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Protein

Lysozyme g-like protein 1

Gene

LYG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

Carbohydrate-Active enZymes

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CAZyi
GH23 Glycoside Hydrolase Family 23

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysozyme g-like protein 1 (EC:3.2.1.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LYG1
ORF Names:UNQ1939/PRO4422
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000144214.9

Human Gene Nomenclature Database

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HGNCi
HGNC:27014 LYG1

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8N1E2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162394698

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
LYG1

Domain mapping of disease mutations (DMDM)

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DMDMi
47117245

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001202320 – 194Lysozyme g-like protein 1Add BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi24 ↔ 80By similarity
Disulfide bondi38 ↔ 49By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8N1E2

PRoteomics IDEntifications database

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PRIDEi
Q8N1E2

ProteomicsDB human proteome resource

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ProteomicsDBi
71589

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8N1E2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8N1E2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000144214 Expressed in 109 organ(s), highest expression level in adult mammalian kidney

CleanEx database of gene expression profiles

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CleanExi
HS_LYG1

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8N1E2 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q8N1E2, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8N1E2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N1E2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 23 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IWM4 Eukaryota
ENOG41115RI LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000017614

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000247036

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006299

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N1E2

Identification of Orthologs from Complete Genome Data

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OMAi
SCDFCND

Database of Orthologous Groups

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OrthoDBi
EOG091G0LPR

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8N1E2

TreeFam database of animal gene trees

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TreeFami
TF329826

Family and domain databases

Conserved Domains Database

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CDDi
cd01021 GEWL, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002152 Glyco_hydro_23
IPR023346 Lysozyme-like_dom_sf

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF001065 Lysozyme_g, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00749 LYSOZYMEG

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53955 SSF53955, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N1E2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSALWLLLGL LALMDLSESS NWGCYGNIQS LDTPGASCGI GRRHGLNYCG
60 70 80 90 100
VRASERLAEI DMPYLLKYQP MMQTIGQKYC MDPAVIAGVL SRKSPGDKIL
110 120 130 140 150
VNMGDRTSMV QDPGSQAPTS WISESQVSQT TEVLTTRIKE IQRRFPTWTP
160 170 180 190
DQYLRGGLCA YSGGAGYVRS SQDLSCDFCN DVLARAKYLK RHGF
Length:194
Mass (Da):21,431
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42B0FC864AEF8C20
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY358988 mRNA Translation: AAQ89347.1
AC079447 Genomic DNA Translation: AAX93256.1
CH471127 Genomic DNA Translation: EAX01872.1
BC029126 mRNA Translation: AAH29126.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2043.1

NCBI Reference Sequences

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RefSeqi
NP_777558.1, NM_174898.2
XP_005263926.1, XM_005263869.2
XP_005263927.1, XM_005263870.3
XP_005263928.1, XM_005263871.4
XP_011508882.1, XM_011510580.2
XP_016858800.1, XM_017003311.1
XP_016858801.1, XM_017003312.1
XP_016858802.1, XM_017003313.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.164589

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000308528; ENSP00000311320; ENSG00000144214
ENST00000409448; ENSP00000386923; ENSG00000144214

Database of genes from NCBI RefSeq genomes

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GeneIDi
129530

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:129530

UCSC genome browser

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UCSCi
uc002szy.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358988 mRNA Translation: AAQ89347.1
AC079447 Genomic DNA Translation: AAX93256.1
CH471127 Genomic DNA Translation: EAX01872.1
BC029126 mRNA Translation: AAH29126.1
CCDSiCCDS2043.1
RefSeqiNP_777558.1, NM_174898.2
XP_005263926.1, XM_005263869.2
XP_005263927.1, XM_005263870.3
XP_005263928.1, XM_005263871.4
XP_011508882.1, XM_011510580.2
XP_016858800.1, XM_017003311.1
XP_016858801.1, XM_017003312.1
XP_016858802.1, XM_017003313.1
UniGeneiHs.164589

3D structure databases

ProteinModelPortaliQ8N1E2
SMRiQ8N1E2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8N1E2, 2 interactors

Protein family/group databases

CAZyiGH23 Glycoside Hydrolase Family 23

PTM databases

iPTMnetiQ8N1E2
PhosphoSitePlusiQ8N1E2

Polymorphism and mutation databases

BioMutaiLYG1
DMDMi47117245

Proteomic databases

PaxDbiQ8N1E2
PRIDEiQ8N1E2
ProteomicsDBi71589

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
129530
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308528; ENSP00000311320; ENSG00000144214
ENST00000409448; ENSP00000386923; ENSG00000144214
GeneIDi129530
KEGGihsa:129530
UCSCiuc002szy.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
129530
EuPathDBiHostDB:ENSG00000144214.9

GeneCards: human genes, protein and diseases

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GeneCardsi
LYG1
HGNCiHGNC:27014 LYG1
neXtProtiNX_Q8N1E2
PharmGKBiPA162394698

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWM4 Eukaryota
ENOG41115RI LUCA
GeneTreeiENSGT00390000017614
HOGENOMiHOG000247036
HOVERGENiHBG006299
InParanoidiQ8N1E2
OMAiSCDFCND
OrthoDBiEOG091G0LPR
PhylomeDBiQ8N1E2
TreeFamiTF329826

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
129530

Protein Ontology

More...
PROi
PR:Q8N1E2

Gene expression databases

BgeeiENSG00000144214 Expressed in 109 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_LYG1
GenevisibleiQ8N1E2 HS

Family and domain databases

CDDicd01021 GEWL, 1 hit
InterProiView protein in InterPro
IPR002152 Glyco_hydro_23
IPR023346 Lysozyme-like_dom_sf
PIRSFiPIRSF001065 Lysozyme_g, 1 hit
PRINTSiPR00749 LYSOZYMEG
SUPFAMiSSF53955 SSF53955, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLYG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N1E2
Secondary accession number(s): Q53RV9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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