Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 133 (17 Jun 2020)
Sequence version 2 (13 Feb 2019)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Beta/gamma crystallin domain-containing protein 2

Gene

CRYBG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLectin

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM13 Carbohydrate-Binding Module Family 13

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta/gamma crystallin domain-containing protein 2Imported
Alternative name(s):
Absent in melanoma 1-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRYBG2Imported
Synonyms:AIM1L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000176092.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17295 CRYBG2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N1P7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55057

Open Targets

More...
OpenTargetsi
ENSG00000176092

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24650

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N1P7 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CRYBG2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74750904

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002851051 – 1661Beta/gamma crystallin domain-containing protein 2Add BLAST1661

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N1P7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N1P7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N1P7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N1P7

PeptideAtlas

More...
PeptideAtlasi
Q8N1P7

PRoteomics IDEntifications database

More...
PRIDEi
Q8N1P7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71626

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N1P7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N1P7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176092 Expressed in lower esophagus mucosa and 186 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N1P7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N1P7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000176092 Tissue enhanced (esophagus, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120378, 27 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000310435

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N1P7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N1P7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini986 – 1023Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST38
Domaini1024 – 1067Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST44
Domaini1073 – 1113Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini1114 – 1156Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43
Domaini1168 – 1213Beta/gamma crystallin 'Greek key' 5PROSITE-ProRule annotationAdd BLAST46
Domaini1214 – 1256Beta/gamma crystallin 'Greek key' 6PROSITE-ProRule annotationAdd BLAST43
Domaini1262 – 1302Beta/gamma crystallin 'Greek key' 7PROSITE-ProRule annotationAdd BLAST41
Domaini1303 – 1345Beta/gamma crystallin 'Greek key' 8PROSITE-ProRule annotationAdd BLAST43
Domaini1356 – 1393Beta/gamma crystallin 'Greek key' 9PROSITE-ProRule annotationAdd BLAST38
Domaini1394 – 1437Beta/gamma crystallin 'Greek key' 10PROSITE-ProRule annotationAdd BLAST44
Domaini1443 – 1483Beta/gamma crystallin 'Greek key' 11PROSITE-ProRule annotationAdd BLAST41
Domaini1484 – 1525Beta/gamma crystallin 'Greek key' 12PROSITE-ProRule annotationAdd BLAST42
Domaini1569 – 1659Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi352 – 442Pro-richPROSITE-ProRule annotationAdd BLAST91

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IERF Eukaryota
ENOG4110BHM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157740

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002147_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N1P7

Identification of Orthologs from Complete Genome Data

More...
OMAi
GAQMEAP

Database of Orthologous Groups

More...
OrthoDBi
89929at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N1P7

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00030 Crystall, 6 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01367 BGCRYSTALLIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00458 RICIN, 1 hit
SM00247 XTALbg, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49695 SSF49695, 3 hits
SSF50370 SSF50370, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 12 hits
PS50231 RICIN_B_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8N1P7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEAGGPMAR AKARVVSATL TWRQRPPTQE EIKHGFHKVS LVSGAQMEAP
60 70 80 90 100
QKEMFEFSRR EEVEVNGFAT QEEETVNCQG PRDTAGSKNF QSHGPIFSKK
110 120 130 140 150
YIPPPKEKRP EGRLKEAVDQ SDGSRQAPRT EPPCVGAMAR TELLVPLPGP
160 170 180 190 200
REPSPHPGVG LTSGSSRSLE EYRVTRTVRT TTVVGGHVDR RMSSSVTVRP
210 220 230 240 250
VSSGEALPRG RQVSRMVPPV VVGSPPGSPS RSQAVKVLSN LVPAGHSPPA
260 270 280 290 300
SHLPRPTAGG PRSTGLGSTV GAALRQLPET GTAELKDSSA LASTGIPASA
310 320 330 340 350
HLPKNQDAPA ACPDRDQGRA PDARACELWQ VLGAPSSTEL PLQTSQGQAS
360 370 380 390 400
VPSSPRLETH VPSPGLTHPA KQPVVPTHPG ARLTPLVLPP KKKDGPVDPP
410 420 430 440 450
AATVLPMVRS EHVTVPGQPP APSTTRRKDV PSPGGLSAPS SPRNKFVQNS
460 470 480 490 500
ENVPVLPFTQ REVVKGPGAP AASSPTRKEV VQGSSASAAS SPTWKEVVKG
510 520 530 540 550
PGAPAASSPT QKEVVQGSSA PAALFPTWKE VVKGPGAPDA SFPTWKEVVK
560 570 580 590 600
GPGAPAASSP TQKEVVQGSG APAALSTTPK EVVKGPGAPA ASSPTQKEVV
610 620 630 640 650
KGPCAPAASS PTQKEVVQGS GAPAALSPKS TEVVQGPKGS SSIQKEAVQG
660 670 680 690 700
IAGSLAPPLT KEETVQGPIA PATSLPKQDK GVQDSEGSPI SSLTQKEVVQ
710 720 730 740 750
DPDALPAPSS SVDRVSPSPG GTPAPVPTGA EASTESQLVS DPTEGKTCTE
760 770 780 790 800
TSREEDEVAL AADLEIFLDT LRSMEPPEIL RTHRLPRAPR SSYLSMYATL
810 820 830 840 850
PAIEEDQLGP WVLGPGPQEV PSLEEKEEEE EEEPENPYLS DDEKLQRRQE
860 870 880 890 900
KAGPSPSRDL HPARPTQVSC SPLEMMKKHV AGTKGPHSEL GLELQGGSRP
910 920 930 940 950
TSRLGGSLLF GSLVPTAKEA STPEPLGTKL SALLPHGAPG LRKVPGQLPL
960 970 980 990 1000
LCSERSSPTE KLACSLPLEG WSPALKTQGK LNTRPGKVIF FSESGCQGSG
1010 1020 1030 1040 1050
REVWGDIVDA SGWAPVASIR VVRGCWVLYE EPEFRGQKLV LPEGDMELRT
1060 1070 1080 1090 1100
PGTKWSPQGI GSLRRVVWDY STPEISLFSE EGLKGEQVKL TEALKNSQGL
1110 1120 1130 1140 1150
EKPLQVASAT VSAGLWLLYP KPLFEDTPYI LEPGEYPTSE AWGTSDPSVG
1160 1170 1180 1190 1200
SLKPMRLGCP SVEKPGEPRA VVYEAPGFQG RSWEVSRDIY NLQQPEDSQS
1210 1220 1230 1240 1250
PHLASVGSLR VLGGCWVGYE KEGFRGHQYL LEEGEYPDWS HWGGYDELLT
1260 1270 1280 1290 1300
SLRVIRTDFG DPAVVLFEAM DFEGHGVEVS KALPDVELVQ HGPSTQAIHV
1310 1320 1330 1340 1350
LSGVWVAYQE VGFSGEQYVL EKGVYRNCED WGAGNSTLAS LQPVLQVGEH
1360 1370 1380 1390 1400
DLHFVSKIQL FSRPDFLGDH FSFEDDQAAL PASFRPQSCR VHGGSWILFD
1410 1420 1430 1440 1450
ETNFEGDQHI LSEGEFPTLT AMGCLASTVL GSLQKVSLHF SEPSIFLYGL
1460 1470 1480 1490 1500
ECFEGKEIEL SREVRSLQAE GFNNHVLSVR IKGGIWVLCE HSDFRGRQWL
1510 1520 1530 1540 1550
VGSCEITNWL TYSGTQRVGS LYPIKQRRVY FRLWNAALGG FLAVPDHVED
1560 1570 1580 1590 1600
MKAGRVVVAD PQAGGSCIWY YEDGLLKNQM APTMSLQVIG PPSPGSKVVL
1610 1620 1630 1640 1650
WAESRLPRQT WSISESGHIC SQMFEGQILD VKGGRGYDRD HVVLWEPDED
1660
RASQIWTIHV L
Length:1,661
Mass (Da):177,913
Last modified:February 13, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD35FF16D993D8071
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PIR9E9PIR9_HUMAN
Beta/gamma crystallin domain-contai...
CRYBG2
1,559Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ET48E7ET48_HUMAN
Beta/gamma crystallin domain-contai...
CRYBG2
1,985Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EX92E7EX92_HUMAN
Beta/gamma crystallin domain-contai...
CRYBG2
352Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KQW1J3KQW1_HUMAN
Beta/gamma crystallin domain-contai...
CRYBG2
296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI36871 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC04533 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0488351294S → N. Corresponds to variant dbSNP:rs10751735Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL451139 Genomic DNA No translation available.
AK095339 mRNA Translation: BAC04533.1 Different initiation.
BC136870 mRNA Translation: AAI36871.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_001034864.2, NM_001039775.3
XP_005245975.1, XM_005245918.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000308182; ENSP00000310435; ENSG00000176092

