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Entry version 140 (16 Oct 2019)
Sequence version 3 (18 May 2010)
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Protein

RNA exonuclease 1 homolog

Gene

REXO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to have no detectable effect on transcription elongation in vitro.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA exonuclease 1 homolog (EC:3.1.-.-)
Alternative name(s):
Elongin-A-binding protein 1
Short name:
EloA-BP1
Transcription elongation factor B polypeptide 3-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:REXO1
Synonyms:ELOABP1, KIAA1138, TCEB3BP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24616 REXO1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609614 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N1G1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57455

Open Targets

More...
OpenTargetsi
ENSG00000079313

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671077

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N1G1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
REXO1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452990

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002392321 – 1221RNA exonuclease 1 homologAdd BLAST1221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei191Omega-N-methylarginineCombined sources1
Modified residuei287PhosphoserineBy similarity1
Modified residuei289PhosphoserineBy similarity1
Modified residuei358PhosphoserineCombined sources1
Modified residuei459PhosphoserineCombined sources1
Modified residuei499PhosphoserineCombined sources1
Modified residuei526PhosphoserineBy similarity1
Modified residuei610PhosphoserineCombined sources1
Modified residuei914PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N1G1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N1G1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N1G1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N1G1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N1G1

PeptideAtlas

More...
PeptideAtlasi
Q8N1G1

PRoteomics IDEntifications database

More...
PRIDEi
Q8N1G1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71599

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N1G1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N1G1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000079313 Expressed in 90 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N1G1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N1G1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042155
HPA042552

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TCEA2 and ELOA.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121526, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N1G1, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000170168

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N1G1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1060 – 1209ExonucleaseAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni498 – 577Interaction with ELOA1 PublicationAdd BLAST80

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili86 – 115Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi188 – 197Poly-Gly10
Compositional biasi375 – 380Poly-Lys6
Compositional biasi537 – 592Ser-richAdd BLAST56

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the REXO1/REXO3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2248 Eukaryota
COG0847 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158590

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000039979

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N1G1

KEGG Orthology (KO)

More...
KOi
K14570

Identification of Orthologs from Complete Genome Data

More...
OMAi
MCNYHPK

Database of Orthologous Groups

More...
OrthoDBi
227856at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N1G1

TreeFam database of animal gene trees

More...
TreeFami
TF350172

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06145 REX1_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031736 EloA-BP1
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR034922 REX1-like_exo
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15870 EloA-BP1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00479 EXOIII, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8N1G1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRSTGFFRA IDCPYWSGAP GGPCRRPYCH FRHRGARGSG APGDGGEAPP
60 70 80 90 100
AAGLGYDPYN PELPKPPAQR ENGTLGLGEE PRPDVLELEL VNQAIEAVRS
110 120 130 140 150
EVELEQRRYR ELLETTREHR SAEAPALAPR GPNASPTVGP DEDAFPLAFD
160 170 180 190 200
YSPGSHGLLS PDAGYQPTPL AAPAEPGSKY SLASLDRGQG RGGGGGGALE
210 220 230 240 250
YVPKAVSQPR RHSRPVPSGK YVVDNSRPPT DLEYDPLSNY SARHLSRASS
260 270 280 290 300
RDERAAKRPR GSRGSEPYTP APKKLCDPFG SCDARFSDSE DEAATVPGNE
310 320 330 340 350
PTTASTPKAR ADPEIKATGQ PPSKEGLEAE GGGLRETKET AVQCDVGDLQ
360 370 380 390 400
PPPAKPASPA QVQSSQDGGC PKEGKPKKKK TGAPPAPSCK DGAQGKDKTK
410 420 430 440 450
DKGRGRPVEK PRADKKGPQA SSPRRKAERP EGTKKKPSSA TPVATSGKGR
460 470 480 490 500
PDRPARRPSP TSGDSRPAAG RGPPRPLQLP DRKSTKAPSG KLVERKARSL
510 520 530 540 550
DEGASQDAPK LKKRALSHAD LFGDESEDEA AGPGVPSVWP SALPSLSSDS
560 570 580 590 600
DSDSDSSLGF PEAQGPPKRL KASPPPSPAP SSSSSSSSST SSAGADVDYS
610 620 630 640 650
ALEKEVDFDS DPMEECLRIF NESTSVKTED RGRLARQPPK EEKSEEKGLS
660 670 680 690 700
GLTTLFPGQK RRISHLSKQG QEVEPPRRGP AVPPARPPTA QEVCYLRAQQ
710 720 730 740 750
AQRASASLLQ APARLAEKSP SVHISAPGEK RRIAHIPNPR LAAAPTGAKR
760 770 780 790 800
TLAASGSQSS NGPEPGGQQL KTRTLSGMAS KTTTTIIPKR IAHSPSLQSL
810 820 830 840 850
KKPIIPKEFG GKVPTVIRQR YLNLFIEECL KFCTSNQEAI EKALNEEKVA
860 870 880 890 900
YDRSPSKNIY LNVAVNTLKK LRGLAPSAVP GLSKTSGRRV VSHEVVLGGR
910 920 930 940 950
LAAKTSFSLS RPSSPRVEDL KGAALYSRLR EYLLTQDQLK ENGYPFPHPE
960 970 980 990 1000
RPGGAIIFTA EEKRPKDSSC RTCCRCGTEY LVSSSGRCIR DEECYYHWGR
1010 1020 1030 1040 1050
LRRNRVAGGW ETQYMCCSAA AGSVGCQVAK QHVQDGRKER LEGFVKTFEK
1060 1070 1080 1090 1100
ELSGDTHPGI YALDCEMSYT TYGLELTRVT VVDTDVHVVY DTFVKPDNEI
1110 1120 1130 1140 1150
VDYNTRFSGV TEADLADTSV TLRDVQAVLL SMFSADTILI GHSLESDLLA
1160 1170 1180 1190 1200
LKVIHSTVVD TSVLFPHRLG LPYKRSLRNL MADYLRQIIQ DNVDGHSSSE
1210 1220
DAGACMHLVI WKVREDAKTK R
Length:1,221
Mass (Da):131,510
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4165C5394664B021
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y7I5A0A2R8Y7I5_HUMAN
RNA exonuclease 1 homolog
REXO1
530Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESH4K7ESH4_HUMAN
RNA exonuclease 1 homolog
REXO1
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WY50A0A087WY50_HUMAN
RNA exonuclease 1 homolog
REXO1
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86452 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39S → P in BAA86452 (PubMed:10574461).Curated1
Sequence conflicti39S → P in AAH32244 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057148408V → A. Corresponds to variant dbSNP:rs10415018Ensembl.1
Natural variantiVAR_060444759S → P3 PublicationsCorresponds to variant dbSNP:rs4807145Ensembl.1
Natural variantiVAR_057149804I → V. Corresponds to variant dbSNP:rs34831403Ensembl.1
Natural variantiVAR_026587886S → G1 PublicationCorresponds to variant dbSNP:rs2396359Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB032964 mRNA Translation: BAA86452.1 Different initiation.
AC012615 Genomic DNA No translation available.
BC032244 mRNA Translation: AAH32244.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32866.1

NCBI Reference Sequences

More...
RefSeqi
NP_065746.3, NM_020695.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000170168; ENSP00000170168; ENSG00000079313

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57455

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57455

UCSC genome browser

More...
UCSCi
uc002lua.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032964 mRNA Translation: BAA86452.1 Different initiation.
AC012615 Genomic DNA No translation available.
BC032244 mRNA Translation: AAH32244.1
CCDSiCCDS32866.1
RefSeqiNP_065746.3, NM_020695.3

3D structure databases

SMRiQ8N1G1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121526, 7 interactors
IntActiQ8N1G1, 5 interactors
STRINGi9606.ENSP00000170168

PTM databases

iPTMnetiQ8N1G1
PhosphoSitePlusiQ8N1G1

Polymorphism and mutation databases

BioMutaiREXO1
DMDMi296452990

Proteomic databases

EPDiQ8N1G1
jPOSTiQ8N1G1
MassIVEiQ8N1G1
MaxQBiQ8N1G1
PaxDbiQ8N1G1
PeptideAtlasiQ8N1G1
PRIDEiQ8N1G1
ProteomicsDBi71599

Genome annotation databases

EnsembliENST00000170168; ENSP00000170168; ENSG00000079313
GeneIDi57455
KEGGihsa:57455
UCSCiuc002lua.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57455
DisGeNETi57455

GeneCards: human genes, protein and diseases

More...
GeneCardsi
REXO1
HGNCiHGNC:24616 REXO1
HPAiHPA042155
HPA042552
MIMi609614 gene
neXtProtiNX_Q8N1G1
OpenTargetsiENSG00000079313
PharmGKBiPA142671077

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2248 Eukaryota
COG0847 LUCA
GeneTreeiENSGT00940000158590
HOGENOMiHOG000039979
InParanoidiQ8N1G1
KOiK14570
OMAiMCNYHPK
OrthoDBi227856at2759
PhylomeDBiQ8N1G1
TreeFamiTF350172

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
REXO1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57455
PharosiQ8N1G1

Protein Ontology

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PROi
PR:Q8N1G1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000079313 Expressed in 90 organ(s), highest expression level in testis
ExpressionAtlasiQ8N1G1 baseline and differential
GenevisibleiQ8N1G1 HS

Family and domain databases

CDDicd06145 REX1_like, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR031736 EloA-BP1
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR034922 REX1-like_exo
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF15870 EloA-BP1, 1 hit
SMARTiView protein in SMART
SM00479 EXOIII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiREXO1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N1G1
Secondary accession number(s): Q9ULT2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 18, 2010
Last modified: October 16, 2019
This is version 140 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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