UniProtKB - Q8N158 (GPC2_HUMAN)
Glypican-2
GPC2
Functioni
GO - Biological processi
- cell migration Source: GO_Central
- glycosaminoglycan biosynthetic process Source: Reactome
- glycosaminoglycan catabolic process Source: Reactome
- neuron differentiation Source: Ensembl
- positive regulation of neuron projection development Source: UniProtKB
- regulation of protein localization to membrane Source: GO_Central
- regulation of signal transduction Source: InterPro
- retinoid metabolic process Source: Reactome
- smoothened signaling pathway Source: GO_Central
Enzyme and pathway databases
Reactomei | R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-2022928 HS-GAG biosynthesis R-HSA-2024096 HS-GAG degradation R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type R-HSA-3560801 Defective B3GAT3 causes JDSSDHD R-HSA-3656237 Defective EXT2 causes exostoses 2 R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-975634 Retinoid metabolism and transport |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:GPC2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4450 GPC2 |
MIMi | 618446 gene |
neXtProti | NX_Q8N158 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; GPI-anchor By similarity; Extracellular side By similarity
Extracellular region or secreted
- extracellular space By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: LIFEdb
Extracellular region or secreted
- collagen-containing extracellular matrix Source: InterPro
- extracellular region Source: GO_Central
- extracellular space Source: UniProtKB-SubCell
Golgi apparatus
- Golgi lumen Source: Reactome
Lysosome
- lysosomal lumen Source: Reactome
Plasma Membrane
- anchored component of plasma membrane Source: InterPro
- plasma membrane Source: Reactome
Other locations
- cell surface Source: GO_Central
- synapse Source: GO_Central
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 221914 |
OpenTargetsi | ENSG00000213420 |
PharmGKBi | PA28831 |
Miscellaneous databases
Pharosi | Q8N158 |
Polymorphism and mutation databases
BioMutai | GPC2 |
DMDMi | 60390116 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000012303 | 24 – 554 | Glypican-2Add BLAST | 531 | |
ChainiPRO_0000333841 | 24 – ? | Secreted glypican-2 | ||
PropeptideiPRO_0000012304 | 555 – 579 | Removed in mature formSequence analysisAdd BLAST | 25 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 55 | O-linked (Xyl...) (heparan sulfate) serineSequence analysis | 1 | |
Glycosylationi | 92 | O-linked (Xyl...) (heparan sulfate) serineSequence analysis | 1 | |
Glycosylationi | 155 | O-linked (Xyl...) (heparan sulfate) serineSequence analysis | 1 | |
Glycosylationi | 500 | O-linked (Xyl...) (heparan sulfate) serineSequence analysis | 1 | |
Glycosylationi | 502 | O-linked (Xyl...) (heparan sulfate) serineSequence analysis | 1 | |
Lipidationi | 554 | GPI-anchor amidated glycineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, ProteoglycanProteomic databases
EPDi | Q8N158 |
jPOSTi | Q8N158 |
MassIVEi | Q8N158 |
PaxDbi | Q8N158 |
PeptideAtlasi | Q8N158 |
PRIDEi | Q8N158 |
ProteomicsDBi | 71563 |
PTM databases
iPTMneti | Q8N158 |
PhosphoSitePlusi | Q8N158 |
Expressioni
Gene expression databases
Bgeei | ENSG00000213420 Expressed in 174 organ(s), highest expression level in forebrain |
ExpressionAtlasi | Q8N158 baseline and differential |
Genevisiblei | Q8N158 HS |
Organism-specific databases
HPAi | CAB025423 HPA053945 |
Interactioni
Subunit structurei
Interacts (via heparan sulfate) with PTN; this interaction promotes neurite outgrowth through binding of PTN with chondroitin sulfate of proteoglycans, thereby releasing PTPRS of chondroitin sulfate proteoglycans (CSPGs) and leading to binding with heparan sulfate of GPC2.
Interacts (heparan sulfate chain) with MDK; this interaction is inhibited by heparin followed by chondroitin sulfate E; this interaction induces GPC2 clustering through heparan sulfate chain; this interaction induces neuronal cell adhesion and neurite outgrowth (By similarity).
By similarityProtein-protein interaction databases
BioGridi | 128766, 1 interactor |
STRINGi | 9606.ENSP00000292377 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3821 Eukaryota ENOG410XST2 LUCA |
GeneTreei | ENSGT00950000182687 |
HOGENOMi | HOG000253003 |
InParanoidi | Q8N158 |
KOi | K08108 |
OMAi | AAPCWTG |
OrthoDBi | 611422at2759 |
PhylomeDBi | Q8N158 |
TreeFami | TF105317 |
Family and domain databases
InterProi | View protein in InterPro IPR001863 Glypican IPR031181 Glypican-2 IPR019803 Glypican_CS |
PANTHERi | PTHR10822 PTHR10822, 1 hit PTHR10822:SF24 PTHR10822:SF24, 1 hit |
Pfami | View protein in Pfam PF01153 Glypican, 1 hit |
PROSITEi | View protein in PROSITE PS01207 GLYPICAN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MSALRPLLLL LLPLCPGPGP GPGSEAKVTR SCAETRQVLG ARGYSLNLIP
60 70 80 90 100
PALISGEHLR VCPQEYTCCS SETEQRLIRE TEATFRGLVE DSGSFLVHTL
110 120 130 140 150
AARHRKFDEF FLEMLSVAQH SLTQLFSHSY GRLYAQHALI FNGLFSRLRD
160 170 180 190 200
FYGESGEGLD DTLADFWAQL LERVFPLLHP QYSFPPDYLL CLSRLASSTD
210 220 230 240 250
GSLQPFGDSP RRLRLQITRT LVAARAFVQG LETGRNVVSE ALKVPVSEGC
260 270 280 290 300
SQALMRLIGC PLCRGVPSLM PCQGFCLNVV RGCLSSRGLE PDWGNYLDGL
310 320 330 340 350
LILADKLQGP FSFELTAESI GVKISEGLMY LQENSAKVSA QVFQECGPPD
360 370 380 390 400
PVPARNRRAP PPREEAGRLW SMVTEEERPT TAAGTNLHRL VWELRERLAR
410 420 430 440 450
MRGFWARLSL TVCGDSRMAA DASLEAAPCW TGAGRGRYLP PVVGGSPAEQ
460 470 480 490 500
VNNPELKVDA SGPDVPTRRR RLQLRAATAR MKTAALGHDL DGQDADEDAS
510 520 530 540 550
GSGGGQQYAD DWMAGAVAPP ARPPRPPYPP RRDGSGGKGG GGSARYNQGR
560 570
SRSGGASIGF HTQTILILSL SALALLGPR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0J9YXG7 | A0A0J9YXG7_HUMAN | Glypican-2 | GPC2 | 134 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036045 | 200 | D → N in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1333017606Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096281 mRNA Translation: BAC04745.1 AL834418 mRNA Translation: CAD39080.1 CH236956 Genomic DNA Translation: EAL23846.1 CH471091 Genomic DNA Translation: EAW76578.1 BC027972 mRNA Translation: AAH27972.1 |
CCDSi | CCDS5689.1 |
RefSeqi | NP_689955.1, NM_152742.2 |
Genome annotation databases
Ensembli | ENST00000292377; ENSP00000292377; ENSG00000213420 |
GeneIDi | 221914 |
KEGGi | hsa:221914 |
UCSCi | uc003utv.3 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096281 mRNA Translation: BAC04745.1 AL834418 mRNA Translation: CAD39080.1 CH236956 Genomic DNA Translation: EAL23846.1 CH471091 Genomic DNA Translation: EAW76578.1 BC027972 mRNA Translation: AAH27972.1 |
CCDSi | CCDS5689.1 |
RefSeqi | NP_689955.1, NM_152742.2 |
3D structure databases
SMRi | Q8N158 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 128766, 1 interactor |
STRINGi | 9606.ENSP00000292377 |
PTM databases
iPTMneti | Q8N158 |
PhosphoSitePlusi | Q8N158 |
Polymorphism and mutation databases
BioMutai | GPC2 |
DMDMi | 60390116 |
Proteomic databases
EPDi | Q8N158 |
jPOSTi | Q8N158 |
MassIVEi | Q8N158 |
PaxDbi | Q8N158 |
PeptideAtlasi | Q8N158 |
PRIDEi | Q8N158 |
ProteomicsDBi | 71563 |
Protocols and materials databases
DNASUi | 221914 |
Genome annotation databases
Ensembli | ENST00000292377; ENSP00000292377; ENSG00000213420 |
GeneIDi | 221914 |
KEGGi | hsa:221914 |
UCSCi | uc003utv.3 human |
Organism-specific databases
CTDi | 221914 |
DisGeNETi | 221914 |
GeneCardsi | GPC2 |
HGNCi | HGNC:4450 GPC2 |
HPAi | CAB025423 HPA053945 |
MIMi | 618446 gene |
neXtProti | NX_Q8N158 |
OpenTargetsi | ENSG00000213420 |
PharmGKBi | PA28831 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3821 Eukaryota ENOG410XST2 LUCA |
GeneTreei | ENSGT00950000182687 |
HOGENOMi | HOG000253003 |
InParanoidi | Q8N158 |
KOi | K08108 |
OMAi | AAPCWTG |
OrthoDBi | 611422at2759 |
PhylomeDBi | Q8N158 |
TreeFami | TF105317 |
Enzyme and pathway databases
Reactomei | R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-2022928 HS-GAG biosynthesis R-HSA-2024096 HS-GAG degradation R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type R-HSA-3560801 Defective B3GAT3 causes JDSSDHD R-HSA-3656237 Defective EXT2 causes exostoses 2 R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-975634 Retinoid metabolism and transport |
Miscellaneous databases
GeneWikii | Glypican_2 |
GenomeRNAii | 221914 |
Pharosi | Q8N158 |
PROi | PR:Q8N158 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000213420 Expressed in 174 organ(s), highest expression level in forebrain |
ExpressionAtlasi | Q8N158 baseline and differential |
Genevisiblei | Q8N158 HS |
Family and domain databases
InterProi | View protein in InterPro IPR001863 Glypican IPR031181 Glypican-2 IPR019803 Glypican_CS |
PANTHERi | PTHR10822 PTHR10822, 1 hit PTHR10822:SF24 PTHR10822:SF24, 1 hit |
Pfami | View protein in Pfam PF01153 Glypican, 1 hit |
PROSITEi | View protein in PROSITE PS01207 GLYPICAN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPC2_HUMAN | |
Accessioni | Q8N158Primary (citable) accession number: Q8N158 Secondary accession number(s): A4D2A7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2005 |
Last sequence update: | October 1, 2002 | |
Last modified: | September 18, 2019 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot