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Entry version 105 (08 May 2019)
Sequence version 2 (18 May 2010)
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Protein

UPF0462 protein C4orf33

Gene

C4orf33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UPF0462 protein C4orf33
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C4orf33
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27025 C4orf33

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N1A6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000151470

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162379743

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C4orf33

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002957141 – 199UPF0462 protein C4orf33Add BLAST199

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8N1A6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N1A6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N1A6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N1A6

PeptideAtlas

More...
PeptideAtlasi
Q8N1A6

PRoteomics IDEntifications database

More...
PRIDEi
Q8N1A6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71579

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8N1A6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N1A6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000151470 Expressed in 166 organ(s), highest expression level in C1 segment of cervical spinal cord

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N1A6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N1A6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA061199

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126319, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N1A6, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000281146

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N1A6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0462 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IHBZ Eukaryota
ENOG4111M8H LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006284

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007615

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N1A6

Identification of Orthologs from Complete Genome Data

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OMAi
PWNYFPP

Database of Orthologous Groups

More...
OrthoDBi
1462707at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N1A6

TreeFam database of animal gene trees

More...
TreeFami
TF313077

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029674 C4orf33

The PANTHER Classification System

More...
PANTHERi
PTHR31475:SF3 PTHR31475:SF3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8N1A6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFKIEHTWD GFPVKHEPVF IRLNPGDRGV MMDISAPFFR DPPAPLGEPG
60 70 80 90 100
KPFNELWDYE VVEAFFLNDI TEQYLEVELC PHGQHLVLLL SGRRNVWKQE
110 120 130 140 150
LPLSFRMSRG ETKWEGKAYL PWSYFPPNVT KFNSFAIHGS KDKRSYEALY
160 170 180 190
PVPQHELQQG QKPDFHCLEY FKSFNFNTLL GEEWKQPESD LWLIEKCDI
Length:199
Mass (Da):23,468
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i797E0259540AFAA4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RD26D6RD26_HUMAN
UPF0462 protein C4orf33
C4orf33
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIT3D6RIT3_HUMAN
UPF0462 protein C4orf33
C4orf33
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIS3D6RIS3_HUMAN
UPF0462 protein C4orf33
C4orf33
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti130T → A in BAC03568 (PubMed:14702039).Curated1
Sequence conflicti159Q → R in AAH16358 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03333440R → M. Corresponds to variant dbSNP:rs35199409Ensembl.1
Natural variantiVAR_033335104S → L. Corresponds to variant dbSNP:rs2271570Ensembl.1
Natural variantiVAR_033336107M → V3 PublicationsCorresponds to variant dbSNP:rs337277Ensembl.1
Natural variantiVAR_033337166H → R1 PublicationCorresponds to variant dbSNP:rs17351999Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK091022 mRNA Translation: BAC03568.1
BX538164 mRNA Translation: CAD98044.1
AC093826 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05162.1
CH471056 Genomic DNA Translation: EAX05166.1
BC016358 mRNA Translation: AAH16358.1
BC032582 mRNA Translation: AAH32582.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3741.1

NCBI Reference Sequences

More...
RefSeqi
NP_001093253.1, NM_001099783.1
NP_775758.2, NM_173487.2
XP_005262791.1, XM_005262734.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000281146; ENSP00000281146; ENSG00000151470
ENST00000425929; ENSP00000401090; ENSG00000151470

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
132321

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:132321

UCSC genome browser

More...
UCSCi
uc003igu.5 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091022 mRNA Translation: BAC03568.1
BX538164 mRNA Translation: CAD98044.1
AC093826 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05162.1
CH471056 Genomic DNA Translation: EAX05166.1
BC016358 mRNA Translation: AAH16358.1
BC032582 mRNA Translation: AAH32582.1
CCDSiCCDS3741.1
RefSeqiNP_001093253.1, NM_001099783.1
NP_775758.2, NM_173487.2
XP_005262791.1, XM_005262734.4

3D structure databases

SMRiQ8N1A6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi126319, 3 interactors
IntActiQ8N1A6, 3 interactors
STRINGi9606.ENSP00000281146

PTM databases

iPTMnetiQ8N1A6
PhosphoSitePlusiQ8N1A6

Polymorphism and mutation databases

BioMutaiC4orf33

Proteomic databases

EPDiQ8N1A6
jPOSTiQ8N1A6
MaxQBiQ8N1A6
PaxDbiQ8N1A6
PeptideAtlasiQ8N1A6
PRIDEiQ8N1A6
ProteomicsDBi71579

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
132321
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281146; ENSP00000281146; ENSG00000151470
ENST00000425929; ENSP00000401090; ENSG00000151470
GeneIDi132321
KEGGihsa:132321
UCSCiuc003igu.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
132321

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C4orf33

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0004500
HGNCiHGNC:27025 C4orf33
HPAiHPA061199
neXtProtiNX_Q8N1A6
OpenTargetsiENSG00000151470
PharmGKBiPA162379743

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHBZ Eukaryota
ENOG4111M8H LUCA
GeneTreeiENSGT00390000006284
HOGENOMiHOG000007615
InParanoidiQ8N1A6
OMAiPWNYFPP
OrthoDBi1462707at2759
PhylomeDBiQ8N1A6
TreeFamiTF313077

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
132321

Protein Ontology

More...
PROi
PR:Q8N1A6

Gene expression databases

BgeeiENSG00000151470 Expressed in 166 organ(s), highest expression level in C1 segment of cervical spinal cord
ExpressionAtlasiQ8N1A6 baseline and differential
GenevisibleiQ8N1A6 HS

Family and domain databases

InterProiView protein in InterPro
IPR029674 C4orf33
PANTHERiPTHR31475:SF3 PTHR31475:SF3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD033_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N1A6
Secondary accession number(s): D3DNY2, Q6PJF3, Q8NBC5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 18, 2010
Last modified: May 8, 2019
This is version 105 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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