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Entry version 132 (16 Oct 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Prominin-2

Gene

PROM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cholesterol binding Source: UniProtKB

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prominin-2
Short name:
PROM-2
Alternative name(s):
Prominin-like protein 2
Short name:
hPROML2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PROM2
Synonyms:PROML2
ORF Names:UNQ2521/PRO6014
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20685 PROM2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N271

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 106ExtracellularSequence analysisAdd BLAST80
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 153CytoplasmicSequence analysisAdd BLAST26
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 426ExtracellularSequence analysisAdd BLAST252
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Topological domaini448 – 472CytoplasmicSequence analysisAdd BLAST25
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 779ExtracellularSequence analysisAdd BLAST286
Transmembranei780 – 800HelicalSequence analysisAdd BLAST21
Topological domaini801 – 834CytoplasmicSequence analysisAdd BLAST34

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
150696

Open Targets

More...
OpenTargetsi
ENSG00000155066

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134861956

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N271

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PROM2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74728673

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033123927 – 834Prominin-2Add BLAST808

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi270N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei727PhosphoserineCombined sources1
Modified residuei818PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N271

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N271

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N271

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N271

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N271

PeptideAtlas

More...
PeptideAtlasi
Q8N271

PRoteomics IDEntifications database

More...
PRIDEi
Q8N271

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71663 [Q8N271-1]
71664 [Q8N271-2]
71665 [Q8N271-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1643

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N271

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N271

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in saliva within small membrane particles (at protein level). Expressed in kidney, prostate, trachea, esophagus, salivary gland, thyroid gland, mammary gland adrenal gland, placenta, stomach, spinal cord and liver. In submucosal tumor, expressed in spindle-shaped or stellate stromal cells. Expressed in prostate cancer cell lines.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000155066 Expressed in 181 organ(s), highest expression level in vagina

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N271 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N271 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB046005
HPA063728

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds cholesterol.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127318, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N271, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000318270

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the prominin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4331 Eukaryota
ENOG410XRG0 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063586

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115705

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N271

KEGG Orthology (KO)

More...
KOi
K15602

Identification of Orthologs from Complete Genome Data

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OMAi
FIDTPGN

Database of Orthologous Groups

More...
OrthoDBi
1129032at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N271

TreeFam database of animal gene trees

More...
TreeFami
TF324631

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008795 Prominin

The PANTHER Classification System

More...
PANTHERi
PTHR22730 PTHR22730, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05478 Prominin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N271-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKHTLALLAP LLGLGLGLAL SQLAAGATDC KFLGPAEHLT FTPAARARWL
60 70 80 90 100
APRVRAPGLL DSLYGTVRRF LSVVQLNPFP SELVKALLNE LASVKVNEVV
110 120 130 140 150
RYEAGYVVCA VIAGLYLLLV PTAGLCFCCC RCHRRCGGRV KTEHKALACE
160 170 180 190 200
RAALMVFLLL TTLLLLIGVV CAFVTNQRTH EQMGPSIEAM PETLLSLWGL
210 220 230 240 250
VSDVPQELQA VAQQFSLPQE QVSEELDGVG VSIGSAIHTQ LRSSVYPLLA
260 270 280 290 300
AVGSLGQVLQ VSVHHLQTLN ATVVELQAGQ QDLEPAIREH RDRLLELLQE
310 320 330 340 350
ARCQGDCAGA LSWARTLELG ADFSQVPSVD HVLHQLKGVP EANFSSMVQE
360 370 380 390 400
ENSTFNALPA LAAMQTSSVV QELKKAVAQQ PEGVRTLAEG FPGLEAASRW
410 420 430 440 450
AQALQEVEES SRPYLQEVQR YETYRWIVGC VLCSVVLFVV LCNLLGLNLG
460 470 480 490 500
IWGLSARDDP SHPEAKGEAG ARFLMAGVGL SFLFAAPLIL LVFATFLVGG
510 520 530 540 550
NVQTLVCQSW ENGELFEFAD TPGNLPPSMN LSQLLGLRKN ISIHQAYQQC
560 570 580 590 600
KEGAALWTVL QLNDSYDLEE HLDINQYTNK LRQELQSLKV DTQSLDLLSS
610 620 630 640 650
AARRDLEALQ SSGLQRIHYP DFLVQIQRPV VKTSMEQLAQ ELQGLAQAQD
660 670 680 690 700
NSVLGQRLQE EAQGLRNLHQ EKVVPQQSLV AKLNLSVRAL ESSAPNLQLE
710 720 730 740 750
TSDVLANVTY LKGELPAWAA RILRNVSECF LAREMGYFSQ YVAWVREEVT
760 770 780 790 800
QRIATCQPLS GALDNSRVIL CDMMADPWNA FWFCLAWCTF FLIPSIIFAV
810 820 830
KTSKYFRPIR KRLSSTSSEE TQLFHIPRVT SLKL
Length:834
Mass (Da):91,883
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95C4D88AED2806A3
GO
Isoform 2 (identifier: Q8N271-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     576-624: Missing.

Show »
Length:785
Mass (Da):86,255
Checksum:i1D8CE2DDEDCAFF48
GO
Isoform 3 (identifier: Q8N271-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-474: Missing.

Show »
Length:360
Mass (Da):40,582
Checksum:i5290577CC0DFC262
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WDW5F8WDW5_HUMAN
Prominin-2
PROM2
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC03657 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti340P → L in BAF83055 (PubMed:14702039).Curated1
Sequence conflicti513G → S in BAC03657 (PubMed:14702039).Curated1
Sequence conflicti701T → A in BAC03657 (PubMed:14702039).Curated1
Sequence conflicti704V → I in BAC03657 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042749508Q → R4 PublicationsCorresponds to variant dbSNP:rs12992066Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0331481 – 474Missing in isoform 3. 1 PublicationAdd BLAST474
Alternative sequenceiVSP_033149576 – 624Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF245303 mRNA Translation: AAM10541.1
AF245304 mRNA Translation: AAM10542.1
AY358377 mRNA Translation: AAQ88743.1
AK091175 mRNA Translation: BAC03599.1
AK091408 mRNA Translation: BAC03657.1 Different initiation.
AK290366 mRNA Translation: BAF83055.1
AC009238 Genomic DNA Translation: AAY14751.1
CH471219 Genomic DNA Translation: EAX10718.1
BC113877 mRNA Translation: AAI13878.1
BC114525 mRNA Translation: AAI14526.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2012.1 [Q8N271-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001159449.1, NM_001165977.2 [Q8N271-1]
NP_001159450.1, NM_001165978.2 [Q8N271-1]
NP_653308.2, NM_144707.3 [Q8N271-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000317620; ENSP00000318270; ENSG00000155066 [Q8N271-1]
ENST00000317668; ENSP00000318520; ENSG00000155066 [Q8N271-1]
ENST00000403131; ENSP00000385716; ENSG00000155066 [Q8N271-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
150696

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:150696

UCSC genome browser

More...
UCSCi
uc002suh.3 human [Q8N271-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245303 mRNA Translation: AAM10541.1
AF245304 mRNA Translation: AAM10542.1
AY358377 mRNA Translation: AAQ88743.1
AK091175 mRNA Translation: BAC03599.1
AK091408 mRNA Translation: BAC03657.1 Different initiation.
AK290366 mRNA Translation: BAF83055.1
AC009238 Genomic DNA Translation: AAY14751.1
CH471219 Genomic DNA Translation: EAX10718.1
BC113877 mRNA Translation: AAI13878.1
BC114525 mRNA Translation: AAI14526.1
CCDSiCCDS2012.1 [Q8N271-1]
RefSeqiNP_001159449.1, NM_001165977.2 [Q8N271-1]
NP_001159450.1, NM_001165978.2 [Q8N271-1]
NP_653308.2, NM_144707.3 [Q8N271-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi127318, 3 interactors
IntActiQ8N271, 2 interactors
STRINGi9606.ENSP00000318270

PTM databases

GlyConnecti1643
iPTMnetiQ8N271
PhosphoSitePlusiQ8N271

Polymorphism and mutation databases

BioMutaiPROM2
DMDMi74728673

Proteomic databases

EPDiQ8N271
jPOSTiQ8N271
MassIVEiQ8N271
MaxQBiQ8N271
PaxDbiQ8N271
PeptideAtlasiQ8N271
PRIDEiQ8N271
ProteomicsDBi71663 [Q8N271-1]
71664 [Q8N271-2]
71665 [Q8N271-3]

Genome annotation databases

EnsembliENST00000317620; ENSP00000318270; ENSG00000155066 [Q8N271-1]
ENST00000317668; ENSP00000318520; ENSG00000155066 [Q8N271-1]
ENST00000403131; ENSP00000385716; ENSG00000155066 [Q8N271-1]
GeneIDi150696
KEGGihsa:150696
UCSCiuc002suh.3 human [Q8N271-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
150696
DisGeNETi150696

GeneCards: human genes, protein and diseases

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GeneCardsi
PROM2
HGNCiHGNC:20685 PROM2
HPAiCAB046005
HPA063728
neXtProtiNX_Q8N271
OpenTargetsiENSG00000155066
PharmGKBiPA134861956

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4331 Eukaryota
ENOG410XRG0 LUCA
GeneTreeiENSGT00530000063586
HOGENOMiHOG000115705
InParanoidiQ8N271
KOiK15602
OMAiFIDTPGN
OrthoDBi1129032at2759
PhylomeDBiQ8N271
TreeFamiTF324631

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PROM2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
150696
PharosiQ8N271

Protein Ontology

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PROi
PR:Q8N271

Gene expression databases

BgeeiENSG00000155066 Expressed in 181 organ(s), highest expression level in vagina
ExpressionAtlasiQ8N271 baseline and differential
GenevisibleiQ8N271 HS

Family and domain databases

InterProiView protein in InterPro
IPR008795 Prominin
PANTHERiPTHR22730 PTHR22730, 1 hit
PfamiView protein in Pfam
PF05478 Prominin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPROM2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N271
Secondary accession number(s): A8K2V1
, Q2HIX6, Q8NB84, Q8TAE2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2002
Last modified: October 16, 2019
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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