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Protein

Zinc finger protein 82 homolog

Gene

ZFP82

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 192C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 82 homolog
Short name:
Zfp-82
Alternative name(s):
Zinc finger protein 545
Gene namesi
Name:ZFP82
Synonyms:KIAA1948, ZNF545
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000181007.8
HGNCiHGNC:28682 ZFP82
neXtProtiNX_Q8N141

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi284406
OpenTargetsiENSG00000181007
PharmGKBiPA162409714

Polymorphism and mutation databases

BioMutaiZFP82
DMDMi74762511

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002331641 – 532Zinc finger protein 82 homologAdd BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki126Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8N141
MaxQBiQ8N141
PaxDbiQ8N141
PeptideAtlasiQ8N141
PRIDEiQ8N141
ProteomicsDBi71549

PTM databases

iPTMnetiQ8N141
PhosphoSitePlusiQ8N141

Expressioni

Gene expression databases

BgeeiENSG00000181007 Expressed in 196 organ(s), highest expression level in secondary oocyte
CleanExiHS_ZFP82
ExpressionAtlasiQ8N141 baseline and differential
GenevisibleiQ8N141 HS

Organism-specific databases

HPAiHPA051669
HPA060470

Interactioni

Protein-protein interaction databases

BioGridi129864, 2 interactors
IntActiQ8N141, 1 interactor
STRINGi9606.ENSP00000431265

Structurei

3D structure databases

ProteinModelPortaliQ8N141
SMRiQ8N141
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 77KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 192C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8N141
KOiK09228
OMAiHQRIHFV
OrthoDBiEOG091G02KC
PhylomeDBiQ8N141
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N141-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRSVMFSD VSIDFSPEEW EYLDLEQKDL YRDVMLENYS NLVSLGCFIS
60 70 80 90 100
KPDVISSLEQ GKEPWKVVRK GRRQYPDLET KYETKKLSLE NDIYEINLSQ
110 120 130 140 150
WKIMERIENH GLKGLILKND WESTGKIEGQ ERPQEGYFSS VKMPSEKVSS
160 170 180 190 200
YQKRTSVTPH QRLHFVDKPY ECKECGKAFR VRQQLTFHHR IHTGEKPYEC
210 220 230 240 250
KECGMAFRQT AHLTRHQRLH SGEKLYECKE CGEAFICGAD LRVHQKMHIG
260 270 280 290 300
EKPYECKECG KAFRVRGQLT LHQRIHTGEK PYVCKECGKA FRQYAHLTRH
310 320 330 340 350
QKLNSADRLY ECKECGKAFL CGSGLRVHHK LHTGEKPYEC KECGKAFRVR
360 370 380 390 400
QQLTLHQRIH TGEKPYECKE CGKTFSRGYH LILHHRIHTG EKPYECKECW
410 420 430 440 450
KAFSRYSQLI SHQSIHIGVK PYDCKECGKA FRLLSQLTQH QSIHIGEKPY
460 470 480 490 500
KCKECGKAFR LRQKLTLHQS IHTGEKPFEC KECRKAFRLN SSLIQHLRIH
510 520 530
SGEKPYECKE CKKAFRQHSH LTHHLKIHNV KI
Length:532
Mass (Da):62,578
Last modified:October 1, 2002 - v1
Checksum:i39B18CE288A82DDC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ERD5K7ERD5_HUMAN
Zinc finger protein 82 homolog
ZFP82
49Annotation score:

Sequence cautioni

The sequence BAB85534 differs from that shown. Probable cloning artifact.Curated
The sequence BAB85534 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128E → G in BAC11308 (PubMed:14702039).Curated1
Sequence conflicti158T → A in BAC11308 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074942 mRNA Translation: BAC11308.1
AL834267 mRNA Translation: CAD38942.1
BC032577 mRNA Translation: AAH32577.1
AB075828 mRNA Translation: BAB85534.1 Sequence problems.
CCDSiCCDS12493.1
RefSeqiNP_597723.1, NM_133466.3
UniGeneiHs.558734

Genome annotation databases

EnsembliENST00000392161; ENSP00000431265; ENSG00000181007
GeneIDi284406
KEGGihsa:284406
UCSCiuc002ody.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074942 mRNA Translation: BAC11308.1
AL834267 mRNA Translation: CAD38942.1
BC032577 mRNA Translation: AAH32577.1
AB075828 mRNA Translation: BAB85534.1 Sequence problems.
CCDSiCCDS12493.1
RefSeqiNP_597723.1, NM_133466.3
UniGeneiHs.558734

3D structure databases

ProteinModelPortaliQ8N141
SMRiQ8N141
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129864, 2 interactors
IntActiQ8N141, 1 interactor
STRINGi9606.ENSP00000431265

PTM databases

iPTMnetiQ8N141
PhosphoSitePlusiQ8N141

Polymorphism and mutation databases

BioMutaiZFP82
DMDMi74762511

Proteomic databases

EPDiQ8N141
MaxQBiQ8N141
PaxDbiQ8N141
PeptideAtlasiQ8N141
PRIDEiQ8N141
ProteomicsDBi71549

Protocols and materials databases

DNASUi284406
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392161; ENSP00000431265; ENSG00000181007
GeneIDi284406
KEGGihsa:284406
UCSCiuc002ody.2 human

Organism-specific databases

CTDi284406
DisGeNETi284406
EuPathDBiHostDB:ENSG00000181007.8
GeneCardsiZFP82
HGNCiHGNC:28682 ZFP82
HPAiHPA051669
HPA060470
neXtProtiNX_Q8N141
OpenTargetsiENSG00000181007
PharmGKBiPA162409714
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8N141
KOiK09228
OMAiHQRIHFV
OrthoDBiEOG091G02KC
PhylomeDBiQ8N141
TreeFamiTF341817

Miscellaneous databases

GenomeRNAii284406
PROiPR:Q8N141

Gene expression databases

BgeeiENSG00000181007 Expressed in 196 organ(s), highest expression level in secondary oocyte
CleanExiHS_ZFP82
ExpressionAtlasiQ8N141 baseline and differential
GenevisibleiQ8N141 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZFP82_HUMAN
AccessioniPrimary (citable) accession number: Q8N141
Secondary accession number(s): Q8NC63, Q8TF53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2002
Last modified: October 10, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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