UniProtKB - Q8N1B3 (CCNQ_HUMAN)
Protein
Cyclin-Q
Gene
CCNQ
Organism
Homo sapiens (Human)
Status
Functioni
Activating cyclin for the cyclin-associated kinase CDK10.2 Publications
Miscellaneous
Silencing with siRNAs phenocopies CDK10 silencing in increasing c-Raf and in conferring tamoxifen resistance to breast cancer cells.
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Cyclin |
Enzyme and pathway databases
PathwayCommonsi | Q8N1B3 |
SignaLinki | Q8N1B3 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-QAlternative name(s): CDK10-activating cyclin Cyclin-M Cyclin-related protein FAM58A |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000262919.7 |
HGNCi | HGNC:28434, CCNQ |
MIMi | 300708, gene |
neXtProti | NX_Q8N1B3 |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Pathology & Biotechi
Involvement in diseasei
Toe syndactyly, telecanthus, and anogenital and renal malformations (STAR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by anal, genital and renal tract anomalies, facial dysmorphism and syndactyly. Features include anal stenosis, a rectovaginal fistula, clitoral hypertrophy, a pelvic right kidney, toe syndactyly, and telecanthus.
Related information in OMIMOrganism-specific databases
DisGeNETi | 92002 |
MalaCardsi | CCNQ |
MIMi | 300707, phenotype |
OpenTargetsi | ENSG00000262919 |
Orphaneti | 140952, Syndactyly-telecanthus-anogenital and renal malformations syndrome |
PharmGKBi | PA142671863 |
Miscellaneous databases
Pharosi | Q8N1B3, Tdark |
Polymorphism and mutation databases
BioMutai | CCNQ |
DMDMi | 156630447 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000297567 | 1 – 248 | Cyclin-QAdd BLAST | 248 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q8N1B3 |
jPOSTi | Q8N1B3 |
MassIVEi | Q8N1B3 |
MaxQBi | Q8N1B3 |
PaxDbi | Q8N1B3 |
PeptideAtlasi | Q8N1B3 |
PRIDEi | Q8N1B3 |
ProteomicsDBi | 71580 [Q8N1B3-1] 71581 [Q8N1B3-2] |
PTM databases
iPTMneti | Q8N1B3 |
PhosphoSitePlusi | Q8N1B3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000262919, Expressed in amniotic fluid and 215 other tissues |
ExpressionAtlasi | Q8N1B3, baseline and differential |
Genevisiblei | Q8N1B3, HS |
Organism-specific databases
HPAi | ENSG00000262919, Low tissue specificity |
Interactioni
Subunit structurei
Associates with CDK10 to promote its kinase activity.
Interacts with SALL1.
2 PublicationsBinary interactionsi
Q8N1B3
With | #Exp. | IntAct |
---|---|---|
CDK10 - isoform 1 [Q15131-1] | 7 | EBI-3925043,EBI-11507283 |
Protein-protein interaction databases
BioGRIDi | 124901, 19 interactors |
ComplexPortali | CPX-326, Cyclin M-CDK10 complex |
IntActi | Q8N1B3, 15 interactors |
MINTi | Q8N1B3 |
STRINGi | 9606.ENSP00000402949 |
Miscellaneous databases
RNActi | Q8N1B3, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 6 – 10 | Poly-Gly | 5 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0834, Eukaryota |
GeneTreei | ENSGT00940000155445 |
HOGENOMi | CLU_022000_2_0_1 |
InParanoidi | Q8N1B3 |
OMAi | IFECAAK |
OrthoDBi | 958680at2759 |
PhylomeDBi | Q8N1B3 |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR028759, Cyclin-Q IPR043198, Cyclin/Ssn8 IPR006671, Cyclin_N |
PANTHERi | PTHR10026, PTHR10026, 1 hit PTHR10026:SF70, PTHR10026:SF70, 1 hit |
Pfami | View protein in Pfam PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits |
SUPFAMi | SSF47954, SSF47954, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N1B3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEAPEGGGGG PAARGPEGQP APEARVHFRV ARFIMEAGVK LGMRSIPIAT
60 70 80 90 100
ACTIYHKFFC ETNLDAYDPY LIAMSSIYLA GKVEEQHLRT RDIINVSNRY
110 120 130 140 150
FNPSGEPLEL DSRFWELRDS IVQCELLMLR VLRFQVSFQH PHKYLLHYLV
160 170 180 190 200
SLQNWLNRHS WQRTPVAVTA WALLRDSYHG ALCLRFQAQH IAVAVLYLAL
210 220 230 240
QVYGVEVPAE VEAEKPWWQV FNDDLTKPII DNIVSDLIQI YTMDTEIP
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087X0G9 | A0A087X0G9_HUMAN | Cyclin-Q | CCNQ | 96 | Annotation score: | ||
A0A087X1W3 | A0A087X1W3_HUMAN | Cyclin-Q | CCNQ | 170 | Annotation score: | ||
K7EM37 | K7EM37_HUMAN | Cyclin-Q | CCNQ | 141 | Annotation score: | ||
H7C3N1 | H7C3N1_HUMAN | Cyclin-Q | CCNQ | 94 | Annotation score: | ||
A0A087WY98 | A0A087WY98_HUMAN | Cyclin-Q | CCNQ | 39 | Annotation score: | ||
A0A087WUL6 | A0A087WUL6_HUMAN | Cyclin-Q | CCNQ | 39 | Annotation score: |
Sequence cautioni
The sequence AAH01909 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH07232 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH32121 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH71851 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034642 | 183 | C → S1 PublicationCorresponds to variant dbSNP:rs17850173Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034527 | 219 – 238 | Missing in isoform 2. 1 PublicationAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC001909 mRNA Translation: AAH01909.4 Different initiation. BC007232 mRNA Translation: AAH07232.4 Different initiation. BC032121 mRNA Translation: AAH32121.1 Different initiation. BC071851 mRNA Translation: AAH71851.1 Different initiation. DQ323993 mRNA Translation: ABC88595.1 AY445048 mRNA Translation: AAS20614.1 |
CCDSi | CCDS76054.1 [Q8N1B3-2] |
RefSeqi | NP_001124469.1, NM_001130997.2 [Q8N1B3-2] NP_689487.2, NM_152274.4 [Q8N1B3-1] |
Genome annotation databases
Ensembli | ENST00000440428; ENSP00000402949; ENSG00000262919 [Q8N1B3-2] ENST00000576892; ENSP00000461135; ENSG00000262919 [Q8N1B3-1] |
GeneIDi | 92002 |
KEGGi | hsa:92002 |
UCSCi | uc033fat.2, human [Q8N1B3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC001909 mRNA Translation: AAH01909.4 Different initiation. BC007232 mRNA Translation: AAH07232.4 Different initiation. BC032121 mRNA Translation: AAH32121.1 Different initiation. BC071851 mRNA Translation: AAH71851.1 Different initiation. DQ323993 mRNA Translation: ABC88595.1 AY445048 mRNA Translation: AAS20614.1 |
CCDSi | CCDS76054.1 [Q8N1B3-2] |
RefSeqi | NP_001124469.1, NM_001130997.2 [Q8N1B3-2] NP_689487.2, NM_152274.4 [Q8N1B3-1] |
3D structure databases
SMRi | Q8N1B3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124901, 19 interactors |
ComplexPortali | CPX-326, Cyclin M-CDK10 complex |
IntActi | Q8N1B3, 15 interactors |
MINTi | Q8N1B3 |
STRINGi | 9606.ENSP00000402949 |
PTM databases
iPTMneti | Q8N1B3 |
PhosphoSitePlusi | Q8N1B3 |
Polymorphism and mutation databases
BioMutai | CCNQ |
DMDMi | 156630447 |
Proteomic databases
EPDi | Q8N1B3 |
jPOSTi | Q8N1B3 |
MassIVEi | Q8N1B3 |
MaxQBi | Q8N1B3 |
PaxDbi | Q8N1B3 |
PeptideAtlasi | Q8N1B3 |
PRIDEi | Q8N1B3 |
ProteomicsDBi | 71580 [Q8N1B3-1] 71581 [Q8N1B3-2] |
Protocols and materials databases
Antibodypediai | 73523, 28 antibodies |
DNASUi | 92002 |
Genome annotation databases
Ensembli | ENST00000440428; ENSP00000402949; ENSG00000262919 [Q8N1B3-2] ENST00000576892; ENSP00000461135; ENSG00000262919 [Q8N1B3-1] |
GeneIDi | 92002 |
KEGGi | hsa:92002 |
UCSCi | uc033fat.2, human [Q8N1B3-1] |
Organism-specific databases
CTDi | 92002 |
DisGeNETi | 92002 |
EuPathDBi | HostDB:ENSG00000262919.7 |
GeneCardsi | CCNQ |
HGNCi | HGNC:28434, CCNQ |
HPAi | ENSG00000262919, Low tissue specificity |
MalaCardsi | CCNQ |
MIMi | 300707, phenotype 300708, gene |
neXtProti | NX_Q8N1B3 |
OpenTargetsi | ENSG00000262919 |
Orphaneti | 140952, Syndactyly-telecanthus-anogenital and renal malformations syndrome |
PharmGKBi | PA142671863 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0834, Eukaryota |
GeneTreei | ENSGT00940000155445 |
HOGENOMi | CLU_022000_2_0_1 |
InParanoidi | Q8N1B3 |
OMAi | IFECAAK |
OrthoDBi | 958680at2759 |
PhylomeDBi | Q8N1B3 |
Enzyme and pathway databases
PathwayCommonsi | Q8N1B3 |
SignaLinki | Q8N1B3 |
Miscellaneous databases
BioGRID-ORCSi | 92002, 13 hits in 68 CRISPR screens |
ChiTaRSi | FAM58A, human |
GenomeRNAii | 92002 |
Pharosi | Q8N1B3, Tdark |
PROi | PR:Q8N1B3 |
RNActi | Q8N1B3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000262919, Expressed in amniotic fluid and 215 other tissues |
ExpressionAtlasi | Q8N1B3, baseline and differential |
Genevisiblei | Q8N1B3, HS |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR028759, Cyclin-Q IPR043198, Cyclin/Ssn8 IPR006671, Cyclin_N |
PANTHERi | PTHR10026, PTHR10026, 1 hit PTHR10026:SF70, PTHR10026:SF70, 1 hit |
Pfami | View protein in Pfam PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits |
SUPFAMi | SSF47954, SSF47954, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCNQ_HUMAN | |
Accessioni | Q8N1B3Primary (citable) accession number: Q8N1B3 Secondary accession number(s): Q2I380 Q9BUU1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | August 21, 2007 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations