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Entry version 143 (12 Aug 2020)
Sequence version 4 (28 Mar 2018)
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Protein

Serine/threonine-protein kinase 11-interacting protein

Gene

STK11IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate STK11/LKB1 function by controlling its subcellular localization.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8N1F8

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695, Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase 11-interacting protein
Alternative name(s):
LKB1-interacting protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STK11IP
Synonyms:KIAA1898, LIP1, LKB1IP, STK11IP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000144589.20

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19184, STK11IP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607172, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N1F8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
114790

Open Targets

More...
OpenTargetsi
ENSG00000144589

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38822

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N1F8, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STK11IP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452972

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003174621 – 1088Serine/threonine-protein kinase 11-interacting proteinAdd BLAST1088

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei387PhosphoserineCombined sources1
Modified residuei389PhosphoserineCombined sources1
Modified residuei392PhosphoserineCombined sources1
Modified residuei470PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei761PhosphoserineCombined sources1
Modified residuei773PhosphoserineCombined sources1
Modified residuei777PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N1F8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N1F8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N1F8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N1F8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N1F8

PeptideAtlas

More...
PeptideAtlasi
Q8N1F8

PRoteomics IDEntifications database

More...
PRIDEi
Q8N1F8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
11298

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N1F8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N1F8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144589, Expressed in right testis and 182 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N1F8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N1F8, HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a ternary complex composed of STK11/LKB1, STK11IP and SMAD4.

Interacts with STK11/LKB1 and SMAD4.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125352, 26 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N1F8, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000295641

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N1F8, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati109 – 130LRR 1Add BLAST22
Repeati132 – 152LRR 2Add BLAST21
Repeati164 – 185LRR 3Add BLAST22
Repeati187 – 209LRR 4Add BLAST23
Repeati210 – 231LRR 5Add BLAST22
Repeati233 – 254LRR 6Add BLAST22
Repeati255 – 276LRR 7Add BLAST22
Repeati280 – 301LRR 8Add BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi474 – 593Glu-richAdd BLAST120

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the STK11IP family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1859, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158471

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N1F8

Database of Orthologous Groups

More...
OrthoDBi
1041637at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N1F8

TreeFam database of animal gene trees

More...
TreeFami
TF326448

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR031782, LIP1_N
IPR032675, LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15904, LIP1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8N1F8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTAQRDSLL WKLAGLLRES GDVVLSGCST LSLLTPTLQQ LNHVFELHLG
60 70 80 90 100
PWGPGQTGFV ALPSHPADSP VILQLQFLFD VLQKTLSLKL VHVAGPGPTG
110 120 130 140 150
PIKIFPFKSL RHLELRGVPL HCLHGLRGIY SQLETLICSR SLQALEELLS
160 170 180 190 200
ACGGDFCSAL PWLALLSANF SYNALTALDS SLRLLSALRF LNLSHNQVQD
210 220 230 240 250
CQGFLMDLCE LHHLDISYNR LHLVPRMGPS GAALGVLILR GNELRSLHGL
260 270 280 290 300
EQLRNLRHLD LAYNLLEGHR ELSPLWLLAE LRKLYLEGNP LWFHPEHRAA
310 320 330 340 350
TAQYLSPRAR DAATGFLLDG KVLSLTDFQT HTSLGLSPMG PPLPWPVGST
360 370 380 390 400
PETSGGPDLS DSLSSGGVVT QPLLHKVKSR VRVRRASISE PSDTDPEPRT
410 420 430 440 450
LNPSPAGWFV QQHPELELMS SFRERFGRNW LQYRSHLEPS GNPLPATPTT
460 470 480 490 500
SAPSAPPASS QGPDTAPRPS PPQEEARGPQ ESPQKMSEEV RAEPQEEEEE
510 520 530 540 550
KEGKEEKEEG EMVEQGEEEA GEEEEEEQDQ KEVEAELCRP LLVCPLEGPE
560 570 580 590 600
GVRGRECFLR VTSAHLFEVE LQAARTLERL ELQSLEAAEI EPEAQAQRSP
610 620 630 640 650
RPTGSDLLPG APILSLRFSY ICPDRQLRRY LVLEPDAHAA VQELLAVLTP
660 670 680 690 700
VTNVAREQLG EARDLLLGRF QCLRCGHEFK PEEPRMGLDS EEGWRPLFQK
710 720 730 740 750
TESPAVCPNC GSDHVVLLAV SRGTPNRERK QGEQSLAPSP SASPVCHPPG
760 770 780 790 800
HGDHLDRAKN SPPQAPSTRD HGSWSLSPPP ERCGLRSVDH RLRLFLDVEV
810 820 830 840 850
FSDAQEEFQC CLKVPVALAG HTGEFMCLVV VSDRRLYLLK VTGEMREPPA
860 870 880 890 900
SWLQLTLAVP LQDLSGIELG LAGQSLRLEW AAGAGRCVLL PRDARHCRAF
910 920 930 940 950
LEELLDVLQS LPPAWRNCVS ATEEEVTPQH RLWPLLEKDS SLEARQFFYL
960 970 980 990 1000
RAFLVEGPST CLVSLLLTPS TLFLLDEDAA GSPAEPSPPA ASGEASEKVP
1010 1020 1030 1040 1050
PSGPGPAVRV REQQPLSSLS SVLLYRSAPE DLRLLFYDEV SRLESFWALR
1060 1070 1080
VVCQEQLTAL LAWIREPWEE LFSIGLRTVI QEALALDR
Length:1,088
Mass (Da):120,259
Last modified:March 28, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB5EA45D6C1B7BEF8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYE5M0QYE5_HUMAN
Serine/threonine-protein kinase 11-...
STK11IP
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2J7H7C2J7_HUMAN
Serine/threonine-protein kinase 11-...
STK11IP
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERV2E7ERV2_HUMAN
Serine/threonine-protein kinase 11-...
STK11IP
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C236H7C236_HUMAN
Serine/threonine-protein kinase 11-...
STK11IP
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH34051 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAL49726 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti337S → N in AAL49726 (PubMed:11741830).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038529382R → H1 PublicationCorresponds to variant dbSNP:rs17855575Ensembl.1
Natural variantiVAR_038530399R → G1 PublicationCorresponds to variant dbSNP:rs17855576Ensembl.1
Natural variantiVAR_038531552V → I2 PublicationsCorresponds to variant dbSNP:rs673951Ensembl.1
Natural variantiVAR_038532741S → F3 PublicationsCorresponds to variant dbSNP:rs627530Ensembl.1
Natural variantiVAR_0385331074I → V1 PublicationCorresponds to variant dbSNP:rs17853279Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF450267 mRNA Translation: AAL49726.1 Different initiation.
AC009955 Genomic DNA No translation available.
BC014114 mRNA Translation: AAH14114.2
BC034051 mRNA Translation: AAH34051.1 Different initiation.
AB067485 mRNA Translation: BAB67791.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46521.2

NCBI Reference Sequences

More...
RefSeqi
NP_443134.3, NM_052902.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000456909; ENSP00000389383; ENSG00000144589

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114790

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:114790

UCSC genome browser

More...
UCSCi
uc002vml.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450267 mRNA Translation: AAL49726.1 Different initiation.
AC009955 Genomic DNA No translation available.
BC014114 mRNA Translation: AAH14114.2
BC034051 mRNA Translation: AAH34051.1 Different initiation.
AB067485 mRNA Translation: BAB67791.1
CCDSiCCDS46521.2
RefSeqiNP_443134.3, NM_052902.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125352, 26 interactors
IntActiQ8N1F8, 17 interactors
STRINGi9606.ENSP00000295641

PTM databases

iPTMnetiQ8N1F8
PhosphoSitePlusiQ8N1F8

Polymorphism and mutation databases

BioMutaiSTK11IP
DMDMi296452972

Proteomic databases

EPDiQ8N1F8
jPOSTiQ8N1F8
MassIVEiQ8N1F8
MaxQBiQ8N1F8
PaxDbiQ8N1F8
PeptideAtlasiQ8N1F8
PRIDEiQ8N1F8
ProteomicsDBi11298

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34344, 132 antibodies

The DNASU plasmid repository

More...
DNASUi
114790

Genome annotation databases

EnsembliENST00000456909; ENSP00000389383; ENSG00000144589
GeneIDi114790
KEGGihsa:114790
UCSCiuc002vml.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114790
DisGeNETi114790
EuPathDBiHostDB:ENSG00000144589.20

GeneCards: human genes, protein and diseases

More...
GeneCardsi
STK11IP
HGNCiHGNC:19184, STK11IP
MIMi607172, gene
neXtProtiNX_Q8N1F8
OpenTargetsiENSG00000144589
PharmGKBiPA38822

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1859, Eukaryota
GeneTreeiENSGT00940000158471
InParanoidiQ8N1F8
OrthoDBi1041637at2759
PhylomeDBiQ8N1F8
TreeFamiTF326448

Enzyme and pathway databases

PathwayCommonsiQ8N1F8
ReactomeiR-HSA-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
114790, 4 hits in 856 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
114790
PharosiQ8N1F8, Tdark

Protein Ontology

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PROi
PR:Q8N1F8
RNActiQ8N1F8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000144589, Expressed in right testis and 182 other tissues
ExpressionAtlasiQ8N1F8, baseline and differential
GenevisibleiQ8N1F8, HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR031782, LIP1_N
IPR032675, LRR_dom_sf
PfamiView protein in Pfam
PF15904, LIP1, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS11IP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N1F8
Secondary accession number(s): C9JQV3
, Q8NAW9, Q8WXE4, Q96CN3, Q96PY9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 28, 2018
Last modified: August 12, 2020
This is version 143 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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