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UniProtKB - Q8N201 (INT1_HUMAN)

Entry version 140 (23 Feb 2022)
Sequence version 2 (16 May 2006)
Previous versions | rss
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Protein

Integrator complex subunit 1

Gene

INTS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).

1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • snRNA processing Source: HGNC-UCL
  • U2 snRNA 3'-end processing Source: GO_Central
Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N201

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6807505, RNA polymerase II transcribes snRNA genes

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8N201

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8N201

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrator complex subunit 1
Short name:
Int1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INTS1
Synonyms:KIAA1440
ORF Names:UNQ1821/PRO3434
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24555, INTS1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611345, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N201

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000164880

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1159 – 1179HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies (NDCAGF)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neurodevelopmental disorder characterized by severe global developmental delay with motor impairment, cognitive delays, absent or severely limited speech, dysmorphic features, hypotonia and cataracts.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08335277R → C in NDCAGF; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200649090EnsemblClinVar.1
Natural variantiVAR_083353549M → V in NDCAGF. 1 PublicationCorresponds to variant dbSNP:rs1030646527EnsemblClinVar.1
Natural variantiVAR_0833541784 – 2190Missing in NDCAGF; decreased protein abundance. 1 PublicationAdd BLAST407
Natural variantiVAR_0833551874P → L in NDCAGF; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1162809128EnsemblClinVar.1
Natural variantiVAR_0833561961 – 2190Missing in NDCAGF. 1 PublicationAdd BLAST230
Natural variantiVAR_0833572164L → P in NDCAGF; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1302980015Ensembl.1

Keywords - Diseasei

Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		26173

MalaCards human disease database

More...MalaCardsi		INTS1
MIMi618571, phenotype

Open Targets

More...OpenTargetsi		ENSG00000164880

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA144596420

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N201, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		INTS1

Domain mapping of disease mutations (DMDM)

More...DMDMi		97052424

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002360441 – 2190Integrator complex subunit 1Add BLAST2190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei13PhosphoserineCombined sources1
Modified residuei47N6-acetyllysineCombined sources1
Modified residuei83PhosphothreonineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei307PhosphoserineCombined sources1
Modified residuei924PhosphoserineCombined sources1
Modified residuei1318PhosphoserineCombined sources1
Modified residuei1326PhosphoserineBy similarity1
Modified residuei1327PhosphoserineBy similarity1
Modified residuei1395PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N201

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N201

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N201

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N201

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N201

PeptideAtlas

More...PeptideAtlasi		Q8N201

PRoteomics IDEntifications database

More...PRIDEi		Q8N201

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71646

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N201

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N201

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000164880, Expressed in right hemisphere of cerebellum and 223 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N201, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N201, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000164880, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12 (PubMed:16239144).

Interacts with ESRRB, ESRRB is probably not a core component of the multiprotein complex Integrator and this association is a bridge for the interaction with the multiprotein complex Integrator; attracts the transcriptional machinery (By similarity).

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117596, 145 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8N201

Database of interacting proteins

More...DIPi		DIP-48476N

Protein interaction database and analysis system

More...IntActi		Q8N201, 28 interactors

Molecular INTeraction database

More...MINTi		Q8N201

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000385722

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N201, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N201

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 61DisorderedSequence analysisAdd BLAST61
Regioni922 – 945DisorderedSequence analysisAdd BLAST24
Regioni1311 – 1334DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi34 – 48Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Integrator subunit 1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4596, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000015743

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001690_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N201

Identification of Orthologs from Complete Genome Data

More...OMAi		DTKTEMI

Database of Orthologous Groups

More...OrthoDBi		357673at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N201

TreeFam database of animal gene trees

More...TreeFami		TF313809

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR022145, DUF3677
IPR038902, INTS1

The PANTHER Classification System

More...PANTHERi		PTHR21224, PTHR21224, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12432, DUF3677, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N201-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRAKPTTVR RPSAAAKPSG HPPPGDFIAL GSKGQANESK TASTLLKPAP 
        60         70         80         90        100
SGLPSERKRD AAAALSSASA LTGLTKRPKL SSTPPLSALG RLAEAAVAEK 
       110        120        130        140        150
RAISPSIKEP SVVPIEVLPT VLLDEIEAAE LEGNDDRIEG VLCGAVKQLK 
       160        170        180        190        200
VTRAKPDSTL YLSLMYLAKI KPNIFATEGV IEALCSLLRR DASINFKAKG 
       210        220        230        240        250
NSLVSVLACN LLMAAYEEDE NWPEIFVKVY IEDSLGERIW VDSPHCKTFV 
       260        270        280        290        300
DNIQTAFNTR MPPRSVLLQG EAGRVAGDLG AGSSPHPSLT EEEDSQTELL 
       310        320        330        340        350
IAEEKLSPEQ EGQLMPRYEE LAESVEEYVL DMLRDQLNRR QPIDNVSRNL 
       360        370        380        390        400
LRLLTSTCGY KEVRLLAVQK LEMWLQNPKL TRPAQDLLMS VCMNCNTHGS 
       410        420        430        440        450
EDMDVISHLI KIRLKPKVLL NHFMLCIREL LSAHKDNLGT TIKLVIFNEL 
       460        470        480        490        500
SSARNPNNMQ VLYTALQHSS ELAPKFLAMV FQDLLTNKDD YLRASRALLR 
       510        520        530        540        550
EIIKQTKHEI NFQAFCLGLM QERKEPQYLE MEFKERFVVH ITDVLAVSMM 
       560        570        580        590        600
LGITAQVKEA GIAWDKGEKR NLEVLRSFQN QIAAIQRDAV WWLHTVVPSI 
       610        620        630        640        650
SKLAPKDYVH CLHKVLFTEQ PETYYKWDNW PPESDRNFFL RLCSEVPILE 
       660        670        680        690        700
DTLMRILVIG LSRELPLGPA DAMELADHLV KRAAAVQADD VEVLKVGRTQ 
       710        720        730        740        750
LIDAVLNLCT YHHPENIQLP PGYQPPNLAI STLYWKAWPL LLVVAAFNPE 
       760        770        780        790        800
NIGLAAWEEY PTLKMLMEMV MTNNYSYPPC TLTDEETRTE MLNRELQTAQ 
       810        820        830        840        850
REKQEILAFE GHLAAASTKQ TITESSSLLL SQLTSLDPQG PPRRPPPHIL 
       860        870        880        890        900
DQVKSLNQSL RLGHLLCRSR NPDFLLHIIQ RQASSQSMPW LADLVQSSEG 
       910        920        930        940        950
SLDVLPVQCL CEFLLHDAVD DAASGEEDDE GESKEQKAKK RQRQQKQRQL 
       960        970        980        990       1000
LGRLQDLLLG PKADEQTTCE VLDYFLRRLG SSQVASRVLA MKGLSLVLSE 
      1010       1020       1030       1040       1050
GSLRDGEEKE PPMEEDVGDT DVLQGYQWLL RDLPRLPLFD SVRSTTALAL 
      1060       1070       1080       1090       1100
QQAIHMETDP QTISAYLIYL SQHTPVEEQA QHSDLALDVA RLVVERSTIM 
      1110       1120       1130       1140       1150
SHLFSKLSPS AASDAVLSAL LSIFSRYVRR MRQSKEGEEV YSWSESQDQV 
      1160       1170       1180       1190       1200
FLRWSSGETA TMHILVVHAM VILLTLGPPR ADDSEFQALL DIWFPEEKPL 
      1210       1220       1230       1240       1250
PTAFLVDTSE EALLLPDWLK LRMIRSEVLR LVDAALQDLE PQQLLLFVQS 
      1260       1270       1280       1290       1300
FGIPVSSMSK LLQFLDQAVA HDPQTLEQNI MDKNYMAHLV EVQHERGASG 
      1310       1320       1330       1340       1350
GQTFHSLLTA SLPPRRDSTE APKPKSSPEQ PIGQGRIRVG TQLRVLGPED 
      1360       1370       1380       1390       1400
DLAGMFLQIF PLSPDPRWQS SSPRPVALAL QQALGQELAR VVQGSPEVPG 
      1410       1420       1430       1440       1450
ITVRVLQALA TLLSSPHGGA LVMSMHRSHF LACPLLRQLC QYQRCVPQDT 
      1460       1470       1480       1490       1500
GFSSLFLKVL LQMLQWLDSP GVEGGPLRAQ LRMLASQASA GRRLSDVRGG 
      1510       1520       1530       1540       1550
LLRLAEALAF RQDLEVVSST VRAVIATLRS GEQCSVEPDL ISKVLQGLIE 
      1560       1570       1580       1590       1600
VRSPHLEELL TAFFSATADA ASPFPACKPV VVVSSLLLQE EEPLAGGKPG 
      1610       1620       1630       1640       1650
ADGGSLEAVR LGPSSGLLVD WLEMLDPEVV SSCPDLQLRL LFSRRKGKGQ 
      1660       1670       1680       1690       1700
AQVPSFRPYL LTLFTHQSSW PTLHQCIRVL LGKSREQRFD PSASLDFLWA 
      1710       1720       1730       1740       1750
CIHVPRIWQG RDQRTPQKRR EELVLRVQGP ELISLVELIL AEAETRSQDG 
      1760       1770       1780       1790       1800
DTAACSLIQA RLPLLLSCCC GDDESVRKVT EHLSGCIQQW GDSVLGRRCR 
      1810       1820       1830       1840       1850
DLLLQLYLQR PELRVPVPEV LLHSEGAASS SVCKLDGLIH RFITLLADTS 
      1860       1870       1880       1890       1900
DSRALENRGA DASMACRKLA VAHPLLLLRH LPMIAALLHG RTHLNFQEFR 
      1910       1920       1930       1940       1950
QQNHLSCFLH VLGLLELLQP HVFRSEHQGA LWDCLLSFIR LLLNYRKSSR 
      1960       1970       1980       1990       2000
HLAAFINKFV QFIHKYITYN APAAISFLQK HADPLHDLSF DNSDLVMLKS 
      2010       2020       2030       2040       2050
LLAGLSLPSR DDRTDRGLDE EGEEESSAGS LPLVSVSLFT PLTAAEMAPY 
      2060       2070       2080       2090       2100
MKRLSRGQTV EDLLEVLSDI DEMSRRRPEI LSFFSTNLQR LMSSAEECCR 
      2110       2120       2130       2140       2150
NLAFSLALRS MQNSPSIAAA FLPTFMYCLG SQDFEVVQTA LRNLPEYALL 
      2160       2170       2180       2190
CQEHAAVLLH RAFLVGMYGQ MDPSAQISEA LRILHMEAVM
Length:2,190
Mass (Da):244,297
Last modified:May 16, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i342FF560BF3F61F6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C582H7C582_HUMAN
Integrator complex subunit 1
INTS1
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ88846 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti636R → Y (PubMed:16421571).Curated1
Sequence conflicti1862A → G in BAA92678 (PubMed:10718198).Curated1
Sequence conflicti2004G → V in CAB70710 (PubMed:17974005).Curated1
Sequence conflicti2105S → C in CAB70710 (PubMed:17974005).Curated1
Sequence conflicti2162A → AF in CAB70710 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08335277R → C in NDCAGF; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200649090EnsemblClinVar.1
Natural variantiVAR_049627172P → L. Corresponds to variant dbSNP:rs3752714Ensembl.1
Natural variantiVAR_083353549M → V in NDCAGF. 1 PublicationCorresponds to variant dbSNP:rs1030646527EnsemblClinVar.1
Natural variantiVAR_0833541784 – 2190Missing in NDCAGF; decreased protein abundance. 1 PublicationAdd BLAST407
Natural variantiVAR_0833551874P → L in NDCAGF; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1162809128EnsemblClinVar.1
Natural variantiVAR_0833561961 – 2190Missing in NDCAGF. 1 PublicationAdd BLAST230
Natural variantiVAR_0833572164L → P in NDCAGF; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1302980015Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC102953 Genomic DNA No translation available.
AC093734 Genomic DNA No translation available.
AB037861 mRNA Translation: BAA92678.1
AY358482 mRNA Translation: AAQ88846.1 Different initiation.
BC013367 mRNA Translation: AAH13367.2
BC018777 mRNA Translation: AAH18777.1
BC069262 mRNA Translation: AAH69262.1
AL050110 mRNA Translation: CAB43278.2
AL137358 mRNA Translation: CAB70710.3
BK005720 mRNA Translation: DAA05720.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47526.1

Protein sequence database of the Protein Information Resource

More...PIRi		T08758
T46429

NCBI Reference Sequences

More...RefSeqi		NP_001073922.2, NM_001080453.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000404767; ENSP00000385722; ENSG00000164880

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26173

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:26173

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000404767.8; ENSP00000385722.3; NM_001080453.3; NP_001073922.2

UCSC genome browser

More...UCSCi		uc003skn.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102953 Genomic DNA No translation available.
AC093734 Genomic DNA No translation available.
AB037861 mRNA Translation: BAA92678.1
AY358482 mRNA Translation: AAQ88846.1 Different initiation.
BC013367 mRNA Translation: AAH13367.2
BC018777 mRNA Translation: AAH18777.1
BC069262 mRNA Translation: AAH69262.1
AL050110 mRNA Translation: CAB43278.2
AL137358 mRNA Translation: CAB70710.3
BK005720 mRNA Translation: DAA05720.1
CCDSiCCDS47526.1
PIRiT08758
T46429
RefSeqiNP_001073922.2, NM_001080453.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7CUNelectron microscopy3.50A1-2190[»]
SMRiQ8N201
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117596, 145 interactors
CORUMiQ8N201
DIPiDIP-48476N
IntActiQ8N201, 28 interactors
MINTiQ8N201
STRINGi9606.ENSP00000385722

PTM databases

iPTMnetiQ8N201
PhosphoSitePlusiQ8N201

Genetic variation databases

BioMutaiINTS1
DMDMi97052424

Proteomic databases

EPDiQ8N201
jPOSTiQ8N201
MassIVEiQ8N201
MaxQBiQ8N201
PaxDbiQ8N201
PeptideAtlasiQ8N201
PRIDEiQ8N201
ProteomicsDBi71646

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		5500, 102 antibodies from 18 providers

The DNASU plasmid repository

More...DNASUi		26173

Genome annotation databases

EnsembliENST00000404767; ENSP00000385722; ENSG00000164880
GeneIDi26173
KEGGihsa:26173
MANE-SelectiENST00000404767.8; ENSP00000385722.3; NM_001080453.3; NP_001073922.2
UCSCiuc003skn.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26173
DisGeNETi26173

GeneCards: human genes, protein and diseases

More...GeneCardsi		INTS1
HGNCiHGNC:24555, INTS1
HPAiENSG00000164880, Low tissue specificity
MalaCardsiINTS1
MIMi611345, gene
618571, phenotype
neXtProtiNX_Q8N201
OpenTargetsiENSG00000164880
PharmGKBiPA144596420
VEuPathDBiHostDB:ENSG00000164880

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4596, Eukaryota
GeneTreeiENSGT00390000015743
HOGENOMiCLU_001690_0_0_1
InParanoidiQ8N201
OMAiDTKTEMI
OrthoDBi357673at2759
PhylomeDBiQ8N201
TreeFamiTF313809

Enzyme and pathway databases

PathwayCommonsiQ8N201
ReactomeiR-HSA-6807505, RNA polymerase II transcribes snRNA genes
SignaLinkiQ8N201
SIGNORiQ8N201

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		26173, 629 hits in 1042 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		INTS1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		26173
PharosiQ8N201, Tbio

Protein Ontology

More...PROi		PR:Q8N201
RNActiQ8N201, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000164880, Expressed in right hemisphere of cerebellum and 223 other tissues
ExpressionAtlasiQ8N201, baseline and differential
GenevisibleiQ8N201, HS

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR022145, DUF3677
IPR038902, INTS1
PANTHERiPTHR21224, PTHR21224, 1 hit
PfamiView protein in Pfam
PF12432, DUF3677, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINT1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N201
Secondary accession number(s): A6NJ44
, Q6NT70, Q6UX74, Q8WV40, Q96D36, Q9NTD1, Q9P2A8, Q9Y3W8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: February 23, 2022
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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