PDIK1L

Functionⁱ

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	37	ATPPROSITE-ProRule annotation		1
Active siteⁱ	164	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	14 – 22	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein serine/threonine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

meiotic cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q8N165

SignaLinkⁱ

Q8N165

Protein family/group databases

MoonDBⁱ	Q8N165 Predicted

MoonDBⁱ

Q8N165 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase PDIK1L (EC:2.7.11.1) Alternative name(s): PDLIM1-interacting kinase 1-like
Gene namesⁱ	Name:PDIK1L Synonyms:CLIK1L
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000175087.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18981 PDIK1L
MIMⁱ	610785 gene
neXtProtⁱ	NX_Q8N165

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	149420
Open Targets More...OpenTargetsⁱ	ENSG00000175087
PharmGKBⁱ	PA134959839

Polymorphism and mutation databases

BioMutaⁱ	PDIK1L
DMDMⁱ	74762512

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086494	1 – 341	Serine/threonine-protein kinase PDIK1LAdd BLAST		341

Proteomic databases

EPDⁱ	Q8N165
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N165
PaxDbⁱ	Q8N165
PeptideAtlas More...PeptideAtlasⁱ	Q8N165
PRIDEⁱ	Q8N165
ProteomicsDBⁱ	71568

PTM databases

iPTMnetⁱ	Q8N165
PhosphoSitePlusⁱ	Q8N165

Expressionⁱ

Tissue specificityⁱ

Expressed in liver, kidney, pancreas, spleen, thymus and prostate.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000175087 Expressed in 196 organ(s), highest expression level in neocortex
CleanExⁱ	HS_PDIK1L
ExpressionAtlasⁱ	Q8N165 baseline and differential
Genevisibleⁱ	Q8N165 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA064157

HPAⁱ

HPA064157

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
C1orf174	Q8IYL3	9	EBI-6423298,EBI-715898
CTDSPL2	Q05D32	4	EBI-6423298,EBI-10039222

Protein-protein interaction databases

BioGridⁱ	127209, 9 interactors
IntActⁱ	Q8N165, 5 interactors
STRINGⁱ	9606.ENSP00000363387

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N165
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	8 – 334	Protein kinasePROSITE-ProRule annotationAdd BLAST		327

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0595 Eukaryota ENOG410XR01 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137951
HOGENOMⁱ	HOG000231155
HOVERGENⁱ	HBG056829
InParanoidⁱ	Q8N165
KEGG Orthology (KO) More...KOⁱ	K17539
OMAⁱ	HRNQIIH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07MU
PhylomeDBⁱ	Q8N165
TreeFamⁱ	TF105336

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q8N165-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVSSQPKYDL IREVGRGSYG VVYEAVIRKT SARVAVKKIR CHAPENVELA 
        60         70         80         90        100
LREFWALSSI KSQHPNVIHL EECILQKDGM VQKMSHGSNS SLYLQLVETS 
       110        120        130        140        150
LKGEIAFDPR SAYYLWFVMD FCDGGDMNEY LLSRKPNRKT NTSFMLQLSS 
       160        170        180        190        200
ALAFLHKNQI IHRDLKPDNI LISQTRLDTS DLEPTLKVAD FGLSKVCSAS 
       210        220        230        240        250
GQNPEEPVSV NKCFLSTACG TDFYMAPEVW EGHYTAKADI FALGIIIWAM 
       260        270        280        290        300
LERITFIDTE TKKELLGSYV KQGTEIVPVG EALLENPKME LLIPVKKKSM 
       310        320        330        340 
NGRMKQLIKE MLAANPQDRP DAFELELRLV QIAFKDSSWE T

Length:341

Mass (Da):38,546

Last modified:October 1, 2002 - v1

Checksum:ⁱ0676FA66CCCA1364

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	X6RHF8	X6RHF8_HUMAN		Serine/threonine-protein kinase PDI... Serine/threonine-protein kinase PDIK1L	PDIK1L	191	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF411102 mRNA Translation: AAN03661.1 AK312872 mRNA Translation: BAG35724.1 AL391650 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07845.1 CH471059 Genomic DNA Translation: EAX07846.1 CH471059 Genomic DNA Translation: EAX07847.1 BC028713 mRNA Translation: AAH28713.1 AL834290 mRNA Translation: CAD38964.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS274.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001230461.1, NM_001243532.1 NP_001230462.1, NM_001243533.1 NP_690048.1, NM_152835.4 XP_005245800.1, XM_005245743.4
UniGeneⁱ	Hs.468801 Hs.736837

Genome annotation databases

Ensemblⁱ	ENST00000374269; ENSP00000363387; ENSG00000175087 ENST00000374271; ENSP00000363389; ENSG00000175087 ENST00000619836; ENSP00000480635; ENSG00000175087
GeneIDⁱ	149420
KEGGⁱ	hsa:149420
UCSC genome browser More...UCSCⁱ	uc001blj.5 human

Protein	Similar proteins		Species	Score	Length	Source
Q8N165	Uncharacterized protein		AOTNA		405	UniRef100_Q8N165
Serine/threonine-protein kinase PDIK1L (Fragment)		HUMAN		191
PDIK1L isoform 4 (Fragment)		PONAB		191
PDIK1L isoform 2 (Fragment)		PANTR		191
PDLIM1 interacting kinase 1 like		MACMU		341
+17

Protein	Similar proteins		Species	Score	Length	Source
Q8N165	Serine/threonine-protein kinase PDIK1L		MOUSE		341	UniRef90_Q8N165
Serine/threonine-protein kinase PDIK1L		PONAB		340
Uncharacterized protein		AOTNA		405
Serine/threonine-protein kinase PDIK1L (Fragment)		HUMAN		191
PDIK1L isoform 2 (Fragment)		PANTR		191
+128

Protein	Similar proteins		Species	Score	Length	Source
Q8N165	Serine/threonine-protein kinase PDIK1L		MOUSE		341	UniRef50_Q8N165
Serine/threonine-protein kinase PDIK1L		PONAB		340
Serine/threonine-protein kinase pdik1l		DANRE		341
Serine/threonine-protein kinase pdik1l-B		XENLA		339
Uncharacterized protein		AOTNA		405
+362

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF411102 mRNA Translation: AAN03661.1 AK312872 mRNA Translation: BAG35724.1 AL391650 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07845.1 CH471059 Genomic DNA Translation: EAX07846.1 CH471059 Genomic DNA Translation: EAX07847.1 BC028713 mRNA Translation: AAH28713.1 AL834290 mRNA Translation: CAD38964.1
CCDSⁱ	CCDS274.1
RefSeqⁱ	NP_001230461.1, NM_001243532.1 NP_001230462.1, NM_001243533.1 NP_690048.1, NM_152835.4 XP_005245800.1, XM_005245743.4
UniGeneⁱ	Hs.468801 Hs.736837

3D structure databases

ProteinModelPortalⁱ	Q8N165
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127209, 9 interactors
IntActⁱ	Q8N165, 5 interactors
STRINGⁱ	9606.ENSP00000363387

Protein family/group databases

MoonDBⁱ	Q8N165 Predicted

MoonDBⁱ

Q8N165 Predicted

PTM databases

iPTMnetⁱ	Q8N165
PhosphoSitePlusⁱ	Q8N165

Polymorphism and mutation databases

BioMutaⁱ	PDIK1L
DMDMⁱ	74762512

Proteomic databases

EPDⁱ	Q8N165
MaxQBⁱ	Q8N165
PaxDbⁱ	Q8N165
PeptideAtlasⁱ	Q8N165
PRIDEⁱ	Q8N165
ProteomicsDBⁱ	71568

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	149420
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000374269; ENSP00000363387; ENSG00000175087 ENST00000374271; ENSP00000363389; ENSG00000175087 ENST00000619836; ENSP00000480635; ENSG00000175087
GeneIDⁱ	149420
KEGGⁱ	hsa:149420
UCSCⁱ	uc001blj.5 human

Organism-specific databases

CTDⁱ	149420
DisGeNETⁱ	149420
EuPathDBⁱ	HostDB:ENSG00000175087.9
GeneCardsⁱ	PDIK1L
HGNCⁱ	HGNC:18981 PDIK1L
HPAⁱ	HPA064157
MIMⁱ	610785 gene
neXtProtⁱ	NX_Q8N165
OpenTargetsⁱ	ENSG00000175087
PharmGKBⁱ	PA134959839
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0595 Eukaryota ENOG410XR01 LUCA
GeneTreeⁱ	ENSGT00880000137951
HOGENOMⁱ	HOG000231155
HOVERGENⁱ	HBG056829
InParanoidⁱ	Q8N165
KOⁱ	K17539
OMAⁱ	HRNQIIH
OrthoDBⁱ	EOG091G07MU
PhylomeDBⁱ	Q8N165
TreeFamⁱ	TF105336

Enzyme and pathway databases

SignaLinkⁱ	Q8N165

SignaLinkⁱ

Q8N165

Miscellaneous databases

GenomeRNAiⁱ	149420
Protein Ontology More...PROⁱ	PR:Q8N165
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000175087 Expressed in 196 organ(s), highest expression level in neocortex
CleanExⁱ	HS_PDIK1L
ExpressionAtlasⁱ	Q8N165 baseline and differential
Genevisibleⁱ	Q8N165 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PDK1L_HUMAN
Accessionⁱ	Q8N165Primary (citable) accession number: Q8N165 Secondary accession number(s): B2R777 , D3DPK2, Q5T2I0, Q8NDB3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N165 (PDK1L_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Serine/threonine-protein kinase PDIK1L

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