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Entry version 139 (13 Feb 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Vacuolar protein sorting-associated protein 52 homolog

Gene

VPS52

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Rab GTPase binding Source: GO_Central
  • syntaxin binding Source: UniProtKB

GO - Biological processi

  • ectodermal cell differentiation Source: Ensembl
  • embryonic ectodermal digestive tract development Source: Ensembl
  • endocytic recycling Source: UniProtKB
  • Golgi to vacuole transport Source: GO_Central
  • lysosomal transport Source: MGI
  • protein transport Source: UniProtKB-KW
  • retrograde transport, endosome to Golgi Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 52 homolog
Alternative name(s):
SAC2 suppressor of actin mutations 2-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VPS52
Synonyms:SACM2L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000223501.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10518 VPS52

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603443 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N1B4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6293

Open Targets

More...
OpenTargetsi
ENSG00000223501

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34926

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VPS52

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74750887

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002133152 – 723Vacuolar protein sorting-associated protein 52 homologAdd BLAST722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei355PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N1B4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N1B4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N1B4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N1B4

PeptideAtlas

More...
PeptideAtlasi
Q8N1B4

PRoteomics IDEntifications database

More...
PRIDEi
Q8N1B4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71582

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N1B4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N1B4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000223501 Expressed in 231 organ(s), highest expression level in left lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N1B4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N1B4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042667
HPA048128

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54 (PubMed:27440922, PubMed:15878329, PubMed:20685960). Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin (PubMed:25799061, PubMed:27440922). EIPR1 interacts with both EARP and GARP complexes and mediates the recruitment of the GARP complex to the trans-Golgi network (PubMed:27440922). Interacts with RAB6A and STX10 (PubMed:15878329, PubMed:20685960). Interacts with UHRF1BP1L (PubMed:20163565).5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9WMX22EBI-2799833,EBI-6863748From Hepatitis C virus genotype 1b (isolate Con1).
AAMPC9JG973EBI-2799833,EBI-10176499
ATP6V1DQ6PJ053EBI-2799833,EBI-10253919
ATP6V1DQ8N5Z93EBI-2799833,EBI-10266952
ATP6V1DQ9Y5K85EBI-2799833,EBI-2684998
C1orf109Q9NX045EBI-2799833,EBI-8643161
CCDC146Q8IYE0-23EBI-2799833,EBI-10247802
DDX6P261965EBI-2799833,EBI-351257
EPM2AIP1Q7L7755EBI-2799833,EBI-6255981
FAM184AQ6P9G83EBI-2799833,EBI-10253239
GFM2Q969S93EBI-2799833,EBI-2371750
GOLGA1Q928055EBI-2799833,EBI-6164177
HAUS1Q96CS23EBI-2799833,EBI-2514791
HEATR1Q96ES53EBI-2799833,EBI-10285245
HEL-S-61V9HW293EBI-2799833,EBI-10330057
HGSA0A0S2Z4Q43EBI-2799833,EBI-16429135
HGSO149643EBI-2799833,EBI-740220
KANK2Q63ZY33EBI-2799833,EBI-2556193
KIAA1217Q5T5P2-63EBI-2799833,EBI-10188326
KLC3Q6P5973EBI-2799833,EBI-1643885
LMO4P619683EBI-2799833,EBI-2798728
METTL13Q8N6R03EBI-2799833,EBI-1053295
MFAP1P550815EBI-2799833,EBI-1048159
MRPL11Q9Y3B73EBI-2799833,EBI-5453723
NFKBIBQ156533EBI-2799833,EBI-352889
NOP2P460873EBI-2799833,EBI-356811
PIMREGQ9BSJ63EBI-2799833,EBI-2568609
PPP1R18Q6NYC85EBI-2799833,EBI-2557469
PRKAA1Q131313EBI-2799833,EBI-1181405
PRKAA2P546463EBI-2799833,EBI-1383852
RAB4AP203383EBI-2799833,EBI-722284
RNF41Q9H4P45EBI-2799833,EBI-2130266
SH2D4AQ9H7883EBI-2799833,EBI-747035
STX11O755583EBI-2799833,EBI-714135
TBC1D22BQ9NU195EBI-2799833,EBI-8787464
TCEANCQ8N8B73EBI-2799833,EBI-954696
TEAD4D3DUQ63EBI-2799833,EBI-10176734
TEAD4Q155613EBI-2799833,EBI-747736
THAP11Q96EK43EBI-2799833,EBI-1790529
TPM3P067533EBI-2799833,EBI-355607
TPM3Q5VU623EBI-2799833,EBI-10184033
TRAF6Q9Y4K35EBI-2799833,EBI-359276
TSSK3Q96PN85EBI-2799833,EBI-3918381
TSTD2Q5T7W75EBI-2799833,EBI-8994397
TXLNAP402225EBI-2799833,EBI-359793
TXN2Q997575EBI-2799833,EBI-2932492
USP2O756045EBI-2799833,EBI-743272
VPS28Q548N13EBI-2799833,EBI-10243107
VPS28Q9UK414EBI-2799833,EBI-727424
VPS50Q96JG67EBI-2799833,EBI-11044388
VPS51Q9UID3-14EBI-2799833,EBI-16067837
WTAPQ150075EBI-2799833,EBI-751647
ZMAT2Q96NC03EBI-2799833,EBI-2682299

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112200, 82 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8N1B4

Database of interacting proteins

More...
DIPi
DIP-57843N

Protein interaction database and analysis system

More...
IntActi
Q8N1B4, 130 interactors

Molecular INTeraction database

More...
MINTi
Q8N1B4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000409952

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8N1B4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N1B4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili107 – 127Sequence analysisAdd BLAST21
Coiled coili194 – 215Sequence analysisAdd BLAST22

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS52 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1961 Eukaryota
ENOG410XNZ1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008815

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052966

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N1B4

KEGG Orthology (KO)

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KOi
K20298

Identification of Orthologs from Complete Genome Data

More...
OMAi
YKFRKPM

Database of Orthologous Groups

More...
OrthoDBi
158568at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N1B4

TreeFam database of animal gene trees

More...
TreeFami
TF314937

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007258 Vps52

The PANTHER Classification System

More...
PANTHERi
PTHR14190 PTHR14190, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04129 Vps52, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N1B4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAATMAAA ARELVLRAGT SDMEEEEGPL AGGPGLQEPL QLGELDITSD
60 70 80 90 100
EFILDEVDVH IQANLEDELV KEALKTGVDL RHYSKQVELE LQQIEQKSIR
110 120 130 140 150
DYIQESENIA SLHNQITACD AVLERMEQML GAFQSDLSSI SSEIRTLQEQ
160 170 180 190 200
SGAMNIRLRN RQAVRGKLGE LVDGLVVPSA LVTAILEAPV TEPRFLEQLQ
210 220 230 240 250
ELDAKAAAVR EQEARGTAAC ADVRGVLDRL RVKAVTKIRE FILQKIYSFR
260 270 280 290 300
KPMTNYQIPQ TALLKYRFFY QFLLGNERAT AKEIRDEYVE TLSKIYLSYY
310 320 330 340 350
RSYLGRLMKV QYEEVAEKDD LMGVEDTAKK GFFSKPSLRS RNTIFTLGTR
360 370 380 390 400
GSVISPTELE APILVPHTAQ RGEQRYPFEA LFRSQHYALL DNSCREYLFI
410 420 430 440 450
CEFFVVSGPA AHDLFHAVMG RTLSMTLKHL DSYLADCYDA IAVFLCIHIV
460 470 480 490 500
LRFRNIAAKR DVPALDRYWE QVLALLWPRF ELILEMNVQS VRSTDPQRLG
510 520 530 540 550
GLDTRPHYIT RRYAEFSSAL VSINQTIPNE RTMQLLGQLQ VEVENFVLRV
560 570 580 590 600
AAEFSSRKEQ LVFLINNYDM MLGVLMERAA DDSKEVESFQ QLLNARTQEF
610 620 630 640 650
IEELLSPPFG GLVAFVKEAE ALIERGQAER LRGEEARVTQ LIRGFGSSWK
660 670 680 690 700
SSVESLSQDV MRSFTNFRNG TSIIQGALTQ LIQLYHRFHR VLSQPQLRAL
710 720
PARAELINIH HLMVELKKHK PNF
Length:723
Mass (Da):82,221
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC0961E2BE50B24DF
GO
Isoform 2 (identifier: Q8N1B4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.

Note: No experimental confirmation available.
Show »
Length:598
Mass (Da):68,496
Checksum:iA5901265E5EEDBC7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PI03E9PI03_HUMAN
Vacuolar protein sorting-associated...
VPS52
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JIG2A0A0G2JIG2_HUMAN
Vacuolar protein sorting-associated...
VPS52
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAI95619 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti710H → P in BAD96587 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0564761 – 125Missing in isoform 2. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK297935 mRNA Translation: BAG60251.1
AK222867 mRNA Translation: BAD96587.1
AL645940 Genomic DNA No translation available.
AL031228 Genomic DNA Translation: CAI95619.1 Sequence problems.
BX248408 Genomic DNA No translation available.
CR759786 Genomic DNA No translation available.
CR759817 Genomic DNA No translation available.
CR762434 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03688.1
BC032108 mRNA Translation: AAH32108.1
BC040114 mRNA Translation: AAH40114.2
AL390171 mRNA Translation: CAB99099.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4770.2 [Q8N1B4-1]

