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Protein

Carbonic anhydrase 13

Gene

CA13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reversible hydration of carbon dioxide.

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+1 Publication

Activity regulationi

Inhibited by acetazolamide.1 Publication

Kineticsi

  1. KM=13.8 mM for CO21 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Active sitei65Proton acceptorBy similarity1
    Active sitei68By similarity1
    Metal bindingi95Zinc; catalytic1 Publication1
    Metal bindingi97Zinc; catalytic1 Publication1
    Metal bindingi120Zinc; catalytic1 Publication1
    Active sitei129By similarity1

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Molecular functionLyase
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiR-HSA-1475029 Reversible hydration of carbon dioxide

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbonic anhydrase 13 (EC:4.2.1.1)
    Alternative name(s):
    Carbonate dehydratase XIII
    Carbonic anhydrase XIII
    Short name:
    CA-XIII
    Gene namesi
    Name:CA13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 8

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000185015.7
    HGNCiHGNC:14914 CA13
    MIMi611436 gene
    neXtProtiNX_Q8N1Q1

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi377677
    OpenTargetsiENSG00000185015
    PharmGKBiPA134891311

    Chemistry databases

    ChEMBLiCHEMBL3912
    DrugBankiDB00909 Zonisamide

    Polymorphism and mutation databases

    BioMutaiCA13
    DMDMi30580350

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000774401 – 262Carbonic anhydrase 13Add BLAST262

    Proteomic databases

    EPDiQ8N1Q1
    MaxQBiQ8N1Q1
    PaxDbiQ8N1Q1
    PeptideAtlasiQ8N1Q1
    PRIDEiQ8N1Q1
    ProteomicsDBi71627

    2D gel databases

    OGPiQ8N1Q1

    PTM databases

    iPTMnetiQ8N1Q1
    PhosphoSitePlusiQ8N1Q1

    Expressioni

    Tissue specificityi

    Expressed in thymus, small intestine, spleen, prostate, ovary, colon and testis.1 Publication

    Gene expression databases

    BgeeiENSG00000185015 Expressed in 183 organ(s), highest expression level in jejunal mucosa
    CleanExiHS_CA13
    GenevisibleiQ8N1Q1 HS

    Organism-specific databases

    HPAiCAB025567
    HPA024689

    Interactioni

    Protein-protein interaction databases

    IntActiQ8N1Q1, 3 interactors

    Chemistry databases

    BindingDBiQ8N1Q1

    Structurei

    Secondary structure

    1262
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    ProteinModelPortaliQ8N1Q1
    SMRiQ8N1Q1
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8N1Q1

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini4 – 261Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST258

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni200 – 201Substrate bindingBy similarity2

    Sequence similaritiesi

    Belongs to the alpha-carbonic anhydrase family.Curated

    Phylogenomic databases

    eggNOGiKOG0382 Eukaryota
    COG3338 LUCA
    GeneTreeiENSGT00760000118915
    HOGENOMiHOG000112637
    HOVERGENiHBG002837
    InParanoidiQ8N1Q1
    KOiK01672
    OMAiNGPIHWN
    OrthoDBiEOG091G0XFM
    PhylomeDBiQ8N1Q1
    TreeFamiTF316425

    Family and domain databases

    Gene3Di3.10.200.10, 1 hit
    InterProiView protein in InterPro
    IPR001148 CA_dom
    IPR036398 CA_dom_sf
    IPR023561 Carbonic_anhydrase_a-class
    IPR018338 Carbonic_anhydrase_a-class_CS
    PANTHERiPTHR18952 PTHR18952, 1 hit
    PfamiView protein in Pfam
    PF00194 Carb_anhydrase, 1 hit
    SMARTiView protein in SMART
    SM01057 Carb_anhydrase, 1 hit
    SUPFAMiSSF51069 SSF51069, 1 hit
    PROSITEiView protein in PROSITE
    PS00162 ALPHA_CA_1, 1 hit
    PS51144 ALPHA_CA_2, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q8N1Q1-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSRLSWGYRE HNGPIHWKEF FPIADGDQQS PIEIKTKEVK YDSSLRPLSI
    60 70 80 90 100
    KYDPSSAKII SNSGHSFNVD FDDTENKSVL RGGPLTGSYR LRQVHLHWGS
    110 120 130 140 150
    ADDHGSEHIV DGVSYAAELH VVHWNSDKYP SFVEAAHEPD GLAVLGVFLQ
    160 170 180 190 200
    IGEPNSQLQK ITDTLDSIKE KGKQTRFTNF DLLSLLPPSW DYWTYPGSLT
    210 220 230 240 250
    VPPLLESVTW IVLKQPINIS SQQLAKFRSL LCTAEGEAAA FLVSNHRPPQ
    260
    PLKGRKVRAS FH
    Length:262
    Mass (Da):29,443
    Last modified:October 1, 2002 - v1
    Checksum:iAE677F028ED729FE
    GO

