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UniProtKB - Q8N1Q8 (THEM5_HUMAN)

Entry version 132 (02 Dec 2020)
Sequence version 2 (17 Apr 2007)
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Protein

Acyl-coenzyme A thioesterase THEM5

Gene

THEM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters (PubMed:22586271). Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin (PubMed:22586271). Required for normal mitochondrial function (PubMed:22586271).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.4 µM for palmitoyl-CoA (C16:0)1 Publication
  2. KM=4.2 µM for stearoyl-CoA (C18:0)1 Publication
  3. KM=2.9 µM for oleoyl-CoA (C18:1)1 Publication
  4. KM=4.2 µM for linoleoyl-CoA (C18:2)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei167Proton donor/acceptorBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processFatty acid metabolism, Lipid metabolism

    Enzyme and pathway databases

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		Q8N1Q8

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-77289, Mitochondrial Fatty Acid Beta-Oxidation

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		Q8N1Q8

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...    SwissLipidsi    		SLP:000000659

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Acyl-coenzyme A thioesterase THEM5 (EC:3.1.2.21 Publication)
    Short name:
    Acyl-CoA thioesterase THEM5
    Alternative name(s):
    Acyl-coenzyme A thioesterase 15
    Thioesterase superfamily member 5
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:THEM5
    Synonyms:ACOT15
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Eukaryotic Pathogen and Host Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000196407.11

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:26755, THEM5

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		615653, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q8N1Q8

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Mitochondrion

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi160G → A: Strongly reduces enzyme activity. Abolishes enzyme activity; when associated with A-183. 1 Publication1
    Mutagenesisi167D → A: Abolishes enzyme activity. 1 Publication1
    Mutagenesisi183T → A: Reduces enzyme activity. Abolishes enzyme activity; when associated with A-160. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		284486

    Open Targets

    More...    OpenTargetsi    		ENSG00000196407

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA142670814

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		Q8N1Q8, Tbio

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		THEM5

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		145566964

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002845191 – 247Acyl-coenzyme A thioesterase THEM5Add BLAST247

    Proteomic databases

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		Q8N1Q8

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q8N1Q8

    PeptideAtlas

    More...    PeptideAtlasi    		Q8N1Q8

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q8N1Q8

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		71628

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q8N1Q8

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q8N1Q8

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000196407, Expressed in zone of skin and 111 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q8N1Q8, baseline and differential

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000196407, Group enriched (skin, tongue)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		129888, 8 interactors

    Protein interaction database and analysis system

    More...    IntActi    		Q8N1Q8, 3 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000357807

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q8N1Q8, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1247
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q8N1Q8

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the THEM4/THEM5 thioesterase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG4781, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000161937

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_072603_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q8N1Q8

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		QVEGQGY

    Database of Orthologous Groups

    More...    OrthoDBi    		1322443at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q8N1Q8

    TreeFam database of animal gene trees

    More...    TreeFami    		TF332518

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR029069, HotDog_dom_sf
    IPR006683, Thioestr_dom

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF03061, 4HBT, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF54637, SSF54637, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    Q8N1Q8-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MIRRCFQVAA RLGHHRGLLE APRILPRLNP ASAFGSSTDS MFSRFLPEKT 
            60         70         80         90        100
    DLKDYALPNA SWCSDMLSLY QEFLEKTKSS GWIKLPSFKS NRDHIRGLKL 
           110        120        130        140        150
    PSGLAVSSDK GDCRIFTRCI QVEGQGFEYV IFFQPTQKKS VCLFQPGSYL 
           160        170        180        190        200
    EGPPGFAHGG SLAAMMDETF SKTAFLAGEG LFTLSLNIRF KNLIPVDSLV 
           210        220        230        240 
    VMDVELDKIE DQKLYMSCIA HSRDQQTVYA KSSGVFLQLQ LEEESPQ
    Length:247
    Mass (Da):27,677
    Last modified:April 17, 2007 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55117AE70FFC183F
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    H0Y6P4H0Y6P4_HUMAN
    Acyl-coenzyme A thioesterase THEM5
    THEM5
    		119Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03176455Y → S. Corresponds to variant dbSNP:rs16833597Ensembl.1
    Natural variantiVAR_031765197D → G. Corresponds to variant dbSNP:rs6587625Ensembl.1
    Natural variantiVAR_031766206L → V2 PublicationsCorresponds to variant dbSNP:rs6587624Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AK095283 mRNA Translation: BAC04521.1
    AL450992 Genomic DNA No translation available.
    BC101610 mRNA Translation: AAI01611.1
    BC112239 mRNA Translation: AAI12240.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS1005.1

