Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger CCHC domain-containing protein 24

Gene

ZCCHC24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri132 – 149CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 24
Gene namesi
Name:ZCCHC24
Synonyms:C10orf56
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165424.6
HGNCiHGNC:26911 ZCCHC24
neXtProtiNX_Q8N2G6

Pathology & Biotechi

Organism-specific databases

DisGeNETi219654
OpenTargetsiENSG00000165424
PharmGKBiPA162409573

Polymorphism and mutation databases

BioMutaiZCCHC24
DMDMi74759814

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002742891 – 241Zinc finger CCHC domain-containing protein 24Add BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65PhosphoserineCombined sources1
Modified residuei93PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N2G6
MaxQBiQ8N2G6
PaxDbiQ8N2G6
PeptideAtlasiQ8N2G6
PRIDEiQ8N2G6
ProteomicsDBi71696

PTM databases

iPTMnetiQ8N2G6
PhosphoSitePlusiQ8N2G6

Expressioni

Gene expression databases

BgeeiENSG00000165424
CleanExiHS_ZCCHC24
ExpressionAtlasiQ8N2G6 baseline and differential
GenevisibleiQ8N2G6 HS

Organism-specific databases

HPAiHPA038348

Interactioni

Protein-protein interaction databases

BioGridi128561, 2 interactors
STRINGi9606.ENSP00000361411

Structurei

3D structure databases

ProteinModelPortaliQ8N2G6
SMRiQ8N2G6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri132 – 149CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IKHM Eukaryota
ENOG410ZS5N LUCA
GeneTreeiENSGT00390000008264
HOGENOMiHOG000273902
HOVERGENiHBG089647
InParanoidiQ8N2G6
OMAiTDHFSDL
OrthoDBiEOG091G0BHI
PhylomeDBiQ8N2G6
TreeFamiTF319664

Family and domain databases

InterProiView protein in InterPro
IPR033446 Zcchc24_zf-3CxxC
IPR025829 Zn_knuckle_CX2CX3GHX4C
IPR027377 Znf-3CxxC
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF17180 zf-3CxxC_2, 1 hit
PF13696 zf-CCHC_2, 1 hit
SMARTiView protein in SMART
SM01328 zf-3CxxC, 1 hit
SUPFAMiSSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N2G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLSAIDTS AASVYQPAQL LNWVYLSLQD THQASAFDAF RPEPTAGAAP
60 70 80 90 100
PELAFGKGRP EQLGSPLHSS YLNSFFQLQR GEALSNSVYK GASPYGSLNN
110 120 130 140 150
IADGLSSLTE HFSDLTLTSE ARKPSKRPPP NYLCHLCFNK GHYIKDCPQA
160 170 180 190 200
RPKGEGLTPY QGKKRCFGEY KCPKCKRKWM SGNSWANMGQ ECIKCHINVY
210 220 230 240
PHKQRPLEKP DGLDVSDQSK EHPQHLCEKC KVLGYYCRRV Q
Length:241
Mass (Da):26,955
Last modified:October 1, 2002 - v1
Checksum:iF5C8C8E5AEE241FC
GO

Sequence cautioni

The sequence AAH39249 differs from that shown. Reason: Frameshift at position 33.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48A → T in AAH39249 (PubMed:15489334).Curated1
Sequence conflicti152P → T in AAH39249 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03024943E → V1 PublicationCorresponds to variant dbSNP:rs17852581Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075279 mRNA Translation: BAC11516.1
AL133481 Genomic DNA No translation available.
BC028617 mRNA Translation: AAH28617.1
BC039249 mRNA Translation: AAH39249.1 Frameshift.
BC053564 mRNA Translation: AAH53564.1
CCDSiCCDS7359.1
RefSeqiNP_699198.2, NM_153367.3
UniGeneiHs.523080

Genome annotation databases

EnsembliENST00000372336; ENSP00000361411; ENSG00000165424
GeneIDi219654
KEGGihsa:219654
UCSCiuc001kak.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZCH24_HUMAN
AccessioniPrimary (citable) accession number: Q8N2G6
Secondary accession number(s): Q5U5T9, Q8TAG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health