UniProtKB - Q8N2C7 (UNC80_HUMAN)
Protein
Protein unc-80 homolog
Gene
UNC80
Organism
Homo sapiens (Human)
Status
Functioni
Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular calcium.By similarity
GO - Molecular functioni
- cation channel activity Source: GO_Central
GO - Biological processi
- cation homeostasis Source: GO_Central
- ion transmembrane transport Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | Q8N2C7 |
Reactomei | R-HSA-2672351, Stimuli-sensing channels |
Protein family/group databases
TCDBi | 1.A.1.11.15, the voltage-gated ion channel (vic) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Protein unc-80 homolog |
Gene namesi | Name:UNC80 Synonyms:C2orf21, KIAA1843 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26582, UNC80 |
MIMi | 612636, gene |
neXtProti | NX_Q8N2C7 |
VEuPathDBi | HostDB:ENSG00000144406.18 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- axon Source: GO_Central
- cation channel complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 2268 – 2288 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2398 – 2418 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2785 – 2805 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2831 – 2851 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Involvement in diseasei
Hypotonia, infantile, with psychomotor retardation and characteristic facies 2 (IHPRF2)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, neurodegenerative disease characterized by severe truncal hypotonia since birth or early infancy, progressive peripheral spasticity, and profound psychomotor developmental delay. Some patients may have seizures.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_075874 | 189 | V → M in IHPRF2. 1 PublicationCorresponds to variant dbSNP:rs864321623EnsemblClinVar. | 1 | |
Natural variantiVAR_075875 | 1700 | P → S in IHPRF2. 1 PublicationCorresponds to variant dbSNP:rs869025316EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, NeurodegenerationOrganism-specific databases
DisGeNETi | 285175 |
GeneReviewsi | UNC80 |
MalaCardsi | UNC80 |
MIMi | 616801, phenotype |
OpenTargetsi | ENSG00000144406 |
Orphaneti | 371364, Hypotonia-speech impairment-severe cognitive delay syndrome |
PharmGKBi | PA165697705 |
Miscellaneous databases
Pharosi | Q8N2C7, Tdark |
Genetic variation databases
BioMutai | UNC80 |
DMDMi | 226698393 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089348 | 1 – 3258 | Protein unc-80 homologAdd BLAST | 3258 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 257 | PhosphoserineBy similarity | 1 | |
Modified residuei | 525 | PhosphoserineBy similarity | 1 | |
Modified residuei | 3042 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylated on tyrosine residues.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8N2C7 |
MassIVEi | Q8N2C7 |
PaxDbi | Q8N2C7 |
PeptideAtlasi | Q8N2C7 |
PRIDEi | Q8N2C7 |
ProteomicsDBi | 71677 [Q8N2C7-1] 71678 [Q8N2C7-2] 71679 [Q8N2C7-3] 71680 [Q8N2C7-4] 71681 [Q8N2C7-5] 71682 [Q8N2C7-6] 8128 |
PTM databases
iPTMneti | Q8N2C7 |
PhosphoSitePlusi | Q8N2C7 |
Expressioni
Tissue specificityi
Moderately expressed in fetal brain, spinal cord, skeletal muscle, thymus, spleen, fetal liver, small intestine, colon, kidney and uterus. Highly expressed in adrenal gland, prostate and testis, as well as in brain and cerebellum.1 Publication
Gene expression databases
Bgeei | ENSG00000144406, Expressed in cerebellar vermis and 120 other tissues |
ExpressionAtlasi | Q8N2C7, baseline and differential |
Genevisiblei | Q8N2C7, HS |
Organism-specific databases
HPAi | ENSG00000144406, Group enriched (adrenal gland, brain, pituitary gland, testis) |
Interactioni
Subunit structurei
Found in a complex with NALCN, UNC79 and UNC80; UNC80 bridges NALCN to UNC79.
Interacts with NALCN.
Interacts with UNC79.