    NCBI Reference Sequences

    More...    RefSeqi    		NP_872384.1, NM_182578.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000368817; ENSP00000357807; ENSG00000196407

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		284486

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:284486

    UCSC genome browser

    More...    UCSCi    		uc021oyw.2, human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AK095283 mRNA Translation: BAC04521.1
    AL450992 Genomic DNA No translation available.
    BC101610 mRNA Translation: AAI01611.1
    BC112239 mRNA Translation: AAI12240.1
    CCDSiCCDS1005.1
    RefSeqiNP_872384.1, NM_182578.3

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4AE7X-ray1.45A35-247[»]
    SMRiQ8N1Q8
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi129888, 8 interactors
    IntActiQ8N1Q8, 3 interactors
    STRINGi9606.ENSP00000357807

    Chemistry databases

    SwissLipidsiSLP:000000659

    PTM databases

    iPTMnetiQ8N1Q8
    PhosphoSitePlusiQ8N1Q8

    Polymorphism and mutation databases

    BioMutaiTHEM5
    DMDMi145566964

    Proteomic databases

    MassIVEiQ8N1Q8
    PaxDbiQ8N1Q8
    PeptideAtlasiQ8N1Q8
    PRIDEiQ8N1Q8
    ProteomicsDBi71628

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		34076, 63 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		284486

    Genome annotation databases

    EnsembliENST00000368817; ENSP00000357807; ENSG00000196407
    GeneIDi284486
    KEGGihsa:284486
    UCSCiuc021oyw.2, human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		284486
    DisGeNETi284486
    EuPathDBiHostDB:ENSG00000196407.11

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		THEM5
    HGNCiHGNC:26755, THEM5
    HPAiENSG00000196407, Group enriched (skin, tongue)
    MIMi615653, gene
    neXtProtiNX_Q8N1Q8
    OpenTargetsiENSG00000196407
    PharmGKBiPA142670814

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG4781, Eukaryota
    GeneTreeiENSGT00940000161937
    HOGENOMiCLU_072603_0_0_1
    InParanoidiQ8N1Q8
    OMAiQVEGQGY
    OrthoDBi1322443at2759
    PhylomeDBiQ8N1Q8
    TreeFamiTF332518

    Enzyme and pathway databases

    PathwayCommonsiQ8N1Q8
    ReactomeiR-HSA-77289, Mitochondrial Fatty Acid Beta-Oxidation
    SABIO-RKiQ8N1Q8

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		284486, 12 hits in 842 CRISPR screens

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		284486
    PharosiQ8N1Q8, Tbio

    Protein Ontology

    More...    PROi    		PR:Q8N1Q8
    RNActiQ8N1Q8, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000196407, Expressed in zone of skin and 111 other tissues
    ExpressionAtlasiQ8N1Q8, baseline and differential

    Family and domain databases

    InterProiView protein in InterPro
    IPR029069, HotDog_dom_sf
    IPR006683, Thioestr_dom
    PfamiView protein in Pfam
    PF03061, 4HBT, 1 hit
    SUPFAMiSSF54637, SSF54637, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHEM5_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N1Q8
    Secondary accession number(s): Q5T1C3
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: April 17, 2007
    Last modified: December 2, 2020
    This is version 132 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families
    5. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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