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UniProtKB - Q8N228 (SCML4_HUMAN)

Entry version 145 (23 Feb 2022)
Sequence version 2 (20 May 2008)
Previous versions | rss
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Protein

Sex comb on midleg-like protein 4

Gene

SCML4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N228

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8N228

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sex comb on midleg-like protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCML4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:21397, SCML4

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N228

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000146285

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		256380

Open Targets

More...OpenTargetsi		ENSG00000146285

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134946179

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N228, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SCML4

Domain mapping of disease mutations (DMDM)

More...DMDMi		189046183

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003371711 – 414Sex comb on midleg-like protein 4Add BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei55PhosphoserineBy similarity1
Modified residuei65PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N228

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N228

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N228

PeptideAtlas

More...PeptideAtlasi		Q8N228

PRoteomics IDEntifications database

More...PRIDEi		Q8N228

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71650 [Q8N228-1]
71651 [Q8N228-2]
71652 [Q8N228-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N228

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N228

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8N228

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000146285, Expressed in blood and 137 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N228, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N228, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000146285, Tissue enhanced (intestine, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129164, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q8N228, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358016

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N228, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N228

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini288 – 354SAMAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni257 – 343DisorderedSequence analysisAdd BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi257 – 273Polar residuesSequence analysisAdd BLAST17
Compositional biasi310 – 333Polar residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SCM family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3766, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157463

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_045829_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N228

Identification of Orthologs from Complete Genome Data

More...OMAi		TEECLVN

Database of Orthologous Groups

More...OrthoDBi		229086at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N228

TreeFam database of animal gene trees

More...TreeFami		TF106488

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.50, 1 hit
3.90.1150.190, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR033763, SCML2_RBR
IPR021987, SLED
IPR038348, SLED_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17208, RBR, 1 hit
PF00536, SAM_1, 1 hit
PF12140, SLED, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00454, SAM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47769, SSF47769, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N228-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQSQRIPGRK RGRPSLHSTP MKMAVHNLYS ASAGSLPAVK IPKKRGRKPG 
        60         70         80         90        100
YKIKSRVLMT PLALSPPRST PEPDLSSIPQ DAATVPSLAA PQALTVCLYI 
       110        120        130        140        150
NKQANAGPYL ERKKVQQLPE HFGPERPSAV LQQAVQACID CAHQQKLVFS 
       160        170        180        190        200
LVKQGYGGEM VSVSASFDGK QHLRSLPVVN SIGYVLRFLA KLCRSLLCDD 
       210        220        230        240        250
LFSHQPFPRG CSASEKVQEK EEGRMESVKT VTTEEYLVNP VGMNRYSVDT 
       260        270        280        290        300
SASTFNHRGS LHPSSSLYCK RQNSGDSHLG GGPAATAGGP RTSPMSSGGP 
       310        320        330        340        350
SAPGLRPPAS SPKRNTTSLE GNRCASSPSQ DAQDARRPRS RNPSAWTVED 
       360        370        380        390        400
VVWFVKDADP QALGPHVELF RKHEIDGNAL LLLKSDMVMK YLGLKLGPAL 
       410 
KLCYHIDKLK QAKF
Length:414
Mass (Da):45,023
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i666A3DEAAF2A82D0
GO
Isoform 2 (identifier: Q8N228-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Show »
Length:356
Mass (Da):38,587
Checksum:iE66C0BDE66D227CE
GO
Isoform 3 (identifier: Q8N228-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: MQSQRIPGRK...PGYKIKSRVL → MPCQRTAWIGCDRQRTPPFHWREIKSRVL
     325-334: ASSPSQDAQD → GNVMHASASH
     335-414: Missing.

Show »
Length:305
Mass (Da):32,976
Checksum:iE55703D2BE89FEA3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J1S9A0A0B4J1S9_HUMAN
Sex comb on midleg-like protein 4
SCML4
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2X1F2Z2X1_HUMAN
Sex comb on midleg-like protein 4
SCML4
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0T5Q5T0T5_HUMAN
Sex comb on midleg-like protein 4
SCML4
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043669126R → Q1 PublicationCorresponds to variant dbSNP:rs6934505Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0339431 – 58Missing in isoform 2. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_0339441 – 58MQSQR…KSRVL → MPCQRTAWIGCDRQRTPPFH WREIKSRVL in isoform 3. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_033945325 – 334ASSPSQDAQD → GNVMHASASH in isoform 3. 1 Publication10
Alternative sequenceiVSP_033946335 – 414Missing in isoform 3. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK093571 mRNA Translation: BAC04198.1
AL512592 Genomic DNA No translation available.
AL096816 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48394.1
CH471051 Genomic DNA Translation: EAW48395.1
BC033286 mRNA Translation: AAH33286.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5060.2 [Q8N228-1]
CCDS69163.1 [Q8N228-2]

NCBI Reference Sequences

More...RefSeqi		NP_001273337.1, NM_001286408.1 [Q8N228-2]
NP_932347.2, NM_198081.4 [Q8N228-1]
XP_011534008.1, XM_011535706.1 [Q8N228-2]
XP_016866167.1, XM_017010678.1 [Q8N228-1]
XP_016866168.1, XM_017010679.1 [Q8N228-1]
XP_016866169.1, XM_017010680.1 [Q8N228-1]
XP_016866170.1, XM_017010681.1 [Q8N228-1]
XP_016866172.1, XM_017010683.1 [Q8N228-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369020; ENSP00000358016; ENSG00000146285
ENST00000369021; ENSP00000358017; ENSG00000146285 [Q8N228-3]
ENST00000369022; ENSP00000358018; ENSG00000146285 [Q8N228-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		256380

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:256380

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000369020.8; ENSP00000358016.3; NM_198081.5; NP_932347.2

UCSC genome browser

More...UCSCi		uc003prz.6, human [Q8N228-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093571 mRNA Translation: BAC04198.1
AL512592 Genomic DNA No translation available.
AL096816 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48394.1
CH471051 Genomic DNA Translation: EAW48395.1
BC033286 mRNA Translation: AAH33286.1
CCDSiCCDS5060.2 [Q8N228-1]
CCDS69163.1 [Q8N228-2]
RefSeqiNP_001273337.1, NM_001286408.1 [Q8N228-2]
NP_932347.2, NM_198081.4 [Q8N228-1]
XP_011534008.1, XM_011535706.1 [Q8N228-2]
XP_016866167.1, XM_017010678.1 [Q8N228-1]
XP_016866168.1, XM_017010679.1 [Q8N228-1]
XP_016866169.1, XM_017010680.1 [Q8N228-1]
XP_016866170.1, XM_017010681.1 [Q8N228-1]
XP_016866172.1, XM_017010683.1 [Q8N228-2]

3D structure databases

SMRiQ8N228
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129164, 5 interactors
IntActiQ8N228, 5 interactors
STRINGi9606.ENSP00000358016

PTM databases

iPTMnetiQ8N228
PhosphoSitePlusiQ8N228
SwissPalmiQ8N228

Genetic variation databases

BioMutaiSCML4
DMDMi189046183

Proteomic databases

jPOSTiQ8N228
MassIVEiQ8N228
PaxDbiQ8N228
PeptideAtlasiQ8N228
PRIDEiQ8N228
ProteomicsDBi71650 [Q8N228-1]
71651 [Q8N228-2]
71652 [Q8N228-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32183, 61 antibodies from 19 providers

The DNASU plasmid repository

More...DNASUi		256380

Genome annotation databases

EnsembliENST00000369020; ENSP00000358016; ENSG00000146285
ENST00000369021; ENSP00000358017; ENSG00000146285 [Q8N228-3]
ENST00000369022; ENSP00000358018; ENSG00000146285 [Q8N228-2]
GeneIDi256380
KEGGihsa:256380
MANE-SelectiENST00000369020.8; ENSP00000358016.3; NM_198081.5; NP_932347.2
UCSCiuc003prz.6, human [Q8N228-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		256380
DisGeNETi256380

GeneCards: human genes, protein and diseases

More...GeneCardsi		SCML4
HGNCiHGNC:21397, SCML4
HPAiENSG00000146285, Tissue enhanced (intestine, lymphoid tissue)
neXtProtiNX_Q8N228
OpenTargetsiENSG00000146285
PharmGKBiPA134946179
VEuPathDBiHostDB:ENSG00000146285

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3766, Eukaryota
GeneTreeiENSGT00940000157463
HOGENOMiCLU_045829_0_0_1
InParanoidiQ8N228
OMAiTEECLVN
OrthoDBi229086at2759
PhylomeDBiQ8N228
TreeFamiTF106488

Enzyme and pathway databases

PathwayCommonsiQ8N228
SignaLinkiQ8N228

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		256380, 7 hits in 1041 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SCML4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		256380
PharosiQ8N228, Tdark

Protein Ontology

More...PROi		PR:Q8N228
RNActiQ8N228, protein

Gene expression databases

BgeeiENSG00000146285, Expressed in blood and 137 other tissues
ExpressionAtlasiQ8N228, baseline and differential
GenevisibleiQ8N228, HS

Family and domain databases

Gene3Di1.10.150.50, 1 hit
3.90.1150.190, 1 hit
InterProiView protein in InterPro
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR033763, SCML2_RBR
IPR021987, SLED
IPR038348, SLED_sf
PfamiView protein in Pfam
PF17208, RBR, 1 hit
PF00536, SAM_1, 1 hit
PF12140, SLED, 1 hit
SMARTiView protein in SMART
SM00454, SAM, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCML4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N228
Secondary accession number(s): B0QZ10
, B0QZ11, B7ZBX3, Q5JXD0, Q5T0T6, Q8IYY6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: February 23, 2022
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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