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Entry version 142 (17 Jun 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Centrobin

Gene

CNTROB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrobin
Alternative name(s):
Centrosomal BRCA2-interacting protein
LYST-interacting protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNTROB
Synonyms:LIP8
ORF Names:PP1221
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170037.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29616 CNTROB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611425 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N137

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
116840

Open Targets

More...
OpenTargetsi
ENSG00000170037

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485436

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N137 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CNTROB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74728485

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000762401 – 903CentrobinAdd BLAST903

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei80PhosphoserineCombined sources1
Modified residuei790PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N137

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N137

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N137

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N137

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N137

PeptideAtlas

More...
PeptideAtlasi
Q8N137

PRoteomics IDEntifications database

More...
PRIDEi
Q8N137

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71538 [Q8N137-1]
71539 [Q8N137-2]
71540 [Q8N137-3]
71541 [Q8N137-4]
71542 [Q8N137-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N137

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N137

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Preferentially incorporated into the newly assembled daughter centriole during centriole assembly at the late G1 or early S phase. Remains in the daughter centrioles throughout the cell cycle. At the next cycle of centriole duplication, its amount on the original daughter centriole eventually decreases.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170037 Expressed in testis and 187 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N137 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N137 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000170037 Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LYST.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125533, 126 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N137, 133 interactors

Molecular INTeraction database

More...
MINTi
Q8N137

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000369614

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N137 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N137

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni365 – 903Required for centrosome localizationAdd BLAST539

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili196 – 560Sequence analysisAdd BLAST365

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi573 – 777Pro-richAdd BLAST205

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410ISM1 Eukaryota
ENOG4111JSV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00610000086191

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_344733_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N137

KEGG Orthology (KO)

More...
KOi
K16468

Identification of Orthologs from Complete Genome Data

More...
OMAi
ELNGQHQ

Database of Orthologous Groups

More...
OrthoDBi
247531at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N137

TreeFam database of animal gene trees

More...
TreeFami
TF337444

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038923 Centrobin

The PANTHER Classification System

More...
PANTHERi
PTHR34439 PTHR34439, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N137-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATSADSPSS PLGAEDLLSD SSEPPGLNQV SSEVTSQLYA SLRLSRQAEA
60 70 80 90 100
TARAQLYLPS TSPPHEGLDG FAQELSRSLS VGLEKNLKKK DGSKHIFEME
110 120 130 140 150
SVRGQLQTML QTSRDTAYRD PLIPGAGSER REEDSFDSDS TATLLNTRPL
160 170 180 190 200
QDLSPSSSAQ ALEELFPRYT SLRPGPPLNP PDFQGLRDAL DSEHTRRKHC
210 220 230 240 250
ERHIQSLQTR VLELQQQLAV AVAADRKKDT MIEQLDKTLA RVVEGWNRHE
260 270 280 290 300
AERTEVLRGL QEEHQAAELT RSKQQETVTR LEQSLSEAME ALNREQESAR
310 320 330 340 350
LQQRERETLE EERQALTLRL EAEQQRCCVL QEERDAARAG QLSEHRELET
360 370 380 390 400
LRAALEEERQ TWAQQEHQLK EHYQALQEES QAQLEREKEK SQREAQAAWE
410 420 430 440 450
TQHQLALVQS EVRRLEGELD TARRERDALQ LEMSLVQARY ESQRIQLESE
460 470 480 490 500
LAVQLEQRVT ERLAQAQESS LRQAASLREH HRKQLQDLSG QHQQELASQL
510 520 530 540 550
AQFKVEMAER EERQQQVAED YELRLAREQA RVCELQSGNQ QLEEQRVELV
560 570 580 590 600
ERLQAMLQAH WDEANQLLST TLPPPNPPAP PAGPSSPGPQ EPEKEERRVW
610 620 630 640 650
TMPPMAVALK PVLQQSREAR DELPGAPPVL CSSSSDLSLL LGPSFQSQHS
660 670 680 690 700
FQPLEPKPDL TSSTAGAFSA LGAFHPDHRA ERPFPEEDPG PDGEGLLKQG
710 720 730 740 750
LPPAQLEGLK NFLHQLLETV PQNNENPSVD LLPPKSGPLT VPSWEEAPQV
760 770 780 790 800
PRIPPPVHKT KVPLAMASSL FRVPEPPSSH SQGSGPSSGS PERGGDGLTF
810 820 830 840 850
PRQLMEVSQL LRLYQARGWG ALPAEDLLLY LKRLEHSGTD GRGDNVPRRN
860 870 880 890 900
TDSRLGEIPR KEIPSQAVPR RLATAPKTEK PPARKKSGHP APSSMRSRGG

