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Protein

Sex comb on midleg-like protein 4

Gene

SCML4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).By similarity

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Sex comb on midleg-like protein 4
Gene namesi
Name:SCML4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000146285.13
HGNCiHGNC:21397 SCML4
neXtProtiNX_Q8N228

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000146285
PharmGKBiPA134946179

Polymorphism and mutation databases

BioMutaiSCML4
DMDMi189046183

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003371711 – 414Sex comb on midleg-like protein 4Add BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphoserineBy similarity1
Modified residuei65PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8N228
PeptideAtlasiQ8N228
PRIDEiQ8N228
ProteomicsDBi71650
71651 [Q8N228-2]
71652 [Q8N228-3]

PTM databases

iPTMnetiQ8N228
PhosphoSitePlusiQ8N228
SwissPalmiQ8N228

Expressioni

Gene expression databases

BgeeiENSG00000146285 Expressed in 120 organ(s), highest expression level in blood
CleanExiHS_SCML4
ExpressionAtlasiQ8N228 baseline and differential
GenevisibleiQ8N228 HS

Organism-specific databases

HPAiHPA063326
HPA065958

Interactioni

Protein-protein interaction databases

BioGridi129164, 3 interactors
IntActiQ8N228, 2 interactors
STRINGi9606.ENSP00000358016

Structurei

3D structure databases

ProteinModelPortaliQ8N228
SMRiQ8N228
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini288 – 354SAMAdd BLAST67

Sequence similaritiesi

Belongs to the SCM family.Curated

Phylogenomic databases

eggNOGiKOG3766 Eukaryota
ENOG410Y4AQ LUCA
GeneTreeiENSGT00760000119024
HOVERGENiHBG056406
InParanoidiQ8N228
KOiK11466
OMAiQALTVCI
OrthoDBiEOG091G05BW
PhylomeDBiQ8N228
TreeFamiTF106488

Family and domain databases

Gene3Di1.20.1380.20, 1 hit
InterProiView protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR033763 SCML2_RBR
IPR021987 SLED
IPR038348 SLED_sf
PfamiView protein in Pfam
PF17208 RBR, 1 hit
PF00536 SAM_1, 1 hit
PF12140 SLED, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N228-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQSQRIPGRK RGRPSLHSTP MKMAVHNLYS ASAGSLPAVK IPKKRGRKPG
60 70 80 90 100
YKIKSRVLMT PLALSPPRST PEPDLSSIPQ DAATVPSLAA PQALTVCLYI
110 120 130 140 150
NKQANAGPYL ERKKVQQLPE HFGPERPSAV LQQAVQACID CAHQQKLVFS
160 170 180 190 200
LVKQGYGGEM VSVSASFDGK QHLRSLPVVN SIGYVLRFLA KLCRSLLCDD
210 220 230 240 250
LFSHQPFPRG CSASEKVQEK EEGRMESVKT VTTEEYLVNP VGMNRYSVDT
260 270 280 290 300
SASTFNHRGS LHPSSSLYCK RQNSGDSHLG GGPAATAGGP RTSPMSSGGP
310 320 330 340 350
SAPGLRPPAS SPKRNTTSLE GNRCASSPSQ DAQDARRPRS RNPSAWTVED
360 370 380 390 400
VVWFVKDADP QALGPHVELF RKHEIDGNAL LLLKSDMVMK YLGLKLGPAL
410
KLCYHIDKLK QAKF
Length:414
Mass (Da):45,023
Last modified:May 20, 2008 - v2
Checksum:i666A3DEAAF2A82D0
GO
Isoform 2 (identifier: Q8N228-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Show »
Length:356
Mass (Da):38,587
Checksum:iE66C0BDE66D227CE
GO
Isoform 3 (identifier: Q8N228-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: MQSQRIPGRK...PGYKIKSRVL → MPCQRTAWIGCDRQRTPPFHWREIKSRVL
     325-334: ASSPSQDAQD → GNVMHASASH
     335-414: Missing.

Show »
Length:305
Mass (Da):32,976
Checksum:iE55703D2BE89FEA3
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T0T5Q5T0T5_HUMAN
Sex comb on midleg-like protein 4
SCML4
198Annotation score:
A0A0B4J1S9A0A0B4J1S9_HUMAN
Sex comb on midleg-like protein 4
SCML4
172Annotation score:
F2Z2X1F2Z2X1_HUMAN
Sex comb on midleg-like protein 4
SCML4
171Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043669126R → Q1 PublicationCorresponds to variant dbSNP:rs6934505Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0339431 – 58Missing in isoform 2. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_0339441 – 58MQSQR…KSRVL → MPCQRTAWIGCDRQRTPPFH WREIKSRVL in isoform 3. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_033945325 – 334ASSPSQDAQD → GNVMHASASH in isoform 3. 1 Publication10
Alternative sequenceiVSP_033946335 – 414Missing in isoform 3. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093571 mRNA Translation: BAC04198.1
AL512592 Genomic DNA No translation available.
AL096816 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48394.1
CH471051 Genomic DNA Translation: EAW48395.1
BC033286 mRNA Translation: AAH33286.1
CCDSiCCDS5060.2 [Q8N228-1]
CCDS69163.1 [Q8N228-2]
RefSeqiNP_001273337.1, NM_001286408.1 [Q8N228-2]
NP_932347.2, NM_198081.4 [Q8N228-1]
XP_011534008.1, XM_011535706.1 [Q8N228-2]
XP_016866167.1, XM_017010678.1 [Q8N228-1]
XP_016866168.1, XM_017010679.1 [Q8N228-1]
XP_016866169.1, XM_017010680.1 [Q8N228-1]
XP_016866170.1, XM_017010681.1 [Q8N228-1]
XP_016866172.1, XM_017010683.1 [Q8N228-2]
UniGeneiHs.486109
Hs.587364

Genome annotation databases

EnsembliENST00000369020; ENSP00000358016; ENSG00000146285 [Q8N228-1]
ENST00000369021; ENSP00000358017; ENSG00000146285 [Q8N228-3]
ENST00000369022; ENSP00000358018; ENSG00000146285 [Q8N228-2]
GeneIDi256380
KEGGihsa:256380
UCSCiuc003prz.6 human [Q8N228-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093571 mRNA Translation: BAC04198.1
AL512592 Genomic DNA No translation available.
AL096816 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48394.1
CH471051 Genomic DNA Translation: EAW48395.1
BC033286 mRNA Translation: AAH33286.1
CCDSiCCDS5060.2 [Q8N228-1]
CCDS69163.1 [Q8N228-2]
RefSeqiNP_001273337.1, NM_001286408.1 [Q8N228-2]
NP_932347.2, NM_198081.4 [Q8N228-1]
XP_011534008.1, XM_011535706.1 [Q8N228-2]
XP_016866167.1, XM_017010678.1 [Q8N228-1]
XP_016866168.1, XM_017010679.1 [Q8N228-1]
XP_016866169.1, XM_017010680.1 [Q8N228-1]
XP_016866170.1, XM_017010681.1 [Q8N228-1]
XP_016866172.1, XM_017010683.1 [Q8N228-2]
UniGeneiHs.486109
Hs.587364

3D structure databases

ProteinModelPortaliQ8N228
SMRiQ8N228
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129164, 3 interactors
IntActiQ8N228, 2 interactors
STRINGi9606.ENSP00000358016

PTM databases

iPTMnetiQ8N228
PhosphoSitePlusiQ8N228
SwissPalmiQ8N228

Polymorphism and mutation databases

BioMutaiSCML4
DMDMi189046183

Proteomic databases

PaxDbiQ8N228
PeptideAtlasiQ8N228
PRIDEiQ8N228
ProteomicsDBi71650
71651 [Q8N228-2]
71652 [Q8N228-3]

Protocols and materials databases

DNASUi256380
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369020; ENSP00000358016; ENSG00000146285 [Q8N228-1]
ENST00000369021; ENSP00000358017; ENSG00000146285 [Q8N228-3]
ENST00000369022; ENSP00000358018; ENSG00000146285 [Q8N228-2]
GeneIDi256380
KEGGihsa:256380
UCSCiuc003prz.6 human [Q8N228-1]

Organism-specific databases

CTDi256380
EuPathDBiHostDB:ENSG00000146285.13
GeneCardsiSCML4
HGNCiHGNC:21397 SCML4
HPAiHPA063326
HPA065958
neXtProtiNX_Q8N228
OpenTargetsiENSG00000146285
PharmGKBiPA134946179
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3766 Eukaryota
ENOG410Y4AQ LUCA
GeneTreeiENSGT00760000119024
HOVERGENiHBG056406
InParanoidiQ8N228
KOiK11466
OMAiQALTVCI
OrthoDBiEOG091G05BW
PhylomeDBiQ8N228
TreeFamiTF106488

Miscellaneous databases

ChiTaRSiSCML4 human
GenomeRNAii256380
PROiPR:Q8N228

Gene expression databases

BgeeiENSG00000146285 Expressed in 120 organ(s), highest expression level in blood
CleanExiHS_SCML4
ExpressionAtlasiQ8N228 baseline and differential
GenevisibleiQ8N228 HS

Family and domain databases

Gene3Di1.20.1380.20, 1 hit
InterProiView protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR033763 SCML2_RBR
IPR021987 SLED
IPR038348 SLED_sf
PfamiView protein in Pfam
PF17208 RBR, 1 hit
PF00536 SAM_1, 1 hit
PF12140 SLED, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCML4_HUMAN
AccessioniPrimary (citable) accession number: Q8N228
Secondary accession number(s): B0QZ10
, B0QZ11, B7ZBX3, Q5JXD0, Q5T0T6, Q8IYY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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