THEMIS

Functionⁱ

Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.By similarity

GO - Biological processⁱ

adaptive immune response Source: UniProtKB-KW
negative T cell selection Source: UniProtKB
positive T cell selection Source: UniProtKB
T cell receptor signaling pathway Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Adaptive immunity, Immunity

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein THEMIS Alternative name(s): Thymocyte-expressed molecule involved in selection
Gene namesⁱ	Name:THEMIS Synonyms:C6orf190, C6orf207
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172673.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21569 THEMIS
MIMⁱ	613607 gene
neXtProtⁱ	NX_Q8N1K5

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	387357
Open Targets More...OpenTargetsⁱ	ENSG00000172673
PharmGKBⁱ	PA165618330

Polymorphism and mutation databases

BioMutaⁱ	THEMIS
DMDMⁱ	150421530

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000252378	1 – 641	Protein THEMISAdd BLAST		641

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	584	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Phosphorylated on Tyr residues quickly after TCR stimulation.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N1K5
PeptideAtlas More...PeptideAtlasⁱ	Q8N1K5
PRIDEⁱ	Q8N1K5
ProteomicsDBⁱ	71609 71610 [Q8N1K5-2] 71611 [Q8N1K5-3]

PTM databases

iPTMnetⁱ	Q8N1K5
PhosphoSitePlusⁱ	Q8N1K5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000172673
CleanExⁱ	HS_C6orf190
ExpressionAtlasⁱ	Q8N1K5 baseline and differential
Genevisibleⁱ	Q8N1K5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA031422 HPA031425

HPAⁱ

HPA031422
HPA031425

Interactionⁱ

Subunit structureⁱ

Interacts with PLCG1, ITK, GRB2, and LAT.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GRB2	P62993	10	EBI-15102259,EBI-401755
HBZ	P0C745	3	EBI-2873538,EBI-16218595	From Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A).
LCK	P06239	3	EBI-15102259,EBI-1348
PLCG1	P19174	3	EBI-15102259,EBI-79387
PRMT6	Q96LA8	2	EBI-2873538,EBI-912440
PTPN6	P29350	4	EBI-2873538,EBI-78260
ZAP70	P43403	3	EBI-15102259,EBI-1211276

Show more details

Protein-protein interaction databases

BioGridⁱ	132289, 4 interactors
IntActⁱ	Q8N1K5, 12 interactors
Molecular INTeraction database More...MINTⁱ	Q8N1K5

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N1K5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 259	CABIT 1Add BLAST		259
Regionⁱ	260 – 518	CABIT 2Add BLAST		259

Sequence similaritiesⁱ

Belongs to the themis family.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063770
InParanoidⁱ	Q8N1K5
OMAⁱ	QGVMKFR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02V6
PhylomeDBⁱ	Q8N1K5

Family and domain databases

InterProⁱ	View protein in InterPro IPR025946 CABIT_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12736 CABIT, 2 hits

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8N1K5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALSLEEFVH SLDLRTLPRV LEIQAGIYLE GSIYEMFGNE CCFSTGEVIK 
        60         70         80         90        100
ITGLKVKKII AEICEQIEGC ESLQPFELPM NFPGLFKIVA DKTPYLTMEE 
       110        120        130        140        150
ITRTIHIGPS RLGHPCFYHQ KDIKLENLII KQGEQIMLNS VEEIDGEIMV 
       160        170        180        190        200
SCAVARNHQT HSFNLPLSQE GEFYECEDER IYTLKEIVEW KIPKNRTRTV 
       210        220        230        240        250
NLTDFSNKWD STNPFPKDFY GTLILKPVYE IQGVMKFRKD IIRILPSLDV 
       260        270        280        290        300
EVKDITDSYD ANWFLQLLST EDLFEMTSKE FPIVTEVIEA PEGNHLPQSI 
       310        320        330        340        350
LQPGKTIVIH KKYQASRILA SEIRSNFPKR HFLIPTSYKG KFKRRPREFP 
       360        370        380        390        400
TAYDLEIAKS EKEPLHVVAT KAFHSPHDKL SSVSVGDQFL VHQSETTEVL 
       410        420        430        440        450
CEGIKKVVNV LACEKILKKS YEAALLPLYM EGGFVEVIHD KKQYPISELC 
       460        470        480        490        500
KQFRLPFNVK VSVRDLSIEE DVLAATPGLQ LEEDITDSYL LISDFANPTE 
       510        520        530        540        550
CWEIPVGRLN MTVQLVSNFS RDAEPFLVRT LVEEITEEQY YMMRRYESSA 
       560        570        580        590        600
SHPPPRPPKH PSVEETKLTL LTLAEERTVD LPKSPKRHHV DITKKLHPNQ 
       610        620        630        640 
AGLDSKVLIG SQNDLVDEEK ERSNRGATAI AETFKNEKHQ K

Length:641

Mass (Da):73,452

Last modified:June 26, 2007 - v3

Checksum:ⁱ30B5325242212E94

GO

Isoform 2 (identifier: Q8N1K5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-35: Missing.

« Hide

        10         20         30         40         50
MFGNECCFST GEVIKITGLK VKKIIAEICE QIEGCESLQP FELPMNFPGL 
        60         70         80         90        100
FKIVADKTPY LTMEEITRTI HIGPSRLGHP CFYHQKDIKL ENLIIKQGEQ 
       110        120        130        140        150
IMLNSVEEID GEIMVSCAVA RNHQTHSFNL PLSQEGEFYE CEDERIYTLK 
       160        170        180        190        200
EIVEWKIPKN RTRTVNLTDF SNKWDSTNPF PKDFYGTLIL KPVYEIQGVM 
       210        220        230        240        250
KFRKDIIRIL PSLDVEVKDI TDSYDANWFL QLLSTEDLFE MTSKEFPIVT 
       260        270        280        290        300
EVIEAPEGNH LPQSILQPGK TIVIHKKYQA SRILASEIRS NFPKRHFLIP 
       310        320        330        340        350
TSYKGKFKRR PREFPTAYDL EIAKSEKEPL HVVATKAFHS PHDKLSSVSV 
       360        370        380        390        400
GDQFLVHQSE TTEVLCEGIK KVVNVLACEK ILKKSYEAAL LPLYMEGGFV 
       410        420        430        440        450
EVIHDKKQYP ISELCKQFRL PFNVKVSVRD LSIEEDVLAA TPGLQLEEDI 
       460        470        480        490        500
TDSYLLISDF ANPTECWEIP VGRLNMTVQL VSNFSRDAEP FLVRTLVEEI 
       510        520        530        540        550
TEEQYYMMRR YESSASHPPP RPPKHPSVEE TKLTLLTLAE ERTVDLPKSP 
       560        570        580        590        600
KRHHVDITKK LHPNQAGLDS KVLIGSQNDL VDEEKERSNR GATAIAETFK 

NEKHQK

Note: No experimental confirmation available.

Show »

Length:606

Mass (Da):69,464

Checksum:ⁱ80D80EBB22A38903

GO

Isoform 3 (identifier: Q8N1K5-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-97: Missing.

