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Protein

Serine/threonine-protein kinase PDIK1L

Gene

PDIK1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37ATPPROSITE-ProRule annotation1
Active sitei164Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 22ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: GO_Central
  • protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8N165

Protein family/group databases

MoonDBiQ8N165 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PDIK1L (EC:2.7.11.1)
Alternative name(s):
PDLIM1-interacting kinase 1-like
Gene namesi
Name:PDIK1L
Synonyms:CLIK1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000175087.9
HGNCiHGNC:18981 PDIK1L
MIMi610785 gene
neXtProtiNX_Q8N165

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi149420
OpenTargetsiENSG00000175087
PharmGKBiPA134959839

Polymorphism and mutation databases

BioMutaiPDIK1L
DMDMi74762512

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000864941 – 341Serine/threonine-protein kinase PDIK1LAdd BLAST341

Proteomic databases

EPDiQ8N165
MaxQBiQ8N165
PaxDbiQ8N165
PeptideAtlasiQ8N165
PRIDEiQ8N165
ProteomicsDBi71568

PTM databases

iPTMnetiQ8N165
PhosphoSitePlusiQ8N165

Expressioni

Tissue specificityi

Expressed in liver, kidney, pancreas, spleen, thymus and prostate.1 Publication

Gene expression databases

BgeeiENSG00000175087 Expressed in 196 organ(s), highest expression level in neocortex
CleanExiHS_PDIK1L
ExpressionAtlasiQ8N165 baseline and differential
GenevisibleiQ8N165 HS

Organism-specific databases

HPAiHPA064157

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi127209, 9 interactors
IntActiQ8N165, 5 interactors
STRINGi9606.ENSP00000363387

Structurei

3D structure databases

ProteinModelPortaliQ8N165
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 334Protein kinasePROSITE-ProRule annotationAdd BLAST327

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0595 Eukaryota
ENOG410XR01 LUCA
GeneTreeiENSGT00880000137951
HOGENOMiHOG000231155
HOVERGENiHBG056829
InParanoidiQ8N165
KOiK17539
OMAiHRNQIIH
OrthoDBiEOG091G07MU
PhylomeDBiQ8N165
TreeFamiTF105336

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N165-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSSQPKYDL IREVGRGSYG VVYEAVIRKT SARVAVKKIR CHAPENVELA
60 70 80 90 100
LREFWALSSI KSQHPNVIHL EECILQKDGM VQKMSHGSNS SLYLQLVETS
110 120 130 140 150
LKGEIAFDPR SAYYLWFVMD FCDGGDMNEY LLSRKPNRKT NTSFMLQLSS
160 170 180 190 200
ALAFLHKNQI IHRDLKPDNI LISQTRLDTS DLEPTLKVAD FGLSKVCSAS
210 220 230 240 250
GQNPEEPVSV NKCFLSTACG TDFYMAPEVW EGHYTAKADI FALGIIIWAM
260 270 280 290 300
LERITFIDTE TKKELLGSYV KQGTEIVPVG EALLENPKME LLIPVKKKSM
310 320 330 340
NGRMKQLIKE MLAANPQDRP DAFELELRLV QIAFKDSSWE T
Length:341
Mass (Da):38,546
Last modified:October 1, 2002 - v1
Checksum:i0676FA66CCCA1364
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RHF8X6RHF8_HUMAN
Serine/threonine-protein kinase PDI...
PDIK1L
191Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411102 mRNA Translation: AAN03661.1
AK312872 mRNA Translation: BAG35724.1
AL391650 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07845.1
CH471059 Genomic DNA Translation: EAX07846.1
CH471059 Genomic DNA Translation: EAX07847.1
BC028713 mRNA Translation: AAH28713.1
AL834290 mRNA Translation: CAD38964.1
CCDSiCCDS274.1
RefSeqiNP_001230461.1, NM_001243532.1
NP_001230462.1, NM_001243533.1
NP_690048.1, NM_152835.4
XP_005245800.1, XM_005245743.4
UniGeneiHs.468801
Hs.736837

Genome annotation databases

EnsembliENST00000374269; ENSP00000363387; ENSG00000175087
ENST00000374271; ENSP00000363389; ENSG00000175087
ENST00000619836; ENSP00000480635; ENSG00000175087
GeneIDi149420
KEGGihsa:149420
UCSCiuc001blj.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411102 mRNA Translation: AAN03661.1
AK312872 mRNA Translation: BAG35724.1
AL391650 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07845.1
CH471059 Genomic DNA Translation: EAX07846.1
CH471059 Genomic DNA Translation: EAX07847.1
BC028713 mRNA Translation: AAH28713.1
AL834290 mRNA Translation: CAD38964.1
CCDSiCCDS274.1
RefSeqiNP_001230461.1, NM_001243532.1
NP_001230462.1, NM_001243533.1
NP_690048.1, NM_152835.4
XP_005245800.1, XM_005245743.4
UniGeneiHs.468801
Hs.736837

3D structure databases

ProteinModelPortaliQ8N165
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127209, 9 interactors
IntActiQ8N165, 5 interactors
STRINGi9606.ENSP00000363387

Protein family/group databases

MoonDBiQ8N165 Predicted

PTM databases

iPTMnetiQ8N165
PhosphoSitePlusiQ8N165

Polymorphism and mutation databases

BioMutaiPDIK1L
DMDMi74762512

Proteomic databases

EPDiQ8N165
MaxQBiQ8N165
PaxDbiQ8N165
PeptideAtlasiQ8N165
PRIDEiQ8N165
ProteomicsDBi71568

Protocols and materials databases

DNASUi149420
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374269; ENSP00000363387; ENSG00000175087
ENST00000374271; ENSP00000363389; ENSG00000175087
ENST00000619836; ENSP00000480635; ENSG00000175087
GeneIDi149420
KEGGihsa:149420
UCSCiuc001blj.5 human

Organism-specific databases

CTDi149420
DisGeNETi149420
EuPathDBiHostDB:ENSG00000175087.9
GeneCardsiPDIK1L
HGNCiHGNC:18981 PDIK1L
HPAiHPA064157
MIMi610785 gene
neXtProtiNX_Q8N165
OpenTargetsiENSG00000175087
PharmGKBiPA134959839
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0595 Eukaryota
ENOG410XR01 LUCA
GeneTreeiENSGT00880000137951
HOGENOMiHOG000231155
HOVERGENiHBG056829
InParanoidiQ8N165
KOiK17539
OMAiHRNQIIH
OrthoDBiEOG091G07MU
PhylomeDBiQ8N165
TreeFamiTF105336

Enzyme and pathway databases

SignaLinkiQ8N165

Miscellaneous databases

GenomeRNAii149420
PROiPR:Q8N165
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175087 Expressed in 196 organ(s), highest expression level in neocortex
CleanExiHS_PDIK1L
ExpressionAtlasiQ8N165 baseline and differential
GenevisibleiQ8N165 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDK1L_HUMAN
AccessioniPrimary (citable) accession number: Q8N165
Secondary accession number(s): B2R777
, D3DPK2, Q5T2I0, Q8NDB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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