UniProtKB - Q8N143 (BCL6B_HUMAN)

BLAST

>sp|Q8N143|BCL6B_HUMAN B-cell CLL/lymphoma 6 member B protein OS=Homo sapiens OX=9606 GN=BCL6B PE=2 SV=2
MGSPAAPEGALGYVREFTRHSSDVLGNLNELRLRGILTDVTLLVGGQPLRAHKAVLIACS
GFFYSIFRGRAGVGVDVLSLPGGPEARGFAPLLDFMYTSRLRLSPATAPAVLAAATYLQM
EHVVQACHRFIQASYEPLGISLRPLEAEPPTPPTAPPPGSPRRSEGHPDPPTESRSCSQG
PPSPASPDPKACNWKKYKYIVLNSQASQAGSLVGERSSGQPCPQARLPSGDEASSSSSSS
SSSSEEGPIPGPQSRLSPTAATVQFKCGAPASTPYLLTSQAQDTSGSPSERARPLPGSEF
FSCQNCEAVAGCSSGLDSLVPGDEDKPYKCQLCRSSFRYKGNLASHRTVHTGEKPYHCSI
CGARFNRPANLKTHSRIHSGEKPYKCETCGSRFVQVAHLRAHVLIHTGEKPYPCPTCGTR
FRHLQTLKSHVRIHTGEKPYHCDPCGLHFRHKSQLRLHLRQKHGAATNTKVHYHILGGP

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History
Entry version 129 (10 Oct 2018)
Sequence version 2 (18 May 2010)
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Protein

B-cell CLL/lymphoma 6 member B protein

Gene

BCL6B

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	328 – 350	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	356 – 378	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	384 – 406	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	412 – 434	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	440 – 463	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of cell differentiation Source: GO_Central
regulation of cell proliferation Source: GO_Central
regulation of inflammatory response Source: GO_Central
type 2 immune response Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: B-cell CLL/lymphoma 6 member B protein Alternative name(s): Bcl6-associated zinc finger protein Zinc finger protein 62
Gene namesⁱ	Name:BCL6B Synonyms:BAZF, ZNF62
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000161940.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1002 BCL6B
MIMⁱ	608992 gene
neXtProtⁱ	NX_Q8N143

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	255877
Open Targets More...OpenTargetsⁱ	ENSG00000161940
PharmGKBⁱ	PA25313

Polymorphism and mutation databases

BioMutaⁱ	BCL6B
DMDMⁱ	296434409

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047100	1 – 479	B-cell CLL/lymphoma 6 member B proteinAdd BLAST		479

Proteomic databases

PaxDbⁱ	Q8N143
PeptideAtlas More...PeptideAtlasⁱ	Q8N143
PRIDEⁱ	Q8N143
ProteomicsDBⁱ	71552
TopDownProteomicsⁱ	Q8N143

PTM databases

iPTMnetⁱ	Q8N143
PhosphoSitePlusⁱ	Q8N143

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed with higher expression found in heart and placenta.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000161940 Expressed in 182 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_BCL6B
ExpressionAtlasⁱ	Q8N143 baseline and differential
Genevisibleⁱ	Q8N143 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA059147 HPA075112

HPAⁱ

HPA059147
HPA075112

Interactionⁱ

Subunit structureⁱ

Associates with BCL6 through the BTB domain.By similarity

Protein-protein interaction databases

BioGridⁱ	129125, 18 interactors
STRINGⁱ	9606.ENSP00000293805

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N143
SMRⁱ	Q8N143
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	38 – 105	BTBPROSITE-ProRule annotationAdd BLAST		68

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	144 – 189	Pro-richAdd BLAST		46
Compositional biasⁱ	234 – 244	Ser-richAdd BLAST		11

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	328 – 350	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	356 – 378	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	384 – 406	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	412 – 434	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	440 – 463	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149041
HOVERGENⁱ	HBG004831
InParanoidⁱ	Q8N143
KEGG Orthology (KO) More...KOⁱ	K22648
OMAⁱ	KVHYHIL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G025U
PhylomeDBⁱ	Q8N143
TreeFamⁱ	TF330912

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 5 hits PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q8N143-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGSPAAPEGA LGYVREFTRH SSDVLGNLNE LRLRGILTDV TLLVGGQPLR 
        60         70         80         90        100
AHKAVLIACS GFFYSIFRGR AGVGVDVLSL PGGPEARGFA PLLDFMYTSR 
       110        120        130        140        150
LRLSPATAPA VLAAATYLQM EHVVQACHRF IQASYEPLGI SLRPLEAEPP 
       160        170        180        190        200
TPPTAPPPGS PRRSEGHPDP PTESRSCSQG PPSPASPDPK ACNWKKYKYI 
       210        220        230        240        250
VLNSQASQAG SLVGERSSGQ PCPQARLPSG DEASSSSSSS SSSSEEGPIP 
       260        270        280        290        300
GPQSRLSPTA ATVQFKCGAP ASTPYLLTSQ AQDTSGSPSE RARPLPGSEF 
       310        320        330        340        350
FSCQNCEAVA GCSSGLDSLV PGDEDKPYKC QLCRSSFRYK GNLASHRTVH 
       360        370        380        390        400
TGEKPYHCSI CGARFNRPAN LKTHSRIHSG EKPYKCETCG SRFVQVAHLR 
       410        420        430        440        450
AHVLIHTGEK PYPCPTCGTR FRHLQTLKSH VRIHTGEKPY HCDPCGLHFR 
       460        470 
HKSQLRLHLR QKHGAATNTK VHYHILGGP

Length:479

Mass (Da):51,531

Last modified:May 18, 2010 - v2

Checksum:ⁱAB04E3331A7DB8E6

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YGW0	H0YGW0_HUMAN	B-cell CLL/lymphoma 6 member B prot... B-cell CLL/lymphoma 6 member B protein	BCL6B	135	Annotation score:
I3L304	I3L304_HUMAN	B-cell CLL/lymphoma 6 member B prot... B-cell CLL/lymphoma 6 member B protein	BCL6B	133	Annotation score:
I3L396	I3L396_HUMAN	B-cell CLL/lymphoma 6 member B prot... B-cell CLL/lymphoma 6 member B protein	BCL6B	111	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	244	S → SS in BAC00962 (PubMed:11855826).Curated	1
Sequence conflictⁱ	244	S → SS in BAC00963 (PubMed:11855826).Curated	1
Sequence conflictⁱ	244	S → SS in AAH59404 (PubMed:15489334).Curated	1
Sequence conflictⁱ	306	C → S in AAH59404 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB076580 mRNA Translation: BAC00962.1 AB076581 Genomic DNA Translation: BAC00963.1 AC040977 Genomic DNA No translation available. BC059404 mRNA Translation: AAH59404.1
PIRⁱ	JC7812
NCBI Reference Sequences More...RefSeqⁱ	NP_862827.1, NM_181844.3
UniGeneⁱ	Hs.22575

Genome annotation databases

Ensemblⁱ	ENST00000293805; ENSP00000293805; ENSG00000161940
GeneIDⁱ	255877
KEGGⁱ	hsa:255877
UCSC genome browser More...UCSCⁱ	uc010clt.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N143	Uncharacterized protein		PANPA		479	UniRef100_Q8N143
B cell CLL/lymphoma 6B		GORGO		479

Protein	Similar proteins		Species	Score	Length	Source
Q8N143	Uncharacterized protein		PANPA		479	UniRef90_Q8N143
B cell CLL/lymphoma 6B		GORGO		479
B-cell CLL/lymphoma 6 member B protein		HETGA		481
B-cell CLL/lymphoma 6, member B (Zinc finger protein), isoform CRA_a		HUMAN		480
Uncharacterized protein		MUSPF		479
+59

Protein	Similar proteins		Species	Score	Length	Source
Q8N143	B-cell CLL/lymphoma 6 member B protein		MOUSE		474	UniRef50_O88282
Uncharacterized protein		NEOLE		488
B-cell CLL/lymphoma 6 member B protein		TUPCH		474
Uncharacterized protein		PIG		591
BCL6B isoform 3		PANTR		493
+147

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB076580 mRNA Translation: BAC00962.1 AB076581 Genomic DNA Translation: BAC00963.1 AC040977 Genomic DNA No translation available. BC059404 mRNA Translation: AAH59404.1
PIRⁱ	JC7812
RefSeqⁱ	NP_862827.1, NM_181844.3
UniGeneⁱ	Hs.22575

3D structure databases

ProteinModelPortalⁱ	Q8N143
SMRⁱ	Q8N143
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129125, 18 interactors
STRINGⁱ	9606.ENSP00000293805

PTM databases

iPTMnetⁱ	Q8N143
PhosphoSitePlusⁱ	Q8N143

Polymorphism and mutation databases

BioMutaⁱ	BCL6B
DMDMⁱ	296434409

Proteomic databases

PaxDbⁱ	Q8N143
PeptideAtlasⁱ	Q8N143
PRIDEⁱ	Q8N143
ProteomicsDBⁱ	71552
TopDownProteomicsⁱ	Q8N143

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	255877
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000293805; ENSP00000293805; ENSG00000161940
GeneIDⁱ	255877
KEGGⁱ	hsa:255877
UCSCⁱ	uc010clt.2 human

Organism-specific databases

CTDⁱ	255877
DisGeNETⁱ	255877
EuPathDBⁱ	HostDB:ENSG00000161940.10
GeneCardsⁱ	BCL6B
HGNCⁱ	HGNC:1002 BCL6B
HPAⁱ	HPA059147 HPA075112
MIMⁱ	608992 gene
neXtProtⁱ	NX_Q8N143
OpenTargetsⁱ	ENSG00000161940
PharmGKBⁱ	PA25313
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00920000149041
HOVERGENⁱ	HBG004831
InParanoidⁱ	Q8N143
KOⁱ	K22648
OMAⁱ	KVHYHIL
OrthoDBⁱ	EOG091G025U
PhylomeDBⁱ	Q8N143
TreeFamⁱ	TF330912

Miscellaneous databases

GenomeRNAiⁱ	255877
Protein Ontology More...PROⁱ	PR:Q8N143
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000161940 Expressed in 182 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_BCL6B
ExpressionAtlasⁱ	Q8N143 baseline and differential
Genevisibleⁱ	Q8N143 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 5 hits PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BCL6B_HUMAN
Accessionⁱ	Q8N143Primary (citable) accession number: Q8N143 Secondary accession number(s): Q6PCB4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
	Last sequence update:	May 18, 2010
	Last modified:	October 10, 2018
	This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N143 (BCL6B_HUMAN)

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B-cell CLL/lymphoma 6 member B protein

BCL6B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