« Hide

        10         20         30         40         50
MEEITRTIHI GPSRLGHPCF YHQKDIKLEN LIIKQGEQIM LNSVEEIDGE 
        60         70         80         90        100
IMVSCAVARN HQTHSFNLPL SQEGEFYECE DERIYTLKEI VEWKIPKNRT 
       110        120        130        140        150
RTVNLTDFSN KWDSTNPFPK DFYGTLILKP VYEIQGVMKF RKDIIRILPS 
       160        170        180        190        200
LDVEVKDITD SYDANWFLQL LSTEDLFEMT SKEFPIVTEV IEAPEGNHLP 
       210        220        230        240        250
QSILQPGKTI VIHKKYQASR ILASEIRSNF PKRHFLIPTS YKGKFKRRPR 
       260        270        280        290        300
EFPTAYDLEI AKSEKEPLHV VATKAFHSPH DKLSSVSVGD QFLVHQSETT 
       310        320        330        340        350
EVLCEGIKKV VNVLACEKIL KKSYEAALLP LYMEGGFVEV IHDKKQYPIS 
       360        370        380        390        400
ELCKQFRLPF NVKVSVRDLS IEEDVLAATP GLQLEEDITD SYLLISDFAN 
       410        420        430        440        450
PTECWEIPVG RLNMTVQLVS NFSRDAEPFL VRTLVEEITE EQYYMMRRYE 
       460        470        480        490        500
SSASHPPPRP PKHPSVEETK LTLLTLAEER TVDLPKSPKR HHVDITKKLH 
       510        520        530        540 
PNQAGLDSKV LIGSQNDLVD EEKERSNRGA TAIAETFKNE KHQK

Note: No experimental confirmation available.

Show »

Length:544

Mass (Da):62,568

Checksum:ⁱ3BCFA122086FFA1D

GO

Isoform 4 (identifier: Q8N1K5-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
586-586: K → KAGVQWRDLGSLQPLPPGFKQFSASASHVAGITGTPHHVQ

« Hide

        10         20         30         40         50
MALSLEEFVH SLDLRTLPRV LEIQAGIYLE GSIYEMFGNE CCFSTGEVIK 
        60         70         80         90        100
ITGLKVKKII AEICEQIEGC ESLQPFELPM NFPGLFKIVA DKTPYLTMEE 
       110        120        130        140        150
ITRTIHIGPS RLGHPCFYHQ KDIKLENLII KQGEQIMLNS VEEIDGEIMV 
       160        170        180        190        200
SCAVARNHQT HSFNLPLSQE GEFYECEDER IYTLKEIVEW KIPKNRTRTV 
       210        220        230        240        250
NLTDFSNKWD STNPFPKDFY GTLILKPVYE IQGVMKFRKD IIRILPSLDV 
       260        270        280        290        300
EVKDITDSYD ANWFLQLLST EDLFEMTSKE FPIVTEVIEA PEGNHLPQSI 
       310        320        330        340        350
LQPGKTIVIH KKYQASRILA SEIRSNFPKR HFLIPTSYKG KFKRRPREFP 
       360        370        380        390        400
TAYDLEIAKS EKEPLHVVAT KAFHSPHDKL SSVSVGDQFL VHQSETTEVL 
       410        420        430        440        450
CEGIKKVVNV LACEKILKKS YEAALLPLYM EGGFVEVIHD KKQYPISELC 
       460        470        480        490        500
KQFRLPFNVK VSVRDLSIEE DVLAATPGLQ LEEDITDSYL LISDFANPTE 
       510        520        530        540        550
CWEIPVGRLN MTVQLVSNFS RDAEPFLVRT LVEEITEEQY YMMRRYESSA 
       560        570        580        590        600
SHPPPRPPKH PSVEETKLTL LTLAEERTVD LPKSPKAGVQ WRDLGSLQPL 
       610        620        630        640        650
PPGFKQFSAS ASHVAGITGT PHHVQRHHVD ITKKLHPNQA GLDSKVLIGS 
       660        670        680
QNDLVDEEKE RSNRGATAIA ETFKNEKHQK

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »

Length:680

Mass (Da):77,515

Checksum:ⁱ949C286B5CC7558F

GO

Sequence cautionⁱ

The sequence BAC05194 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

The sequence BAG52943 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence CAI13397 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence CAI17111 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	63	I → V in BAF84735 (PubMed:14702039).Curated	1
Sequence conflictⁱ	72	S → F in BAG53994 (PubMed:14702039).Curated	1
Sequence conflictⁱ	220	Y → C in BAG53994 (PubMed:14702039).Curated	1
Sequence conflictⁱ	482	E → K in BAG53994 (PubMed:14702039).Curated	1
Sequence conflictⁱ	510	N → S in CAE45941 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_027846	284	V → G. Corresponds to variant dbSNP:rs11968051Ensembl.		1
Natural variantⁱVAR_027847	630	I → V4 PublicationsCorresponds to variant dbSNP:rs675531Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_037964	1 – 97	Missing in isoform 3. CuratedAdd BLAST	97
Alternative sequenceⁱVSP_037965	1 – 35	Missing in isoform 2. 1 PublicationAdd BLAST	35
Alternative sequenceⁱVSP_055714	586	K → KAGVQWRDLGSLQPLPPGFK QFSASASHVAGITGTPHHVQ in isoform 4. Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK094863 mRNA Translation: BAG52943.1 Different initiation. CH471051 Genomic DNA Translation: EAW48092.1 BC130516 mRNA Translation: AAI30517.1 AK124031 mRNA Translation: BAG53994.1 AK128377 mRNA Translation: BAG54669.1 AK292046 mRNA Translation: BAF84735.1 AL035470 Genomic DNA No translation available. AL365224, AL356432 Genomic DNA Translation: CAI17110.1 AL365224, AL356432 Genomic DNA Translation: CAI17111.1 Sequence problems. AL356432, AL365224 Genomic DNA Translation: CAI13396.1 AL356432, AL365224 Genomic DNA Translation: CAI13397.1 Sequence problems. AK097903 mRNA Translation: BAC05194.1 Sequence problems. BX640890 mRNA Translation: CAE45941.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34534.1 [Q8N1K5-1] CCDS55055.1 [Q8N1K5-2] CCDS55056.1 [Q8N1K5-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001010923.1, NM_001010923.2 [Q8N1K5-1] NP_001158157.1, NM_001164685.1 [Q8N1K5-4] NP_001158159.1, NM_001164687.1 [Q8N1K5-2] NP_001305460.1, NM_001318531.1 [Q8N1K5-3] XP_011534118.1, XM_011535816.1 [Q8N1K5-3]
UniGeneⁱ	Hs.661756

Genome annotation databases

Ensemblⁱ	ENST00000368248; ENSP00000357231; ENSG00000172673 [Q8N1K5-1] ENST00000368250; ENSP00000357233; ENSG00000172673 [Q8N1K5-1] ENST00000537166; ENSP00000439863; ENSG00000172673 [Q8N1K5-2] ENST00000610842; ENSP00000480630; ENSG00000275122 [Q8N1K5-1] ENST00000613862; ENSP00000480967; ENSG00000275122 [Q8N1K5-1] ENST00000614155; ENSP00000484170; ENSG00000275122 [Q8N1K5-2] ENST00000630369; ENSP00000487358; ENSG00000172673 [Q8N1K5-4]
GeneIDⁱ	387357
KEGGⁱ	hsa:387357
UCSC genome browser More...UCSCⁱ	uc010kfb.3 human [Q8N1K5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q8N1K5	Protein THEMIS		HUMAN		562
Q8N1K5-2				606

Protein	Similar proteins		Species	Score	Length
Q8N1K5	Protein THEMIS		HUMAN		562
THEMIS isoform 5		PANTR		680
Thymocyte selection associated		MACMU		680
Thymocyte selection associated		Cebus capucinus imitator		680
THEMIS isoform 5		PONAB		680
+73

Protein	Similar proteins		Species	Score	Length
Q8N1K5	Protein THEMIS		MOUSE		636
UPI000A31A41E		MUSCR		636
UPI000A30BA94		MUSPA		631
Protein THEMIS isoform B		ALLMI		686
UPI00093B8E8C		CROPO		686
+289

