UniProtKB - Q8N283 (ANR35_HUMAN)
Protein
Ankyrin repeat domain-containing protein 35
Gene
ANKRD35
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Ankyrin repeat domain-containing protein 35 |
Gene namesi | Name:ANKRD35 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000198483.12 |
HGNCi | HGNC:26323, ANKRD35 |
neXtProti | NX_Q8N283 |
Pathology & Biotechi
Organism-specific databases
PharmGKBi | PA134896362 |
Miscellaneous databases
Pharosi | Q8N283, Tdark |
Polymorphism and mutation databases
BioMutai | ANKRD35 |
DMDMi | 109940222 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000243910 | 1 – 1001 | Ankyrin repeat domain-containing protein 35Add BLAST | 1001 |
Proteomic databases
EPDi | Q8N283 |
MassIVEi | Q8N283 |
MaxQBi | Q8N283 |
PaxDbi | Q8N283 |
PeptideAtlasi | Q8N283 |
PRIDEi | Q8N283 |
ProteomicsDBi | 4511 71667 [Q8N283-1] |
PTM databases
iPTMneti | Q8N283 |
PhosphoSitePlusi | Q8N283 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198483, Expressed in upper arm skin and 208 other tissues |
ExpressionAtlasi | Q8N283, baseline and differential |
Genevisiblei | Q8N283, HS |
Organism-specific databases
HPAi | ENSG00000198483, Tissue enhanced (skin) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127165, 3 interactors |
IntActi | Q8N283, 7 interactors |
MINTi | Q8N283 |
STRINGi | 9606.ENSP00000347802 |
Miscellaneous databases
RNActi | Q8N283, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 53 – 82 | ANK 1Add BLAST | 30 | |
Repeati | 86 – 115 | ANK 2Add BLAST | 30 | |
Repeati | 119 – 148 | ANK 3Add BLAST | 30 | |
Repeati | 152 – 181 | ANK 4Add BLAST | 30 | |
Repeati | 185 – 214 | ANK 5Add BLAST | 30 | |
Repeati | 218 – 247 | ANK 6Add BLAST | 30 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 295 – 344 | Sequence analysisAdd BLAST | 50 | |
Coiled coili | 610 – 696 | Sequence analysisAdd BLAST | 87 | |
Coiled coili | 733 – 810 | Sequence analysisAdd BLAST | 78 | |
Coiled coili | 851 – 968 | Sequence analysisAdd BLAST | 118 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 527 – 533 | Poly-Ala | 7 |
Keywords - Domaini
ANK repeat, Coiled coil, RepeatPhylogenomic databases
eggNOGi | ENOG502QXWS, Eukaryota |
HOGENOMi | CLU_298955_0_0_1 |
InParanoidi | Q8N283 |
OrthoDBi | 1514637at2759 |
PhylomeDBi | Q8N283 |
TreeFami | TF331274 |
Family and domain databases
Gene3Di | 1.25.40.20, 2 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 2 hits |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 5 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N283-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKRIFSCSST QVAVERWNRH DQKLLEAVHR GDVGRVAALA SRKSARPTKL
60 70 80 90 100
DSNGQSPFHL AASKGLTECL TILLANGADI NSKNEDGSTA LHLATISCQP
110 120 130 140 150
QCVKVLLQHG ANEDAVDAEN RSPLHWAASS GCASSVLLLC DHEAFLDVLD
160 170 180 190 200
NDGRTPLMIA SLGGHAAICS QLLQRGARVN VTDKNDKSAL ILACEKGSAE
210 220 230 240 250
VAELLLSHGA DAGAVDSTGH DALHYALHTQ DKALWRHLQQ ALSRRRRGGQ
260 270 280 290 300
RLVQHPDLAS QASPSEPQAG SPPKSSWRAE PEEEQEEKED EDPCSEEWRW
310 320 330 340 350
KYEEERRKVV RLEQELVQKT EECKTQAAAY LDLENQIREQ AQELGVLLSW
360 370 380 390 400
EPRASGKQGS SLRPGGDGME QGCPKDLLAE STQELKKQQQ AAATVNPVLA
410 420 430 440 450
PKKAEDSAPG KIQYEVHGRS QPEEQGPPQS PASETIRKAT GQQLTTNGAQ
460 470 480 490 500
TFGPDHADQL PAGQKESSQV LGVEPGGTVA EPVGPAAMNQ LLLQLREELA
510 520 530 540 550
AVWREKDAAR GALSRPVMEG ALGTPRAEAA AAAWEKMEAR LERVLARLEW
560 570 580 590 600
AKAGLQVKPE VPSQESREGA LKAAPGSIKQ DEEKEKRVPG ARGEPLGALG
610 620 630 640 650
GEKALGGLAK GQLEKEMSVL RLSNSNLLEE LGELGRERQR LQRELQSLSQ
660 670 680 690 700
RLQREFVPKP EAQVQLQQLR QSVGLLTNEL AMEKEATEKL RKLLASQSSG
710 720 730 740 750
LRGLWDCLPA DLVGERSAQS KAAESLEELR ACISTLVDRH REAQQVLARL
760 770 780 790 800
QEENQQLRGS LSPCREPGTS LKAPASPQVA ALEQDLGKLE EELRAVQATM
810 820 830 840 850
SGKSQEIGKL KQLLYQATEE VAELRAREAA SLRQHEKTRG SLVAQAQAWG
860 870 880 890 900
QELKALLEKY NTACREVGRL REAVAEERRR SGDLAAQAAE QERQASEMRG
910 920 930 940 950
RSEQFEKTAE LLKEKMEHLI GACRDKEAKI KELLKKLEQL SEEVLAIRGE
960 970 980 990 1000
NARLALQLQD SQKNHEEIIS TYRNHLLNAA RGYMEHEVYN ILLQILSMEE
E
