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Entry version 165 (12 Aug 2020)
Sequence version 3 (18 May 2010)
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Protein

Dedicator of cytokinesis protein 4

Gene

DOCK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435).3 Publications
Has a higher guanine nucleotide exchange factor activity compared to other isoforms.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q8N1I0

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-983231, Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dedicator of cytokinesis protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DOCK4
Synonyms:KIAA0716
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000128512.19

Human Gene Nomenclature Database

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HGNCi
HGNC:19192, DOCK4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607679, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N1I0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
9732

Open Targets

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OpenTargetsi
ENSG00000128512

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134939318

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q8N1I0, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DOCK4

Domain mapping of disease mutations (DMDM)

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DMDMi
296439369

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001899901 – 1966Dedicator of cytokinesis protein 4Add BLAST1966

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei167PhosphotyrosineBy similarity1
Modified residuei193PhosphothreonineBy similarity1
Modified residuei1599PhosphoserineBy similarity1
Modified residuei1607PhosphoserineBy similarity1
Modified residuei1614PhosphoserineCombined sources1
Modified residuei1618PhosphoserineCombined sources1
Modified residuei1620PhosphoserineCombined sources1
Modified residuei1631PhosphoserineBy similarity1
Modified residuei1769PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N1I0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N1I0

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8N1I0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N1I0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N1I0

PeptideAtlas

More...
PeptideAtlasi
Q8N1I0

PRoteomics IDEntifications database

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PRIDEi
Q8N1I0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71603 [Q8N1I0-1]
71604 [Q8N1I0-2]
71605 [Q8N1I0-3]
71606 [Q8N1I0-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N1I0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N1I0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary.1 Publication
May be specifically expressed in the brain and eye.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000128512, Expressed in endothelial cell and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8N1I0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8N1I0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000128512, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with nucleotide-free Rap1; functions as a guanine nucleotide exchange factor (GEF) for Rap1 (PubMed:12628187).

Interacts (via DOCKER domain) with RAC1; functions as a guanine nucleotide exchange factor (GEF) for RAC1 (PubMed:16464467).

Interacts with the SH3 domain of CRK (PubMed:12628187).

Interacts with FASLG (PubMed:19807924).

Interacts with ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2 (PubMed:20679435).

Interacts with USH1C (via PDZ 1 domain) (PubMed:16464467).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
115081, 28 interactors

Protein interaction database and analysis system

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IntActi
Q8N1I0, 16 interactors

Molecular INTeraction database

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MINTi
Q8N1I0

STRING: functional protein association networks

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STRINGi
9606.ENSP00000404179

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q8N1I0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N1I0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 67SH3PROSITE-ProRule annotationAdd BLAST62
Domaini401 – 574C2 DOCK-typePROSITE-ProRule annotationAdd BLAST174
Domaini1190 – 1596DOCKERPROSITE-ProRule annotationAdd BLAST407

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1788 – 1794SH3-bindingSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1642 – 1863Ser-richAdd BLAST222
Compositional biasi1875 – 1960Pro-richAdd BLAST86

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DOCKER domain mediates interaction with small GTPases like RAC1 and is required for their activation.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain, SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1998, Eukaryota
KOG3166, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000155659

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N1I0

KEGG Orthology (KO)

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KOi
K17697

Database of Orthologous Groups

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OrthoDBi
102580at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8N1I0

TreeFam database of animal gene trees

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TreeFami
TF300423

Family and domain databases

Conserved Domains Database

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CDDi
cd08695, C2_Dock-B, 1 hit
cd12049, SH3_DOCK4_B, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1270.350, 1 hit
1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR037811, C2_Dock-B
IPR035892, C2_domain_sf
IPR027007, DHR-1_domain
IPR027357, DHR-2
IPR026791, DOCK
IPR037014, DOCK4
IPR035769, DOCK4_SH3
IPR010703, DOCK_C
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C
IPR032376, DOCK_N
IPR042455, DOCK_N_sub1
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

