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Protein

Ly6/PLAUR domain-containing protein 1

Gene

LYPD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Ly6/PLAUR domain-containing protein 1
Alternative name(s):
Putative HeLa tumor suppressor
Short name:
PHTS
Gene namesi
Name:LYPD1
Synonyms:LYPDC1
ORF Names:PSEC0181, UNQ3079/PRO9917
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000150551.10
HGNCiHGNC:28431 LYPD1
MIMi610450 gene
neXtProtiNX_Q8N2G4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi116372
OpenTargetsiENSG00000150551
PharmGKBiPA134862471

Polymorphism and mutation databases

BioMutaiLYPD1
DMDMi92058725

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000022674121 – 117Ly6/PLAUR domain-containing protein 1Add BLAST97
PropeptideiPRO_0000226742118 – 141Removed in mature formSequence analysisAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 54By similarity
Disulfide bondi28 ↔ 37By similarity
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi46 ↔ 77By similarity
Disulfide bondi88 ↔ 100By similarity
Disulfide bondi101 ↔ 106By similarity
Lipidationi117GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ8N2G4
PeptideAtlasiQ8N2G4
PRIDEiQ8N2G4
ProteomicsDBi71693
71694 [Q8N2G4-2]
71695 [Q8N2G4-3]

Expressioni

Gene expression databases

BgeeiENSG00000150551 Expressed in 114 organ(s), highest expression level in nucleus accumbens
CleanExiHS_LYPD1
ExpressionAtlasiQ8N2G4 baseline and differential
GenevisibleiQ8N2G4 HS

Interactioni

Subunit structurei

Interacts with CHRNA4 and nAChRs containing alpha-4:beta-2 (CHRNA4:CHRNB2) and alpha-7 (CHRNA7) subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125502, 25 interactors
IntActiQ8N2G4, 1 interactor
STRINGi9606.ENSP00000380605

Structurei

3D structure databases

ProteinModelPortaliQ8N2G4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 107UPAR/Ly6Add BLAST83

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWWH Eukaryota
ENOG410XU3J LUCA
GeneTreeiENSGT00390000002215
HOGENOMiHOG000113415
HOVERGENiHBG081940
InParanoidiQ8N2G4
OMAiTFCGLFW
OrthoDBiEOG091G0UX4
PhylomeDBiQ8N2G4
TreeFamiTF332325

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N2G4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWVLGIAATF CGLFLLPGFA LQIQCYQCEE FQLNNDCSSP EFIVNCTVNV
60 70 80 90 100
QDMCQKEVME QSAGIMYRKS CASSAACLIA SAGYQSFCSP GKLNSVCISC
110 120 130 140
CNTPLCNGPR PKKRGSSASA LRPGLRTTIL FLKLALFSAH C
Length:141
Mass (Da):15,240
Last modified:March 7, 2006 - v2
Checksum:iCFA6D98BA90792E3
GO
Isoform 2 (identifier: Q8N2G4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQAPRAAPAAPLSYDRRPRDSGRM

Note: No experimental confirmation available.
Show »
Length:164
Mass (Da):17,762
Checksum:iF0775B25672A1252
GO
Isoform 3 (identifier: Q8N2G4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MWVLG → MQAPRAAPAAPLSYDRRLRGS

Note: No experimental confirmation available.
Show »
Length:157
Mass (Da):16,920
Checksum:i126998C032DB6AC5
GO
Isoform 4 (identifier: Q8N2G4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.

Note: Gene prediction based on EST data.
Show »
Length:89
Mass (Da):9,423
Checksum:i471F6EDA17CC2E71
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WD77F8WD77_HUMAN
Ly6/PLAUR domain-containing protein...
LYPD1
39Annotation score:

Sequence cautioni

The sequence BAC11647 differs from that shown. Reason: Frameshift at position 136.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107N → S in BAC85518 (PubMed:14702039).Curated1
Sequence conflicti133K → R in BAC85518 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0469811 – 52Missing in isoform 4. CuratedAdd BLAST52
Alternative sequenceiVSP_0215831 – 5MWVLG → MQAPRAAPAAPLSYDRRLRG S in isoform 3. 1 Publication5
Alternative sequenceiVSP_0215841M → MQAPRAAPAAPLSYDRRPRD SGRM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358628 mRNA Translation: AAQ88991.1
AK094501 mRNA Translation: BAC04368.1
AK130005 mRNA Translation: BAC85273.1
AK123029 mRNA Translation: BAC85518.1
AK075487 mRNA Translation: BAC11647.1 Frameshift.
AC010974 Genomic DNA No translation available.
AC079773 Genomic DNA No translation available.
BC017318 mRNA Translation: AAH17318.1
CCDSiCCDS42759.1 [Q8N2G4-1]
CCDS46416.1 [Q8N2G4-4]
RefSeqiNP_001070895.1, NM_001077427.3 [Q8N2G4-4]
NP_001308163.1, NM_001321234.1 [Q8N2G4-3]
NP_001308164.1, NM_001321235.1 [Q8N2G4-4]
NP_653187.3, NM_144586.6 [Q8N2G4-1]
UniGeneiHs.432395

Genome annotation databases

EnsembliENST00000345008; ENSP00000340563; ENSG00000150551 [Q8N2G4-4]
ENST00000397463; ENSP00000380605; ENSG00000150551 [Q8N2G4-1]
GeneIDi116372
KEGGihsa:116372
UCSCiuc002ttn.4 human [Q8N2G4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358628 mRNA Translation: AAQ88991.1
AK094501 mRNA Translation: BAC04368.1
AK130005 mRNA Translation: BAC85273.1
AK123029 mRNA Translation: BAC85518.1
AK075487 mRNA Translation: BAC11647.1 Frameshift.
AC010974 Genomic DNA No translation available.
AC079773 Genomic DNA No translation available.
BC017318 mRNA Translation: AAH17318.1
CCDSiCCDS42759.1 [Q8N2G4-1]
CCDS46416.1 [Q8N2G4-4]
RefSeqiNP_001070895.1, NM_001077427.3 [Q8N2G4-4]
NP_001308163.1, NM_001321234.1 [Q8N2G4-3]
NP_001308164.1, NM_001321235.1 [Q8N2G4-4]
NP_653187.3, NM_144586.6 [Q8N2G4-1]
UniGeneiHs.432395

3D structure databases

ProteinModelPortaliQ8N2G4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125502, 25 interactors
IntActiQ8N2G4, 1 interactor
STRINGi9606.ENSP00000380605

Polymorphism and mutation databases

BioMutaiLYPD1
DMDMi92058725

Proteomic databases

PaxDbiQ8N2G4
PeptideAtlasiQ8N2G4
PRIDEiQ8N2G4
ProteomicsDBi71693
71694 [Q8N2G4-2]
71695 [Q8N2G4-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345008; ENSP00000340563; ENSG00000150551 [Q8N2G4-4]
ENST00000397463; ENSP00000380605; ENSG00000150551 [Q8N2G4-1]
GeneIDi116372
KEGGihsa:116372
UCSCiuc002ttn.4 human [Q8N2G4-1]

Organism-specific databases

CTDi116372
DisGeNETi116372
EuPathDBiHostDB:ENSG00000150551.10
GeneCardsiLYPD1
HGNCiHGNC:28431 LYPD1
MIMi610450 gene
neXtProtiNX_Q8N2G4
OpenTargetsiENSG00000150551
PharmGKBiPA134862471
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWWH Eukaryota
ENOG410XU3J LUCA
GeneTreeiENSGT00390000002215
HOGENOMiHOG000113415
HOVERGENiHBG081940
InParanoidiQ8N2G4
OMAiTFCGLFW
OrthoDBiEOG091G0UX4
PhylomeDBiQ8N2G4
TreeFamiTF332325

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

ChiTaRSiLYPD1 human
GeneWikiiLYPD1
GenomeRNAii116372
PROiPR:Q8N2G4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150551 Expressed in 114 organ(s), highest expression level in nucleus accumbens
CleanExiHS_LYPD1
ExpressionAtlasiQ8N2G4 baseline and differential
GenevisibleiQ8N2G4 HS

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiLYPD1_HUMAN
AccessioniPrimary (citable) accession number: Q8N2G4
Secondary accession number(s): H7BXW6
, Q6ZP52, Q6ZWI4, Q96AC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: November 7, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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