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UniProtKB - Q8N1B3 (CCNQ_HUMAN)

Entry version 135 (02 Dec 2020)
Sequence version 2 (21 Aug 2007)
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Protein

Cyclin-Q

Gene

CCNQ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activating cyclin for the cyclin-associated kinase CDK10.2 Publications

Miscellaneous

Silencing with siRNAs phenocopies CDK10 silencing in increasing c-Raf and in conferring tamoxifen resistance to breast cancer cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N1B3

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8N1B3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin-Q
Alternative name(s):
CDK10-activating cyclin
Cyclin-M
Cyclin-related protein FAM58A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCNQImported
Synonyms:FAM58A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000262919.7

Human Gene Nomenclature Database

More...HGNCi		HGNC:28434, CCNQ

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300708, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N1B3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Toe syndactyly, telecanthus, and anogenital and renal malformations (STAR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by anal, genital and renal tract anomalies, facial dysmorphism and syndactyly. Features include anal stenosis, a rectovaginal fistula, clitoral hypertrophy, a pelvic right kidney, toe syndactyly, and telecanthus.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		92002

MalaCards human disease database

More...MalaCardsi		CCNQ
MIMi300707, phenotype

Open Targets

More...OpenTargetsi		ENSG00000262919

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		140952, Syndactyly-telecanthus-anogenital and renal malformations syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671863

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N1B3, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCNQ

Domain mapping of disease mutations (DMDM)

More...DMDMi		156630447

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002975671 – 248Cyclin-QAdd BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N1B3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N1B3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N1B3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N1B3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N1B3

PeptideAtlas

More...PeptideAtlasi		Q8N1B3

PRoteomics IDEntifications database

More...PRIDEi		Q8N1B3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71580 [Q8N1B3-1]
71581 [Q8N1B3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N1B3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N1B3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000262919, Expressed in amniotic fluid and 215 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N1B3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N1B3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000262919, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with CDK10 to promote its kinase activity.

Interacts with SALL1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124901, 19 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-326, Cyclin M-CDK10 complex

Protein interaction database and analysis system

More...IntActi		Q8N1B3, 15 interactors

Molecular INTeraction database

More...MINTi		Q8N1B3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000402949

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N1B3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N1B3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi6 – 10Poly-Gly5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin-like FAM58 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0834, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155445

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022000_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N1B3

Identification of Orthologs from Complete Genome Data

More...OMAi		IFECAAK

Database of Orthologous Groups

More...OrthoDBi		958680at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N1B3

Family and domain databases

Conserved Domains Database

More...CDDi		cd00043, CYCLIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR028759, Cyclin-Q
IPR043198, Cyclin/Ssn8
IPR006671, Cyclin_N

The PANTHER Classification System

More...PANTHERi		PTHR10026, PTHR10026, 1 hit
PTHR10026:SF70, PTHR10026:SF70, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00134, Cyclin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00385, CYCLIN, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47954, SSF47954, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N1B3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAPEGGGGG PAARGPEGQP APEARVHFRV ARFIMEAGVK LGMRSIPIAT 
        60         70         80         90        100
ACTIYHKFFC ETNLDAYDPY LIAMSSIYLA GKVEEQHLRT RDIINVSNRY 
       110        120        130        140        150
FNPSGEPLEL DSRFWELRDS IVQCELLMLR VLRFQVSFQH PHKYLLHYLV 
       160        170        180        190        200
SLQNWLNRHS WQRTPVAVTA WALLRDSYHG ALCLRFQAQH IAVAVLYLAL 
       210        220        230        240 
QVYGVEVPAE VEAEKPWWQV FNDDLTKPII DNIVSDLIQI YTMDTEIP
Length:248
Mass (Da):28,369
Last modified:August 21, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7C11BC5D23BFB82
GO
Isoform 2 (identifier: Q8N1B3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-238: Missing.

Show »
Length:228
Mass (Da):26,114
Checksum:i1849A4531BC802BC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0G9A0A087X0G9_HUMAN
Cyclin-Q
CCNQ
96Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1W3A0A087X1W3_HUMAN
Cyclin-Q
CCNQ
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM37K7EM37_HUMAN
Cyclin-Q
CCNQ
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3N1H7C3N1_HUMAN
Cyclin-Q
CCNQ
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WY98A0A087WY98_HUMAN
Cyclin-Q
CCNQ
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WUL6A0A087WUL6_HUMAN
Cyclin-Q
CCNQ
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH01909 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH07232 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH32121 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH71851 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034642183C → S1 PublicationCorresponds to variant dbSNP:rs17850173Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034527219 – 238Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC001909 mRNA Translation: AAH01909.4 Different initiation.
BC007232 mRNA Translation: AAH07232.4 Different initiation.
BC032121 mRNA Translation: AAH32121.1 Different initiation.
BC071851 mRNA Translation: AAH71851.1 Different initiation.
DQ323993 mRNA Translation: ABC88595.1
AY445048 mRNA Translation: AAS20614.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS76054.1 [Q8N1B3-2]

NCBI Reference Sequences

More...RefSeqi		NP_001124469.1, NM_001130997.2 [Q8N1B3-2]
NP_689487.2, NM_152274.4 [Q8N1B3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000440428; ENSP00000402949; ENSG00000262919 [Q8N1B3-2]
ENST00000576892; ENSP00000461135; ENSG00000262919 [Q8N1B3-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		92002

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:92002

UCSC genome browser

More...UCSCi		uc033fat.2, human [Q8N1B3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001909 mRNA Translation: AAH01909.4 Different initiation.
BC007232 mRNA Translation: AAH07232.4 Different initiation.
BC032121 mRNA Translation: AAH32121.1 Different initiation.
BC071851 mRNA Translation: AAH71851.1 Different initiation.
DQ323993 mRNA Translation: ABC88595.1
AY445048 mRNA Translation: AAS20614.1
CCDSiCCDS76054.1 [Q8N1B3-2]
RefSeqiNP_001124469.1, NM_001130997.2 [Q8N1B3-2]
NP_689487.2, NM_152274.4 [Q8N1B3-1]

3D structure databases

SMRiQ8N1B3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124901, 19 interactors
ComplexPortaliCPX-326, Cyclin M-CDK10 complex
IntActiQ8N1B3, 15 interactors
MINTiQ8N1B3
STRINGi9606.ENSP00000402949

PTM databases

iPTMnetiQ8N1B3
PhosphoSitePlusiQ8N1B3

Polymorphism and mutation databases

BioMutaiCCNQ
DMDMi156630447

Proteomic databases

EPDiQ8N1B3
jPOSTiQ8N1B3
MassIVEiQ8N1B3
MaxQBiQ8N1B3
PaxDbiQ8N1B3
PeptideAtlasiQ8N1B3
PRIDEiQ8N1B3
ProteomicsDBi71580 [Q8N1B3-1]
71581 [Q8N1B3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		73523, 28 antibodies

The DNASU plasmid repository

More...DNASUi		92002

Genome annotation databases

EnsembliENST00000440428; ENSP00000402949; ENSG00000262919 [Q8N1B3-2]
ENST00000576892; ENSP00000461135; ENSG00000262919 [Q8N1B3-1]
GeneIDi92002
KEGGihsa:92002
UCSCiuc033fat.2, human [Q8N1B3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		92002
DisGeNETi92002
EuPathDBiHostDB:ENSG00000262919.7

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCNQ
HGNCiHGNC:28434, CCNQ
HPAiENSG00000262919, Low tissue specificity
MalaCardsiCCNQ
MIMi300707, phenotype
300708, gene
neXtProtiNX_Q8N1B3
OpenTargetsiENSG00000262919
Orphaneti140952, Syndactyly-telecanthus-anogenital and renal malformations syndrome
PharmGKBiPA142671863

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0834, Eukaryota
GeneTreeiENSGT00940000155445
HOGENOMiCLU_022000_2_0_1
InParanoidiQ8N1B3
OMAiIFECAAK
OrthoDBi958680at2759
PhylomeDBiQ8N1B3

Enzyme and pathway databases

PathwayCommonsiQ8N1B3
SignaLinkiQ8N1B3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		92002, 13 hits in 68 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FAM58A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		92002
PharosiQ8N1B3, Tdark

Protein Ontology

More...PROi		PR:Q8N1B3
RNActiQ8N1B3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000262919, Expressed in amniotic fluid and 215 other tissues
ExpressionAtlasiQ8N1B3, baseline and differential
GenevisibleiQ8N1B3, HS

Family and domain databases

CDDicd00043, CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR028759, Cyclin-Q
IPR043198, Cyclin/Ssn8
IPR006671, Cyclin_N
PANTHERiPTHR10026, PTHR10026, 1 hit
PTHR10026:SF70, PTHR10026:SF70, 1 hit
PfamiView protein in Pfam
PF00134, Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385, CYCLIN, 2 hits
SUPFAMiSSF47954, SSF47954, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCNQ_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N1B3
Secondary accession number(s): Q2I380
, Q330J9, Q96IU5, Q9BUU1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: December 2, 2020
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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