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_05920768N → S. Corresponds to variant dbSNP:rs4740046Ensembl.1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK095314 mRNA Translation: BAC04528.1
    BC052602 mRNA Translation: AAH52602.1
    CCDSiCCDS6236.1
    RefSeqiNP_940986.1, NM_198584.2
    UniGeneiHs.127189

    Genome annotation databases

    EnsembliENST00000321764; ENSP00000318912; ENSG00000185015
    GeneIDi377677
    KEGGihsa:377677
    UCSCiuc003ydg.3 human

    Keywords - Coding sequence diversityi

    Polymorphism

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK095314 mRNA Translation: BAC04528.1
    BC052602 mRNA Translation: AAH52602.1
    CCDSiCCDS6236.1
    RefSeqiNP_940986.1, NM_198584.2
    UniGeneiHs.127189

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3CZVX-ray2.00A/B1-262[»]
    3D0NX-ray1.55A/B1-262[»]
    3DA2X-ray2.05A/B1-261[»]
    4HU1X-ray1.95A/B1-262[»]
    4KNMX-ray1.90A/B1-262[»]
    4KNNX-ray1.40A/B1-262[»]
    4QIZX-ray1.55A/B1-262[»]
    4QJPX-ray1.62A/B1-262[»]
    4QJXX-ray1.95A1-262[»]
    4QSJX-ray1.70A/B1-262[»]
    5E2NX-ray1.53A/B1-262[»]
    5LLAX-ray1.50A/B1-262[»]
    5LLNX-ray1.60A/B1-262[»]
    5OGJX-ray1.06A/B1-262[»]
    5OHHX-ray1.42A/B1-262[»]
    ProteinModelPortaliQ8N1Q1
    SMRiQ8N1Q1
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    IntActiQ8N1Q1, 3 interactors

    Chemistry databases

    BindingDBiQ8N1Q1
    ChEMBLiCHEMBL3912
    DrugBankiDB00909 Zonisamide

    PTM databases

    iPTMnetiQ8N1Q1
    PhosphoSitePlusiQ8N1Q1

    Polymorphism and mutation databases

    BioMutaiCA13
    DMDMi30580350

    2D gel databases

    OGPiQ8N1Q1

    Proteomic databases

    EPDiQ8N1Q1
    MaxQBiQ8N1Q1
    PaxDbiQ8N1Q1
    PeptideAtlasiQ8N1Q1
    PRIDEiQ8N1Q1
    ProteomicsDBi71627

    Protocols and materials databases

    DNASUi377677
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000321764; ENSP00000318912; ENSG00000185015
    GeneIDi377677
    KEGGihsa:377677
    UCSCiuc003ydg.3 human

    Organism-specific databases

    CTDi377677
    DisGeNETi377677
    EuPathDBiHostDB:ENSG00000185015.7
    GeneCardsiCA13
    HGNCiHGNC:14914 CA13
    HPAiCAB025567
    HPA024689
    MIMi611436 gene
    neXtProtiNX_Q8N1Q1
    OpenTargetsiENSG00000185015
    PharmGKBiPA134891311
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG0382 Eukaryota
    COG3338 LUCA
    GeneTreeiENSGT00760000118915
    HOGENOMiHOG000112637
    HOVERGENiHBG002837
    InParanoidiQ8N1Q1
    KOiK01672
    OMAiNGPIHWN
    OrthoDBiEOG091G0XFM
    PhylomeDBiQ8N1Q1
    TreeFamiTF316425

    Enzyme and pathway databases

    ReactomeiR-HSA-1475029 Reversible hydration of carbon dioxide

    Miscellaneous databases

    ChiTaRSiCA13 human
    EvolutionaryTraceiQ8N1Q1
    GenomeRNAii377677
    PROiPR:Q8N1Q1
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000185015 Expressed in 183 organ(s), highest expression level in jejunal mucosa
    CleanExiHS_CA13
    GenevisibleiQ8N1Q1 HS

    Family and domain databases

    Gene3Di3.10.200.10, 1 hit
    InterProiView protein in InterPro
    IPR001148 CA_dom
    IPR036398 CA_dom_sf
    IPR023561 Carbonic_anhydrase_a-class
    IPR018338 Carbonic_anhydrase_a-class_CS
    PANTHERiPTHR18952 PTHR18952, 1 hit
    PfamiView protein in Pfam
    PF00194 Carb_anhydrase, 1 hit
    SMARTiView protein in SMART
    SM01057 Carb_anhydrase, 1 hit
    SUPFAMiSSF51069 SSF51069, 1 hit
    PROSITEiView protein in PROSITE
    PS00162 ALPHA_CA_1, 1 hit
    PS51144 ALPHA_CA_2, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiCAH13_HUMAN
    AccessioniPrimary (citable) accession number: Q8N1Q1
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
    Last sequence update: October 1, 2002
    Last modified: November 7, 2018
    This is version 141 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
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