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PANTHERi
PTHR45653, PTHR45653, 1 hit
PTHR45653:SF7, PTHR45653:SF7, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF16172, DOCK_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51650, C2_DOCK, 1 hit
PS51651, DOCKER, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N1I0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWIPTEHEKY GVVIASFRGT VPYGLSLEIG DTVQILEKCD GWYRGFALKN
60 70 80 90 100
PNIKGIFPSS YVHLKNACVK NKGQFEMVIP TEDSVITEMT STLRDWGTMW
110 120 130 140 150
KQLYVRNEGD LFHRLWHIMN EILDLRRQVL VGHLTHDRMK DVKRHITARL
160 170 180 190 200
DWGNEQLGLD LVPRKEYAMV DPEDISITEL YRLMEHRHRK KDTPVQASSH
210 220 230 240 250
HLFVQMKSLM CSNLGEELEV IFSLFDSKEN RPISERFFLR LNRNGLPKAP
260 270 280 290 300
DKPERHCSLF VDLGSSELRK DIYITVHIIR IGRMGAGEKK NACSVQYRRP
310 320 330 340 350
FGCAVLSIAD LLTGETKDDL ILKVYMCNTE SEWYQIHENI IKKLNARYNL
360 370 380 390 400
TGSNAGLAVS LQLLHGDIEQ IRREYSSVFS HGVSITRKLG FSNIIMPGEM
410 420 430 440 450
RNDLYITIER GEFEKGGKSV ARNVEVTMFI VDSSGQTLKD FISFGSGEPP
460 470 480 490 500
ASEYHSFVLY HNNSPRWSEL LKLPIPVDKF RGAHIRFEFR HCSTKEKGEK
510 520 530 540 550
KLFGFSFVPL MQEDGRTLPD GTHELIVHKC EENTNLQDTT RYLKLPFSKG
560 570 580 590 600
IFLGNNNQAM KATKESFCIT SFLCSTKLTQ NGDMLDLLKW RTHPDKITGC
610 620 630 640 650
LSKLKEIDGS EIVKFLQDTL DTLFGILDEN SQKYGSKVFD SLVHIINLLQ
660 670 680 690 700
DSKFHHFKPV MDTYIESHFA GALAYRDLIK VLKWYVDRIT EAERQEHIQE
710 720 730 740 750
VLKAQEYIFK YIVQSRRLFS LATGGQNEEE FRCCIQELLM SVRFFLSQES
760 770 780 790 800
KGSGALSQSQ AVFLSSFPAV YSELLKLFDV REVANLVQDT LGSLPTILHV
810 820 830 840 850
DDSLQAIKLQ CIGKTVESQL YTNPDSRYIL LPVVLHHLHI HLQEQKDLIM
860 870 880 890 900
CARILSNVFC LIKKNSSEKS VLEEIDVIVA SLLDILLRTI LEITSRPQPS
910 920 930 940 950
SSAMRFQFQD VTGEFVACLL SLLRQMTDRH YQQLLDSFNT KEELRDFLLQ
960 970 980 990 1000
IFTVFRILIR PEMFPKDWTV MRLVANNVII TTVLYLSDAL RKNFLNENFD