By similarityProtein-protein interaction databases
BioGRIDi | 130032, 6 interactors |
IntActi | Q8N2C7, 5 interactors |
MINTi | Q8N2C7 |
STRINGi | 9606.ENSP00000391088 |
Miscellaneous databases
RNActi | Q8N2C7, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 720 – 766 | Gly-richAdd BLAST | 47 |
Sequence similaritiesi
Belongs to the unc-80 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSTP, Eukaryota |
GeneTreei | ENSGT00640000091496 |
HOGENOMi | CLU_000495_1_0_1 |
InParanoidi | Q8N2C7 |
OMAi | FYQWAEA |
OrthoDBi | 82175at2759 |
PhylomeDBi | Q8N2C7 |
TreeFami | TF313531 |
Family and domain databases
InterProi | View protein in InterPro IPR031542, UNC80_N |
Pfami | View protein in Pfam PF15778, UNC80, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N2C7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVKRKSSEGQ EQDGGRGIPL PIQTFLWRQT SAFLRPKLGK QYEASCVSFE
60 70 80 90 100
RVLVENKLHG LSPALSEAIQ SISRWELVQA ALPHVLHCTA TLLSNRNKLG
110 120 130 140 150
HQDKLGVAET KLLHTLHWML LEAPQDCNNE RFGGTDRGSS WGGSSSAFIH
160 170 180 190 200
QVENQGSPGQ PCQSSSNDEE ENNRRKIFQN SMATVELFVF LFAPLVHRIK
210 220 230 240 250
ESDLTFRLAS GLVIWQPMWE HRQPGVSGFT ALVKPIRNII TAKRSSPINS
260 270 280 290 300
QSRTCESPNQ DARHLEGLQV VCETFQSDSI SPKATISGCH RGNSFDGSLS
310 320 330 340 350
SQTSQERGPS HSRASLVIPP CQRSRYATYF DVAVLRCLLQ PHWSEEGTQW
360 370 380 390 400
SLMYYLQRLR HMLEEKPEKP PEPDIPLLPR PRSSSMVAAA PSLVNTHKTQ
410 420 430 440 450
DLTMKCNEEE KSLSSEAFSK VSLTNLRRSA VPDLSSDLGM NIFKKFKSRK
460 470 480 490 500
EDRERKGSIP FHHTGKRRPR RMGVPFLLHE DHLDVSPTRS TFSFGSFSGL
510 520 530 540 550
GEDRRGIEKG GWQTTILGKL TRRGSSDAAT EMESLSARHS HSHHTLVSDL
560 570 580 590 600
PDPSNSHGEN TVKEVRSQIS TITVATFNTT LASFNVGYAD FFNEHMRKLC
610 620 630 640 650
NQVPIPEMPH EPLACANLPR SLTDSCINYS YLEDTEHIDG TNNFVHKNGM
660 670 680 690 700
LDLSVVLKAV YLVLNHDISS RICDVALNIV ECLLQLGVVP CVEKNRKKSE
710 720 730 740 750
NKENETLEKR PSEGAFQFKG VSGSSTCGFG GPAVSGAGDG GGEEGGGGDG
760 770 780 790 800
GGGGGDGGGG GGGGGGPYEK NDKNQEKDES TPVSNHRLAL TMLIKIVKSL
810 820 830 840 850
GCAYGCGEGH RGLSGDRLRH QVFRENAQNC LTKLYKLDKM QFRQTMRDYV
860 870 880 890 900
NKDSLNNVVD FLHALLGFCM EPVTDNKAGF GNNFTTVDNK STAQNVEGII
910 920 930 940 950
VSAMFKSLIT RCASTTHELH SPENLGLYCD IRQLVQFIKE AHGNVFRRVA
960 970 980 990 1000
LSALLDSAEK LAPGKKVEEN EQESKPAGSK RSEAGSIVDK GQVSSAPEEC
1010 1020 1030 1040 1050
RSFMSGRPSQ TPEHDEQMQG ANLGRKDFWR KMFKSQSAAS DTSSQSEQDT
1060 1070 1080 1090 1100
SECTTAHSGT TSDRRARSRS RRISLRKKLK LPIGKRNWLK RSSLSGLADG
1110 1120 1130 1140 1150
VEDLLDISSV DRLSFIRQSS KVKFTSAVKL SEGGPGSGME NGRDEEENFF
1160 1170 1180 1190 1200
KRLGCHSFDD HLSPNQDGGK SKNVVNLGAI RQGMKRFQFL LNCCEPGTIP
1210 1220 1230 1240 1250
DASILAAALD LEAPVVARAA LFLECARFVH RCNRGNWPEW MKGHHVNITK
1260 1270 1280 1290 1300
KGLSRGRSPI VGNKRNQKLQ WNAAKLFYQW GDAIGVRLNE LCHGESESPA
1310 1320 1330 1340 1350
NLLGLIYDEE TKRRLRKEDE EEDFLDDSTV NPSKCGCPFA LKMAACQLLL
1360 1370 1380 1390 1400
EITTFLRETF SCLPRPRTEP LVDLESCRLR LDPELDRHRY ERKISFAGVL
1410 1420 1430 1440 1450
DENEDSKDSL HSSSHTLKSD AGVEEKKEGS PWSASEPSIE PEGMSNAGAE
1460 1470 1480 1490 1500
ENYHRNMSWL HVMILLCNQQ SFICTHVDYC HPHCYLHHSR SCARLVRAIK
1510 1520 1530 1540 1550
LLYGDSVDSL RESSNISSVA LRGKKQKECS DKSCLRTPSL KKRVSDANLE
1560 1570 1580 1590 1600
GKKDSGMLKY IRLQVMSLSP APLSLLIKAA PILTEEMYGD IQPAAWELLL
1610 1620 1630 1640 1650
SMDEHMAGAA AAMFLLCAVK VPEAVSDMLM SEFHHPETVQ RLNAVLKFHT
1660 1670 1680 1690 1700
LWRFRYQVWP RMEEGAQQIF KIPPPSINFT LPSPVLGMPS VPMFDPPWVP
1710 1720 1730 1740 1750
QCSGSVQDPI NEDQSKSFSA RAVSRSHQRA EHILKNLQQE EEKKRLGREA
1760 1770 1780 1790 1800
SLITAIPITQ EACYEPTCTP NSEPEEEVEE VTNLASRRLS VSPSCTSSTS
1810 1820 1830 1840 1850
HRNYSFRRGS VWSVRSAVSA EDEEHTTEHT PNHHVPQPPQ AVFPACICAA
1860 1870 1880 1890 1900
VLPIVHLMED GEVREDGVAV SAVAQQVLWN CLIEDPSTVL RHFLEKLTIS
1910 1920 1930 1940 1950
NRQDELMYML RKLLLNIGDF PAQTSHILFN YLVGLIMYFV RTPCEWGMDA
1960 1970 1980 1990 2000
ISATLTFLWE VVGYVEGLFF KDLKQTMKKE QCEVKLLVTA SMPGTKTLVV
2010 2020 2030 2040 2050
HGQNECDIPT QLPVHEDTQF EALLKECLEF FNIPESQSTH YFLMDKRWNL
2060 2070 2080 2090 2100
IHYNKTYVRD IYPFRRSVSP QLNLVHMHPE KGQELIQKQV FTRKLEEVGR
2110 2120 2130 2140 2150
VLFLISLTQK IPTAHKQSHV SMLQEDLLRL PSFPRSAIDA EFSLFSDPQA
2160 2170 2180 2190 2200
GKELFGLDTL QKSLWIQLLE EMFLGMPSEF PWGDEIMLFL NVFNGALILH
2210 2220 2230 2240 2250
PEDSALLRQY AATVINTAVH FNHLFSLSGY QWILPTMLQV YSDYESNPQL
2260 2270 2280 2290 2300
RQAIEFACHQ FYILHRKPFV LQLFASVAPL LEFPDAANNG PSKGVSAQCL
2310 2320 2330 2340 2350
FDLLQSLEGE TTDILDILEL VKAEKPLKSL DFCYGNEDLT FSISEAIKLC
2360 2370 2380 2390 2400
VTVVAYAPES FRSLQMLMVL EALVPCYLQK LKRQTSQVET VPAAREEIAA
2410 2420 2430 2440 2450
TAALATSLQA LLYSVEVLTR PMTAPQMSRC DQGHKGTTTA NHTMSSGVNT
2460 2470 2480 2490 2500
RYQEQGAKLH FIRENLHLLE EGQGIPREEL DERIAREEFR RPRESLLNIC
2510 2520 2530 2540 2550
TEFYKHCGPR LKILQNLAGE PRVIALELLD VKSHMRLAEI AHSLLKLAPY
2560 2570 2580 2590 2600
DTQTMESRGL RRYIMEMLPI TDWTAEAVRP ALILILKRLD RMFNKIHKMP
2610 2620 2630 2640 2650
TLRRQVEWEP ASNLIEGVCL TLQRQPIISF LPHLRSLINV CVNLVMGVVG
2660 2670 2680 2690 2700
PSSVADGLPL LHLSPYLSPP LPFSTAVVRL VALQIQALKE DFPLSHVISP
2710 2720 2730 2740 2750
FTNQERREGM LLNLLIPFVL TVGSGSKDSP WLEQPEVQLL LQTVINVLLP
2760 2770 2780 2790 2800
PRIISTSRSK NFMLESSPAH CSTPGDAGKD LRREGLAEST SQAAYLALKV
2810 2820 2830 2840 2850
ILVCFERQLG SQWYWLSLQV KEMALRKVGG LALWDFLDFI VRTRIPIFVL
2860 2870 2880 2890 2900
LRPFIQCKLL AQPAENHEEL SARQHIADQL ERRFIPRPLC KSSLIAEFNS
2910 2920 2930 2940 2950
ELKILKEAVH SGSAYQGKTS ISTVGTSTSA YRLSLATMSR SNTGTGTVWE
2960 2970 2980 2990 3000
QDSEPSQQAS QDTLSRTDEE DEENDSISMP SVVSEQEAYL LSAIGRRRFS
3010 3020 3030 3040 3050
SHVSSMSVPQ AEVGMLPSQS EPNVLDDSQG LAAEGSLSRV ASIQSEPGQQ
3060 3070 3080 3090 3100
NLLVQQPLGR KRGLRQLRRP LLSRQKTQTE PRNRQGARLS TTRRSIQPKT
3110 3120 3130 3140 3150
KPSADQKRSV TFIEAQPEPA AAPTDALPAT GQLQGCSPAP SRKPEAMDEP
3160 3170 3180 3190 3200
VLTSSPAIVV ADLHSVSPKQ SENFPTEEGE KEEDTEAQGA TAHSPLSAQL
3210 3220 3230 3240 3250
SDPDDFTGLE TSSLLQHGDT VLHISEENGM ENPLLSSQFT FTPTELGKTD
AVLDESHV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A669KAW8 | A0A669KAW8_HUMAN | Protein unc-80 homolog | UNC80 | 3,256 | Annotation score: | ||
