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Protein

EP300-interacting inhibitor of differentiation 3

Gene

EID3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.1 Publication
Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.1 Publication

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processDNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3108214 SUMOylation of DNA damage response and repair proteins

Names & Taxonomyi

Protein namesi
Recommended name:
EP300-interacting inhibitor of differentiation 3
Short name:
EID-3
Alternative name(s):
E1A-like inhibitor of differentiation 3
EID-1-like inhibitor of differentiation 3
Non-structural maintenance of chromosomes element 4 homolog B
Short name:
NS4EB
Short name:
Non-SMC element 4 homolog B
Gene namesi
Name:EID3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000255150.1
HGNCiHGNC:32961 EID3
MIMi612986 gene
neXtProtiNX_Q8N140

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus, Telomere

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000255150
PharmGKBiPA162384552

Polymorphism and mutation databases

BioMutaiEID3
DMDMi74728487

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003159051 – 333EP300-interacting inhibitor of differentiation 3Add BLAST333

Proteomic databases

EPDiQ8N140
MaxQBiQ8N140
PaxDbiQ8N140
PeptideAtlasiQ8N140
PRIDEiQ8N140
ProteomicsDBi71548

PTM databases

iPTMnetiQ8N140
PhosphoSitePlusiQ8N140

Expressioni

Tissue specificityi

Highly expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000255150 Expressed in 149 organ(s), highest expression level in testis
CleanExiHS_EID3
ExpressionAtlasiQ8N140 baseline and differential
GenevisibleiQ8N140 HS

Organism-specific databases

HPAiHPA059367

Interactioni

Subunit structurei

Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3; EID3 seems to be a testis-specific subunit. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Homodimer, and heterodimer with EID2 (By similarity). Interacts with the C-terminal region of CREBBP.By similarity3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi138924, 30 interactors
IntActiQ8N140, 8 interactors
STRINGi9606.ENSP00000435619

Structurei

3D structure databases

ProteinModelPortaliQ8N140
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NSE4 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG2866 Eukaryota
COG5125 LUCA
GeneTreeiENSGT00390000011476
HOVERGENiHBG107841
InParanoidiQ8N140
KOiK22826
OMAiADEEKCR
OrthoDBiEOG091G0GO8
PhylomeDBiQ8N140
TreeFamiTF313999

Family and domain databases

InterProiView protein in InterPro
IPR027786 Nse4/EID
IPR014854 Nse4_C
IPR029225 Nse4_Nse3-bd
PANTHERiPTHR16140 PTHR16140, 1 hit
PfamiView protein in Pfam
PF15412 Nse4-Nse3_bdg, 1 hit
PF08743 Nse4_C, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N140-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKMDVSVRAA GCSDDLSSGE ADVDPKLLEL TADEEKCRSI RRQYRQLMYC
60 70 80 90 100
VRQNREDIVS SANNSLTEAL EEANVLFDGV SRTREAALDA RFLVMASDLG
110 120 130 140 150
KEKAKQLNSD MNFFNQLAFC DFLFLFVGLN WMEGDPDKLS DCDDSIALSF
160 170 180 190 200
WKAIEKEATS WMVKAETFHF VFGSFKLERS APKPRLEHQK KVRKMEENGN
210 220 230 240 250
MPTKLQKLDL SSYPEATEKN VERILGLLQT YFRKYPDTPV SYFEFVIDPN
260 270 280 290 300
SFSRTVENIF YVSFIVRDGF ARIRLDEDRL PILEPMNVNQ MGEGNDSSCH
310 320 330
GRKQGVISLT LQEWKNIVAA FEISEAMITY SSY
Length:333
Mass (Da):38,168
Last modified:October 1, 2002 - v1
Checksum:i3B35D08977C47C5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098698 mRNA Translation: BAC05385.1
CH471054 Genomic DNA Translation: EAW97747.1
BC027612 mRNA Translation: AAH27612.1
CCDSiCCDS53822.1
RefSeqiNP_001008395.1, NM_001008394.2
UniGeneiHs.659857

Genome annotation databases

EnsembliENST00000527879; ENSP00000435619; ENSG00000255150
GeneIDi493861
KEGGihsa:493861
UCSCiuc001tkw.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098698 mRNA Translation: BAC05385.1
CH471054 Genomic DNA Translation: EAW97747.1
BC027612 mRNA Translation: AAH27612.1
CCDSiCCDS53822.1
RefSeqiNP_001008395.1, NM_001008394.2
UniGeneiHs.659857

3D structure databases

ProteinModelPortaliQ8N140
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi138924, 30 interactors
IntActiQ8N140, 8 interactors
STRINGi9606.ENSP00000435619

PTM databases

iPTMnetiQ8N140
PhosphoSitePlusiQ8N140

Polymorphism and mutation databases

BioMutaiEID3
DMDMi74728487

Proteomic databases

EPDiQ8N140
MaxQBiQ8N140
PaxDbiQ8N140
PeptideAtlasiQ8N140
PRIDEiQ8N140
ProteomicsDBi71548

Protocols and materials databases

DNASUi493861
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000527879; ENSP00000435619; ENSG00000255150
GeneIDi493861
KEGGihsa:493861
UCSCiuc001tkw.4 human

Organism-specific databases

CTDi493861
EuPathDBiHostDB:ENSG00000255150.1
GeneCardsiEID3
HGNCiHGNC:32961 EID3
HPAiHPA059367
MIMi612986 gene
neXtProtiNX_Q8N140
OpenTargetsiENSG00000255150
PharmGKBiPA162384552
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2866 Eukaryota
COG5125 LUCA
GeneTreeiENSGT00390000011476
HOVERGENiHBG107841
InParanoidiQ8N140
KOiK22826
OMAiADEEKCR
OrthoDBiEOG091G0GO8
PhylomeDBiQ8N140
TreeFamiTF313999

Enzyme and pathway databases

ReactomeiR-HSA-3108214 SUMOylation of DNA damage response and repair proteins

Miscellaneous databases

GenomeRNAii493861
PROiPR:Q8N140
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000255150 Expressed in 149 organ(s), highest expression level in testis
CleanExiHS_EID3
ExpressionAtlasiQ8N140 baseline and differential
GenevisibleiQ8N140 HS

Family and domain databases

InterProiView protein in InterPro
IPR027786 Nse4/EID
IPR014854 Nse4_C
IPR029225 Nse4_Nse3-bd
PANTHERiPTHR16140 PTHR16140, 1 hit
PfamiView protein in Pfam
PF15412 Nse4-Nse3_bdg, 1 hit
PF08743 Nse4_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEID3_HUMAN
AccessioniPrimary (citable) accession number: Q8N140
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: October 10, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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