UniProtKB - Q8N201 (INT1_HUMAN)
Integrator complex subunit 1
INTS1
Functioni
GO - Biological processi
- snRNA processing Source: HGNC-UCL
- snRNA transcription by RNA polymerase II Source: Reactome
- U2 snRNA 3'-end processing Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q8N201 |
Reactomei | R-HSA-6807505, RNA polymerase II transcribes snRNA genes |
SIGNORi | Q8N201 |
Names & Taxonomyi
Protein namesi | Recommended name: Integrator complex subunit 1Short name: Int1 |
Gene namesi | Name:INTS1 Synonyms:KIAA1440 ORF Names:UNQ1821/PRO3434 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24555, INTS1 |
MIMi | 611345, gene |
neXtProti | NX_Q8N201 |
VEuPathDBi | HostDB:ENSG00000164880.15 |
Subcellular locationi
Nucleus
- Nucleus membrane Curated; Single-pass membrane protein Curated
Nucleus
- integrator complex Source: HGNC-UCL
- nuclear membrane Source: UniProtKB-SubCell
- nucleoplasm Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1159 – 1179 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies (NDCAGF)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083352 | 77 | R → C in NDCAGF; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200649090EnsemblClinVar. | 1 | |
Natural variantiVAR_083353 | 549 | M → V in NDCAGF. 1 PublicationCorresponds to variant dbSNP:rs1030646527EnsemblClinVar. | 1 | |
Natural variantiVAR_083354 | 1784 – 2190 | Missing in NDCAGF; decreased protein abundance. 1 PublicationAdd BLAST | 407 | |
Natural variantiVAR_083355 | 1874 | P → L in NDCAGF; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1162809128EnsemblClinVar. | 1 | |
Natural variantiVAR_083356 | 1961 – 2190 | Missing in NDCAGF. 1 PublicationAdd BLAST | 230 | |
Natural variantiVAR_083357 | 2164 | L → P in NDCAGF; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1302980015Ensembl. | 1 |
Keywords - Diseasei
Disease variant, Mental retardationOrganism-specific databases
DisGeNETi | 26173 |
MalaCardsi | INTS1 |
MIMi | 618571, phenotype |
OpenTargetsi | ENSG00000164880 |
PharmGKBi | PA144596420 |
Miscellaneous databases
Pharosi | Q8N201, Tdark |
Genetic variation databases
BioMutai | INTS1 |
DMDMi | 97052424 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000236044 | 1 – 2190 | Integrator complex subunit 1Add BLAST | 2190 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 13 | PhosphoserineCombined sources | 1 | |
Modified residuei | 47 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 83 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 87 | PhosphoserineCombined sources | 1 | |
Modified residuei | 307 | PhosphoserineCombined sources | 1 | |
Modified residuei | 924 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1318 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1326 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1327 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1395 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8N201 |
jPOSTi | Q8N201 |
MassIVEi | Q8N201 |
MaxQBi | Q8N201 |
PaxDbi | Q8N201 |
PeptideAtlasi | Q8N201 |
PRIDEi | Q8N201 |
ProteomicsDBi | 71646 |
PTM databases
iPTMneti | Q8N201 |
PhosphoSitePlusi | Q8N201 |
Expressioni
Gene expression databases
Bgeei | ENSG00000164880, Expressed in right hemisphere of cerebellum and 222 other tissues |
ExpressionAtlasi | Q8N201, baseline and differential |
Genevisiblei | Q8N201, HS |
Organism-specific databases
HPAi | ENSG00000164880, Low tissue specificity |
Interactioni
Subunit structurei
Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12 (PubMed:16239144).
Interacts with ESRRB, ESRRB is probably not a core component of the multiprotein complex Integrator and this association is a bridge for the interaction with the multiprotein complex Integrator; attracts the transcriptional machinery (By similarity).
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 117596, 92 interactors |
CORUMi | Q8N201 |
DIPi | DIP-48476N |
IntActi | Q8N201, 25 interactors |
MINTi | Q8N201 |
STRINGi | 9606.ENSP00000385722 |
Miscellaneous databases
RNActi | Q8N201, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 61 – 64 | Poly-Ala | 4 | |
Compositional biasi | 1580 – 1583 | Poly-Val | 4 | |
Compositional biasi | 1875 – 1878 | Poly-Leu | 4 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4596, Eukaryota |
GeneTreei | ENSGT00390000015743 |
HOGENOMi | CLU_001690_0_0_1 |
InParanoidi | Q8N201 |
OMAi | AAWDGYP |
OrthoDBi | 357673at2759 |
PhylomeDBi | Q8N201 |
TreeFami | TF313809 |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR022145, DUF3677 IPR038902, INTS1 |
PANTHERi | PTHR21224, PTHR21224, 1 hit |
Pfami | View protein in Pfam PF12432, DUF3677, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MNRAKPTTVR RPSAAAKPSG HPPPGDFIAL GSKGQANESK TASTLLKPAP
60 70 80 90 100
SGLPSERKRD AAAALSSASA LTGLTKRPKL SSTPPLSALG RLAEAAVAEK
110 120 130 140 150
RAISPSIKEP SVVPIEVLPT VLLDEIEAAE LEGNDDRIEG VLCGAVKQLK
160 170 180 190 200
VTRAKPDSTL YLSLMYLAKI KPNIFATEGV IEALCSLLRR DASINFKAKG
210 220 230 240 250
NSLVSVLACN LLMAAYEEDE NWPEIFVKVY IEDSLGERIW VDSPHCKTFV
260 270 280 290 300
DNIQTAFNTR MPPRSVLLQG EAGRVAGDLG AGSSPHPSLT EEEDSQTELL
310 320 330 340 350
IAEEKLSPEQ EGQLMPRYEE LAESVEEYVL DMLRDQLNRR QPIDNVSRNL
360 370 380 390 400
LRLLTSTCGY KEVRLLAVQK LEMWLQNPKL TRPAQDLLMS VCMNCNTHGS
410 420 430 440 450
EDMDVISHLI KIRLKPKVLL NHFMLCIREL LSAHKDNLGT TIKLVIFNEL
460 470 480 490 500
SSARNPNNMQ VLYTALQHSS ELAPKFLAMV FQDLLTNKDD YLRASRALLR
510 520 530 540 550
EIIKQTKHEI NFQAFCLGLM QERKEPQYLE MEFKERFVVH ITDVLAVSMM
560 570 580 590 600
LGITAQVKEA GIAWDKGEKR NLEVLRSFQN QIAAIQRDAV WWLHTVVPSI
610 620 630 640 650
SKLAPKDYVH CLHKVLFTEQ PETYYKWDNW PPESDRNFFL RLCSEVPILE
660 670 680 690 700
DTLMRILVIG LSRELPLGPA DAMELADHLV KRAAAVQADD VEVLKVGRTQ
710 720 730 740 750
LIDAVLNLCT YHHPENIQLP PGYQPPNLAI STLYWKAWPL LLVVAAFNPE
760 770 780 790 800
NIGLAAWEEY PTLKMLMEMV MTNNYSYPPC TLTDEETRTE MLNRELQTAQ
810 820 830 840 850
REKQEILAFE GHLAAASTKQ TITESSSLLL SQLTSLDPQG PPRRPPPHIL
860 870 880 890 900
DQVKSLNQSL RLGHLLCRSR NPDFLLHIIQ RQASSQSMPW LADLVQSSEG
910 920 930 940 950
SLDVLPVQCL CEFLLHDAVD DAASGEEDDE GESKEQKAKK RQRQQKQRQL
960 970 980 990 1000
LGRLQDLLLG PKADEQTTCE VLDYFLRRLG SSQVASRVLA MKGLSLVLSE
1010 1020 1030 1040 1050
GSLRDGEEKE PPMEEDVGDT DVLQGYQWLL RDLPRLPLFD SVRSTTALAL
1060 1070 1080 1090 1100
QQAIHMETDP QTISAYLIYL SQHTPVEEQA QHSDLALDVA RLVVERSTIM
1110 1120 1130 1140 1150
SHLFSKLSPS AASDAVLSAL LSIFSRYVRR MRQSKEGEEV YSWSESQDQV
1160 1170 1180 1190 1200
FLRWSSGETA TMHILVVHAM VILLTLGPPR ADDSEFQALL DIWFPEEKPL
1210 1220 1230 1240 1250
PTAFLVDTSE EALLLPDWLK LRMIRSEVLR LVDAALQDLE PQQLLLFVQS
1260 1270 1280 1290 1300
FGIPVSSMSK LLQFLDQAVA HDPQTLEQNI MDKNYMAHLV EVQHERGASG
1310 1320 1330 1340 1350
GQTFHSLLTA SLPPRRDSTE APKPKSSPEQ PIGQGRIRVG TQLRVLGPED
1360 1370 1380 1390 1400
DLAGMFLQIF PLSPDPRWQS SSPRPVALAL QQALGQELAR VVQGSPEVPG
1410 1420 1430 1440 1450
ITVRVLQALA TLLSSPHGGA LVMSMHRSHF LACPLLRQLC QYQRCVPQDT
1460 1470 1480 1490 1500
GFSSLFLKVL LQMLQWLDSP GVEGGPLRAQ LRMLASQASA GRRLSDVRGG
1510 1520 1530 1540 1550
LLRLAEALAF RQDLEVVSST VRAVIATLRS GEQCSVEPDL ISKVLQGLIE
1560 1570 1580 1590 1600
VRSPHLEELL TAFFSATADA ASPFPACKPV VVVSSLLLQE EEPLAGGKPG
1610 1620 1630 1640 1650
ADGGSLEAVR LGPSSGLLVD WLEMLDPEVV SSCPDLQLRL LFSRRKGKGQ
1660 1670 1680 1690 1700
AQVPSFRPYL LTLFTHQSSW PTLHQCIRVL LGKSREQRFD PSASLDFLWA
1710 1720 1730 1740 1750
CIHVPRIWQG RDQRTPQKRR EELVLRVQGP ELISLVELIL AEAETRSQDG
1760 1770 1780 1790 1800
DTAACSLIQA RLPLLLSCCC GDDESVRKVT EHLSGCIQQW GDSVLGRRCR
1810 1820 1830 1840 1850
DLLLQLYLQR PELRVPVPEV LLHSEGAASS SVCKLDGLIH RFITLLADTS
1860 1870 1880 1890 1900
DSRALENRGA DASMACRKLA VAHPLLLLRH LPMIAALLHG RTHLNFQEFR
1910 1920 1930 1940 1950
QQNHLSCFLH VLGLLELLQP HVFRSEHQGA LWDCLLSFIR LLLNYRKSSR
1960 1970 1980 1990 2000
HLAAFINKFV QFIHKYITYN APAAISFLQK HADPLHDLSF DNSDLVMLKS
2010 2020 2030 2040 2050
LLAGLSLPSR DDRTDRGLDE EGEEESSAGS LPLVSVSLFT PLTAAEMAPY
2060 2070 2080 2090 2100
MKRLSRGQTV EDLLEVLSDI DEMSRRRPEI LSFFSTNLQR LMSSAEECCR
2110 2120 2130 2140 2150
NLAFSLALRS MQNSPSIAAA FLPTFMYCLG SQDFEVVQTA LRNLPEYALL
2160 2170 2180 2190
CQEHAAVLLH RAFLVGMYGQ MDPSAQISEA LRILHMEAVM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C582 | H7C582_HUMAN | Integrator complex subunit 1 | INTS1 | 128 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 636 | R → Y (PubMed:16421571).Curated | 1 | |
Sequence conflicti | 1862 | A → G in BAA92678 (PubMed:10718198).Curated | 1 | |
Sequence conflicti | 2004 | G → V in CAB70710 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 2105 | S → C in CAB70710 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 2162 | A → AF in CAB70710 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083352 | 77 | R → C in NDCAGF; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200649090EnsemblClinVar. | 1 | |
Natural variantiVAR_049627 | 172 | P → L. Corresponds to variant dbSNP:rs3752714Ensembl. | 1 | |
Natural variantiVAR_083353 | 549 | M → V in NDCAGF. 1 PublicationCorresponds to variant dbSNP:rs1030646527EnsemblClinVar. | 1 | |
Natural variantiVAR_083354 | 1784 – 2190 | Missing in NDCAGF; decreased protein abundance. 1 PublicationAdd BLAST | 407 | |
Natural variantiVAR_083355 | 1874 | P → L in NDCAGF; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1162809128EnsemblClinVar. | 1 | |
Natural variantiVAR_083356 | 1961 – 2190 | Missing in NDCAGF. 1 PublicationAdd BLAST | 230 | |
Natural variantiVAR_083357 | 2164 | L → P in NDCAGF; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1302980015Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC102953 Genomic DNA No translation available. AC093734 Genomic DNA No translation available. AB037861 mRNA Translation: BAA92678.1 AY358482 mRNA Translation: AAQ88846.1 Different initiation. BC013367 mRNA Translation: AAH13367.2 BC018777 mRNA Translation: AAH18777.1 BC069262 mRNA Translation: AAH69262.1 AL050110 mRNA Translation: CAB43278.2 AL137358 mRNA Translation: CAB70710.3 BK005720 mRNA Translation: DAA05720.1 |
CCDSi | CCDS47526.1 |
PIRi | T08758 T46429 |
RefSeqi | NP_001073922.2, NM_001080453.2 |
Genome annotation databases
Ensembli | ENST00000404767; ENSP00000385722; ENSG00000164880 |
GeneIDi | 26173 |
KEGGi | hsa:26173 |
UCSCi | uc003skn.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC102953 Genomic DNA No translation available. AC093734 Genomic DNA No translation available. AB037861 mRNA Translation: BAA92678.1 AY358482 mRNA Translation: AAQ88846.1 Different initiation. BC013367 mRNA Translation: AAH13367.2 BC018777 mRNA Translation: AAH18777.1 BC069262 mRNA Translation: AAH69262.1 AL050110 mRNA Translation: CAB43278.2 AL137358 mRNA Translation: CAB70710.3 BK005720 mRNA Translation: DAA05720.1 |
CCDSi | CCDS47526.1 |
PIRi | T08758 T46429 |
RefSeqi | NP_001073922.2, NM_001080453.2 |
3D structure databases
SMRi | Q8N201 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117596, 92 interactors |
CORUMi | Q8N201 |
DIPi | DIP-48476N |
IntActi | Q8N201, 25 interactors |
MINTi | Q8N201 |
STRINGi | 9606.ENSP00000385722 |
PTM databases
iPTMneti | Q8N201 |
PhosphoSitePlusi | Q8N201 |
Genetic variation databases
BioMutai | INTS1 |
DMDMi | 97052424 |
Proteomic databases
EPDi | Q8N201 |
jPOSTi | Q8N201 |
MassIVEi | Q8N201 |
MaxQBi | Q8N201 |
PaxDbi | Q8N201 |
PeptideAtlasi | Q8N201 |
PRIDEi | Q8N201 |
ProteomicsDBi | 71646 |
Protocols and materials databases
Antibodypediai | 5500, 100 antibodies |
Genome annotation databases
Ensembli | ENST00000404767; ENSP00000385722; ENSG00000164880 |
GeneIDi | 26173 |
KEGGi | hsa:26173 |
UCSCi | uc003skn.3, human |
Organism-specific databases
CTDi | 26173 |
DisGeNETi | 26173 |
GeneCardsi | INTS1 |
HGNCi | HGNC:24555, INTS1 |
HPAi | ENSG00000164880, Low tissue specificity |
MalaCardsi | INTS1 |
MIMi | 611345, gene 618571, phenotype |
neXtProti | NX_Q8N201 |
OpenTargetsi | ENSG00000164880 |
PharmGKBi | PA144596420 |
VEuPathDBi | HostDB:ENSG00000164880.15 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4596, Eukaryota |
GeneTreei | ENSGT00390000015743 |
HOGENOMi | CLU_001690_0_0_1 |
InParanoidi | Q8N201 |
OMAi | AAWDGYP |
OrthoDBi | 357673at2759 |
PhylomeDBi | Q8N201 |
TreeFami | TF313809 |
Enzyme and pathway databases
PathwayCommonsi | Q8N201 |
Reactomei | R-HSA-6807505, RNA polymerase II transcribes snRNA genes |
SIGNORi | Q8N201 |
Miscellaneous databases
BioGRID-ORCSi | 26173, 611 hits in 870 CRISPR screens |
ChiTaRSi | INTS1, human |
GenomeRNAii | 26173 |
Pharosi | Q8N201, Tdark |
PROi | PR:Q8N201 |
RNActi | Q8N201, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164880, Expressed in right hemisphere of cerebellum and 222 other tissues |
ExpressionAtlasi | Q8N201, baseline and differential |
Genevisiblei | Q8N201, HS |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR022145, DUF3677 IPR038902, INTS1 |
PANTHERi | PTHR21224, PTHR21224, 1 hit |
Pfami | View protein in Pfam PF12432, DUF3677, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | INT1_HUMAN | |
Accessioni | Q8N201Primary (citable) accession number: Q8N201 Secondary accession number(s): A6NJ44 Q9Y3W8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | May 16, 2006 | |
Last modified: | February 10, 2021 | |
This is version 136 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families