A0A669KBC5 | A0A669KBC5_HUMAN | Protein unc-80 homolog | UNC80 | 3,324 | Annotation score: | ||
H3BLU5 | H3BLU5_HUMAN | Protein unc-80 homolog | UNC80 | 546 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 185 | V → A in BAC03521 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 272 | C → R in BAC03521 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 826 | N → Q in BAB47472 (PubMed:11347906).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033656 | 131 | R → W. Corresponds to variant dbSNP:rs35822936EnsemblClinVar. | 1 | |
Natural variantiVAR_075874 | 189 | V → M in IHPRF2. 1 PublicationCorresponds to variant dbSNP:rs864321623EnsemblClinVar. | 1 | |
Natural variantiVAR_060196 | 1505 | D → G. Corresponds to variant dbSNP:rs4673492Ensembl. | 1 | |
Natural variantiVAR_075875 | 1700 | P → S in IHPRF2. 1 PublicationCorresponds to variant dbSNP:rs869025316EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036741 | 1 – 2554 | Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST | 2554 | |
Alternative sequenceiVSP_036742 | 314 – 320 | ASLVIPP → STFHFPP in isoform 3. 2 Publications | 7 | |
Alternative sequenceiVSP_036743 | 321 – 3258 | Missing in isoform 3. 2 PublicationsAdd BLAST | 2938 | |
Alternative sequenceiVSP_054289 | 822 – 826 | Missing in isoform 7. Curated | 5 | |
Alternative sequenceiVSP_031528 | 2604 – 3258 | Missing in isoform 2. 1 PublicationAdd BLAST | 655 | |
Alternative sequenceiVSP_036744 | 3020 – 3038 | Missing in isoform 5 and isoform 7. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_036745 | 3020 | S → R in isoform 4 and isoform 6. 1 Publication | 1 | |
Alternative sequenceiVSP_036746 | 3021 – 3258 | Missing in isoform 4 and isoform 6. 1 PublicationAdd BLAST | 238 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027583 mRNA Translation: BAB55211.1 AK090815 mRNA Translation: BAC03521.1 AK299022 mRNA Translation: BAG61101.1 AK302830 mRNA Translation: BAG64025.1 AC006385 Genomic DNA No translation available. AC006464 Genomic DNA No translation available. AC007038 Genomic DNA No translation available. CH471063 Genomic DNA Translation: EAW70468.1 BC136690 mRNA Translation: AAI36691.1 BC136693 mRNA Translation: AAI36694.1 AB058746 mRNA Translation: BAB47472.2 |
CCDSi | CCDS2387.2 [Q8N2C7-7] CCDS46504.1 [Q8N2C7-1] |
RefSeqi | NP_115893.1, NM_032504.1 [Q8N2C7-1] NP_872393.3, NM_182587.3 [Q8N2C7-7] |
Genome annotation databases
Ensembli | ENST00000272845; ENSP00000272845; ENSG00000144406 [Q8N2C7-7] ENST00000439458; ENSP00000391088; ENSG00000144406 [Q8N2C7-1] |
GeneIDi | 285175 |
KEGGi | hsa:285175 |
UCSCi | uc010zjc.1, human [Q8N2C7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027583 mRNA Translation: BAB55211.1 AK090815 mRNA Translation: BAC03521.1 AK299022 mRNA Translation: BAG61101.1 AK302830 mRNA Translation: BAG64025.1 AC006385 Genomic DNA No translation available. AC006464 Genomic DNA No translation available. AC007038 Genomic DNA No translation available. CH471063 Genomic DNA Translation: EAW70468.1 BC136690 mRNA Translation: AAI36691.1 BC136693 mRNA Translation: AAI36694.1 AB058746 mRNA Translation: BAB47472.2 |
CCDSi | CCDS2387.2 [Q8N2C7-7] CCDS46504.1 [Q8N2C7-1] |
RefSeqi | NP_115893.1, NM_032504.1 [Q8N2C7-1] NP_872393.3, NM_182587.3 [Q8N2C7-7] |
3D structure databases
SMRi | Q8N2C7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130032, 6 interactors |
IntActi | Q8N2C7, 5 interactors |
MINTi | Q8N2C7 |
STRINGi | 9606.ENSP00000391088 |
Protein family/group databases
TCDBi | 1.A.1.11.15, the voltage-gated ion channel (vic) superfamily |
PTM databases
iPTMneti | Q8N2C7 |
PhosphoSitePlusi | Q8N2C7 |
Genetic variation databases
BioMutai | UNC80 |
DMDMi | 226698393 |
Proteomic databases
EPDi | Q8N2C7 |
MassIVEi | Q8N2C7 |
PaxDbi | Q8N2C7 |
PeptideAtlasi | Q8N2C7 |
PRIDEi | Q8N2C7 |
ProteomicsDBi | 71677 [Q8N2C7-1] 71678 [Q8N2C7-2] 71679 [Q8N2C7-3] 71680 [Q8N2C7-4] 71681 [Q8N2C7-5] 71682 [Q8N2C7-6] 8128 |
Protocols and materials databases
Antibodypediai | 52283, 64 antibodies |
DNASUi | 285175 |
Genome annotation databases
Ensembli | ENST00000272845; ENSP00000272845; ENSG00000144406 [Q8N2C7-7] ENST00000439458; ENSP00000391088; ENSG00000144406 [Q8N2C7-1] |
GeneIDi | 285175 |
KEGGi | hsa:285175 |
UCSCi | uc010zjc.1, human [Q8N2C7-1] |
Organism-specific databases
CTDi | 285175 |
DisGeNETi | 285175 |
GeneCardsi | UNC80 |
GeneReviewsi | UNC80 |
HGNCi | HGNC:26582, UNC80 |
HPAi | ENSG00000144406, Group enriched (adrenal gland, brain, pituitary gland, testis) |
MalaCardsi | UNC80 |
MIMi | 612636, gene 616801, phenotype |
neXtProti | NX_Q8N2C7 |
OpenTargetsi | ENSG00000144406 |
Orphaneti | 371364, Hypotonia-speech impairment-severe cognitive delay syndrome |
PharmGKBi | PA165697705 |
VEuPathDBi | HostDB:ENSG00000144406.18 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSTP, Eukaryota |
GeneTreei | ENSGT00640000091496 |
HOGENOMi | CLU_000495_1_0_1 |
InParanoidi | Q8N2C7 |
OMAi | FYQWAEA |
OrthoDBi | 82175at2759 |
PhylomeDBi | Q8N2C7 |
TreeFami | TF313531 |
Enzyme and pathway databases
PathwayCommonsi | Q8N2C7 |
Reactomei | R-HSA-2672351, Stimuli-sensing channels |
Miscellaneous databases
BioGRID-ORCSi | 285175, 4 hits in 863 CRISPR screens |
ChiTaRSi | UNC80, human |
GenomeRNAii | 285175 |
Pharosi | Q8N2C7, Tdark |
PROi | PR:Q8N2C7 |
RNActi | Q8N2C7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000144406, Expressed in cerebellar vermis and 120 other tissues |
ExpressionAtlasi | Q8N2C7, baseline and differential |
Genevisiblei | Q8N2C7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR031542, UNC80_N |
Pfami | View protein in Pfam PF15778, UNC80, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UNC80_HUMAN | |
Accessioni | Q8N2C7Primary (citable) accession number: Q8N2C7 Secondary accession number(s): B2RN50 Q96SS0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | March 24, 2009 | |
Last modified: | February 10, 2021 | |
This is version 125 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM