2296441Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK075265 mRNA Translation: BAC11507.1
AL139243 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49884.1
CH471066 Genomic DNA Translation: EAW49885.1
BC006131 mRNA Translation: AAH06131.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7474.1

NCBI Reference Sequences

More...
RefSeqi
NP_116098.2, NM_032709.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370575; ENSP00000359607; ENSG00000119943

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84795

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84795

UCSC genome browser

More...
UCSCi
uc001kpc.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075265 mRNA Translation: BAC11507.1
AL139243 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49884.1
CH471066 Genomic DNA Translation: EAW49885.1
BC006131 mRNA Translation: AAH06131.1
CCDSiCCDS7474.1
RefSeqiNP_116098.2, NM_032709.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124263, 3 interactors
IntActiQ8N2H3, 3 interactors
MINTiQ8N2H3
STRINGi9606.ENSP00000359607

PTM databases

iPTMnetiQ8N2H3
PhosphoSitePlusiQ8N2H3

Polymorphism and mutation databases

BioMutaiPYROXD2
DMDMi109820933

Proteomic databases

jPOSTiQ8N2H3
MaxQBiQ8N2H3
PaxDbiQ8N2H3
PeptideAtlasiQ8N2H3
PRIDEiQ8N2H3
ProteomicsDBi71699

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84795
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370575; ENSP00000359607; ENSG00000119943
GeneIDi84795
KEGGihsa:84795
UCSCiuc001kpc.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84795
DisGeNETi84795

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PYROXD2
HGNCiHGNC:23517 PYROXD2
HPAiHPA037566
HPA037567
HPA067394
MIMi617889 gene
neXtProtiNX_Q8N2H3
OpenTargetsiENSG00000119943
PharmGKBiPA165549043

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4254 Eukaryota
COG1233 LUCA
GeneTreeiENSGT00390000011684
HOGENOMiHOG000238954
InParanoidiQ8N2H3
OMAiNIFHCAM
OrthoDBi392025at2759
PhylomeDBiQ8N2H3
TreeFamiTF315188

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84795

Protein Ontology

More...
PROi
PR:Q8N2H3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119943 Expressed in 192 organ(s), highest expression level in right uterine tube
GenevisibleiQ8N2H3 HS

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPYRD2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N2H3
Secondary accession number(s): D3DR61, Q5TAA9, Q9BRQ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: May 8, 2019
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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