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK094863 mRNA Translation: BAG52943.1 Different initiation. CH471051 Genomic DNA Translation: EAW48092.1 BC130516 mRNA Translation: AAI30517.1 AK124031 mRNA Translation: BAG53994.1 AK128377 mRNA Translation: BAG54669.1 AK292046 mRNA Translation: BAF84735.1 AL035470 Genomic DNA No translation available. AL365224, AL356432 Genomic DNA Translation: CAI17110.1 AL365224, AL356432 Genomic DNA Translation: CAI17111.1 Sequence problems. AL356432, AL365224 Genomic DNA Translation: CAI13396.1 AL356432, AL365224 Genomic DNA Translation: CAI13397.1 Sequence problems. AK097903 mRNA Translation: BAC05194.1 Sequence problems. BX640890 mRNA Translation: CAE45941.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34534.1 [Q8N1K5-1] CCDS55055.1 [Q8N1K5-2] CCDS55056.1 [Q8N1K5-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001010923.1, NM_001010923.2 [Q8N1K5-1] NP_001158157.1, NM_001164685.1 [Q8N1K5-4] NP_001158159.1, NM_001164687.1 [Q8N1K5-2] NP_001305460.1, NM_001318531.1 [Q8N1K5-3] XP_011534118.1, XM_011535816.1 [Q8N1K5-3]
UniGeneⁱ	Hs.661756

3D structure databases

ProteinModelPortalⁱ	Q8N1K5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	132289, 4 interactors
IntActⁱ	Q8N1K5, 12 interactors
Molecular INTeraction database More...MINTⁱ	Q8N1K5

PTM databases

iPTMnetⁱ	Q8N1K5
PhosphoSitePlusⁱ	Q8N1K5

Polymorphism and mutation databases

BioMutaⁱ	THEMIS
DMDMⁱ	150421530

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N1K5
PeptideAtlas More...PeptideAtlasⁱ	Q8N1K5
PRIDEⁱ	Q8N1K5
ProteomicsDBⁱ	71609 71610 [Q8N1K5-2] 71611 [Q8N1K5-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	387357
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368248; ENSP00000357231; ENSG00000172673 [Q8N1K5-1] ENST00000368250; ENSP00000357233; ENSG00000172673 [Q8N1K5-1] ENST00000537166; ENSP00000439863; ENSG00000172673 [Q8N1K5-2] ENST00000610842; ENSP00000480630; ENSG00000275122 [Q8N1K5-1] ENST00000613862; ENSP00000480967; ENSG00000275122 [Q8N1K5-1] ENST00000614155; ENSP00000484170; ENSG00000275122 [Q8N1K5-2] ENST00000630369; ENSP00000487358; ENSG00000172673 [Q8N1K5-4]
GeneIDⁱ	387357
KEGGⁱ	hsa:387357
UCSC genome browser More...UCSCⁱ	uc010kfb.3 human [Q8N1K5-1]

Organism-specific databases

CTDⁱ	387357
DisGeNET More...DisGeNETⁱ	387357
EuPathDBⁱ	HostDB:ENSG00000172673.10
GeneCardsⁱ	THEMIS
H-InvDBⁱ	HIX0006207
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21569 THEMIS
Human Protein Atlas More...HPAⁱ	HPA031422 HPA031425
MIMⁱ	613607 gene
neXtProtⁱ	NX_Q8N1K5
Open Targets More...OpenTargetsⁱ	ENSG00000172673
PharmGKBⁱ	PA165618330
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063770
InParanoidⁱ	Q8N1K5
OMAⁱ	QGVMKFR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02V6
PhylomeDBⁱ	Q8N1K5

Miscellaneous databases

GeneWikiⁱ	Protein_THEMIS
GenomeRNAiⁱ	387357
Protein Ontology More...PROⁱ	PR:Q8N1K5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000172673
CleanExⁱ	HS_C6orf190
ExpressionAtlasⁱ	Q8N1K5 baseline and differential
Genevisibleⁱ	Q8N1K5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR025946 CABIT_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12736 CABIT, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	THMS1_HUMAN
Accessionⁱ	Q8N1K5Primary (citable) accession number: Q8N1K5 Secondary accession number(s): A1L4F0 Q6MZT7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
	Last sequence update:	June 26, 2007
	Last modified:	July 18, 2018
	This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q8N1K5 (THMS1_HUMAN)

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Protein THEMIS

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