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UniProtKB - Q8N143 (BCL6B_HUMAN)

Entry version 142 (12 Aug 2020)
Sequence version 2 (18 May 2010)
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Protein

B-cell CLL/lymphoma 6 member B protein

Gene

BCL6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri328 – 350C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 463C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
B-cell CLL/lymphoma 6 member B protein
Alternative name(s):
Bcl6-associated zinc finger protein
Zinc finger protein 62
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCL6B
Synonyms:BAZF, ZNF62
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000161940.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:1002, BCL6B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608992, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N143

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		255877

Open Targets

More...OpenTargetsi		ENSG00000161940

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25313

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N143, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BCL6B

Domain mapping of disease mutations (DMDM)

More...DMDMi		296434409

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000471001 – 479B-cell CLL/lymphoma 6 member B proteinAdd BLAST479

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N143

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N143

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N143

PeptideAtlas

More...PeptideAtlasi		Q8N143

PRoteomics IDEntifications database

More...PRIDEi		Q8N143

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71552

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q8N143

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N143

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N143

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed with higher expression found in heart and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000161940, Expressed in heart left ventricle and 194 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N143, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N143, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000161940, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with BCL6 through the BTB domain.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129125, 21 interactors

Protein interaction database and analysis system

More...IntActi		Q8N143, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000293805

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N143, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N143

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 105BTBPROSITE-ProRule annotationAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi144 – 189Pro-richAdd BLAST46
Compositional biasi234 – 244Ser-richAdd BLAST11

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri328 – 350C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 463C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159844

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_024196_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N143

KEGG Orthology (KO)

More...KOi		K22648

Identification of Orthologs from Complete Genome Data

More...OMAi		VCGARFN

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N143

TreeFam database of animal gene trees

More...TreeFami		TF330912

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000210, BTB/POZ_dom
IPR011333, SKP1/BTB/POZ_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00651, BTB, 1 hit
PF00096, zf-C2H2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00225, BTB, 1 hit
SM00355, ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54695, SSF54695, 1 hit
SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50097, BTB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8N143-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSPAAPEGA LGYVREFTRH SSDVLGNLNE LRLRGILTDV TLLVGGQPLR 
        60         70         80         90        100
AHKAVLIACS GFFYSIFRGR AGVGVDVLSL PGGPEARGFA PLLDFMYTSR 
       110        120        130        140        150
LRLSPATAPA VLAAATYLQM EHVVQACHRF IQASYEPLGI SLRPLEAEPP 
       160        170        180        190        200
TPPTAPPPGS PRRSEGHPDP PTESRSCSQG PPSPASPDPK ACNWKKYKYI 
       210        220        230        240        250
VLNSQASQAG SLVGERSSGQ PCPQARLPSG DEASSSSSSS SSSSEEGPIP 
       260        270        280        290        300
GPQSRLSPTA ATVQFKCGAP ASTPYLLTSQ AQDTSGSPSE RARPLPGSEF 
       310        320        330        340        350
FSCQNCEAVA GCSSGLDSLV PGDEDKPYKC QLCRSSFRYK GNLASHRTVH 
       360        370        380        390        400
TGEKPYHCSI CGARFNRPAN LKTHSRIHSG EKPYKCETCG SRFVQVAHLR 
       410        420        430        440        450
AHVLIHTGEK PYPCPTCGTR FRHLQTLKSH VRIHTGEKPY HCDPCGLHFR 
       460        470 
HKSQLRLHLR QKHGAATNTK VHYHILGGP
Length:479
Mass (Da):51,531
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB04E3331A7DB8E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YGW0H0YGW0_HUMAN
B-cell CLL/lymphoma 6 member B prot...
BCL6B
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L396I3L396_HUMAN
B-cell CLL/lymphoma 6 member B prot...
BCL6B
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L304I3L304_HUMAN
B-cell CLL/lymphoma 6 member B prot...
BCL6B
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti244S → SS in BAC00962 (PubMed:11855826).Curated1
Sequence conflicti244S → SS in BAC00963 (PubMed:11855826).Curated1
Sequence conflicti244S → SS in AAH59404 (PubMed:15489334).Curated1
Sequence conflicti306C → S in AAH59404 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB076580 mRNA Translation: BAC00962.1
AB076581 Genomic DNA Translation: BAC00963.1
AC040977 Genomic DNA No translation available.
BC059404 mRNA Translation: AAH59404.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42248.1

Protein sequence database of the Protein Information Resource

More...PIRi		JC7812

NCBI Reference Sequences

More...RefSeqi		NP_862827.1, NM_181844.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000293805; ENSP00000293805; ENSG00000161940

Database of genes from NCBI RefSeq genomes

More...GeneIDi		255877

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:255877

UCSC genome browser

More...UCSCi		uc010clt.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076580 mRNA Translation: BAC00962.1
AB076581 Genomic DNA Translation: BAC00963.1
AC040977 Genomic DNA No translation available.
BC059404 mRNA Translation: AAH59404.1
CCDSiCCDS42248.1
PIRiJC7812
RefSeqiNP_862827.1, NM_181844.3

3D structure databases

SMRiQ8N143
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129125, 21 interactors
IntActiQ8N143, 2 interactors
STRINGi9606.ENSP00000293805

PTM databases

iPTMnetiQ8N143
PhosphoSitePlusiQ8N143

Polymorphism and mutation databases

BioMutaiBCL6B
DMDMi296434409

Proteomic databases

jPOSTiQ8N143
MassIVEiQ8N143
PaxDbiQ8N143
PeptideAtlasiQ8N143
PRIDEiQ8N143
ProteomicsDBi71552
TopDownProteomicsiQ8N143

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23875, 73 antibodies

The DNASU plasmid repository

More...DNASUi		255877

Genome annotation databases

EnsembliENST00000293805; ENSP00000293805; ENSG00000161940
GeneIDi255877
KEGGihsa:255877
UCSCiuc010clt.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		255877
DisGeNETi255877
EuPathDBiHostDB:ENSG00000161940.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		BCL6B
HGNCiHGNC:1002, BCL6B
HPAiENSG00000161940, Low tissue specificity
MIMi608992, gene
neXtProtiNX_Q8N143
OpenTargetsiENSG00000161940
PharmGKBiPA25313

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000159844
HOGENOMiCLU_024196_2_0_1
InParanoidiQ8N143
KOiK22648
OMAiVCGARFN
OrthoDBi1318335at2759
PhylomeDBiQ8N143
TreeFamiTF330912

Enzyme and pathway databases

PathwayCommonsiQ8N143

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		255877, 5 hits in 895 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		255877
PharosiQ8N143, Tbio

Protein Ontology

More...PROi		PR:Q8N143
RNActiQ8N143, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000161940, Expressed in heart left ventricle and 194 other tissues
ExpressionAtlasiQ8N143, baseline and differential
GenevisibleiQ8N143, HS

Family and domain databases

InterProiView protein in InterPro
IPR000210, BTB/POZ_dom
IPR011333, SKP1/BTB/POZ_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00651, BTB, 1 hit
PF00096, zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225, BTB, 1 hit
SM00355, ZnF_C2H2, 5 hits
SUPFAMiSSF54695, SSF54695, 1 hit
SSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50097, BTB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCL6B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N143
Secondary accession number(s): Q6PCB4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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