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Entry version 132 (10 Feb 2021)
Sequence version 2 (27 Jun 2006)
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Protein

Ankyrin repeat domain-containing protein 35

Gene

ANKRD35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8N283

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 35
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKRD35
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26323, ANKRD35

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N283

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000198483.12

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134896362

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N283, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANKRD35

Domain mapping of disease mutations (DMDM)

More...
DMDMi
109940222

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002439101 – 1001Ankyrin repeat domain-containing protein 35Add BLAST1001

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N283

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N283

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N283

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N283

PeptideAtlas

More...
PeptideAtlasi
Q8N283

PRoteomics IDEntifications database

More...
PRIDEi
Q8N283

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
4511
71667 [Q8N283-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N283

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N283

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198483, Expressed in upper arm skin and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N283, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N283, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000198483, Tissue enhanced (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127165, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N283, 7 interactors

Molecular INTeraction database

More...
MINTi
Q8N283

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000347802

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N283, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N283

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati53 – 82ANK 1Add BLAST30
Repeati86 – 115ANK 2Add BLAST30
Repeati119 – 148ANK 3Add BLAST30
Repeati152 – 181ANK 4Add BLAST30
Repeati185 – 214ANK 5Add BLAST30
Repeati218 – 247ANK 6Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili295 – 344Sequence analysisAdd BLAST50
Coiled coili610 – 696Sequence analysisAdd BLAST87
Coiled coili733 – 810Sequence analysisAdd BLAST78
Coiled coili851 – 968Sequence analysisAdd BLAST118

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi527 – 533Poly-Ala7

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QXWS, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_298955_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N283

Database of Orthologous Groups

More...
OrthoDBi
1514637at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N283

TreeFam database of animal gene trees

More...
TreeFami
TF331274

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N283-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRIFSCSST QVAVERWNRH DQKLLEAVHR GDVGRVAALA SRKSARPTKL
60 70 80 90 100
DSNGQSPFHL AASKGLTECL TILLANGADI NSKNEDGSTA LHLATISCQP
110 120 130 140 150
QCVKVLLQHG ANEDAVDAEN RSPLHWAASS GCASSVLLLC DHEAFLDVLD
160 170 180 190 200
NDGRTPLMIA SLGGHAAICS QLLQRGARVN VTDKNDKSAL ILACEKGSAE
210 220 230 240 250
VAELLLSHGA DAGAVDSTGH DALHYALHTQ DKALWRHLQQ ALSRRRRGGQ
260 270 280 290 300
RLVQHPDLAS QASPSEPQAG SPPKSSWRAE PEEEQEEKED EDPCSEEWRW
310 320 330 340 350
KYEEERRKVV RLEQELVQKT EECKTQAAAY LDLENQIREQ AQELGVLLSW
360 370 380 390 400
EPRASGKQGS SLRPGGDGME QGCPKDLLAE STQELKKQQQ AAATVNPVLA
410 420 430 440 450
PKKAEDSAPG KIQYEVHGRS QPEEQGPPQS PASETIRKAT GQQLTTNGAQ
460 470 480 490 500
TFGPDHADQL PAGQKESSQV LGVEPGGTVA EPVGPAAMNQ LLLQLREELA
510 520 530 540 550
AVWREKDAAR GALSRPVMEG ALGTPRAEAA AAAWEKMEAR LERVLARLEW
560 570 580 590 600
AKAGLQVKPE VPSQESREGA LKAAPGSIKQ DEEKEKRVPG ARGEPLGALG
610 620 630 640 650
GEKALGGLAK GQLEKEMSVL RLSNSNLLEE LGELGRERQR LQRELQSLSQ
660 670 680 690 700
RLQREFVPKP EAQVQLQQLR QSVGLLTNEL AMEKEATEKL RKLLASQSSG
710 720 730 740 750
LRGLWDCLPA DLVGERSAQS KAAESLEELR ACISTLVDRH REAQQVLARL
760 770 780 790 800
QEENQQLRGS LSPCREPGTS LKAPASPQVA ALEQDLGKLE EELRAVQATM
810 820 830 840 850
SGKSQEIGKL KQLLYQATEE VAELRAREAA SLRQHEKTRG SLVAQAQAWG
860 870 880 890 900
QELKALLEKY NTACREVGRL REAVAEERRR SGDLAAQAAE QERQASEMRG
910 920 930 940 950
RSEQFEKTAE LLKEKMEHLI GACRDKEAKI KELLKKLEQL SEEVLAIRGE
960 970 980 990 1000
NARLALQLQD SQKNHEEIIS TYRNHLLNAA RGYMEHEVYN ILLQILSMEE

E
Length:1,001
Mass (Da):109,966
Last modified:June 27, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA7B90CF32E3F842
GO
Isoform 2 (identifier: Q8N283-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-137: HGANEDAVDAENRSPLHWAASSGCASSVL → PPLAVPQVCSCCVTTKPSWTCWIMMDVHP
     138-1001: Missing.

Show »
Length:137
Mass (Da):14,894
Checksum:i47DCC2F764124DE8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6XZD3F6XZD3_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD35
911Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB71597 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti188S → A in BAB71597 (PubMed:14702039).Curated1
Sequence conflicti820E → G in BAC03587 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04827853N → K. Corresponds to variant dbSNP:rs6658371Ensembl.1
Natural variantiVAR_026870428P → S2 PublicationsCorresponds to variant dbSNP:rs6670984Ensembl.1
Natural variantiVAR_061017592R → Q. Corresponds to variant dbSNP:rs41315701Ensembl.1
Natural variantiVAR_033506978N → D. Corresponds to variant dbSNP:rs16827032Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056916109 – 137HGANE…ASSVL → PPLAVPQVCSCCVTTKPSWT CWIMMDVHP in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_056917138 – 1001Missing in isoform 2. 1 PublicationAdd BLAST864

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK057853 mRNA Translation: BAB71597.1 Different initiation.
AK091120 mRNA Translation: BAC03587.1
AK296861 mRNA Translation: BAG59424.1
AL160282 Genomic DNA No translation available.
BC101618 mRNA Translation: AAI01619.1
BC101620 mRNA Translation: AAI01621.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS72867.1 [Q8N283-1]

NCBI Reference Sequences

More...
RefSeqi
NP_653299.4, NM_144698.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355594; ENSP00000347802; ENSG00000198483

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
148741

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:148741

UCSC genome browser

More...
UCSCi
uc001eob.2, human [Q8N283-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057853 mRNA Translation: BAB71597.1 Different initiation.
AK091120 mRNA Translation: BAC03587.1
AK296861 mRNA Translation: BAG59424.1
AL160282 Genomic DNA No translation available.
BC101618 mRNA Translation: AAI01619.1
BC101620 mRNA Translation: AAI01621.1
CCDSiCCDS72867.1 [Q8N283-1]
RefSeqiNP_653299.4, NM_144698.4

3D structure databases

SMRiQ8N283
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127165, 3 interactors
IntActiQ8N283, 7 interactors
MINTiQ8N283
STRINGi9606.ENSP00000347802

PTM databases

iPTMnetiQ8N283
PhosphoSitePlusiQ8N283

Genetic variation databases

BioMutaiANKRD35
DMDMi109940222

Proteomic databases

EPDiQ8N283
MassIVEiQ8N283
MaxQBiQ8N283
PaxDbiQ8N283
PeptideAtlasiQ8N283
PRIDEiQ8N283
ProteomicsDBi4511
71667 [Q8N283-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
49637, 12 antibodies

Genome annotation databases

EnsembliENST00000355594; ENSP00000347802; ENSG00000198483
GeneIDi148741
KEGGihsa:148741
UCSCiuc001eob.2, human [Q8N283-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
148741

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ANKRD35
HGNCiHGNC:26323, ANKRD35
HPAiENSG00000198483, Tissue enhanced (skin)
neXtProtiNX_Q8N283
PharmGKBiPA134896362
VEuPathDBiHostDB:ENSG00000198483.12

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QXWS, Eukaryota
HOGENOMiCLU_298955_0_0_1
InParanoidiQ8N283
OrthoDBi1514637at2759
PhylomeDBiQ8N283
TreeFamiTF331274

Enzyme and pathway databases

PathwayCommonsiQ8N283

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
148741, 10 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ANKRD35, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
148741
PharosiQ8N283, Tdark

Protein Ontology

More...
PROi
PR:Q8N283
RNActiQ8N283, protein

Gene expression databases

BgeeiENSG00000198483, Expressed in upper arm skin and 208 other tissues
ExpressionAtlasiQ8N283, baseline and differential
GenevisibleiQ8N283, HS

Family and domain databases

Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 2 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 5 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANR35_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N283
Secondary accession number(s): A6NEU0
, B4DL62, Q3MJ10, Q96LS3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: February 10, 2021
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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