UniProtKB - Q8N143 (BCL6B_HUMAN)
Protein
B-cell CLL/lymphoma 6 member B protein
Gene
BCL6B
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 328 – 350 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 356 – 378 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 384 – 406 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 412 – 434 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 440 – 463 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of cell differentiation Source: GO_Central
- regulation of cell population proliferation Source: GO_Central
- regulation of cytokine production Source: GO_Central
- regulation of immune system process Source: GO_Central
- regulation of inflammatory response Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- type 2 immune response Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8N143 |
Names & Taxonomyi
Protein namesi | Recommended name: B-cell CLL/lymphoma 6 member B proteinAlternative name(s): Bcl6-associated zinc finger protein Zinc finger protein 62 |
Gene namesi | Name:BCL6B Synonyms:BAZF, ZNF62 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1002, BCL6B |
MIMi | 608992, gene |
neXtProti | NX_Q8N143 |
VEuPathDBi | HostDB:ENSG00000161940.10 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleoplasm Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 255877 |
OpenTargetsi | ENSG00000161940 |
PharmGKBi | PA25313 |
Miscellaneous databases
Pharosi | Q8N143, Tbio |
Genetic variation databases
BioMutai | BCL6B |
DMDMi | 296434409 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047100 | 1 – 479 | B-cell CLL/lymphoma 6 member B proteinAdd BLAST | 479 |
Proteomic databases
jPOSTi | Q8N143 |
MassIVEi | Q8N143 |
PaxDbi | Q8N143 |
PeptideAtlasi | Q8N143 |
PRIDEi | Q8N143 |
ProteomicsDBi | 71552 |
TopDownProteomicsi | Q8N143 |
PTM databases
iPTMneti | Q8N143 |
PhosphoSitePlusi | Q8N143 |
Expressioni
Tissue specificityi
Ubiquitously expressed with higher expression found in heart and placenta.1 Publication
Gene expression databases
Bgeei | ENSG00000161940, Expressed in heart left ventricle and 194 other tissues |
ExpressionAtlasi | Q8N143, baseline and differential |
Genevisiblei | Q8N143, HS |
Organism-specific databases
HPAi | ENSG00000161940, Low tissue specificity |
Interactioni
Subunit structurei
Associates with BCL6 through the BTB domain.
By similarityProtein-protein interaction databases
BioGRIDi | 129125, 32 interactors |
IntActi | Q8N143, 2 interactors |
STRINGi | 9606.ENSP00000293805 |
Miscellaneous databases
RNActi | Q8N143, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 105 | BTBPROSITE-ProRule annotationAdd BLAST | 68 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 144 – 189 | Pro-richAdd BLAST | 46 | |
Compositional biasi | 234 – 244 | Ser-richAdd BLAST | 11 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 328 – 350 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 356 – 378 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 384 – 406 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 412 – 434 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 440 – 463 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159844 |
HOGENOMi | CLU_024196_2_0_1 |
InParanoidi | Q8N143 |
OMAi | VCGARFN |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8N143 |
TreeFami | TF330912 |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q8N143-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSPAAPEGA LGYVREFTRH SSDVLGNLNE LRLRGILTDV TLLVGGQPLR
60 70 80 90 100
AHKAVLIACS GFFYSIFRGR AGVGVDVLSL PGGPEARGFA PLLDFMYTSR
110 120 130 140 150
LRLSPATAPA VLAAATYLQM EHVVQACHRF IQASYEPLGI SLRPLEAEPP
160 170 180 190 200
TPPTAPPPGS PRRSEGHPDP PTESRSCSQG PPSPASPDPK ACNWKKYKYI
210 220 230 240 250
VLNSQASQAG SLVGERSSGQ PCPQARLPSG DEASSSSSSS SSSSEEGPIP
260 270 280 290 300
GPQSRLSPTA ATVQFKCGAP ASTPYLLTSQ AQDTSGSPSE RARPLPGSEF
310 320 330 340 350
FSCQNCEAVA GCSSGLDSLV PGDEDKPYKC QLCRSSFRYK GNLASHRTVH
360 370 380 390 400
TGEKPYHCSI CGARFNRPAN LKTHSRIHSG EKPYKCETCG SRFVQVAHLR
410 420 430 440 450
AHVLIHTGEK PYPCPTCGTR FRHLQTLKSH VRIHTGEKPY HCDPCGLHFR
460 470
HKSQLRLHLR QKHGAATNTK VHYHILGGP
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YGW0 | H0YGW0_HUMAN | B-cell CLL/lymphoma 6 member B prot... | BCL6B | 135 | Annotation score: | ||
I3L304 | I3L304_HUMAN | B-cell CLL/lymphoma 6 member B prot... | BCL6B | 133 | Annotation score: | ||
I3L396 | I3L396_HUMAN | B-cell CLL/lymphoma 6 member B prot... | BCL6B | 111 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 244 | S → SS in BAC00962 (PubMed:11855826).Curated | 1 | |
Sequence conflicti | 244 | S → SS in BAC00963 (PubMed:11855826).Curated | 1 | |
Sequence conflicti | 244 | S → SS in AAH59404 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 306 | C → S in AAH59404 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB076580 mRNA Translation: BAC00962.1 AB076581 Genomic DNA Translation: BAC00963.1 AC040977 Genomic DNA No translation available. BC059404 mRNA Translation: AAH59404.1 |
CCDSi | CCDS42248.1 |
PIRi | JC7812 |
RefSeqi | NP_862827.1, NM_181844.3 |
Genome annotation databases
Ensembli | ENST00000293805; ENSP00000293805; ENSG00000161940 |
GeneIDi | 255877 |
KEGGi | hsa:255877 |
UCSCi | uc010clt.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB076580 mRNA Translation: BAC00962.1 AB076581 Genomic DNA Translation: BAC00963.1 AC040977 Genomic DNA No translation available. BC059404 mRNA Translation: AAH59404.1 |
CCDSi | CCDS42248.1 |
PIRi | JC7812 |
RefSeqi | NP_862827.1, NM_181844.3 |
3D structure databases
SMRi | Q8N143 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129125, 32 interactors |
IntActi | Q8N143, 2 interactors |
STRINGi | 9606.ENSP00000293805 |
PTM databases
iPTMneti | Q8N143 |
PhosphoSitePlusi | Q8N143 |
Genetic variation databases
BioMutai | BCL6B |
DMDMi | 296434409 |
Proteomic databases
jPOSTi | Q8N143 |
MassIVEi | Q8N143 |
PaxDbi | Q8N143 |
PeptideAtlasi | Q8N143 |
PRIDEi | Q8N143 |
ProteomicsDBi | 71552 |
TopDownProteomicsi | Q8N143 |
Protocols and materials databases
Antibodypediai | 23875, 77 antibodies |
DNASUi | 255877 |
Genome annotation databases
Ensembli | ENST00000293805; ENSP00000293805; ENSG00000161940 |
GeneIDi | 255877 |
KEGGi | hsa:255877 |
UCSCi | uc010clt.2, human |
Organism-specific databases
CTDi | 255877 |
DisGeNETi | 255877 |
GeneCardsi | BCL6B |
HGNCi | HGNC:1002, BCL6B |
HPAi | ENSG00000161940, Low tissue specificity |
MIMi | 608992, gene |
neXtProti | NX_Q8N143 |
OpenTargetsi | ENSG00000161940 |
PharmGKBi | PA25313 |
VEuPathDBi | HostDB:ENSG00000161940.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159844 |
HOGENOMi | CLU_024196_2_0_1 |
InParanoidi | Q8N143 |
OMAi | VCGARFN |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8N143 |
TreeFami | TF330912 |
Enzyme and pathway databases
PathwayCommonsi | Q8N143 |
Miscellaneous databases
BioGRID-ORCSi | 255877, 6 hits in 1018 CRISPR screens |
GenomeRNAii | 255877 |
Pharosi | Q8N143, Tbio |
PROi | PR:Q8N143 |
RNActi | Q8N143, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000161940, Expressed in heart left ventricle and 194 other tissues |
ExpressionAtlasi | Q8N143, baseline and differential |
Genevisiblei | Q8N143, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BCL6B_HUMAN | |
Accessioni | Q8N143Primary (citable) accession number: Q8N143 Secondary accession number(s): Q6PCB4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2004 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot