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Entry version 128 (08 May 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Armadillo repeat-containing protein 10

Gene

ARMC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53.2 Publications

Miscellaneous

Depletion of isoform 2 results in cell apoptosis while its overexpression in cells leads to accelerated growth rate and tumorogenicity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DBD domain binding Source: UniProtKB
  • p53 binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processGrowth regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Armadillo repeat-containing protein 10
Alternative name(s):
Splicing variant involved in hepatocarcinogenesis protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARMC10
Synonyms:SVH
ORF Names:PSEC0198
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21706 ARMC10

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611864 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N2F6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 27HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
83787

Open Targets

More...
OpenTargetsi
ENSG00000170632

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162376895

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARMC10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74714720

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002977071 – 343Armadillo repeat-containing protein 10Add BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei45PhosphoserineCombined sources1
Modified residuei85PhosphothreonineBy similarity1
Isoform 2 (identifier: Q8N2F6-2)
Modified residuei45PhosphoserineCombined sources1
Modified residuei50PhosphothreonineCombined sources1
Isoform 4 (identifier: Q8N2F6-4)
Modified residuei45PhosphoserineCombined sources1
Modified residuei50PhosphothreonineCombined sources1
Isoform 5 (identifier: Q8N2F6-5)
Modified residuei45PhosphoserineCombined sources1
Modified residuei50PhosphothreonineCombined sources1
Isoform 6 (identifier: Q8N2F6-6)
Modified residuei45PhosphoserineCombined sources1
Modified residuei50PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N2F6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N2F6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N2F6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N2F6

PeptideAtlas

More...
PeptideAtlasi
Q8N2F6

PRoteomics IDEntifications database

More...
PRIDEi
Q8N2F6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71688
71689 [Q8N2F6-2]
71690 [Q8N2F6-3]
71691 [Q8N2F6-4]
71692 [Q8N2F6-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N2F6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N2F6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8N2F6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues tested with higher expression in placenta, liver, kidney, heart and brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170632 Expressed in 185 organ(s), highest expression level in amniotic fluid

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N2F6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N2F6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA011036
HPA011057

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the DNA-binding domain of p53/TP53.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123762, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N2F6, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000319412

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N2F6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati138 – 180ARMAdd BLAST43

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVCU Eukaryota
ENOG4112958 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159546

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231611

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N2F6

Identification of Orthologs from Complete Genome Data

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OMAi
MMDDIVQ

Database of Orthologous Groups

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OrthoDBi
860703at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N2F6

TreeFam database of animal gene trees

More...
TreeFami
TF335652

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR006911 ARM-rpt_dom
IPR016024 ARM-type_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04826 Arm_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N2F6-1) [UniParc]FASTAAdd to basket
Also known as: SVH-A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGGPRGAGWV AAGLLLGAGA CYCIYRLTRG RRRGDRELGI RSSKSAGALE
60 70 80 90 100
EGTSEGQLCG RSARPQTGGT WESQWSKTSQ PEDLTDGSYD DVLNAEQLQK
110 120 130 140 150
LLYLLESTED PVIIERALIT LGNNAAFSVN QAIIRELGGI PIVANKINHS
160 170 180 190 200
NQSIKEKALN ALNNLSVNVE NQIKIKIYIS QVCEDVFSGP LNSAVQLAGL
210 220 230 240 250
TLLTNMTVTN DHQHMLHSYI TDLFQVLLTG NGNTKVQVLK LLLNLSENPA
260 270 280 290 300
MTEGLLRAQV DSSFLSLYDS HVAKEILLRV LTLFQNIKNC LKIEGHLAVQ
310 320 330 340
PTFTEGSLFF LLHGEECAQK IRALVDHHDA EVKEKVVTII PKI
Length:343
Mass (Da):37,540
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8DCA090DF3BBE759
GO
Isoform 2 (identifier: Q8N2F6-2) [UniParc]FASTAAdd to basket
Also known as: SVH-B

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.

Show »
Length:308
Mass (Da):33,850
Checksum:i9F74718D8B96C102
GO
Isoform 3 (identifier: Q8N2F6-3) [UniParc]FASTAAdd to basket
Also known as: SVH-C

The sequence of this isoform differs from the canonical sequence as follows:
     176-234: Missing.

Show »
Length:284
Mass (Da):31,080
Checksum:i73BCB20169E74F90
GO
Isoform 4 (identifier: Q8N2F6-4) [UniParc]FASTAAdd to basket
Also known as: SVH-D

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.
     176-234: Missing.

Show »
Length:249
Mass (Da):27,390
Checksum:iD83F237CF42AD097
GO
Isoform 5 (identifier: Q8N2F6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.
     236-259: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:284
Mass (Da):31,217
Checksum:iD7C4BCDE0E6E888D
GO
Isoform 6 (identifier: Q8N2F6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.
     177-259: Missing.

Note: Gene prediction based on EST data.Combined sources
Show »
Length:225
Mass (Da):24,757
Checksum:i73CD707988B2FE82
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J5N7C9J5N7_HUMAN
Armadillo repeat-containing protein...
ARMC10
233Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXQ8H7BXQ8_HUMAN
Armadillo repeat-containing protein...
ARMC10
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2M7H7C2M7_HUMAN
Armadillo repeat-containing protein...
ARMC10
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXM8H7BXM8_HUMAN
Armadillo repeat-containing protein...
ARMC10
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YWR7A0A0J9YWR7_HUMAN
Armadillo repeat-containing protein...
ARMC10
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXE4A0A0J9YXE4_HUMAN
Armadillo repeat-containing protein...
ARMC10
212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXV5A0A0J9YXV5_HUMAN
Armadillo repeat-containing protein...
ARMC10
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YY38A0A0J9YY38_HUMAN
Armadillo repeat-containing protein...
ARMC10
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAS07482 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti343I → V in BAF84507 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034681190P → S1 PublicationCorresponds to variant dbSNP:rs17849774Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02736147 – 81Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST35
Alternative sequenceiVSP_027362176 – 234Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_047404177 – 259Missing in isoform 6. CuratedAdd BLAST83
Alternative sequenceiVSP_043290236 – 259Missing in isoform 5. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY150851 mRNA Translation: AAN72313.1
AY150852 mRNA Translation: AAN72314.1
AY150853 mRNA Translation: AAN72315.1
AY150854 mRNA Translation: AAN72316.1
AK075500 mRNA Translation: BAC11655.1
AK291818 mRNA Translation: BAF84507.1
AK301565 mRNA Translation: BAG63060.1
AC007683 Genomic DNA Translation: AAS07531.1
AC073127 Genomic DNA Translation: AAS07482.1 Sequence problems.
AC108167 Genomic DNA Translation: AAS07456.1
BC003586 mRNA Translation: AAH03586.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55145.1 [Q8N2F6-3]
CCDS55146.1 [Q8N2F6-2]
CCDS55147.1 [Q8N2F6-5]
CCDS55148.1 [Q8N2F6-4]
CCDS55149.1 [Q8N2F6-6]
CCDS5728.1 [Q8N2F6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001154481.1, NM_001161009.2 [Q8N2F6-2]
NP_001154482.1, NM_001161010.2 [Q8N2F6-3]
NP_001154483.1, NM_001161011.2 [Q8N2F6-5]
NP_001154484.1, NM_001161012.2 [Q8N2F6-4]
NP_001154485.1, NM_001161013.2 [Q8N2F6-6]
NP_114111.2, NM_031905.4 [Q8N2F6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000323716; ENSP00000319412; ENSG00000170632 [Q8N2F6-1]
ENST00000425331; ENSP00000397969; ENSG00000170632 [Q8N2F6-5]
ENST00000428183; ENSP00000396654; ENSG00000170632 [Q8N2F6-3]
ENST00000441711; ENSP00000413619; ENSG00000170632 [Q8N2F6-2]
ENST00000454559; ENSP00000405612; ENSG00000170632 [Q8N2F6-4]
ENST00000541300; ENSP00000440463; ENSG00000170632 [Q8N2F6-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
83787

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:83787

UCSC genome browser

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UCSCi
uc003vaw.3 human [Q8N2F6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150851 mRNA Translation: AAN72313.1
AY150852 mRNA Translation: AAN72314.1
AY150853 mRNA Translation: AAN72315.1
AY150854 mRNA Translation: AAN72316.1
AK075500 mRNA Translation: BAC11655.1
AK291818 mRNA Translation: BAF84507.1
AK301565 mRNA Translation: BAG63060.1
AC007683 Genomic DNA Translation: AAS07531.1
AC073127 Genomic DNA Translation: AAS07482.1 Sequence problems.
AC108167 Genomic DNA Translation: AAS07456.1
BC003586 mRNA Translation: AAH03586.1
CCDSiCCDS55145.1 [Q8N2F6-3]
CCDS55146.1 [Q8N2F6-2]
CCDS55147.1 [Q8N2F6-5]
CCDS55148.1 [Q8N2F6-4]
CCDS55149.1 [Q8N2F6-6]
CCDS5728.1 [Q8N2F6-1]
RefSeqiNP_001154481.1, NM_001161009.2 [Q8N2F6-2]
NP_001154482.1, NM_001161010.2 [Q8N2F6-3]
NP_001154483.1, NM_001161011.2 [Q8N2F6-5]
NP_001154484.1, NM_001161012.2 [Q8N2F6-4]
NP_001154485.1, NM_001161013.2 [Q8N2F6-6]
NP_114111.2, NM_031905.4 [Q8N2F6-1]

3D structure databases

SMRiQ8N2F6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123762, 2 interactors
IntActiQ8N2F6, 6 interactors
STRINGi9606.ENSP00000319412

PTM databases

iPTMnetiQ8N2F6
PhosphoSitePlusiQ8N2F6
SwissPalmiQ8N2F6

Polymorphism and mutation databases

BioMutaiARMC10
DMDMi74714720

Proteomic databases

EPDiQ8N2F6
jPOSTiQ8N2F6
MaxQBiQ8N2F6
PaxDbiQ8N2F6
PeptideAtlasiQ8N2F6
PRIDEiQ8N2F6
ProteomicsDBi71688
71689 [Q8N2F6-2]
71690 [Q8N2F6-3]
71691 [Q8N2F6-4]
71692 [Q8N2F6-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323716; ENSP00000319412; ENSG00000170632 [Q8N2F6-1]
ENST00000425331; ENSP00000397969; ENSG00000170632 [Q8N2F6-5]
ENST00000428183; ENSP00000396654; ENSG00000170632 [Q8N2F6-3]
ENST00000441711; ENSP00000413619; ENSG00000170632 [Q8N2F6-2]
ENST00000454559; ENSP00000405612; ENSG00000170632 [Q8N2F6-4]
ENST00000541300; ENSP00000440463; ENSG00000170632 [Q8N2F6-6]
GeneIDi83787
KEGGihsa:83787
UCSCiuc003vaw.3 human [Q8N2F6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
83787
DisGeNETi83787

GeneCards: human genes, protein and diseases

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GeneCardsi
ARMC10
HGNCiHGNC:21706 ARMC10
HPAiHPA011036
HPA011057
MIMi611864 gene
neXtProtiNX_Q8N2F6
OpenTargetsiENSG00000170632
PharmGKBiPA162376895

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVCU Eukaryota
ENOG4112958 LUCA
GeneTreeiENSGT00940000159546
HOGENOMiHOG000231611
InParanoidiQ8N2F6
OMAiMMDDIVQ
OrthoDBi860703at2759
PhylomeDBiQ8N2F6
TreeFamiTF335652

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ARMC10 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
83787

Protein Ontology

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PROi
PR:Q8N2F6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170632 Expressed in 185 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiQ8N2F6 baseline and differential
GenevisibleiQ8N2F6 HS

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR006911 ARM-rpt_dom
IPR016024 ARM-type_fold
PfamiView protein in Pfam
PF04826 Arm_2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARM10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N2F6
Secondary accession number(s): A8K703
, B4DWJ8, F5GX65, Q75K91, Q75MG6, Q75ML8, Q8IZC1, Q8IZC2, Q8IZC3, Q9BTM6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 1, 2002
Last modified: May 8, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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