CCNQ

Protein namesⁱ	Recommended name: Cyclin-Q Alternative name(s): CDK10-activating cyclin Cyclin-M Cyclin-related protein FAM58A
Gene namesⁱ	Name:CCNQImported Synonyms:FAM58A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000262919.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28434 CCNQ
MIMⁱ	300708 gene
neXtProtⁱ	NX_Q8N1B3

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Toe syndactyly, telecanthus, and anogenital and renal malformations (STAR)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA syndrome characterized by anal, genital and renal tract anomalies, facial dysmorphism and syndactyly. Features include anal stenosis, a rectovaginal fistula, clitoral hypertrophy, a pelvic right kidney, toe syndactyly, and telecanthus.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	92002
MalaCards human disease database More...MalaCardsⁱ	CCNQ
MIMⁱ	300707 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000262919
Orphanetⁱ	140952 Syndactyly-telecanthus-anogenital and renal malformations syndrome
PharmGKBⁱ	PA142671863

Polymorphism and mutation databases

DMDMⁱ	156630447

DMDMⁱ

156630447

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000297567	1 – 248	Cyclin-QAdd BLAST		248

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q8N1B3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N1B3
PaxDbⁱ	Q8N1B3
PeptideAtlas More...PeptideAtlasⁱ	Q8N1B3
PRIDEⁱ	Q8N1B3
ProteomicsDBⁱ	71580 71581 [Q8N1B3-2]

PTM databases

iPTMnetⁱ	Q8N1B3
PhosphoSitePlusⁱ	Q8N1B3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000262919 Expressed in 202 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_FAM58A
ExpressionAtlasⁱ	Q8N1B3 baseline and differential
Genevisibleⁱ	Q8N1B3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA050137 HPA059843

HPAⁱ

HPA050137
HPA059843

Interactionⁱ

Subunit structureⁱ

Associates with CDK10 to promote its kinase activity. Interacts with SALL1.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CDK10	Q15131-1	7	EBI-3925043,EBI-11507283

With

Entry

#Exp.

IntAct

Notes

CDK10

Q15131-1

7

EBI-3925043,EBI-11507283

Protein-protein interaction databases

BioGridⁱ	124901, 19 interactors
ComplexPortalⁱ	CPX-326 Cyclin M-CDK10 complex
IntActⁱ	Q8N1B3, 11 interactors
STRINGⁱ	9606.ENSP00000384396

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N1B3
SMRⁱ	Q8N1B3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	6 – 10	Poly-Gly		5

Sequence similaritiesⁱ

Belongs to the cyclin family. Cyclin-like FAM58 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0834 Eukaryota COG5333 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119191
HOGENOMⁱ	HOG000044948
HOVERGENⁱ	HBG050836
InParanoidⁱ	Q8N1B3
OMAⁱ	IFECAAK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KKP
PhylomeDBⁱ	Q8N1B3

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00043 CYCLIN, 1 hit
InterProⁱ	View protein in InterPro IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR028759 Cyclin-rel_FAM58 IPR006671 Cyclin_N
PANTHERⁱ	PTHR10026:SF101 PTHR10026:SF101, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 2 hits
SUPFAMⁱ	SSF47954 SSF47954, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8N1B3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAPEGGGGG PAARGPEGQP APEARVHFRV ARFIMEAGVK LGMRSIPIAT 
        60         70         80         90        100
ACTIYHKFFC ETNLDAYDPY LIAMSSIYLA GKVEEQHLRT RDIINVSNRY 
       110        120        130        140        150
FNPSGEPLEL DSRFWELRDS IVQCELLMLR VLRFQVSFQH PHKYLLHYLV 
       160        170        180        190        200
SLQNWLNRHS WQRTPVAVTA WALLRDSYHG ALCLRFQAQH IAVAVLYLAL 
       210        220        230        240 
QVYGVEVPAE VEAEKPWWQV FNDDLTKPII DNIVSDLIQI YTMDTEIP

Length:248

Mass (Da):28,369

Last modified:August 21, 2007 - v2

Checksum:ⁱE7C11BC5D23BFB82

GO

Isoform 2 (identifier: Q8N1B3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
219-238: Missing.

« Hide

        10         20         30         40         50
MEAPEGGGGG PAARGPEGQP APEARVHFRV ARFIMEAGVK LGMRSIPIAT 
        60         70         80         90        100
ACTIYHKFFC ETNLDAYDPY LIAMSSIYLA GKVEEQHLRT RDIINVSNRY 
       110        120        130        140        150
FNPSGEPLEL DSRFWELRDS IVQCELLMLR VLRFQVSFQH PHKYLLHYLV 
       160        170        180        190        200
SLQNWLNRHS WQRTPVAVTA WALLRDSYHG ALCLRFQAQH IAVAVLYLAL 
       210        220 
QVYGVEVPAE VEAEKPWWQI YTMDTEIP

Note: No experimental confirmation available.

Show »

Length:228

Mass (Da):26,114

Checksum:ⁱ1849A4531BC802BC

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087X1W3	A0A087X1W3_HUMAN	Cyclin-Q Cyclin-Q	CCNQ	170	Annotation score:
K7EM37	K7EM37_HUMAN	Cyclin-Q Cyclin-Q	CCNQ	141	Annotation score:
H7C3N1	H7C3N1_HUMAN	Cyclin-Q Cyclin-Q	CCNQ	94	Annotation score:
A0A087X0G9	A0A087X0G9_HUMAN	Cyclin-Q Cyclin-Q	CCNQ	96	Annotation score:
A0A087WY98	A0A087WY98_HUMAN	Cyclin-Q Cyclin-Q	CCNQ	39	Annotation score:
A0A087WUL6	A0A087WUL6_HUMAN	Cyclin-Q Cyclin-Q	CCNQ	39	Annotation score:

Sequence cautionⁱ

The sequence AAH01909 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH07232 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH32121 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH71851 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_034642	183	C → S1 PublicationCorresponds to variant dbSNP:rs17850173Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_034527	219 – 238	Missing in isoform 2. 1 PublicationAdd BLAST		20

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC001909 mRNA Translation: AAH01909.4 Different initiation. BC007232 mRNA Translation: AAH07232.4 Different initiation. BC032121 mRNA Translation: AAH32121.1 Different initiation. BC071851 mRNA Translation: AAH71851.1 Different initiation. DQ323993 mRNA Translation: ABC88595.1 AY445048 mRNA Translation: AAS20614.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS76054.1 [Q8N1B3-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001124469.1, NM_001130997.2 [Q8N1B3-2] NP_689487.2, NM_152274.4 [Q8N1B3-1]
UniGeneⁱ	Hs.496943

Genome annotation databases

Ensemblⁱ	ENST00000440428; ENSP00000402949; ENSG00000262919 [Q8N1B3-2] ENST00000576892; ENSP00000461135; ENSG00000262919 [Q8N1B3-1]
GeneIDⁱ	92002
KEGGⁱ	hsa:92002
UCSC genome browser More...UCSCⁱ	uc033fat.2 human [Q8N1B3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q8N1B3	FAM58A isoform 1		PANTR		248	UniRef100_Q8N1B3
Family with sequence similarity 58, member A, isoform CRA_a		HUMAN		214
Q8N1B3-2	FAM58A isoform 4		PANTR		228	UniRef100_K7BUR5

Protein	Similar proteins		Species	Score	Length	Source
Q8N1B3	FAM58A isoform 1		PANTR		248	UniRef90_Q8N1B3
Family with sequence similarity 58, member A, isoform CRA_a		HUMAN		214
Uncharacterized protein		PANPA		250
UPI00062AB0DE		NOMLE		248
UPI0008F493CB		GORGO		228
+3
Q8N1B3-2	Cyclin-related protein FAM58A isoform 1		CALJA		248	UniRef90_F7GVF7
FAM58A isoform 4		PANTR		228
Cyclin-related protein FAM58A isoform 2		MACMU		228
Uncharacterized protein		MACNE		228
Uncharacterized protein		RHIBE		186
+12

Protein	Similar proteins		Species	Score	Length	Source
Q8N1B3	Cyclin-Q		RAT		250	UniRef50_Q8N1B3
Cyclin-Q		MOUSE		250
Cyclin-Q		DANRE		247
Putative cyclin-related protein FAM58B		HUMAN		252
FAM58A isoform 1		PANTR		248
+269

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC001909 mRNA Translation: AAH01909.4 Different initiation. BC007232 mRNA Translation: AAH07232.4 Different initiation. BC032121 mRNA Translation: AAH32121.1 Different initiation. BC071851 mRNA Translation: AAH71851.1 Different initiation. DQ323993 mRNA Translation: ABC88595.1 AY445048 mRNA Translation: AAS20614.1
CCDSⁱ	CCDS76054.1 [Q8N1B3-2]
RefSeqⁱ	NP_001124469.1, NM_001130997.2 [Q8N1B3-2] NP_689487.2, NM_152274.4 [Q8N1B3-1]
UniGeneⁱ	Hs.496943

3D structure databases

ProteinModelPortalⁱ	Q8N1B3
SMRⁱ	Q8N1B3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124901, 19 interactors
ComplexPortalⁱ	CPX-326 Cyclin M-CDK10 complex
IntActⁱ	Q8N1B3, 11 interactors
STRINGⁱ	9606.ENSP00000384396

PTM databases

iPTMnetⁱ	Q8N1B3
PhosphoSitePlusⁱ	Q8N1B3

Polymorphism and mutation databases

DMDMⁱ	156630447

DMDMⁱ

156630447

Proteomic databases

EPDⁱ	Q8N1B3
MaxQBⁱ	Q8N1B3
PaxDbⁱ	Q8N1B3
PeptideAtlasⁱ	Q8N1B3
PRIDEⁱ	Q8N1B3
ProteomicsDBⁱ	71580 71581 [Q8N1B3-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	92002
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000440428; ENSP00000402949; ENSG00000262919 [Q8N1B3-2] ENST00000576892; ENSP00000461135; ENSG00000262919 [Q8N1B3-1]
GeneIDⁱ	92002
KEGGⁱ	hsa:92002
UCSCⁱ	uc033fat.2 human [Q8N1B3-1]

Organism-specific databases

CTDⁱ	92002
DisGeNETⁱ	92002
EuPathDBⁱ	HostDB:ENSG00000262919.7
GeneCardsⁱ	CCNQ
H-InvDBⁱ	HIX0019181 HIX0171824
HGNCⁱ	HGNC:28434 CCNQ
HPAⁱ	HPA050137 HPA059843
MalaCardsⁱ	CCNQ
MIMⁱ	300707 phenotype 300708 gene
neXtProtⁱ	NX_Q8N1B3
OpenTargetsⁱ	ENSG00000262919
Orphanetⁱ	140952 Syndactyly-telecanthus-anogenital and renal malformations syndrome
PharmGKBⁱ	PA142671863
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0834 Eukaryota COG5333 LUCA
GeneTreeⁱ	ENSGT00760000119191
HOGENOMⁱ	HOG000044948
HOVERGENⁱ	HBG050836
InParanoidⁱ	Q8N1B3
OMAⁱ	IFECAAK
OrthoDBⁱ	EOG091G0KKP
PhylomeDBⁱ	Q8N1B3

Enzyme and pathway databases

SignaLinkⁱ	Q8N1B3

SignaLinkⁱ

Q8N1B3

Miscellaneous databases

GenomeRNAiⁱ	92002
Protein Ontology More...PROⁱ	PR:Q8N1B3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000262919 Expressed in 202 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_FAM58A
ExpressionAtlasⁱ	Q8N1B3 baseline and differential
Genevisibleⁱ	Q8N1B3 HS

Family and domain databases

CDDⁱ	cd00043 CYCLIN, 1 hit
InterProⁱ	View protein in InterPro IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR028759 Cyclin-rel_FAM58 IPR006671 Cyclin_N
PANTHERⁱ	PTHR10026:SF101 PTHR10026:SF101, 1 hit
Pfamⁱ	View protein in Pfam PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 2 hits
SUPFAMⁱ	SSF47954 SSF47954, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCNQ_HUMAN
Accessionⁱ	Q8N1B3Primary (citable) accession number: Q8N1B3 Secondary accession number(s): Q2I380 , Q330J9, Q96IU5, Q9BUU1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
	Last sequence update:	August 21, 2007
	Last modified:	November 7, 2018
	This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM

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UniProtKB - Q8N1B3 (CCNQ_HUMAN)

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Cyclin-Q

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