1010 1020 1030 1040 1050
YKIWDSYFYL AVIFINQLCL QLEMFTPSKK KKVLEKYGDM RVTMGCEIFS
1060 1070 1080 1090 1100
MWQNLGEHKL HFIPALIGPF LEVTLIPQPD LRNVMIPIFH DMMDWEQRRS
1110 1120 1130 1140 1150
GNFKQVEAKL IDKLDSLMSE GKGDETYREL FNSILLKKIE RETWRESGVS
1160 1170 1180 1190 1200
LIATVTRLME RLLDYRDCMK MGEVDGKKIG CTVSLLNFYK TELNKEEMYI
1210 1220 1230 1240 1250
RYIHKLYDLH LKAQNFTEAA YTLLLYDELL EWSDRPLREF LTYPMQTEWQ
1260 1270 1280 1290 1300
RKEHLHLTII QNFDRGKCWE NGIILCRKIA EQYESYYDYR NLSKMRMMEA
1310 1320 1330 1340 1350
SLYDKIMDQQ RLEPEFFRVG FYGKKFPFFL RNKEFVCRGH DYERLEAFQQ
1360 1370 1380 1390 1400
RMLNEFPHAI AMQHANQPDE TIFQAEAQYL QIYAVTPIPE SQEVLQREGV
1410 1420 1430 1440 1450
PDNIKSFYKV NHIWKFRYDR PFHKGTKDKE NEFKSLWVER TSLYLVQSLP
1460 1470 1480 1490 1500
GISRWFEVEK REVVEMSPLE NAIEVLENKN QQLKTLISQC QTRQMQNINP
1510 1520 1530 1540 1550
LTMCLNGVID AAVNGGVSRY QEAFFVKEYI LSHPEDGEKI ARLRELMLEQ
1560 1570 1580 1590 1600
AQILEFGLAV HEKFVPQDMR PLHKKLVDQF FVMKSSLGIQ EFSACMQASP
1610 1620 1630 1640 1650
VHFPNGSPRV CRNSAPASVS PDGTRVIPRR SPLSYPAVNR YSSSSLSSQA
1660 1670 1680 1690 1700
SAEVSNITGQ SESSDEVFNM QPSPSTSSLS STHSASPNVT SSAPSSARAS
1710 1720 1730 1740 1750
PLLSDKHKHS RENSCLSPRE RPCSAIYPTP VEPSQRMLFN HIGDGALPRS
1760 1770 1780 1790 1800
DPNLSAPEKA VNPTPSSWSL DSGKEAKNMS DSGKLISPPV PPRPTQTASP
1810 1820 1830 1840 1850
ARHTTSVSPS PAGRSPLKGS VQSFTPSPVE YHSPGLISNS PVLSGSYSSG
1860 1870 1880 1890 1900
ISSLSRCSTS ETSGFENQVN EQSAPLPVPV PVPVPSYGGE EPVRKESKTP
1910 1920 1930 1940 1950
PPYSVYERTL RRPVPLPHSL SIPVTSEPPA LPPKPLAARS SHLENGARRT
1960
DPGPRPRPLP RKVSQL
Length:1,966
Mass (Da):225,206
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CFB6299F7730AA9
GO
Isoform 2 (identifier: Q8N1I0-2) [UniParc]FASTAAdd to basket
Also known as: DOCK4-Ex491 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1134-1134: I → IIPLFGPYPS
     1760-1797: Missing.