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55057

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55057

UCSC genome browser

More...
UCSCi
uc001bmd.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL451139 Genomic DNA No translation available.
AK095339 mRNA Translation: BAC04533.1 Different initiation.
BC136870 mRNA Translation: AAI36871.1 Different initiation.
RefSeqiNP_001034864.2, NM_001039775.3
XP_005245975.1, XM_005245918.2

3D structure databases

SMRiQ8N1P7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120378, 27 interactors
STRINGi9606.ENSP00000310435

Protein family/group databases

CAZyiCBM13 Carbohydrate-Binding Module Family 13

PTM databases

iPTMnetiQ8N1P7
PhosphoSitePlusiQ8N1P7

Polymorphism and mutation databases

BioMutaiCRYBG2
DMDMi74750904

Proteomic databases

EPDiQ8N1P7
MassIVEiQ8N1P7
MaxQBiQ8N1P7
PaxDbiQ8N1P7
PeptideAtlasiQ8N1P7
PRIDEiQ8N1P7
ProteomicsDBi71626

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
30616 111 antibodies

Genome annotation databases

EnsembliENST00000308182; ENSP00000310435; ENSG00000176092
GeneIDi55057
KEGGihsa:55057
UCSCiuc001bmd.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55057
DisGeNETi55057
EuPathDBiHostDB:ENSG00000176092.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CRYBG2
HGNCiHGNC:17295 CRYBG2
HPAiENSG00000176092 Tissue enhanced (esophagus, placenta)
neXtProtiNX_Q8N1P7
OpenTargetsiENSG00000176092
PharmGKBiPA24650

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IERF Eukaryota
ENOG4110BHM LUCA
GeneTreeiENSGT00940000157740
HOGENOMiCLU_002147_0_1_1
InParanoidiQ8N1P7
OMAiGAQMEAP
OrthoDBi89929at2759
PhylomeDBiQ8N1P7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
55057 4 hits in 44 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AIM1L human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55057
PharosiQ8N1P7 Tdark

Protein Ontology

More...
PROi
PR:Q8N1P7
RNActiQ8N1P7 protein

Gene expression databases

BgeeiENSG00000176092 Expressed in lower esophagus mucosa and 186 other tissues
ExpressionAtlasiQ8N1P7 baseline and differential
GenevisibleiQ8N1P7 HS

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF00030 Crystall, 6 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00458 RICIN, 1 hit
SM00247 XTALbg, 6 hits
SUPFAMiSSF49695 SSF49695, 3 hits
SSF50370 SSF50370, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 12 hits
PS50231 RICIN_B_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRBG2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N1P7
Secondary accession number(s): B2RNG3, Q5T137, Q5T150
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 13, 2019
Last modified: June 17, 2020
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again