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Protein

Zinc finger protein 687

Gene

ZNF687

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri533 – 552C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST20
Zinc fingeri705 – 727C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri764 – 787C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri792 – 815C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri827 – 849C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri858 – 881C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri963 – 986C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri993 – 1016C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1135 – 1158C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1200 – 1222C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 687
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF687
Synonyms:KIAA1441
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000143373.17

Human Gene Nomenclature Database

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HGNCi
HGNC:29277 ZNF687

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610568 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8N1G0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Paget disease of bone 6 (PDB6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant form of Paget disease, a disorder of bone remodeling characterized by increased bone turnover affecting one or more sites throughout the skeleton, primarily the axial skeleton. Osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone. PDB6 is characterized by adult onset of bone pain associated with polyostotic bone lesions primarily affecting the axial skeleton. In some cases, the pagetic tissue undergoes neoplastic transformation, resulting in osteosarcoma and, less frequently, in giant cell tumor of bone.
See also OMIM:616833
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076534242S → I in PDB6; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs869025582EnsemblClinVar.1
Natural variantiVAR_076535937P → R in PDB6; enhances nuclear localization; increases expression levels; R-937 containing osteoclasts induced by treatment of peripheral blood mononuclear cells with CSF1 and TNFSF11 exhibit a greater number of nuclei, as well as a larger surface area than did those from the control individuals. 1 PublicationCorresponds to variant dbSNP:rs148402804EnsemblClinVar.1

Organism-specific databases

DisGeNET

More...
DisGeNETi
57592

MalaCards human disease database

More...
MalaCardsi
ZNF687
MIMi616833 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000143373

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
280110 NON RARE IN EUROPE: Paget disease of bone

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670486

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF687

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74759771

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002340051 – 1237Zinc finger protein 687Add BLAST1237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei102PhosphoserineBy similarity1
Modified residuei129PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei148PhosphothreonineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Modified residuei242PhosphoserineCombined sources1
Modified residuei251PhosphoserineCombined sources1
Modified residuei253PhosphoserineCombined sources1
Modified residuei266PhosphoserineCombined sources1
Modified residuei271PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki336Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki372Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei374PhosphoserineCombined sources1
Modified residuei377PhosphothreonineCombined sources1
Cross-linki384Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki397Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki422Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei433PhosphoserineCombined sources1
Cross-linki435Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki439Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki451Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki464Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei495PhosphoserineCombined sources1
Modified residuei900PhosphothreonineCombined sources1
Cross-linki954Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1043Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1057PhosphoserineCombined sources1
Modified residuei1060Omega-N-methylarginineBy similarity1
Modified residuei1082PhosphoserineCombined sources1
Modified residuei1083PhosphoserineCombined sources1
Modified residuei1085PhosphoserineCombined sources1
Modified residuei1101Omega-N-methylarginineBy similarity1
Modified residuei1106PhosphoserineCombined sources1
Modified residuei1118PhosphoserineCombined sources1
Modified residuei1184PhosphoserineBy similarity1
Modified residuei1191PhosphoserineCombined sources1
Modified residuei1211PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8N1G0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8N1G0

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8N1G0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8N1G0

PeptideAtlas

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PeptideAtlasi
Q8N1G0

PRoteomics IDEntifications database

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PRIDEi
Q8N1G0

ProteomicsDB human proteome resource

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ProteomicsDBi
71597
71598 [Q8N1G0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8N1G0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8N1G0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in obvary, muscle, blood and lung.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Up-regulated during osteoclastogenesis induced by treatment of peripheral blood mononuclear cells with CSF1 and TNFSF11, as well as during osteoblastogenesis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143373 Expressed in 162 organ(s), highest expression level in islet of Langerhans

CleanEx database of gene expression profiles

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CleanExi
HS_ZNF687

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8N1G0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8N1G0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021193
HPA023948

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TSPYL2Q9H2G43EBI-1210558,EBI-947459

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121643, 43 interactors

Protein interaction database and analysis system

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IntActi
Q8N1G0, 24 interactors

Molecular INTeraction database

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MINTi
Q8N1G0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000319829

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8N1G0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi130 – 305Pro-richAdd BLAST176
Compositional biasi322 – 325Poly-Ser4
Compositional biasi922 – 926Poly-Ser5
Compositional biasi927 – 930Poly-Glu4
Compositional biasi955 – 962Poly-Gly8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri533 – 552C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST20
Zinc fingeri705 – 727C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri764 – 787C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri792 – 815C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri827 – 849C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri858 – 881C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri963 – 986C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri993 – 1016C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1135 – 1158C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1200 – 1222C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156524

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000010306

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG062228

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N1G0

Identification of Orthologs from Complete Genome Data

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OMAi
FISHKKK

Database of Orthologous Groups

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OrthoDBi
180681at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8N1G0

