UniProtKB - Q8N228 (SCML4_HUMAN)
Protein
Sex comb on midleg-like protein 4
Gene
SCML4
Organism
Homo sapiens (Human)
Status
Functioni
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).By similarity
GO - Molecular functioni
- chromatin binding Source: GO_Central
- histone binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q8N228 |
Names & Taxonomyi
Protein namesi | Recommended name: Sex comb on midleg-like protein 4 |
Gene namesi | Name:SCML4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21397, SCML4 |
neXtProti | NX_Q8N228 |
VEuPathDBi | HostDB:ENSG00000146285.13 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 256380 |
OpenTargetsi | ENSG00000146285 |
PharmGKBi | PA134946179 |
Miscellaneous databases
Pharosi | Q8N228, Tdark |
Genetic variation databases
BioMutai | SCML4 |
DMDMi | 189046183 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000337171 | 1 – 414 | Sex comb on midleg-like protein 4Add BLAST | 414 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 55 | PhosphoserineBy similarity | 1 | |
Modified residuei | 65 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q8N228 |
MassIVEi | Q8N228 |
PaxDbi | Q8N228 |
PeptideAtlasi | Q8N228 |
PRIDEi | Q8N228 |
ProteomicsDBi | 71650 [Q8N228-1] 71651 [Q8N228-2] 71652 [Q8N228-3] |
PTM databases
iPTMneti | Q8N228 |
PhosphoSitePlusi | Q8N228 |
SwissPalmi | Q8N228 |
Expressioni
Gene expression databases
Bgeei | ENSG00000146285, Expressed in blood and 136 other tissues |
ExpressionAtlasi | Q8N228, baseline and differential |
Genevisiblei | Q8N228, HS |
Organism-specific databases
HPAi | ENSG00000146285, Tissue enhanced (blood, lymphoid tissue) |
Interactioni
Binary interactionsi
Hide detailsIsoform 3 [Q8N228-3]
With | #Exp. | IntAct |
---|---|---|
CLIC3 [O95833] | 3 | EBI-17182094,EBI-10192241 |
RIPOR3 [Q96MK2] | 3 | EBI-17182094,EBI-12010512 |
GO - Molecular functioni
- histone binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 129164, 5 interactors |
IntActi | Q8N228, 5 interactors |
STRINGi | 9606.ENSP00000358016 |
Miscellaneous databases
RNActi | Q8N228, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 288 – 354 | SAMAdd BLAST | 67 |
Sequence similaritiesi
Belongs to the SCM family.Curated
Phylogenomic databases
eggNOGi | KOG3766, Eukaryota |
GeneTreei | ENSGT00940000157463 |
HOGENOMi | CLU_045829_0_0_1 |
InParanoidi | Q8N228 |
OMAi | TVCLYVN |
OrthoDBi | 229086at2759 |
PhylomeDBi | Q8N228 |
TreeFami | TF106488 |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit 1.20.1380.20, 1 hit |
InterProi | View protein in InterPro IPR001660, SAM IPR013761, SAM/pointed_sf IPR033763, SCML2_RBR IPR021987, SLED IPR038348, SLED_sf |
Pfami | View protein in Pfam PF17208, RBR, 1 hit PF00536, SAM_1, 1 hit PF12140, SLED, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N228-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQSQRIPGRK RGRPSLHSTP MKMAVHNLYS ASAGSLPAVK IPKKRGRKPG
60 70 80 90 100
YKIKSRVLMT PLALSPPRST PEPDLSSIPQ DAATVPSLAA PQALTVCLYI
110 120 130 140 150
NKQANAGPYL ERKKVQQLPE HFGPERPSAV LQQAVQACID CAHQQKLVFS
160 170 180 190 200
LVKQGYGGEM VSVSASFDGK QHLRSLPVVN SIGYVLRFLA KLCRSLLCDD
210 220 230 240 250
LFSHQPFPRG CSASEKVQEK EEGRMESVKT VTTEEYLVNP VGMNRYSVDT
260 270 280 290 300
SASTFNHRGS LHPSSSLYCK RQNSGDSHLG GGPAATAGGP RTSPMSSGGP
310 320 330 340 350
SAPGLRPPAS SPKRNTTSLE GNRCASSPSQ DAQDARRPRS RNPSAWTVED
360 370 380 390 400
VVWFVKDADP QALGPHVELF RKHEIDGNAL LLLKSDMVMK YLGLKLGPAL
410
KLCYHIDKLK QAKF
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4J1S9 | A0A0B4J1S9_HUMAN | Sex comb on midleg-like protein 4 | SCML4 | 172 | Annotation score: | ||
F2Z2X1 | F2Z2X1_HUMAN | Sex comb on midleg-like protein 4 | SCML4 | 171 | Annotation score: | ||
Q5T0T5 | Q5T0T5_HUMAN | Sex comb on midleg-like protein 4 | SCML4 | 198 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043669 | 126 | R → Q1 PublicationCorresponds to variant dbSNP:rs6934505Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033943 | 1 – 58 | Missing in isoform 2. 1 PublicationAdd BLAST | 58 | |
Alternative sequenceiVSP_033944 | 1 – 58 | MQSQR…KSRVL → MPCQRTAWIGCDRQRTPPFH WREIKSRVL in isoform 3. 1 PublicationAdd BLAST | 58 | |
Alternative sequenceiVSP_033945 | 325 – 334 | ASSPSQDAQD → GNVMHASASH in isoform 3. 1 Publication | 10 | |
Alternative sequenceiVSP_033946 | 335 – 414 | Missing in isoform 3. 1 PublicationAdd BLAST | 80 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093571 mRNA Translation: BAC04198.1 AL512592 Genomic DNA No translation available. AL096816 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48394.1 CH471051 Genomic DNA Translation: EAW48395.1 BC033286 mRNA Translation: AAH33286.1 |
CCDSi | CCDS5060.2 [Q8N228-1] CCDS69163.1 [Q8N228-2] |
RefSeqi | NP_001273337.1, NM_001286408.1 [Q8N228-2] NP_932347.2, NM_198081.4 [Q8N228-1] XP_011534008.1, XM_011535706.1 [Q8N228-2] XP_016866167.1, XM_017010678.1 [Q8N228-1] XP_016866168.1, XM_017010679.1 [Q8N228-1] XP_016866169.1, XM_017010680.1 [Q8N228-1] XP_016866170.1, XM_017010681.1 [Q8N228-1] XP_016866172.1, XM_017010683.1 [Q8N228-2] |
Genome annotation databases
Ensembli | ENST00000369020; ENSP00000358016; ENSG00000146285 [Q8N228-1] ENST00000369021; ENSP00000358017; ENSG00000146285 [Q8N228-3] ENST00000369022; ENSP00000358018; ENSG00000146285 [Q8N228-2] |
GeneIDi | 256380 |
KEGGi | hsa:256380 |
UCSCi | uc003prz.6, human [Q8N228-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093571 mRNA Translation: BAC04198.1 AL512592 Genomic DNA No translation available. AL096816 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48394.1 CH471051 Genomic DNA Translation: EAW48395.1 BC033286 mRNA Translation: AAH33286.1 |
CCDSi | CCDS5060.2 [Q8N228-1] CCDS69163.1 [Q8N228-2] |
RefSeqi | NP_001273337.1, NM_001286408.1 [Q8N228-2] NP_932347.2, NM_198081.4 [Q8N228-1] XP_011534008.1, XM_011535706.1 [Q8N228-2] XP_016866167.1, XM_017010678.1 [Q8N228-1] XP_016866168.1, XM_017010679.1 [Q8N228-1] XP_016866169.1, XM_017010680.1 [Q8N228-1] XP_016866170.1, XM_017010681.1 [Q8N228-1] XP_016866172.1, XM_017010683.1 [Q8N228-2] |
3D structure databases
SMRi | Q8N228 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129164, 5 interactors |
IntActi | Q8N228, 5 interactors |
STRINGi | 9606.ENSP00000358016 |
PTM databases
iPTMneti | Q8N228 |
PhosphoSitePlusi | Q8N228 |
SwissPalmi | Q8N228 |
Genetic variation databases
BioMutai | SCML4 |
DMDMi | 189046183 |
Proteomic databases
jPOSTi | Q8N228 |
MassIVEi | Q8N228 |
PaxDbi | Q8N228 |
PeptideAtlasi | Q8N228 |
PRIDEi | Q8N228 |
ProteomicsDBi | 71650 [Q8N228-1] 71651 [Q8N228-2] 71652 [Q8N228-3] |
Protocols and materials databases
Antibodypediai | 32183, 61 antibodies |
DNASUi | 256380 |
Genome annotation databases
Ensembli | ENST00000369020; ENSP00000358016; ENSG00000146285 [Q8N228-1] ENST00000369021; ENSP00000358017; ENSG00000146285 [Q8N228-3] ENST00000369022; ENSP00000358018; ENSG00000146285 [Q8N228-2] |
GeneIDi | 256380 |
KEGGi | hsa:256380 |
UCSCi | uc003prz.6, human [Q8N228-1] |
Organism-specific databases
CTDi | 256380 |
DisGeNETi | 256380 |
GeneCardsi | SCML4 |
HGNCi | HGNC:21397, SCML4 |
HPAi | ENSG00000146285, Tissue enhanced (blood, lymphoid tissue) |
neXtProti | NX_Q8N228 |
OpenTargetsi | ENSG00000146285 |
PharmGKBi | PA134946179 |
VEuPathDBi | HostDB:ENSG00000146285.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3766, Eukaryota |
GeneTreei | ENSGT00940000157463 |
HOGENOMi | CLU_045829_0_0_1 |
InParanoidi | Q8N228 |
OMAi | TVCLYVN |
OrthoDBi | 229086at2759 |
PhylomeDBi | Q8N228 |
TreeFami | TF106488 |
Enzyme and pathway databases
PathwayCommonsi | Q8N228 |
Miscellaneous databases
BioGRID-ORCSi | 256380, 3 hits in 877 CRISPR screens |
ChiTaRSi | SCML4, human |
GenomeRNAii | 256380 |
Pharosi | Q8N228, Tdark |
PROi | PR:Q8N228 |
RNActi | Q8N228, protein |
Gene expression databases
Bgeei | ENSG00000146285, Expressed in blood and 136 other tissues |
ExpressionAtlasi | Q8N228, baseline and differential |
Genevisiblei | Q8N228, HS |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit 1.20.1380.20, 1 hit |
InterProi | View protein in InterPro IPR001660, SAM IPR013761, SAM/pointed_sf IPR033763, SCML2_RBR IPR021987, SLED IPR038348, SLED_sf |
Pfami | View protein in Pfam PF17208, RBR, 1 hit PF00536, SAM_1, 1 hit PF12140, SLED, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCML4_HUMAN | |
Accessioni | Q8N228Primary (citable) accession number: Q8N228 Secondary accession number(s): B0QZ10 Q8IYY6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | May 20, 2008 | |
Last modified: | February 10, 2021 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families