Protein sequence database of the Protein Information Resource

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PIRi
T51882

NCBI Reference Sequences

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RefSeqi
NP_001276104.1, NM_001289175.1 [Q8N1B4-2]
NP_001276105.1, NM_001289176.1
NP_072047.4, NM_022553.5 [Q8N1B4-1]
XP_016866667.1, XM_017011178.1 [Q8N1B4-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.480356

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000383210; ENSP00000372697; ENSG00000206286 [Q8N1B4-1]
ENST00000428608; ENSP00000406988; ENSG00000236014 [Q8N1B4-1]
ENST00000441058; ENSP00000390831; ENSG00000228425 [Q8N1B4-1]
ENST00000443860; ENSP00000404016; ENSG00000224455 [Q8N1B4-1]
ENST00000445902; ENSP00000409952; ENSG00000223501 [Q8N1B4-1]
ENST00000448042; ENSP00000391197; ENSG00000225590 [Q8N1B4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6293

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6293

UCSC genome browser

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UCSCi
uc003odm.3 human [Q8N1B4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297935 mRNA Translation: BAG60251.1
AK222867 mRNA Translation: BAD96587.1
AL645940 Genomic DNA No translation available.
AL031228 Genomic DNA Translation: CAI95619.1 Sequence problems.
BX248408 Genomic DNA No translation available.
CR759786 Genomic DNA No translation available.
CR759817 Genomic DNA No translation available.
CR762434 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03688.1
BC032108 mRNA Translation: AAH32108.1
BC040114 mRNA Translation: AAH40114.2
AL390171 mRNA Translation: CAB99099.1
CCDSiCCDS4770.2 [Q8N1B4-1]
PIRiT51882
RefSeqiNP_001276104.1, NM_001289175.1 [Q8N1B4-2]
NP_001276105.1, NM_001289176.1
NP_072047.4, NM_022553.5 [Q8N1B4-1]
XP_016866667.1, XM_017011178.1 [Q8N1B4-2]
UniGeneiHs.480356

3D structure databases

ProteinModelPortaliQ8N1B4
SMRiQ8N1B4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112200, 82 interactors
CORUMiQ8N1B4
DIPiDIP-57843N
IntActiQ8N1B4, 130 interactors
MINTiQ8N1B4
STRINGi9606.ENSP00000409952

PTM databases

iPTMnetiQ8N1B4
PhosphoSitePlusiQ8N1B4

Polymorphism and mutation databases

BioMutaiVPS52
DMDMi74750887

Proteomic databases

EPDiQ8N1B4
jPOSTiQ8N1B4
MaxQBiQ8N1B4
PaxDbiQ8N1B4
PeptideAtlasiQ8N1B4
PRIDEiQ8N1B4
ProteomicsDBi71582

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383210; ENSP00000372697; ENSG00000206286 [Q8N1B4-1]
ENST00000428608; ENSP00000406988; ENSG00000236014 [Q8N1B4-1]
ENST00000441058; ENSP00000390831; ENSG00000228425 [Q8N1B4-1]
ENST00000443860; ENSP00000404016; ENSG00000224455 [Q8N1B4-1]
ENST00000445902; ENSP00000409952; ENSG00000223501 [Q8N1B4-1]
ENST00000448042; ENSP00000391197; ENSG00000225590 [Q8N1B4-1]
GeneIDi6293
KEGGihsa:6293
UCSCiuc003odm.3 human [Q8N1B4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6293
DisGeNETi6293
EuPathDBiHostDB:ENSG00000223501.8

GeneCards: human genes, protein and diseases

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GeneCardsi
VPS52
HGNCiHGNC:10518 VPS52
HPAiHPA042667
HPA048128
MIMi603443 gene
neXtProtiNX_Q8N1B4
OpenTargetsiENSG00000223501
PharmGKBiPA34926

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1961 Eukaryota
ENOG410XNZ1 LUCA
GeneTreeiENSGT00390000008815
HOVERGENiHBG052966
InParanoidiQ8N1B4
KOiK20298
OMAiYKFRKPM
OrthoDBi158568at2759
PhylomeDBiQ8N1B4
TreeFamiTF314937

Enzyme and pathway databases

ReactomeiR-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
VPS52 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
VPS52

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6293

Protein Ontology

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PROi
PR:Q8N1B4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000223501 Expressed in 231 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ8N1B4 baseline and differential
GenevisibleiQ8N1B4 HS

Family and domain databases

InterProiView protein in InterPro
IPR007258 Vps52
PANTHERiPTHR14190 PTHR14190, 1 hit
PfamiView protein in Pfam
PF04129 Vps52, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVPS52_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N1B4
Secondary accession number(s): A2BF38
, B0UZZ4, B4DNI9, Q53GR4, Q5JPA0, Q5SQW1, Q8IUN6, Q9NPT5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2002
Last modified: February 13, 2019
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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