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Entry version 169 (16 Oct 2019)
Sequence version 2 (24 Jan 2006)
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Protein

Cell cycle and apoptosis regulator protein 2

Gene

CCAR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:18235501, PubMed:18235502, PubMed:19131338, PubMed:19218236, PubMed:22446626, PubMed:23352644, PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978).15 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Metalloenzyme inhibitor, Repressor
Biological processApoptosis, Biological rhythms, Cell cycle, DNA damage, mRNA processing, mRNA splicing, Transcription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3371453 Regulation of HSF1-mediated heat shock response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell cycle and apoptosis regulator protein 2
Alternative name(s):
Cell division cycle and apoptosis regulator protein 2
DBIRD complex subunit KIAA1967
Deleted in breast cancer gene 1 protein
Short name:
DBC-1
Short name:
DBC.1
NET35
p30 DBC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCAR2
Synonyms:DBC1, KIAA1967
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23360 CCAR2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607359 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8N163

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi243 – 264Missing : Abolishes binding to SIRT1. 1 PublicationAdd BLAST22
Mutagenesisi454T → A: Significantly reduces association with SIRT1. Decreases sumoylation and the interaction of the sumoylated form with SIRT1. Inhibits CCAR2-PSIA3 interaction. Increases CCAR2-SENP1 interaction. Down-regulation of the signals related with the epithelial-mesenchymal transition of gastric cancer cells. 3 Publications1
Mutagenesisi454T → D: Significantly increases association with SIRT1 and induces p53 acetylation and apoptosis. Increases sumoylation and the interaction of the sumoylated form with SIRT1. Promotes CCAR2-PSIA3 interaction. Decreases CCAR2-SENP1 interaction. 2 Publications1
Mutagenesisi591K → R: Loss of sumoylation. 1 Publication1
Mutagenesisi667K → R: No effect on sumoylation. 1 Publication1
Mutagenesisi839K → R: No effect on sumoylation. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
57805

Open Targets

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OpenTargetsi
ENSG00000158941

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134993792

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q8N163

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCAR2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
85701135

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000508131 – 923Cell cycle and apoptosis regulator protein 2Add BLAST923

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei35PhosphothreonineCombined sources1
Modified residuei112N6-acetyllysine; by KAT81 Publication1
Modified residuei123N6-methyllysineCombined sources1
Modified residuei124PhosphoserineCombined sources1
Modified residuei180Omega-N-methylarginineCombined sources1
Modified residuei215N6-acetyllysine; by KAT8Combined sources1 Publication1
Modified residuei454Phosphothreonine; by ATM, ATR and CK2Combined sources2 Publications1
Modified residuei484PhosphothreonineCombined sources1
Modified residuei569PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki591Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3); alternate1 Publication
Cross-linki591Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei627PhosphoserineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei678PhosphoserineCombined sources1
Modified residuei681PhosphoserineCombined sources1
Modified residuei687PhosphoserineCombined sources1
Modified residuei808PhosphoserineCombined sources1
Modified residuei897PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

ATM/ATR-mediated phosphorylation at Thr-454 upon DNA damage promotes binding to SIRT1. Phosphorylation at Thr-454 promotes its sumoylation by switching the binding partner of CCAR2 from SENP1 to PIAS3.2 Publications
Acetylation at Lys-112 and Lys-215 by KAT8 prevents inhibitory binding to SIRT1 and increases its deacetylase activity.1 Publication
Genotoxic stress induces its sumoylation and sumoylation promotes the SIRT1-CCAR2 interaction which in turn inhibits SIRT1-mediated deacetylation of p53/TP53. Sumoylation leads to transcriptional activation of p53/TP53 by sequestering SIRT1 from p53/TP53. Desumoylated by SENP1.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8N163

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8N163

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8N163

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8N163

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8N163

PeptideAtlas

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PeptideAtlasi
Q8N163

PRoteomics IDEntifications database

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PRIDEi
Q8N163

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
71566 [Q8N163-1]
71567 [Q8N163-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8N163

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8N163

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q8N163

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level). Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000158941 Expressed in 190 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8N163 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8N163 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB072827
CAB072828
HPA019907
HPA019943

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the DBIRD complex.

Interacts with ZNF326/ZIRD; the interaction is direct.

Interacts (via N-terminus) with SIRT1, which inhibits the deacetylation of substrates.

Interacts (via N-terminus) with SUV39H1; this interaction abolishes the interaction with SIRT1.

Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity.

Interacts with NR1D1.

Interacts (via N-terminus) with ESR1 and ESR2.

Interacts (via N-terminus) with HDAC3 (via C-terminus).

Interacts with HDAC1 and MED2F.

Interacts with MCC.

Interacts (via N-terminus) with NR1H2 and NR1H3 in a ligand-independent manner.

Interacts with CSNK2A1.

Interacts (via N-terminus) with p53/TP53.

Interacts (via N-terminus) with BRCA1 (via the BRCT domains).

Interacts (via N-terminus) with CHEK2 (via protein kinase domain).

Interacts with PSEM3.

Interacts (via N-terminus) with PSIA3 and SENP1. The sumoylated form shows a preferential interaction with SIRT1 as compared to its unmodified form.

18 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121775, 140 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q8N163

Database of interacting proteins

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DIPi
DIP-38122N

Protein interaction database and analysis system

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IntActi
Q8N163, 77 interactors

Molecular INTeraction database

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MINTi
Q8N163

STRING: functional protein association networks

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STRINGi
9606.ENSP00000310670

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N163

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni610 – 670Interaction with MCC1 PublicationAdd BLAST61
Regioni704 – 923Interaction with NR1D11 PublicationAdd BLAST220

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili829 – 909Sequence analysisAdd BLAST81

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4246 Eukaryota
ENOG4111FW4 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063672

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N163

Identification of Orthologs from Complete Genome Data

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OMAi
LEMQRMV

Database of Orthologous Groups

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OrthoDBi
614048at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8N163

TreeFam database of animal gene trees

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TreeFami
TF316387

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR025224 CCAR1/CCAR2
IPR028811 CCAR2
IPR025954 DBC1/CARP1_inactive_NUDIX_dom
IPR011992 EF-hand-dom_pair
IPR025223 S1-like_RNA-bd_dom

The PANTHER Classification System

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PANTHERi
PTHR14304 PTHR14304, 1 hit
PTHR14304:SF12 PTHR14304:SF12, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF14443 DBC1, 1 hit
PF14444 S1-like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01122 DBC1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47473 SSF47473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N163-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQFKRQRIN PLPGGRNFSG TASTSLLGPP PGLLTPPVAT ELSQNARHLQ
60 70 80 90 100
GGEKQRVFTG IVTSLHDYFG VVDEEVFFQL SVVKGRLPQL GEKVLVKAAY
110 120 130 140 150
NPGQAVPWNA VKVQTLSNQP LLKSPAPPLL HVAALGQKQG ILGAQPQLIF
160 170 180 190 200
QPHRIPPLFP QKPLSLFQTS HTLHLSHLNR FPARGPHGRL DQGRSDDYDS
210 220 230 240 250
KKRKQRAGGE PWGAKKPRHD LPPYRVHLTP YTVDSPICDF LELQRRYRSL
260 270 280 290 300
LVPSDFLSVH LSWLSAFPLS QPFSLHHPSR IQVSSEKEAA PDAGAEPITA
310 320 330 340 350
DSDPAYSSKV LLLSSPGLEE LYRCCMLFVD DMAEPRETPE HPLKQIKFLL
360 370 380 390 400
GRKEEEAVLV GGEWSPSLDG LDPQADPQVL VRTAIRCAQA QTGIDLSGCT
410 420 430 440 450
KWWRFAEFQY LQPGPPRRLQ TVVVYLPDVW TIMPTLEEWE ALCQQKAAEA
460 470 480 490 500
APPTQEAQGE TEPTEQAPDA LEQAADTSRR NAETPEATTQ QETDTDLPEA
510 520 530 540 550
PPPPLEPAVI ARPGCVNLSL HGIVEDRRPK ERISFEVMVL AELFLEMLQR
560 570 580 590 600
DFGYRVYKML LSLPEKVVSP PEPEKEEAAK EEATKEEEAI KEEVVKEPKD
610 620 630 640 650
EAQNEGPATE SEAPLKEDGL LPKPLSSGGE EEEKPRGEAS EDLCEMALDP
660 670 680 690 700
ELLLLRDDGE EEFAGAKLED SEVRSVASNQ SEMEFSSLQD MPKELDPSAV
710 720 730 740 750
LPLDCLLAFV FFDANWCGYL HRRDLERILL TLGIRLSAEQ AKQLVSRVVT
760 770 780 790 800
QNICQYRSLQ YSRQEGLDGG LPEEVLFGNL DLLPPPGKST KPGAAPTEHK
810 820 830 840 850
ALVSHNGSLI NVGSLLQRAE QQDSGRLYLE NKIHTLELKL EESHNRFSAT
860 870 880 890 900
EVTNKTLAAE MQELRVRLAE AEETARTAER QKSQLQRLLQ ELRRRLTPLQ
910 920
LEIQRVVEKA DSWVEKEEPA PSN
Length:923
Mass (Da):102,902
Last modified:January 24, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1733934377E35D21
GO
Isoform 2 (identifier: Q8N163-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     910-923: ADSWVEKEEPAPSN → VRWGWTRRQHSSFP

Note: No experimental confirmation available.
Show »
Length:923
Mass (Da):103,143
Checksum:i3C1BB0DE06A20926
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V119G3V119_HUMAN
Cell cycle and apoptosis regulator ...
CCAR2 KIAA1967, hCG_2043023
598Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB24H0YB24_HUMAN
Cell cycle and apoptosis regulator ...
CCAR2
615Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X2B6A0A087X2B6_HUMAN
Cell cycle and apoptosis regulator ...
CCAR2
272Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHJ4E5RHJ4_HUMAN
Cell cycle and apoptosis regulator ...
CCAR2
277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFJ3E5RFJ3_HUMAN
Cell cycle and apoptosis regulator ...
CCAR2
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGU7E5RGU7_HUMAN
Cell cycle and apoptosis regulator ...
CCAR2
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHH8E5RHH8_HUMAN
Cell cycle and apoptosis regulator ...
CCAR2
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC58H0YC58_HUMAN
Cell cycle and apoptosis regulator ...
CCAR2
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC69H0YC69_HUMAN
Cell cycle and apoptosis regulator ...
CCAR2
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG02472 differs from that shown. Reason: Frameshift.Curated
The sequence BAB85553 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti47R → S in CAD38866 (PubMed:17974005).Curated1
Sequence conflicti47R → S in CAD39017 (PubMed:17974005).Curated1
Sequence conflicti850T → S in AAH65495 (PubMed:15489334).Curated1
Sequence conflicti908E → G in CAD38866 (PubMed:17974005).Curated1
Sequence conflicti908E → G in CAD39017 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017092910 – 923ADSWV…PAPSN → VRWGWTRRQHSSFP in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK096547 mRNA No translation available.
AK314535 mRNA Translation: BAG37126.1
AL834162 mRNA Translation: CAD38866.1
AL834351 mRNA Translation: CAD39016.1
AL834352 mRNA Translation: CAD39017.1
BX640952 mRNA Translation: CAE45976.1
AL137523 mRNA Translation: CAB70788.3
AC037459 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63658.1
CH471080 Genomic DNA Translation: EAW63661.1
BC018269 mRNA Translation: AAH18269.2
BC065495 mRNA Translation: AAH65495.1
AB075847 mRNA Translation: BAB85553.1 Different initiation.
AF293335 mRNA Translation: AAG02472.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS34863.1 [Q8N163-1]

Protein sequence database of the Protein Information Resource

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PIRi
T46368

NCBI Reference Sequences

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RefSeqi
NP_066997.3, NM_021174.5 [Q8N163-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000308511; ENSP00000310670; ENSG00000158941 [Q8N163-1]
ENST00000389279; ENSP00000373930; ENSG00000158941 [Q8N163-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57805

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57805

UCSC genome browser

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UCSCi
uc003xch.4 human [Q8N163-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096547 mRNA No translation available.
AK314535 mRNA Translation: BAG37126.1
AL834162 mRNA Translation: CAD38866.1
AL834351 mRNA Translation: CAD39016.1
AL834352 mRNA Translation: CAD39017.1
BX640952 mRNA Translation: CAE45976.1
AL137523 mRNA Translation: CAB70788.3
AC037459 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63658.1
CH471080 Genomic DNA Translation: EAW63661.1
BC018269 mRNA Translation: AAH18269.2
BC065495 mRNA Translation: AAH65495.1
AB075847 mRNA Translation: BAB85553.1 Different initiation.
AF293335 mRNA Translation: AAG02472.1 Frameshift.
CCDSiCCDS34863.1 [Q8N163-1]
PIRiT46368
RefSeqiNP_066997.3, NM_021174.5 [Q8N163-1]

3D structure databases

SMRiQ8N163
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121775, 140 interactors
CORUMiQ8N163
DIPiDIP-38122N
IntActiQ8N163, 77 interactors
MINTiQ8N163
STRINGi9606.ENSP00000310670

PTM databases

iPTMnetiQ8N163
PhosphoSitePlusiQ8N163
SwissPalmiQ8N163

Polymorphism and mutation databases

BioMutaiCCAR2
DMDMi85701135

Proteomic databases

EPDiQ8N163
jPOSTiQ8N163
MassIVEiQ8N163
MaxQBiQ8N163
PaxDbiQ8N163
PeptideAtlasiQ8N163
PRIDEiQ8N163
ProteomicsDBi71566 [Q8N163-1]
71567 [Q8N163-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57805

Genome annotation databases

EnsembliENST00000308511; ENSP00000310670; ENSG00000158941 [Q8N163-1]
ENST00000389279; ENSP00000373930; ENSG00000158941 [Q8N163-1]
GeneIDi57805
KEGGihsa:57805
UCSCiuc003xch.4 human [Q8N163-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57805
DisGeNETi57805

GeneCards: human genes, protein and diseases

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GeneCardsi
CCAR2
HGNCiHGNC:23360 CCAR2
HPAiCAB072827
CAB072828
HPA019907
HPA019943
MIMi607359 gene
neXtProtiNX_Q8N163
OpenTargetsiENSG00000158941
PharmGKBiPA134993792

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4246 Eukaryota
ENOG4111FW4 LUCA
GeneTreeiENSGT00530000063672
InParanoidiQ8N163
OMAiLEMQRMV
OrthoDBi614048at2759
PhylomeDBiQ8N163
TreeFamiTF316387

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CCAR2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KIAA1967

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57805
PharosiQ8N163

Protein Ontology

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PROi
PR:Q8N163

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000158941 Expressed in 190 organ(s), highest expression level in right testis
ExpressionAtlasiQ8N163 baseline and differential
GenevisibleiQ8N163 HS

Family and domain databases

InterProiView protein in InterPro
IPR025224 CCAR1/CCAR2
IPR028811 CCAR2
IPR025954 DBC1/CARP1_inactive_NUDIX_dom
IPR011992 EF-hand-dom_pair
IPR025223 S1-like_RNA-bd_dom
PANTHERiPTHR14304 PTHR14304, 1 hit
PTHR14304:SF12 PTHR14304:SF12, 1 hit
PfamiView protein in Pfam
PF14443 DBC1, 1 hit
PF14444 S1-like, 1 hit
SMARTiView protein in SMART
SM01122 DBC1, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCAR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N163
Secondary accession number(s): A6NL03
, B2RB79, D3DSR6, Q6P0Q9, Q8N3G7, Q8N8M1, Q8TF34, Q9H9Q9, Q9HD12, Q9NT55
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: October 16, 2019
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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