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Protein

Lysozyme g-like protein 1

Gene

LYG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH23 Glycoside Hydrolase Family 23

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme g-like protein 1 (EC:3.2.1.-)
Gene namesi
Name:LYG1
ORF Names:UNQ1939/PRO4422
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144214.9
HGNCiHGNC:27014 LYG1
neXtProtiNX_Q8N1E2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394698

Polymorphism and mutation databases

BioMutaiLYG1
DMDMi47117245

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001202320 – 194Lysozyme g-like protein 1Add BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 80By similarity
Disulfide bondi38 ↔ 49By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8N1E2
PRIDEiQ8N1E2
ProteomicsDBi71589

PTM databases

iPTMnetiQ8N1E2
PhosphoSitePlusiQ8N1E2

Expressioni

Gene expression databases

BgeeiENSG00000144214
CleanExiHS_LYG1
GenevisibleiQ8N1E2 HS

Interactioni

Protein-protein interaction databases

IntActiQ8N1E2, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ8N1E2
SMRiQ8N1E2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 23 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWM4 Eukaryota
ENOG41115RI LUCA
GeneTreeiENSGT00390000017614
HOGENOMiHOG000247036
HOVERGENiHBG006299
InParanoidiQ8N1E2
OMAiSCDFCND
OrthoDBiEOG091G0LPR
PhylomeDBiQ8N1E2
TreeFamiTF329826

Family and domain databases

CDDicd01021 GEWL, 1 hit
InterProiView protein in InterPro
IPR002152 Glyco_hydro_23
IPR023346 Lysozyme-like_dom_sf
PIRSFiPIRSF001065 Lysozyme_g, 1 hit
PRINTSiPR00749 LYSOZYMEG
SUPFAMiSSF53955 SSF53955, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N1E2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALWLLLGL LALMDLSESS NWGCYGNIQS LDTPGASCGI GRRHGLNYCG
60 70 80 90 100
VRASERLAEI DMPYLLKYQP MMQTIGQKYC MDPAVIAGVL SRKSPGDKIL
110 120 130 140 150
VNMGDRTSMV QDPGSQAPTS WISESQVSQT TEVLTTRIKE IQRRFPTWTP
160 170 180 190
DQYLRGGLCA YSGGAGYVRS SQDLSCDFCN DVLARAKYLK RHGF
Length:194
Mass (Da):21,431
Last modified:October 1, 2002 - v1
Checksum:i42B0FC864AEF8C20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358988 mRNA Translation: AAQ89347.1
AC079447 Genomic DNA Translation: AAX93256.1
CH471127 Genomic DNA Translation: EAX01872.1
BC029126 mRNA Translation: AAH29126.1
CCDSiCCDS2043.1
RefSeqiNP_777558.1, NM_174898.2
XP_005263926.1, XM_005263869.2
XP_005263927.1, XM_005263870.3
XP_005263928.1, XM_005263871.4
XP_011508882.1, XM_011510580.2
XP_016858800.1, XM_017003311.1
XP_016858801.1, XM_017003312.1
XP_016858802.1, XM_017003313.1
UniGeneiHs.164589

Genome annotation databases

EnsembliENST00000308528; ENSP00000311320; ENSG00000144214
ENST00000409448; ENSP00000386923; ENSG00000144214
GeneIDi129530
KEGGihsa:129530
UCSCiuc002szy.3 human

Similar proteinsi

Entry informationi

Entry nameiLYG1_HUMAN
AccessioniPrimary (citable) accession number: Q8N1E2
Secondary accession number(s): Q53RV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2002
Last modified: July 18, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

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