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UniProtKB - Q8N201 (INT1_HUMAN)

Protein

Integrator complex subunit 1

Gene

INTS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).1 Publication1 Publication

GO - Biological processi

  • snRNA processing Source: HGNC
  • snRNA transcription by RNA polymerase II Source: Reactome
  • U2 snRNA 3'-end processing Source: GO_Central
View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 1
Short name:
Int1
Gene namesi
Name:INTS1
Synonyms:KIAA1440
ORF Names:UNQ1821/PRO3434
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000164880.15
HGNCiHGNC:24555 INTS1
MIMi611345 gene
neXtProtiNX_Q8N201

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1159 – 1179HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26173
OpenTargetsiENSG00000164880
PharmGKBiPA144596420

Polymorphism and mutation databases

BioMutaiINTS1
DMDMi97052424

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002360441 – 2190Integrator complex subunit 1Add BLAST2190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Modified residuei47N6-acetyllysineCombined sources1
Modified residuei83PhosphothreonineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei307PhosphoserineCombined sources1
Modified residuei924PhosphoserineCombined sources1
Modified residuei1318PhosphoserineCombined sources1
Modified residuei1326PhosphoserineBy similarity1
Modified residuei1327PhosphoserineBy similarity1
Modified residuei1395PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8N201
MaxQBiQ8N201
PaxDbiQ8N201
PeptideAtlasiQ8N201
PRIDEiQ8N201
ProteomicsDBi71646

PTM databases

iPTMnetiQ8N201
PhosphoSitePlusiQ8N201

Expressioni

Gene expression databases

BgeeiENSG00000164880 Expressed in 210 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ8N201 baseline and differential
GenevisibleiQ8N201 HS

Organism-specific databases

HPAiHPA021658
HPA053009

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12 (PubMed:16239144). Interacts with ESRRB, ESRRB is probably not a core component of the multiprotein complex Integrator and this association is a bridge for the interaction with the multiprotein complex Integrator; attracts the transcriptional machinery (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi117596, 78 interactors
CORUMiQ8N201
DIPiDIP-48476N
IntActiQ8N201, 15 interactors
MINTiQ8N201
STRINGi9606.ENSP00000385722

Structurei

3D structure databases

ProteinModelPortaliQ8N201
SMRiQ8N201
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi61 – 64Poly-Ala4
Compositional biasi1580 – 1583Poly-Val4
Compositional biasi1875 – 1878Poly-Leu4

Sequence similaritiesi

Belongs to the Integrator subunit 1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4596 Eukaryota
ENOG410XTAB LUCA
GeneTreeiENSGT00390000015743
HOVERGENiHBG081799
InParanoidiQ8N201
KOiK13138
OMAiNYFEALT
OrthoDBiEOG091G00L0
PhylomeDBiQ8N201
TreeFamiTF313809

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR022145 DUF3677
IPR038902 INTS1
PANTHERiPTHR21224 PTHR21224, 1 hit
PfamiView protein in Pfam
PF12432 DUF3677, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N201-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRAKPTTVR RPSAAAKPSG HPPPGDFIAL GSKGQANESK TASTLLKPAP 
        60         70         80         90        100
SGLPSERKRD AAAALSSASA LTGLTKRPKL SSTPPLSALG RLAEAAVAEK 
       110        120        130        140        150
RAISPSIKEP SVVPIEVLPT VLLDEIEAAE LEGNDDRIEG VLCGAVKQLK 
       160        170        180        190        200
VTRAKPDSTL YLSLMYLAKI KPNIFATEGV IEALCSLLRR DASINFKAKG 
       210        220        230        240        250
NSLVSVLACN LLMAAYEEDE NWPEIFVKVY IEDSLGERIW VDSPHCKTFV 
       260        270        280        290        300
DNIQTAFNTR MPPRSVLLQG EAGRVAGDLG AGSSPHPSLT EEEDSQTELL 
       310        320        330        340        350
IAEEKLSPEQ EGQLMPRYEE LAESVEEYVL DMLRDQLNRR QPIDNVSRNL 
       360        370        380        390        400
LRLLTSTCGY KEVRLLAVQK LEMWLQNPKL TRPAQDLLMS VCMNCNTHGS 
       410        420        430        440        450
EDMDVISHLI KIRLKPKVLL NHFMLCIREL LSAHKDNLGT TIKLVIFNEL 
       460        470        480        490        500
SSARNPNNMQ VLYTALQHSS ELAPKFLAMV FQDLLTNKDD YLRASRALLR 
       510        520        530        540        550
EIIKQTKHEI NFQAFCLGLM QERKEPQYLE MEFKERFVVH ITDVLAVSMM 
       560        570        580        590        600
LGITAQVKEA GIAWDKGEKR NLEVLRSFQN QIAAIQRDAV WWLHTVVPSI 
       610        620        630        640        650
SKLAPKDYVH CLHKVLFTEQ PETYYKWDNW PPESDRNFFL RLCSEVPILE 
       660        670        680        690        700
DTLMRILVIG LSRELPLGPA DAMELADHLV KRAAAVQADD VEVLKVGRTQ 
       710        720        730        740        750
LIDAVLNLCT YHHPENIQLP PGYQPPNLAI STLYWKAWPL LLVVAAFNPE 
       760        770        780        790        800
NIGLAAWEEY PTLKMLMEMV MTNNYSYPPC TLTDEETRTE MLNRELQTAQ 
       810        820        830        840        850
REKQEILAFE GHLAAASTKQ TITESSSLLL SQLTSLDPQG PPRRPPPHIL 
       860        870        880        890        900
DQVKSLNQSL RLGHLLCRSR NPDFLLHIIQ RQASSQSMPW LADLVQSSEG 
       910        920        930        940        950
SLDVLPVQCL CEFLLHDAVD DAASGEEDDE GESKEQKAKK RQRQQKQRQL 
       960        970        980        990       1000
LGRLQDLLLG PKADEQTTCE VLDYFLRRLG SSQVASRVLA MKGLSLVLSE 
      1010       1020       1030       1040       1050
GSLRDGEEKE PPMEEDVGDT DVLQGYQWLL RDLPRLPLFD SVRSTTALAL 
      1060       1070       1080       1090       1100
QQAIHMETDP QTISAYLIYL SQHTPVEEQA QHSDLALDVA RLVVERSTIM 
      1110       1120       1130       1140       1150
SHLFSKLSPS AASDAVLSAL LSIFSRYVRR MRQSKEGEEV YSWSESQDQV 
      1160       1170       1180       1190       1200
FLRWSSGETA TMHILVVHAM VILLTLGPPR ADDSEFQALL DIWFPEEKPL 
      1210       1220       1230       1240       1250
PTAFLVDTSE EALLLPDWLK LRMIRSEVLR LVDAALQDLE PQQLLLFVQS 
      1260       1270       1280       1290       1300
FGIPVSSMSK LLQFLDQAVA HDPQTLEQNI MDKNYMAHLV EVQHERGASG 
      1310       1320       1330       1340       1350
GQTFHSLLTA SLPPRRDSTE APKPKSSPEQ PIGQGRIRVG TQLRVLGPED 
      1360       1370       1380       1390       1400
DLAGMFLQIF PLSPDPRWQS SSPRPVALAL QQALGQELAR VVQGSPEVPG 
      1410       1420       1430       1440       1450
ITVRVLQALA TLLSSPHGGA LVMSMHRSHF LACPLLRQLC QYQRCVPQDT 
      1460       1470       1480       1490       1500
GFSSLFLKVL LQMLQWLDSP GVEGGPLRAQ LRMLASQASA GRRLSDVRGG 
      1510       1520       1530       1540       1550
LLRLAEALAF RQDLEVVSST VRAVIATLRS GEQCSVEPDL ISKVLQGLIE 
      1560       1570       1580       1590       1600
VRSPHLEELL TAFFSATADA ASPFPACKPV VVVSSLLLQE EEPLAGGKPG 
      1610       1620       1630       1640       1650
ADGGSLEAVR LGPSSGLLVD WLEMLDPEVV SSCPDLQLRL LFSRRKGKGQ 
      1660       1670       1680       1690       1700
AQVPSFRPYL LTLFTHQSSW PTLHQCIRVL LGKSREQRFD PSASLDFLWA 
      1710       1720       1730       1740       1750
CIHVPRIWQG RDQRTPQKRR EELVLRVQGP ELISLVELIL AEAETRSQDG 
      1760       1770       1780       1790       1800
DTAACSLIQA RLPLLLSCCC GDDESVRKVT EHLSGCIQQW GDSVLGRRCR 
      1810       1820       1830       1840       1850
DLLLQLYLQR PELRVPVPEV LLHSEGAASS SVCKLDGLIH RFITLLADTS 
      1860       1870       1880       1890       1900
DSRALENRGA DASMACRKLA VAHPLLLLRH LPMIAALLHG RTHLNFQEFR 
      1910       1920       1930       1940       1950
QQNHLSCFLH VLGLLELLQP HVFRSEHQGA LWDCLLSFIR LLLNYRKSSR 
      1960       1970       1980       1990       2000
HLAAFINKFV QFIHKYITYN APAAISFLQK HADPLHDLSF DNSDLVMLKS 
      2010       2020       2030       2040       2050
LLAGLSLPSR DDRTDRGLDE EGEEESSAGS LPLVSVSLFT PLTAAEMAPY 
      2060       2070       2080       2090       2100
MKRLSRGQTV EDLLEVLSDI DEMSRRRPEI LSFFSTNLQR LMSSAEECCR 
      2110       2120       2130       2140       2150
NLAFSLALRS MQNSPSIAAA FLPTFMYCLG SQDFEVVQTA LRNLPEYALL 
      2160       2170       2180       2190
CQEHAAVLLH RAFLVGMYGQ MDPSAQISEA LRILHMEAVM
Length:2,190
Mass (Da):244,297
Last modified:May 16, 2006 - v2
Checksum:i342FF560BF3F61F6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C582H7C582_HUMAN
Integrator complex subunit 1
INTS1
128Annotation score:

Sequence cautioni

The sequence AAQ88846 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti636R → Y (PubMed:16421571).Curated1
Sequence conflicti1862A → G in BAA92678 (PubMed:10718198).Curated1
Sequence conflicti2004G → V in CAB70710 (PubMed:17974005).Curated1
Sequence conflicti2105S → C in CAB70710 (PubMed:17974005).Curated1
Sequence conflicti2162A → AF in CAB70710 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049627172P → L. Corresponds to variant dbSNP:rs3752714Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102953 Genomic DNA No translation available.
AC093734 Genomic DNA No translation available.
AB037861 mRNA Translation: BAA92678.1
AY358482 mRNA Translation: AAQ88846.1 Different initiation.
BC013367 mRNA Translation: AAH13367.2
BC018777 mRNA Translation: AAH18777.1
BC069262 mRNA Translation: AAH69262.1
AL050110 mRNA Translation: CAB43278.2
AL137358 mRNA Translation: CAB70710.3
BK005720 mRNA Translation: DAA05720.1
CCDSiCCDS47526.1
PIRiT08758
T46429
RefSeqiNP_001073922.2, NM_001080453.2
UniGeneiHs.532188

Genome annotation databases

EnsembliENST00000404767; ENSP00000385722; ENSG00000164880
GeneIDi26173
KEGGihsa:26173
UCSCiuc003skn.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102953 Genomic DNA No translation available.
AC093734 Genomic DNA No translation available.
AB037861 mRNA Translation: BAA92678.1
AY358482 mRNA Translation: AAQ88846.1 Different initiation.
BC013367 mRNA Translation: AAH13367.2
BC018777 mRNA Translation: AAH18777.1
BC069262 mRNA Translation: AAH69262.1
AL050110 mRNA Translation: CAB43278.2
AL137358 mRNA Translation: CAB70710.3
BK005720 mRNA Translation: DAA05720.1
CCDSiCCDS47526.1
PIRiT08758
T46429
RefSeqiNP_001073922.2, NM_001080453.2
UniGeneiHs.532188

3D structure databases

ProteinModelPortaliQ8N201
SMRiQ8N201
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117596, 78 interactors
CORUMiQ8N201
DIPiDIP-48476N
IntActiQ8N201, 15 interactors
MINTiQ8N201
STRINGi9606.ENSP00000385722

PTM databases

iPTMnetiQ8N201
PhosphoSitePlusiQ8N201

Polymorphism and mutation databases

BioMutaiINTS1
DMDMi97052424

Proteomic databases

EPDiQ8N201
MaxQBiQ8N201
PaxDbiQ8N201
PeptideAtlasiQ8N201
PRIDEiQ8N201
ProteomicsDBi71646

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000404767; ENSP00000385722; ENSG00000164880
GeneIDi26173
KEGGihsa:26173
UCSCiuc003skn.3 human

Organism-specific databases

CTDi26173
DisGeNETi26173
EuPathDBiHostDB:ENSG00000164880.15
GeneCardsiINTS1
H-InvDBiHIX0006419
HGNCiHGNC:24555 INTS1
HPAiHPA021658
HPA053009
MIMi611345 gene
neXtProtiNX_Q8N201
OpenTargetsiENSG00000164880
PharmGKBiPA144596420
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4596 Eukaryota
ENOG410XTAB LUCA
GeneTreeiENSGT00390000015743
HOVERGENiHBG081799
InParanoidiQ8N201
KOiK13138
OMAiNYFEALT
OrthoDBiEOG091G00L0
PhylomeDBiQ8N201
TreeFamiTF313809

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes

Miscellaneous databases

ChiTaRSiINTS1 human
GenomeRNAii26173
PROiPR:Q8N201
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164880 Expressed in 210 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ8N201 baseline and differential
GenevisibleiQ8N201 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR022145 DUF3677
IPR038902 INTS1
PANTHERiPTHR21224 PTHR21224, 1 hit
PfamiView protein in Pfam
PF12432 DUF3677, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINT1_HUMAN
AccessioniPrimary (citable) accession number: Q8N201
Secondary accession number(s): A6NJ44
, Q6NT70, Q6UX74, Q8WV40, Q96D36, Q9NTD1, Q9P2A8, Q9Y3W8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: November 7, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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