TreeFam database of animal gene trees

More...
TreeFami
TF329009

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N1G0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDMKTPDFD DLLAAFDIPD IDANEAIHSG PEENEGPGGP GKPEPGVGSE
60 70 80 90 100
SEDTAAASAG DGPGVPAQAS DHGLPPPDIS VVSVIVKNTV CPEQSEALAG
110 120 130 140 150
GSAGDGAQAA GVTKEGPVGP HRMQNGFGSP EPSLPGTPHS PAPPSGGTWK
160 170 180 190 200
EKGMEGKTPL DLFAHFGPEP GDHSDPLPPS APSPTREGAL TPPPFPSSFE
210 220 230 240 250
LAQENGPGMQ PPVSSPPLGA LKQESCSPHH PQVLAQQGSG SSPKATDIPA
260 270 280 290 300
SASPPPVAGV PFFKQSPGHQ SPLASPKVPV CQPLKEEDDD EGPVDKSSPG
310 320 330 340 350
SPQSPSSGAE AADEDSNDSP ASSSSRPLKV RIKTIKTSCG NITRTVTQVP
360 370 380 390 400
SDPDPPAPLA EGAFLAEASL LKLSPATPTS EGPKVVSVQL GDGTRLKGTV
410 420 430 440 450
LPVATIQNAS TAMLMAASVA RKAVVLPGGT ATSPKMIAKN VLGLVPQALP
460 470 480 490 500
KADGRAGLGT GGQKVNGASV VMVQPSKTAT GPSTGGGTVI SRTQSSLVEA
510 520 530 540 550
FNKILNSKNL LPAYRPNLSP PAEAGLALPP TGYRCLECGD AFSLEKSLAR
560 570 580 590 600
HYDRRSMRIE VTCNHCARRL VFFNKCSLLL HAREHKDKGL VMQCSHLVMR
610 620 630 640 650
PVALDQMVGQ PDITPLLPVA VPPVSGPLAL PALGKGEGAI TSSAITTVAA
660 670 680 690 700
EAPVLPLSTE PPAAPATSAY TCFRCLECKE QCRDKAGMAA HFQQLGPPAP
710 720 730 740 750
GATSNVCPTC PMMLPNRCSF SAHQRMHKNR PPHVCPECGG NFLQANFQTH
760 770 780 790 800
LREACLHVSR RVGYRCPSCS VVFGGVNSIK SHIQTSHCEV FHKCPICPMA
810 820 830 840 850
FKSGPSAHAH LYSQHPSFQT QQAKLIYKCA MCDTVFTHKP LLSSHFDQHL
860 870 880 890 900
LPQRVSVFKC PSCPLLFAQK RTMLEHLKNT HQSGRLEETA GKGAGGALLT
910 920 930 940 950
PKTEPEELAV SQGGAAPATE ESSSSSEEEE VPSSPEPPRP AKRPRRELGS
960 970 980 990 1000
KGLKGGGGGP GGWTCGLCHS WFPERDEYVA HMKKEHGKSV KKFPCRLCER
1010 1020 1030 1040 1050
SFCSAPSLRR HVRVNHEGIK RVYPCRYCTE GKRTFSSRLI LEKHVQVRHG
1060 1070 1080 1090 1100
LQLGAQSPGR GTTLARGSSA RAQGPGRKRR QSSDSCSEEP DSTTPPAKSP
1110 1120 1130 1140 1150
RGGPGSGGHG PLRYRSSSST EQSLMMGLRV EDGAQQCLDC GLCFASPGSL
1160 1170 1180 1190 1200
SRHRFISHKK RRGVGKASAL GLGDGEEEAP PSRSDPDGGD SPLPASGGPL
1210 1220 1230
TCKVCGKSCD SPLNLKTHFR THGMAFIRAR QGAVGDN
Length:1,237
Mass (Da):129,529
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD2DC99AA2AF44270
GO
Isoform 2 (identifier: Q8N1G0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1027-1103: YCTEGKRTFS...TPPAKSPRGG → SKGPGLRAVP...GARSETPPVF
     1104-1237: Missing.

Note: No experimental confirmation available.
Show »
Length:1,103
Mass (Da):115,571
Checksum:i3FDC8E46C8F47A9D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y5I5H0Y5I5_HUMAN
Zinc finger protein 687
ZNF687
706Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCX2F8WCX2_HUMAN
Zinc finger protein 687
ZNF687
785Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A3Q2A2A3Q2_HUMAN
Zinc finger protein 687
ZNF687
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6PVV7A6PVV7_HUMAN
Zinc finger protein 687
ZNF687
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92679 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14406 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAH18162 differs from that shown. Reason: Frameshift at position 1062.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti331R → W in CAH18162 (PubMed:17974005).Curated1
Sequence conflicti439K → E in BAB14406 (PubMed:14702039).Curated1
Sequence conflicti515R → G in BAB14406 (PubMed:14702039).Curated1
Sequence conflicti639A → V in CAH18162 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076534242S → I in PDB6; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs869025582EnsemblClinVar.1
Natural variantiVAR_052894259G → E. Corresponds to variant dbSNP:rs3748545Ensembl.1
Natural variantiVAR_052895344R → T. Corresponds to variant dbSNP:rs12045766Ensembl.1
Natural variantiVAR_076535937P → R in PDB6; enhances nuclear localization; increases expression levels; R-937 containing osteoclasts induced by treatment of peripheral blood mononuclear cells with CSF1 and TNFSF11 exhibit a greater number of nuclei, as well as a larger surface area than did those from the control individuals. 1 PublicationCorresponds to variant dbSNP:rs148402804EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0181681027 – 1103YCTEG…SPRGG → SKGPGLRAVPLLPSCPLPFQ VLHRGKTHLQQPPDPRETCP GPARLAAWGPVPWPGDHLGS GFQCQSPGARSETPPVF in isoform 2. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_0181691104 – 1237Missing in isoform 2. 1 PublicationAdd BLAST134