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF6XZD3 | F6XZD3_HUMAN | Ankyrin repeat domain-containing pr... | ANKRD35 | 911 | Annotation score: |
Sequence cautioni
The sequence BAB71597 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 188 | S → A in BAB71597 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 820 | E → G in BAC03587 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048278 | 53 | N → K. Corresponds to variant dbSNP:rs6658371Ensembl. | 1 | |
Natural variantiVAR_026870 | 428 | P → S2 PublicationsCorresponds to variant dbSNP:rs6670984Ensembl. | 1 | |
Natural variantiVAR_061017 | 592 | R → Q. Corresponds to variant dbSNP:rs41315701Ensembl. | 1 | |
Natural variantiVAR_033506 | 978 | N → D. Corresponds to variant dbSNP:rs16827032Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056916 | 109 – 137 | HGANE…ASSVL → PPLAVPQVCSCCVTTKPSWT CWIMMDVHP in isoform 2. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_056917 | 138 – 1001 | Missing in isoform 2. 1 PublicationAdd BLAST | 864 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057853 mRNA Translation: BAB71597.1 Different initiation. AK091120 mRNA Translation: BAC03587.1 AK296861 mRNA Translation: BAG59424.1 AL160282 Genomic DNA No translation available. BC101618 mRNA Translation: AAI01619.1 BC101620 mRNA Translation: AAI01621.1 |
CCDSi | CCDS72867.1 [Q8N283-1] |
RefSeqi | NP_653299.4, NM_144698.4 |
Genome annotation databases
Ensembli | ENST00000355594; ENSP00000347802; ENSG00000198483 |
GeneIDi | 148741 |
KEGGi | hsa:148741 |
UCSCi | uc001eob.2, human [Q8N283-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057853 mRNA Translation: BAB71597.1 Different initiation. AK091120 mRNA Translation: BAC03587.1 AK296861 mRNA Translation: BAG59424.1 AL160282 Genomic DNA No translation available. BC101618 mRNA Translation: AAI01619.1 BC101620 mRNA Translation: AAI01621.1 |
CCDSi | CCDS72867.1 [Q8N283-1] |
RefSeqi | NP_653299.4, NM_144698.4 |
3D structure databases
SMRi | Q8N283 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127165, 3 interactors |
IntActi | Q8N283, 7 interactors |
MINTi | Q8N283 |
STRINGi | 9606.ENSP00000347802 |
PTM databases
iPTMneti | Q8N283 |
PhosphoSitePlusi | Q8N283 |
Polymorphism and mutation databases
BioMutai | ANKRD35 |
DMDMi | 109940222 |
Proteomic databases
EPDi | Q8N283 |
MassIVEi | Q8N283 |
MaxQBi | Q8N283 |
PaxDbi | Q8N283 |
PeptideAtlasi | Q8N283 |
PRIDEi | Q8N283 |
ProteomicsDBi | 4511 71667 [Q8N283-1] |
Protocols and materials databases
Antibodypediai | 49637, 12 antibodies |
Genome annotation databases
Ensembli | ENST00000355594; ENSP00000347802; ENSG00000198483 |
GeneIDi | 148741 |
KEGGi | hsa:148741 |
UCSCi | uc001eob.2, human [Q8N283-1] |
Organism-specific databases
CTDi | 148741 |
EuPathDBi | HostDB:ENSG00000198483.12 |
GeneCardsi | ANKRD35 |
HGNCi | HGNC:26323, ANKRD35 |
HPAi | ENSG00000198483, Tissue enhanced (skin) |
neXtProti | NX_Q8N283 |
PharmGKBi | PA134896362 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QXWS, Eukaryota |
HOGENOMi | CLU_298955_0_0_1 |
InParanoidi | Q8N283 |
OrthoDBi | 1514637at2759 |
PhylomeDBi | Q8N283 |
TreeFami | TF331274 |
Enzyme and pathway databases
PathwayCommonsi | Q8N283 |
Miscellaneous databases
BioGRID-ORCSi | 148741, 10 hits in 844 CRISPR screens |
ChiTaRSi | ANKRD35, human |
GenomeRNAii | 148741 |
Pharosi | Q8N283, Tdark |
PROi | PR:Q8N283 |
RNActi | Q8N283, protein |
Gene expression databases
Bgeei | ENSG00000198483, Expressed in upper arm skin and 208 other tissues |
ExpressionAtlasi | Q8N283, baseline and differential |
Genevisiblei | Q8N283, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 2 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 2 hits |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 5 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANR35_HUMAN | |
Accessioni | Q8N283Primary (citable) accession number: Q8N283 Secondary accession number(s): A6NEU0 Q96LS3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | June 27, 2006 | |
Last modified: | December 2, 2020 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations