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UniProtKB - Q8N158 (GPC2_HUMAN)

Entry version 144 (02 Dec 2020)
Sequence version 1 (01 Oct 2002)
Previous versions | rss
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Protein

Glypican-2

Gene

GPC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N158

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1971475, A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022928, HS-GAG biosynthesis
R-HSA-2024096, HS-GAG degradation
R-HSA-3560783, Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801, Defective B3GAT3 causes JDSSDHD
R-HSA-3656237, Defective EXT2 causes exostoses 2
R-HSA-3656253, Defective EXT1 causes exostoses 1, TRPS2 and CHDS
R-HSA-4420332, Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-975634, Retinoid metabolism and transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glypican-2
Cleaved into the following chain:
Secreted glypican-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000213420.7

Human Gene Nomenclature Database

More...HGNCi		HGNC:4450, GPC2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618446, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N158

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		221914

Open Targets

More...OpenTargetsi		ENSG00000213420

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28831

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N158, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GPC2

Domain mapping of disease mutations (DMDM)

More...DMDMi		60390116

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001230324 – 554Glypican-2Add BLAST531
ChainiPRO_000033384124 – ?Secreted glypican-2
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000012304555 – 579Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi55O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi92O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi155O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi500O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi502O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi554GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Proteoglycan

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N158

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N158

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N158

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N158

PeptideAtlas

More...PeptideAtlasi		Q8N158

PRoteomics IDEntifications database

More...PRIDEi		Q8N158

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71563

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8N158, 5 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N158

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N158

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000213420, Expressed in subventricular zone (inner) (primate) and 186 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N158, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N158, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000213420, Group enriched (lymphoid tissue, skin, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via heparan sulfate) with PTN; this interaction promotes neurite outgrowth through binding of PTN with chondroitin sulfate of proteoglycans, thereby releasing PTPRS of chondroitin sulfate proteoglycans (CSPGs) and leading to binding with heparan sulfate of GPC2.

Interacts (heparan sulfate chain) with MDK; this interaction is inhibited by heparin followed by chondroitin sulfate E; this interaction induces GPC2 clustering through heparan sulfate chain; this interaction induces neuronal cell adhesion and neurite outgrowth (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		128766, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000292377

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N158, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N158

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glypican family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3821, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00990000203655

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_024658_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N158

Identification of Orthologs from Complete Genome Data

More...OMAi		AAPCWTG

Database of Orthologous Groups

More...OrthoDBi		611422at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N158

TreeFam database of animal gene trees

More...TreeFami		TF105317

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001863, Glypican
IPR031181, Glypican-2
IPR019803, Glypican_CS

The PANTHER Classification System

More...PANTHERi		PTHR10822, PTHR10822, 1 hit
PTHR10822:SF24, PTHR10822:SF24, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01153, Glypican, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01207, GLYPICAN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N158-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSALRPLLLL LLPLCPGPGP GPGSEAKVTR SCAETRQVLG ARGYSLNLIP 
        60         70         80         90        100
PALISGEHLR VCPQEYTCCS SETEQRLIRE TEATFRGLVE DSGSFLVHTL 
       110        120        130        140        150
AARHRKFDEF FLEMLSVAQH SLTQLFSHSY GRLYAQHALI FNGLFSRLRD 
       160        170        180        190        200
FYGESGEGLD DTLADFWAQL LERVFPLLHP QYSFPPDYLL CLSRLASSTD 
       210        220        230        240        250
GSLQPFGDSP RRLRLQITRT LVAARAFVQG LETGRNVVSE ALKVPVSEGC 
       260        270        280        290        300
SQALMRLIGC PLCRGVPSLM PCQGFCLNVV RGCLSSRGLE PDWGNYLDGL 
       310        320        330        340        350
LILADKLQGP FSFELTAESI GVKISEGLMY LQENSAKVSA QVFQECGPPD 
       360        370        380        390        400
PVPARNRRAP PPREEAGRLW SMVTEEERPT TAAGTNLHRL VWELRERLAR 
       410        420        430        440        450
MRGFWARLSL TVCGDSRMAA DASLEAAPCW TGAGRGRYLP PVVGGSPAEQ 
       460        470        480        490        500
VNNPELKVDA SGPDVPTRRR RLQLRAATAR MKTAALGHDL DGQDADEDAS 
       510        520        530        540        550
GSGGGQQYAD DWMAGAVAPP ARPPRPPYPP RRDGSGGKGG GGSARYNQGR 
       560        570 
SRSGGASIGF HTQTILILSL SALALLGPR
Length:579
Mass (Da):62,830
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1630E3A22BB83DFA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YXG7A0A0J9YXG7_HUMAN
Glypican-2
GPC2
134Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036045200D → N in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1333017606Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK096281 mRNA Translation: BAC04745.1
AL834418 mRNA Translation: CAD39080.1
CH236956 Genomic DNA Translation: EAL23846.1
CH471091 Genomic DNA Translation: EAW76578.1
BC027972 mRNA Translation: AAH27972.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5689.1

