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Protein

B-cell CLL/lymphoma 6 member B protein

Gene

BCL6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri328 – 350C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 463C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell CLL/lymphoma 6 member B protein
Alternative name(s):
Bcl6-associated zinc finger protein
Zinc finger protein 62
Gene namesi
Name:BCL6B
Synonyms:BAZF, ZNF62
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000161940.10
HGNCiHGNC:1002 BCL6B
MIMi608992 gene
neXtProtiNX_Q8N143

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi255877
OpenTargetsiENSG00000161940
PharmGKBiPA25313

Polymorphism and mutation databases

BioMutaiBCL6B
DMDMi296434409

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471001 – 479B-cell CLL/lymphoma 6 member B proteinAdd BLAST479

Proteomic databases

PaxDbiQ8N143
PeptideAtlasiQ8N143
PRIDEiQ8N143
ProteomicsDBi71552
TopDownProteomicsiQ8N143

PTM databases

iPTMnetiQ8N143
PhosphoSitePlusiQ8N143

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression found in heart and placenta.1 Publication

Gene expression databases

BgeeiENSG00000161940 Expressed in 182 organ(s), highest expression level in heart left ventricle
CleanExiHS_BCL6B
ExpressionAtlasiQ8N143 baseline and differential
GenevisibleiQ8N143 HS

Organism-specific databases

HPAiHPA059147
HPA075112

Interactioni

Subunit structurei

Associates with BCL6 through the BTB domain.By similarity

Protein-protein interaction databases

BioGridi129125, 18 interactors
STRINGi9606.ENSP00000293805

Structurei

3D structure databases

ProteinModelPortaliQ8N143
SMRiQ8N143
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 105BTBPROSITE-ProRule annotationAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi144 – 189Pro-richAdd BLAST46
Compositional biasi234 – 244Ser-richAdd BLAST11

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri328 – 350C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 463C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149041
HOVERGENiHBG004831
InParanoidiQ8N143
KOiK22648
OMAiKVHYHIL
OrthoDBiEOG091G025U
PhylomeDBiQ8N143
TreeFamiTF330912

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8N143-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSPAAPEGA LGYVREFTRH SSDVLGNLNE LRLRGILTDV TLLVGGQPLR
60 70 80 90 100
AHKAVLIACS GFFYSIFRGR AGVGVDVLSL PGGPEARGFA PLLDFMYTSR
110 120 130 140 150
LRLSPATAPA VLAAATYLQM EHVVQACHRF IQASYEPLGI SLRPLEAEPP
160 170 180 190 200
TPPTAPPPGS PRRSEGHPDP PTESRSCSQG PPSPASPDPK ACNWKKYKYI
210 220 230 240 250
VLNSQASQAG SLVGERSSGQ PCPQARLPSG DEASSSSSSS SSSSEEGPIP
260 270 280 290 300
GPQSRLSPTA ATVQFKCGAP ASTPYLLTSQ AQDTSGSPSE RARPLPGSEF
310 320 330 340 350
FSCQNCEAVA GCSSGLDSLV PGDEDKPYKC QLCRSSFRYK GNLASHRTVH
360 370 380 390 400
TGEKPYHCSI CGARFNRPAN LKTHSRIHSG EKPYKCETCG SRFVQVAHLR
410 420 430 440 450
AHVLIHTGEK PYPCPTCGTR FRHLQTLKSH VRIHTGEKPY HCDPCGLHFR
460 470
HKSQLRLHLR QKHGAATNTK VHYHILGGP
Length:479
Mass (Da):51,531
Last modified:May 18, 2010 - v2
Checksum:iAB04E3331A7DB8E6
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YGW0H0YGW0_HUMAN
B-cell CLL/lymphoma 6 member B prot...
BCL6B
135Annotation score:
I3L304I3L304_HUMAN
B-cell CLL/lymphoma 6 member B prot...
BCL6B
133Annotation score:
I3L396I3L396_HUMAN
B-cell CLL/lymphoma 6 member B prot...
BCL6B
111Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti244S → SS in BAC00962 (PubMed:11855826).Curated1
Sequence conflicti244S → SS in BAC00963 (PubMed:11855826).Curated1
Sequence conflicti244S → SS in AAH59404 (PubMed:15489334).Curated1
Sequence conflicti306C → S in AAH59404 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076580 mRNA Translation: BAC00962.1
AB076581 Genomic DNA Translation: BAC00963.1
AC040977 Genomic DNA No translation available.
BC059404 mRNA Translation: AAH59404.1
PIRiJC7812
RefSeqiNP_862827.1, NM_181844.3
UniGeneiHs.22575

Genome annotation databases

EnsembliENST00000293805; ENSP00000293805; ENSG00000161940
GeneIDi255877
KEGGihsa:255877
UCSCiuc010clt.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076580 mRNA Translation: BAC00962.1
AB076581 Genomic DNA Translation: BAC00963.1
AC040977 Genomic DNA No translation available.
BC059404 mRNA Translation: AAH59404.1
PIRiJC7812
RefSeqiNP_862827.1, NM_181844.3
UniGeneiHs.22575

3D structure databases

ProteinModelPortaliQ8N143
SMRiQ8N143
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129125, 18 interactors
STRINGi9606.ENSP00000293805

PTM databases

iPTMnetiQ8N143
PhosphoSitePlusiQ8N143

Polymorphism and mutation databases

BioMutaiBCL6B
DMDMi296434409

Proteomic databases

PaxDbiQ8N143
PeptideAtlasiQ8N143
PRIDEiQ8N143
ProteomicsDBi71552
TopDownProteomicsiQ8N143

Protocols and materials databases

DNASUi255877
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293805; ENSP00000293805; ENSG00000161940
GeneIDi255877
KEGGihsa:255877
UCSCiuc010clt.2 human

Organism-specific databases

CTDi255877
DisGeNETi255877
EuPathDBiHostDB:ENSG00000161940.10
GeneCardsiBCL6B
HGNCiHGNC:1002 BCL6B
HPAiHPA059147
HPA075112
MIMi608992 gene
neXtProtiNX_Q8N143
OpenTargetsiENSG00000161940
PharmGKBiPA25313
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149041
HOVERGENiHBG004831
InParanoidiQ8N143
KOiK22648
OMAiKVHYHIL
OrthoDBiEOG091G025U
PhylomeDBiQ8N143
TreeFamiTF330912

Miscellaneous databases

GenomeRNAii255877
PROiPR:Q8N143
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161940 Expressed in 182 organ(s), highest expression level in heart left ventricle
CleanExiHS_BCL6B
ExpressionAtlasiQ8N143 baseline and differential
GenevisibleiQ8N143 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiBCL6B_HUMAN
AccessioniPrimary (citable) accession number: Q8N143
Secondary accession number(s): Q6PCB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: May 18, 2010
Last modified: October 10, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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