Show »
Length:1,937
Mass (Da):222,218
Checksum:i544451D8A8B23F09
GO
Isoform 3 (identifier: Q8N1I0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1134-1134: I → IIPLFGPYPS

Show »
Length:1,975
Mass (Da):226,178
Checksum:i535C971462E903DB
GO
Isoform 4 (identifier: Q8N1I0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1687: Missing.
     1688-1698: NVTSSAPSSAR → MLMILSLLLFP

Show »
Length:279
Mass (Da):29,833
Checksum:i52A4E7E9F1738323
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y599H0Y599_HUMAN
Dedicator of cytokinesis protein 4
DOCK4
1,999Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J637C9J637_HUMAN
Dedicator of cytokinesis protein 4
DOCK4
849Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7H7H0Y7H7_HUMAN
Dedicator of cytokinesis protein 4
DOCK4
1,389Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJ51A0A590UJ51_HUMAN
Dedicator of cytokinesis protein 4
DOCK4
898Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJM5A0A590UJM5_HUMAN
Dedicator of cytokinesis protein 4
DOCK4
680Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXW1F5GXW1_HUMAN
Dedicator of cytokinesis protein 4
DOCK4
1,094Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDB3C9JDB3_HUMAN
Dedicator of cytokinesis protein 4
DOCK4
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J7D9C9J7D9_HUMAN
Dedicator of cytokinesis protein 4
DOCK4
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WES4F8WES4_HUMAN
Dedicator of cytokinesis protein 4
DOCK4
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC03696 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti945R → K in AAB83946 (PubMed:12853948).Curated1
Sequence conflicti1080D → G in AAO73565 (PubMed:12628187).Curated1
Sequence conflicti1122K → E in BAC03696 (PubMed:14702039).Curated1
Sequence conflicti1379 – 1381YLQ → CIRTYKGWTQFGTAVITDVG RLGTQIITQIN in BAC05221 (PubMed:12853948).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01582387T → I Found in a CNS cancer cell line. 1 PublicationCorresponds to variant dbSNP:rs1396518456Ensembl.1
Natural variantiVAR_057517535N → D. Corresponds to variant dbSNP:rs12705801Ensembl.1
Natural variantiVAR_015824606E → Q1 Publication1
Natural variantiVAR_057518853R → H. Corresponds to variant dbSNP:rs2074130Ensembl.1
Natural variantiVAR_0158251059K → T Found in a CNS cancer cell line. 1 Publication1
Natural variantiVAR_0575191570R → K. Corresponds to variant dbSNP:rs3757650Ensembl.1
Natural variantiVAR_0575201580F → L. Corresponds to variant dbSNP:rs3757651Ensembl.1
Natural variantiVAR_0158261718P → L Found in prostate and ovarian cancer cell lines; abolishes ability to interact with CRK and to activate Rap1. 1 Publication1
Natural variantiVAR_0158271733P → A1 PublicationCorresponds to variant dbSNP:rs150569245Ensembl.1
Natural variantiVAR_0158281755S → P Found in colorectal cancer cell line. 1 Publication1
Natural variantiVAR_0575211822Q → K. Corresponds to variant dbSNP:rs10281942Ensembl.1
Natural variantiVAR_0158291884V → M Found in a prostate cancer cell line. 1 PublicationCorresponds to variant dbSNP:rs369715294Ensembl.1
Natural variantiVAR_0158301914V → I1 PublicationCorresponds to variant dbSNP:rs12705795Ensembl.1
Natural variantiVAR_0158311917P → L1 PublicationCorresponds to variant dbSNP:rs199706346Ensembl.1
Natural variantiVAR_0158321926S → L1 PublicationCorresponds to variant dbSNP:rs34597439Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0077011 – 1687Missing in isoform 4. 1 PublicationAdd BLAST1687
Alternative sequenceiVSP_0077031134I → IIPLFGPYPS in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_0077051688 – 1698NVTSSAPSSAR → MLMILSLLLFP in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0077061760 – 1797Missing in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY233380 mRNA Translation: AAO73565.1
AK091557 mRNA Translation: BAC03696.1 Different initiation.
AK098050 mRNA Translation: BAC05221.1
AC003077 Genomic DNA Translation: AAB83946.1
AC003080 Genomic DNA No translation available.
AC004111 Genomic DNA No translation available.
AC005047 Genomic DNA No translation available.
AB018259 mRNA Translation: BAA34436.3

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47688.1 [Q8N1I0-1]
CCDS87541.1 [Q8N1I0-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
T01438

NCBI Reference Sequences

More...
RefSeqi
NP_055520.3, NM_014705.3 [Q8N1I0-1]
XP_006716251.1, XM_006716188.2
XP_006716252.1, XM_006716189.2 [Q8N1I0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000428084; ENSP00000410746; ENSG00000128512 [Q8N1I0-3]
ENST00000437633; ENSP00000404179; ENSG00000128512 [Q8N1I0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9732

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9732

UCSC genome browser

More...
UCSCi
uc003vfx.4, human [Q8N1I0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY233380 mRNA Translation: AAO73565.1
AK091557 mRNA Translation: BAC03696.1 Different initiation.
AK098050 mRNA Translation: BAC05221.1
AC003077 Genomic DNA Translation: AAB83946.1
AC003080 Genomic DNA No translation available.
AC004111 Genomic DNA No translation available.
AC005047 Genomic DNA No translation available.
AB018259 mRNA Translation: BAA34436.3
CCDSiCCDS47688.1 [Q8N1I0-1]
CCDS87541.1 [Q8N1I0-3]
PIRiT01438
RefSeqiNP_055520.3, NM_014705.3 [Q8N1I0-1]
XP_006716251.1, XM_006716188.2
XP_006716252.1, XM_006716189.2 [Q8N1I0-2]

3D structure databases

SMRiQ8N1I0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115081, 28 interactors
IntActiQ8N1I0, 16 interactors
MINTiQ8N1I0
STRINGi9606.ENSP00000404179

PTM databases

iPTMnetiQ8N1I0
PhosphoSitePlusiQ8N1I0

Polymorphism and mutation databases

BioMutaiDOCK4
DMDMi296439369

Proteomic databases

EPDiQ8N1I0
jPOSTiQ8N1I0
MassIVEiQ8N1I0
MaxQBiQ8N1I0
PaxDbiQ8N1I0
PeptideAtlasiQ8N1I0
PRIDEiQ8N1I0
ProteomicsDBi71603 [Q8N1I0-1]
71604 [Q8N1I0-2]
71605 [Q8N1I0-3]
71606 [Q8N1I0-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31488, 127 antibodies

Genome annotation databases

EnsembliENST00000428084; ENSP00000410746; ENSG00000128512 [Q8N1I0-3]
ENST00000437633; ENSP00000404179; ENSG00000128512 [Q8N1I0-1]
GeneIDi9732
KEGGihsa:9732
UCSCiuc003vfx.4, human [Q8N1I0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9732
DisGeNETi9732
EuPathDBiHostDB:ENSG00000128512.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DOCK4
HGNCiHGNC:19192, DOCK4
HPAiENSG00000128512, Low tissue specificity
MIMi607679, gene
neXtProtiNX_Q8N1I0
OpenTargetsiENSG00000128512
PharmGKBiPA134939318

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1998, Eukaryota
KOG3166, Eukaryota
GeneTreeiENSGT00940000155659
InParanoidiQ8N1I0
KOiK17697
OrthoDBi102580at2759
PhylomeDBiQ8N1I0
TreeFamiTF300423

Enzyme and pathway databases

PathwayCommonsiQ8N1I0
ReactomeiR-HSA-983231, Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
9732, 5 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DOCK4, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Dock4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9732
PharosiQ8N1I0, Tbio

Protein Ontology

More...
PROi
PR:Q8N1I0
RNActiQ8N1I0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000128512, Expressed in endothelial cell and 230 other tissues
ExpressionAtlasiQ8N1I0, baseline and differential
GenevisibleiQ8N1I0, HS

Family and domain databases

CDDicd08695, C2_Dock-B, 1 hit
cd12049, SH3_DOCK4_B, 1 hit
Gene3Di1.20.1270.350, 1 hit
1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR037811, C2_Dock-B
IPR035892, C2_domain_sf
IPR027007, DHR-1_domain
IPR027357, DHR-2
IPR026791, DOCK
IPR037014, DOCK4
IPR035769, DOCK4_SH3
IPR010703, DOCK_C
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C
IPR032376, DOCK_N
IPR042455, DOCK_N_sub1
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR45653, PTHR45653, 1 hit
PTHR45653:SF7, PTHR45653:SF7, 1 hit
PfamiView protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF16172, DOCK_N, 1 hit
SMARTiView protein in SMART
SM00326, SH3, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51650, C2_DOCK, 1 hit
PS51651, DOCKER, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOCK4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N1I0
Secondary accession number(s): O14584, O94824, Q8NB45
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 165 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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