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Protein

Leucine-rich repeat-containing protein 47

Gene

LRRC47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 47
Gene namesi
Name:LRRC47
Synonyms:KIAA1185
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000130764.9
HGNCiHGNC:29207 LRRC47
neXtProtiNX_Q8N1G4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130764
PharmGKBiPA142671507

Polymorphism and mutation databases

BioMutaiLRRC47
DMDMi74750895

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002239262 – 583Leucine-rich repeat-containing protein 47Add BLAST582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei315PhosphoserineCombined sources1
Modified residuei431PhosphoserineCombined sources1
Modified residuei509PhosphotyrosineCombined sources1
Modified residuei518PhosphoserineCombined sources1
Modified residuei520PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8N1G4
MaxQBiQ8N1G4
PaxDbiQ8N1G4
PeptideAtlasiQ8N1G4
PRIDEiQ8N1G4
ProteomicsDBi71601

PTM databases

iPTMnetiQ8N1G4
PhosphoSitePlusiQ8N1G4
SwissPalmiQ8N1G4

Miscellaneous databases

PMAP-CutDBiQ8N1G4

Expressioni

Gene expression databases

BgeeiENSG00000130764 Expressed in 239 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_LRRC47
ExpressionAtlasiQ8N1G4 baseline and differential
GenevisibleiQ8N1G4 HS

Organism-specific databases

HPAiHPA008512
HPA012018

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
gagP045912EBI-2509921,EBI-6179727From Human immunodeficiency virus type 1 group M subtype B (isolate HXB2).

Protein-protein interaction databases

BioGridi121540, 49 interactors
IntActiQ8N1G4, 13 interactors
MINTiQ8N1G4
STRINGi9606.ENSP00000367498

Structurei

3D structure databases

ProteinModelPortaliQ8N1G4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati76 – 95LRR 1Add BLAST20
Repeati100 – 121LRR 2Add BLAST22
Repeati130 – 152LRR 3Add BLAST23
Repeati154 – 175LRR 4Add BLAST22
Repeati180 – 202LRR 5Add BLAST23
Repeati203 – 225LRR 6Add BLAST23
Repeati226 – 246LRR 7Add BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili402 – 437Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 5Poly-Ala4

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG2472 Eukaryota
COG0072 LUCA
COG4886 LUCA
GeneTreeiENSGT00530000063489
HOGENOMiHOG000007166
HOVERGENiHBG066309
InParanoidiQ8N1G4
OMAiSQTKLHE
OrthoDBiEOG091G07VP
PhylomeDBiQ8N1G4
TreeFamiTF315742

Family and domain databases

Gene3Di3.50.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR005146 B3/B4_tRNA-bd
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR020825 Phe-tRNA_synthase_B3/B4
PfamiView protein in Pfam
PF03483 B3_4, 1 hit
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00873 B3_4, 1 hit
SM00369 LRR_TYP, 5 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N1G4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAVSESW PELELAERER RRELLLTGPG LEERVRAAGG QLPPRLFTLP
60 70 80 90 100
LLHYLEVSGC GSLRAPGPGL AQGLPQLHSL VLRRNALGPG LSPELGPLPA
110 120 130 140 150
LRVLDLSGNA LEALPPGQGL GPAEPPGLPQ LQSLNLSGNR LRELPADLAR
160 170 180 190 200
CAPRLQSLNL TGNCLDSFPA ELFRPGALPL LSELAAADNC LRELSPDIAH
210 220 230 240 250
LASLKTLDLS NNQLSEIPAE LADCPKLKEI NFRGNKLRDK RLEKMVSGCQ
260 270 280 290 300
TRSILEYLRV GGRGGGKGKG RAEGSEKEES RRKRRERKQR REGGDGEEQD
310 320 330 340 350
VGDAGRLLLR VLHVSENPVP LTVRVSPEVR DVRPYIVGAV VRGMDLQPGN
360 370 380 390 400
ALKRFLTSQT KLHEDLCEKR TAATLATHEL RAVKGPLLYC ARPPQDLKIV
410 420 430 440 450
PLGRKEAKAK ELVRQLQLEA EEQRKQKKRQ SVSGLHRYLH LLDGNENYPC
460 470 480 490 500
LVDADGDVIS FPPITNSEKT KVKKTTSDLF LEVTSATSLQ ICKDVMDALI
510 520 530 540 550
LKMAEMKKYT LENKEEGSLS DTEADAVSGQ LPDPTTNPSA GKDGPSLLVV
560 570 580
EQVRVVDLEG SLKVVYPSKA DLATAPPHVT VVR
Length:583
Mass (Da):63,473
Last modified:October 1, 2002 - v1
Checksum:iBCCFAE89BCD46031
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KRP5J3KRP5_HUMAN
Leucine-rich repeat-containing prot...
LRRC47
50Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035471193E → D in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_051118545P → L. Corresponds to variant dbSNP:rs11547614Ensembl.1
Natural variantiVAR_051119581V → I. Corresponds to variant dbSNP:rs11547615Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365330 Genomic DNA No translation available.
BC031301 mRNA Translation: AAH31301.1
AB033011 mRNA Translation: BAA86499.1
CCDSiCCDS51.1
RefSeqiNP_065761.1, NM_020710.2
UniGeneiHs.268488

Genome annotation databases

EnsembliENST00000378251; ENSP00000367498; ENSG00000130764
GeneIDi57470
KEGGihsa:57470
UCSCiuc001akx.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365330 Genomic DNA No translation available.
BC031301 mRNA Translation: AAH31301.1
AB033011 mRNA Translation: BAA86499.1
CCDSiCCDS51.1
RefSeqiNP_065761.1, NM_020710.2
UniGeneiHs.268488

3D structure databases

ProteinModelPortaliQ8N1G4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121540, 49 interactors
IntActiQ8N1G4, 13 interactors
MINTiQ8N1G4
STRINGi9606.ENSP00000367498

PTM databases

iPTMnetiQ8N1G4
PhosphoSitePlusiQ8N1G4
SwissPalmiQ8N1G4

Polymorphism and mutation databases

BioMutaiLRRC47
DMDMi74750895

Proteomic databases

EPDiQ8N1G4
MaxQBiQ8N1G4
PaxDbiQ8N1G4
PeptideAtlasiQ8N1G4
PRIDEiQ8N1G4
ProteomicsDBi71601

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378251; ENSP00000367498; ENSG00000130764
GeneIDi57470
KEGGihsa:57470
UCSCiuc001akx.2 human

Organism-specific databases

CTDi57470
EuPathDBiHostDB:ENSG00000130764.9
GeneCardsiLRRC47
HGNCiHGNC:29207 LRRC47
HPAiHPA008512
HPA012018
neXtProtiNX_Q8N1G4
OpenTargetsiENSG00000130764
PharmGKBiPA142671507
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2472 Eukaryota
COG0072 LUCA
COG4886 LUCA
GeneTreeiENSGT00530000063489
HOGENOMiHOG000007166
HOVERGENiHBG066309
InParanoidiQ8N1G4
OMAiSQTKLHE
OrthoDBiEOG091G07VP
PhylomeDBiQ8N1G4
TreeFamiTF315742

Miscellaneous databases

ChiTaRSiLRRC47 human
GenomeRNAii57470
PMAP-CutDBiQ8N1G4
PROiPR:Q8N1G4

Gene expression databases

BgeeiENSG00000130764 Expressed in 239 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_LRRC47
ExpressionAtlasiQ8N1G4 baseline and differential
GenevisibleiQ8N1G4 HS

Family and domain databases

Gene3Di3.50.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR005146 B3/B4_tRNA-bd
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR020825 Phe-tRNA_synthase_B3/B4
PfamiView protein in Pfam
PF03483 B3_4, 1 hit
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00873 B3_4, 1 hit
SM00369 LRR_TYP, 5 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRC47_HUMAN
AccessioniPrimary (citable) accession number: Q8N1G4
Secondary accession number(s): Q9ULN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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