NCBI Reference Sequences

More...RefSeqi		NP_689955.1, NM_152742.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000292377; ENSP00000292377; ENSG00000213420

Database of genes from NCBI RefSeq genomes

More...GeneIDi		221914

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:221914

UCSC genome browser

More...UCSCi		uc003utv.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096281 mRNA Translation: BAC04745.1
AL834418 mRNA Translation: CAD39080.1
CH236956 Genomic DNA Translation: EAL23846.1
CH471091 Genomic DNA Translation: EAW76578.1
BC027972 mRNA Translation: AAH27972.1
CCDSiCCDS5689.1
RefSeqiNP_689955.1, NM_152742.2

3D structure databases

SMRiQ8N158
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128766, 2 interactors
STRINGi9606.ENSP00000292377

PTM databases

GlyGeniQ8N158, 5 sites
iPTMnetiQ8N158
PhosphoSitePlusiQ8N158

Polymorphism and mutation databases

BioMutaiGPC2
DMDMi60390116

Proteomic databases

EPDiQ8N158
jPOSTiQ8N158
MassIVEiQ8N158
PaxDbiQ8N158
PeptideAtlasiQ8N158
PRIDEiQ8N158
ProteomicsDBi71563

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		61583, 119 antibodies

The DNASU plasmid repository

More...DNASUi		221914

Genome annotation databases

EnsembliENST00000292377; ENSP00000292377; ENSG00000213420
GeneIDi221914
KEGGihsa:221914
UCSCiuc003utv.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		221914
DisGeNETi221914
EuPathDBiHostDB:ENSG00000213420.7

GeneCards: human genes, protein and diseases

More...GeneCardsi		GPC2
HGNCiHGNC:4450, GPC2
HPAiENSG00000213420, Group enriched (lymphoid tissue, skin, testis)
MIMi618446, gene
neXtProtiNX_Q8N158
OpenTargetsiENSG00000213420
PharmGKBiPA28831

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3821, Eukaryota
GeneTreeiENSGT00990000203655
HOGENOMiCLU_024658_2_1_1
InParanoidiQ8N158
OMAiAAPCWTG
OrthoDBi611422at2759
PhylomeDBiQ8N158
TreeFamiTF105317

Enzyme and pathway databases

PathwayCommonsiQ8N158
ReactomeiR-HSA-1971475, A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022928, HS-GAG biosynthesis
R-HSA-2024096, HS-GAG degradation
R-HSA-3560783, Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801, Defective B3GAT3 causes JDSSDHD
R-HSA-3656237, Defective EXT2 causes exostoses 2
R-HSA-3656253, Defective EXT1 causes exostoses 1, TRPS2 and CHDS
R-HSA-4420332, Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-975634, Retinoid metabolism and transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		221914, 9 hits in 842 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Glypican_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		221914
PharosiQ8N158, Tbio

Protein Ontology

More...PROi		PR:Q8N158
RNActiQ8N158, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000213420, Expressed in subventricular zone (inner) (primate) and 186 other tissues
ExpressionAtlasiQ8N158, baseline and differential
GenevisibleiQ8N158, HS

Family and domain databases

InterProiView protein in InterPro
IPR001863, Glypican
IPR031181, Glypican-2
IPR019803, Glypican_CS
PANTHERiPTHR10822, PTHR10822, 1 hit
PTHR10822:SF24, PTHR10822:SF24, 1 hit
PfamiView protein in Pfam
PF01153, Glypican, 1 hit
PROSITEiView protein in PROSITE
PS01207, GLYPICAN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGPC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N158
Secondary accession number(s): A4D2A7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 1, 2002
Last modified: December 2, 2020
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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