VWR
Length:903
Mass (Da):101,253
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F8E6DE4CEF51851
GO
Isoform 2 (identifier: Q8N137-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     838-838: G → GYKPGRKEEGFSGWKLDYGEWSG

Show »
Length:925
Mass (Da):103,812
Checksum:i996115AF2E10061C
GO
Isoform 3 (identifier: Q8N137-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     838-838: G → GR

Show »
Length:904
Mass (Da):101,409
Checksum:i10601C3ADA721982
GO
Isoform 4 (identifier: Q8N137-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     526-554: AREQARVCELQSGNQQLEEQRVELVERLQ → LLLDPPAPGLRSPRRRRGGSGLCLPWPWP
     555-903: Missing.

Show »
Length:554
Mass (Da):63,334
Checksum:i41E04379767F8EF7
GO
Isoform 5 (identifier: Q8N137-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     839-864: TDGRGDNVPRRNTDSRLGEIPRKEIP → YKPGRKEEGFSGWKLDYGEWSGCVLH
     865-903: Missing.

Show »
Length:864
Mass (Da):97,113
Checksum:i83F2A5096710E8FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1Z8I3L1Z8_HUMAN
Centrobin
CNTROB
198Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1B0I3L1B0_HUMAN
Centrobin
CNTROB
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0P9I3L0P9_HUMAN
Centrobin
CNTROB
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1A6I3L1A6_HUMAN
Centrobin
CNTROB
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L465I3L465_HUMAN
Centrobin
CNTROB
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1E9I3L1E9_HUMAN
Centrobin
CNTROB
26Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3N2I3L3N2_HUMAN
Centrobin
CNTROB
13Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG49447 differs from that shown. Reason: Frameshift.Curated
The sequence AAG49447 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAC11241 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti582A → D in AAG49447 (PubMed:11984006).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050877439R → Q. Corresponds to variant dbSNP:rs35421969Ensembl.1
Natural variantiVAR_024787578P → Q2 PublicationsCorresponds to variant dbSNP:rs11650083Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016836526 – 554AREQA…VERLQ → LLLDPPAPGLRSPRRRRGGS GLCLPWPWP in isoform 4. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_016837555 – 903Missing in isoform 4. 1 PublicationAdd BLAST349
Alternative sequenceiVSP_016838838G → GYKPGRKEEGFSGWKLDYGE WSG in isoform 2. 1 Publication1
Alternative sequenceiVSP_016839838G → GR in isoform 3. 1 Publication1
Alternative sequenceiVSP_016840839 – 864TDGRG…RKEIP → YKPGRKEEGFSGWKLDYGEW SGCVLH in isoform 5. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_016841865 – 903Missing in isoform 5. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY160226 mRNA Translation: AAO22135.1
AY160227 mRNA Translation: AAO22136.1
AF331638 mRNA Translation: AAL56068.2
AL137669 mRNA Translation: CAH10698.1
AL833907 mRNA Translation: CAD38763.1
AC104581 Genomic DNA No translation available.
BC014055 mRNA Translation: AAH14055.3
BC021134 mRNA Translation: AAH21134.1
AK074847 mRNA Translation: BAC11241.1 Different initiation.
AF141344 mRNA Translation: AAG49447.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS11126.1 [Q8N137-1]
CCDS32557.1 [Q8N137-2]
CCDS82063.1 [Q8N137-3]

NCBI Reference Sequences

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RefSeqi
NP_001032221.1, NM_001037144.5 [Q8N137-2]
NP_001317053.1, NM_001330124.1 [Q8N137-3]
NP_444279.2, NM_053051.3 [Q8N137-1]
XP_016879617.1, XM_017024128.1 [Q8N137-2]
XP_016879618.1, XM_017024129.1 [Q8N137-2]
XP_016879619.1, XM_017024130.1
XP_016879620.1, XM_017024131.1
XP_016879621.1, XM_017024132.1
XP_016879622.1, XM_017024133.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000380262; ENSP00000369614; ENSG00000170037 [Q8N137-2]
ENST00000563694; ENSP00000456335; ENSG00000170037 [Q8N137-1]
ENST00000565740; ENSP00000454840; ENSG00000170037 [Q8N137-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
116840

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:116840

UCSC genome browser

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UCSCi
uc060axe.1 human [Q8N137-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY160226 mRNA Translation: AAO22135.1
AY160227 mRNA Translation: AAO22136.1
AF331638 mRNA Translation: AAL56068.2
AL137669 mRNA Translation: CAH10698.1
AL833907 mRNA Translation: CAD38763.1
AC104581 Genomic DNA No translation available.
BC014055 mRNA Translation: AAH14055.3
BC021134 mRNA Translation: AAH21134.1
AK074847 mRNA Translation: BAC11241.1 Different initiation.
AF141344 mRNA Translation: AAG49447.1 Sequence problems.
CCDSiCCDS11126.1 [Q8N137-1]
CCDS32557.1 [Q8N137-2]
CCDS82063.1 [Q8N137-3]
RefSeqiNP_001032221.1, NM_001037144.5 [Q8N137-2]
NP_001317053.1, NM_001330124.1 [Q8N137-3]
NP_444279.2, NM_053051.3 [Q8N137-1]
XP_016879617.1, XM_017024128.1 [Q8N137-2]
XP_016879618.1, XM_017024129.1 [Q8N137-2]
XP_016879619.1, XM_017024130.1
XP_016879620.1, XM_017024131.1
XP_016879621.1, XM_017024132.1
XP_016879622.1, XM_017024133.1

3D structure databases

SMRiQ8N137
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125533, 126 interactors
IntActiQ8N137, 133 interactors
MINTiQ8N137
STRINGi9606.ENSP00000369614

PTM databases

iPTMnetiQ8N137
PhosphoSitePlusiQ8N137

Polymorphism and mutation databases

BioMutaiCNTROB
DMDMi74728485

Proteomic databases

EPDiQ8N137
jPOSTiQ8N137
MassIVEiQ8N137
MaxQBiQ8N137
PaxDbiQ8N137
PeptideAtlasiQ8N137
PRIDEiQ8N137
ProteomicsDBi71538 [Q8N137-1]
71539 [Q8N137-2]
71540 [Q8N137-3]
71541 [Q8N137-4]
71542 [Q8N137-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
12323 195 antibodies

The DNASU plasmid repository

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DNASUi
116840

Genome annotation databases

EnsembliENST00000380262; ENSP00000369614; ENSG00000170037 [Q8N137-2]
ENST00000563694; ENSP00000456335; ENSG00000170037 [Q8N137-1]
ENST00000565740; ENSP00000454840; ENSG00000170037 [Q8N137-3]
GeneIDi116840
KEGGihsa:116840
UCSCiuc060axe.1 human [Q8N137-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
116840
DisGeNETi116840
EuPathDBiHostDB:ENSG00000170037.13

GeneCards: human genes, protein and diseases

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GeneCardsi
CNTROB
HGNCiHGNC:29616 CNTROB
HPAiENSG00000170037 Tissue enhanced (testis)
MIMi611425 gene
neXtProtiNX_Q8N137
OpenTargetsiENSG00000170037
PharmGKBiPA143485436

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ISM1 Eukaryota
ENOG4111JSV LUCA
GeneTreeiENSGT00610000086191
HOGENOMiCLU_344733_0_0_1
InParanoidiQ8N137
KOiK16468
OMAiELNGQHQ
OrthoDBi247531at2759
PhylomeDBiQ8N137
TreeFamiTF337444

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
116840 15 hits in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CNTROB human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CNTROB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
116840
PharosiQ8N137 Tbio

Protein Ontology

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PROi
PR:Q8N137
RNActiQ8N137 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170037 Expressed in testis and 187 other tissues
ExpressionAtlasiQ8N137 baseline and differential
GenevisibleiQ8N137 HS

Family and domain databases

InterProiView protein in InterPro
IPR038923 Centrobin
PANTHERiPTHR34439 PTHR34439, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNTRB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N137
Secondary accession number(s): A6NHQ1
, Q331K3, Q69YV7, Q8NCB8, Q8WXV3, Q96CQ7, Q9C060
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2002
Last modified: June 17, 2020
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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