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UniProtKB - Q8N165 (PDK1L_HUMAN)
Protein
Serine/threonine-protein kinase PDIK1L
Gene
PDIK1L
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 37 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 164 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 14 – 22 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein kinase activity Source: GO_Central
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
GO - Biological processi
- meiotic cell cycle Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8N165 |
SignaLinki | Q8N165 |
Protein family/group databases
MoonDBi | Q8N165, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase PDIK1L (EC:2.7.11.1)Alternative name(s): PDLIM1-interacting kinase 1-like |
Gene namesi | Name:PDIK1L Synonyms:CLIK1L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18981, PDIK1L |
MIMi | 610785, gene |
neXtProti | NX_Q8N165 |
VEuPathDBi | HostDB:ENSG00000175087 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 149420 |
OpenTargetsi | ENSG00000175087 |
PharmGKBi | PA134959839 |
Miscellaneous databases
Pharosi | Q8N165, Tdark |
Genetic variation databases
BioMutai | PDIK1L |
DMDMi | 74762512 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086494 | 1 – 341 | Serine/threonine-protein kinase PDIK1LAdd BLAST | 341 |
Proteomic databases
MassIVEi | Q8N165 |
MaxQBi | Q8N165 |
PaxDbi | Q8N165 |
PeptideAtlasi | Q8N165 |
PRIDEi | Q8N165 |
ProteomicsDBi | 71568 |
PTM databases
iPTMneti | Q8N165 |
PhosphoSitePlusi | Q8N165 |
Expressioni
Tissue specificityi
Expressed in liver, kidney, pancreas, spleen, thymus and prostate.1 Publication
Gene expression databases
Bgeei | ENSG00000175087, Expressed in neocortex and 213 other tissues |
ExpressionAtlasi | Q8N165, baseline and differential |
Genevisiblei | Q8N165, HS |
Organism-specific databases
HPAi | ENSG00000175087, Low tissue specificity |
Interactioni
Binary interactionsi
Q8N165
Protein-protein interaction databases
BioGRIDi | 127209, 14 interactors |
IntActi | Q8N165, 10 interactors |
STRINGi | 9606.ENSP00000363389 |
Miscellaneous databases
RNActi | Q8N165, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 334 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 327 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0595, Eukaryota |
GeneTreei | ENSGT00940000158412 |
HOGENOMi | CLU_026714_0_0_1 |
InParanoidi | Q8N165 |
OMAi | SMNARMK |
OrthoDBi | 813266at2759 |
PhylomeDBi | Q8N165 |
TreeFami | TF105336 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8N165-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSSQPKYDL IREVGRGSYG VVYEAVIRKT SARVAVKKIR CHAPENVELA
60 70 80 90 100
LREFWALSSI KSQHPNVIHL EECILQKDGM VQKMSHGSNS SLYLQLVETS
110 120 130 140 150
LKGEIAFDPR SAYYLWFVMD FCDGGDMNEY LLSRKPNRKT NTSFMLQLSS
160 170 180 190 200
ALAFLHKNQI IHRDLKPDNI LISQTRLDTS DLEPTLKVAD FGLSKVCSAS
210 220 230 240 250
GQNPEEPVSV NKCFLSTACG TDFYMAPEVW EGHYTAKADI FALGIIIWAM
260 270 280 290 300
LERITFIDTE TKKELLGSYV KQGTEIVPVG EALLENPKME LLIPVKKKSM
310 320 330 340
NGRMKQLIKE MLAANPQDRP DAFELELRLV QIAFKDSSWE T
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketX6RHF8 | X6RHF8_HUMAN | Serine/threonine-protein kinase PDI... | PDIK1L | 191 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF411102 mRNA Translation: AAN03661.1 AK312872 mRNA Translation: BAG35724.1 AL391650 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07845.1 CH471059 Genomic DNA Translation: EAX07846.1 CH471059 Genomic DNA Translation: EAX07847.1 BC028713 mRNA Translation: AAH28713.1 AL834290 mRNA Translation: CAD38964.1 |
CCDSi | CCDS274.1 |
RefSeqi | NP_001230461.1, NM_001243532.1 NP_001230462.1, NM_001243533.1 NP_690048.1, NM_152835.4 XP_005245800.1, XM_005245743.4 |
Genome annotation databases
Ensembli | ENST00000374269; ENSP00000363387; ENSG00000175087 ENST00000374271; ENSP00000363389; ENSG00000175087 ENST00000619836; ENSP00000480635; ENSG00000175087 |
GeneIDi | 149420 |
KEGGi | hsa:149420 |
MANE-Selecti | ENST00000374269.2; ENSP00000363387.1; NM_152835.5; NP_690048.1 |
UCSCi | uc001blj.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF411102 mRNA Translation: AAN03661.1 AK312872 mRNA Translation: BAG35724.1 AL391650 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07845.1 CH471059 Genomic DNA Translation: EAX07846.1 CH471059 Genomic DNA Translation: EAX07847.1 BC028713 mRNA Translation: AAH28713.1 AL834290 mRNA Translation: CAD38964.1 |
CCDSi | CCDS274.1 |
RefSeqi | NP_001230461.1, NM_001243532.1 NP_001230462.1, NM_001243533.1 NP_690048.1, NM_152835.4 XP_005245800.1, XM_005245743.4 |
3D structure databases
SMRi | Q8N165 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127209, 14 interactors |
IntActi | Q8N165, 10 interactors |
STRINGi | 9606.ENSP00000363389 |
Protein family/group databases
MoonDBi | Q8N165, Predicted |
PTM databases
iPTMneti | Q8N165 |
PhosphoSitePlusi | Q8N165 |
Genetic variation databases
BioMutai | PDIK1L |
DMDMi | 74762512 |
Proteomic databases
MassIVEi | Q8N165 |
MaxQBi | Q8N165 |
PaxDbi | Q8N165 |
PeptideAtlasi | Q8N165 |
PRIDEi | Q8N165 |
ProteomicsDBi | 71568 |
Protocols and materials databases
Antibodypediai | 30559, 135 antibodies from 22 providers |
DNASUi | 149420 |
Genome annotation databases
Ensembli | ENST00000374269; ENSP00000363387; ENSG00000175087 ENST00000374271; ENSP00000363389; ENSG00000175087 ENST00000619836; ENSP00000480635; ENSG00000175087 |
GeneIDi | 149420 |
KEGGi | hsa:149420 |
MANE-Selecti | ENST00000374269.2; ENSP00000363387.1; NM_152835.5; NP_690048.1 |
UCSCi | uc001blj.5, human |
Organism-specific databases
CTDi | 149420 |
DisGeNETi | 149420 |
GeneCardsi | PDIK1L |
HGNCi | HGNC:18981, PDIK1L |
HPAi | ENSG00000175087, Low tissue specificity |
MIMi | 610785, gene |
neXtProti | NX_Q8N165 |
OpenTargetsi | ENSG00000175087 |
PharmGKBi | PA134959839 |
VEuPathDBi | HostDB:ENSG00000175087 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0595, Eukaryota |
GeneTreei | ENSGT00940000158412 |
HOGENOMi | CLU_026714_0_0_1 |
InParanoidi | Q8N165 |
OMAi | SMNARMK |
OrthoDBi | 813266at2759 |
PhylomeDBi | Q8N165 |
TreeFami | TF105336 |
Enzyme and pathway databases
PathwayCommonsi | Q8N165 |
SignaLinki | Q8N165 |
Miscellaneous databases
BioGRID-ORCSi | 149420, 3 hits in 1080 CRISPR screens |
GenomeRNAii | 149420 |
Pharosi | Q8N165, Tdark |
PROi | PR:Q8N165 |
RNActi | Q8N165, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175087, Expressed in neocortex and 213 other tissues |
ExpressionAtlasi | Q8N165, baseline and differential |
Genevisiblei | Q8N165, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PDK1L_HUMAN | |
Accessioni | Q8N165Primary (citable) accession number: Q8N165 Secondary accession number(s): B2R777 Q8NDB3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2006 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families