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB037862 mRNA Translation: BAA92679.1 Different initiation.
CR749307 mRNA Translation: CAH18162.1 Frameshift.
AL391069 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53452.1
CH471121 Genomic DNA Translation: EAW53453.1
CH471121 Genomic DNA Translation: EAW53454.1
BC032463 mRNA Translation: AAH32463.1
AK023105 mRNA Translation: BAB14406.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS992.1 [Q8N1G0-1]

NCBI Reference Sequences

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RefSeqi
NP_001291692.1, NM_001304763.1 [Q8N1G0-1]
NP_001291693.1, NM_001304764.1 [Q8N1G0-1]
NP_065883.1, NM_020832.2 [Q8N1G0-1]
XP_011508114.1, XM_011509812.2 [Q8N1G0-1]
XP_011508115.1, XM_011509813.2 [Q8N1G0-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.186756
Hs.225083

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000324048; ENSP00000319829; ENSG00000143373 [Q8N1G0-1]
ENST00000336715; ENSP00000336620; ENSG00000143373 [Q8N1G0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57592

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57592

UCSC genome browser

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UCSCi
uc001exq.4 human [Q8N1G0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037862 mRNA Translation: BAA92679.1 Different initiation.
CR749307 mRNA Translation: CAH18162.1 Frameshift.
AL391069 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53452.1
CH471121 Genomic DNA Translation: EAW53453.1
CH471121 Genomic DNA Translation: EAW53454.1
BC032463 mRNA Translation: AAH32463.1
AK023105 mRNA Translation: BAB14406.1 Different initiation.
CCDSiCCDS992.1 [Q8N1G0-1]
RefSeqiNP_001291692.1, NM_001304763.1 [Q8N1G0-1]
NP_001291693.1, NM_001304764.1 [Q8N1G0-1]
NP_065883.1, NM_020832.2 [Q8N1G0-1]
XP_011508114.1, XM_011509812.2 [Q8N1G0-1]
XP_011508115.1, XM_011509813.2 [Q8N1G0-1]
UniGeneiHs.186756
Hs.225083

3D structure databases

ProteinModelPortaliQ8N1G0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121643, 43 interactors
IntActiQ8N1G0, 24 interactors
MINTiQ8N1G0
STRINGi9606.ENSP00000319829

PTM databases

iPTMnetiQ8N1G0
PhosphoSitePlusiQ8N1G0

Polymorphism and mutation databases

BioMutaiZNF687
DMDMi74759771

Proteomic databases

EPDiQ8N1G0
jPOSTiQ8N1G0
MaxQBiQ8N1G0
PaxDbiQ8N1G0
PeptideAtlasiQ8N1G0
PRIDEiQ8N1G0
ProteomicsDBi71597
71598 [Q8N1G0-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57592
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324048; ENSP00000319829; ENSG00000143373 [Q8N1G0-1]
ENST00000336715; ENSP00000336620; ENSG00000143373 [Q8N1G0-1]
GeneIDi57592
KEGGihsa:57592
UCSCiuc001exq.4 human [Q8N1G0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57592
DisGeNETi57592
EuPathDBiHostDB:ENSG00000143373.17

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF687
HGNCiHGNC:29277 ZNF687
HPAiHPA021193
HPA023948
MalaCardsiZNF687
MIMi610568 gene
616833 phenotype
neXtProtiNX_Q8N1G0
OpenTargetsiENSG00000143373
Orphaneti280110 NON RARE IN EUROPE: Paget disease of bone
PharmGKBiPA142670486

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000156524
HOGENOMiHOG000010306
HOVERGENiHBG062228
InParanoidiQ8N1G0
OMAiFISHKKK
OrthoDBi180681at2759
PhylomeDBiQ8N1G0
TreeFamiTF329009

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF687 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ZNF687

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57592

Protein Ontology

More...
PROi
PR:Q8N1G0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143373 Expressed in 162 organ(s), highest expression level in islet of Langerhans
CleanExiHS_ZNF687
ExpressionAtlasiQ8N1G0 baseline and differential
GenevisibleiQ8N1G0 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN687_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N1G0
Secondary accession number(s): D3DV17
, Q68DQ8, Q9H937, Q9P2A7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2002
Last modified: January 16, 2019
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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