Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 145 (16 Oct 2019)
Sequence version 1 (01 Oct 2002)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Leucine-rich repeat LGI family member 4

Gene

LGI4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5682910 LGI-ADAM interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat LGI family member 4
Alternative name(s):
LGI1-like protein 3
Leucine-rich glioma-inactivated protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LGI4
Synonyms:LGIL3
ORF Names:UNQ6515/PRO21485
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18712 LGI4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608303 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N135

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Arthrogryposis multiplex congenita, neurogenic, with myelin defect (AMCNMY)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of arthrogryposis multiplex congenita, a developmental condition characterized by multiple joint contractures resulting from reduced or absent fetal movements. AMCNMY is an autosomal recessive severe form with onset in utero. Most affected individuals die in utero. Those who survive have generalized contractures and hypotonia. The disorder is caused by a neurogenic defect and poor or absent myelin formation around peripheral nerves rather than by a muscular defect.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080055258R → P in AMCNMY. 1 PublicationCorresponds to variant dbSNP:rs755500591EnsemblClinVar.1
Natural variantiVAR_080056288 – 537Missing in AMCNMY. 1 PublicationAdd BLAST250
Natural variantiVAR_080057434V → D in AMCNMY. 1 PublicationCorresponds to variant dbSNP:rs1064797094EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
163175

MalaCards human disease database

More...
MalaCardsi
LGI4
MIMi617468 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000153902

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2680 Hypomyelination neuropathy-arthrogryposis syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38656

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N135

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LGI4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
32469741

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001771220 – 537Leucine-rich repeat LGI family member 4Add BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N135

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N135

PeptideAtlas

More...
PeptideAtlasi
Q8N135

PRoteomics IDEntifications database

More...
PRIDEi
Q8N135

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71534 [Q8N135-1]
71535 [Q8N135-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N135

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N135

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest expression in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000153902 Expressed in 167 organ(s), highest expression level in tibial nerve

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N135 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N135 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042116
HPA043556

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can bind to ADAM11, ADAM22 and ADAM23.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127855, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000312273

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N135

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati53 – 74LRR 1Add BLAST22
Repeati77 – 98LRR 2Add BLAST22
Repeati101 – 122LRR 3Add BLAST22
Repeati125 – 146LRR 4Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini158 – 208LRRCTAdd BLAST51
Repeati210 – 252EAR 1PROSITE-ProRule annotationAdd BLAST43
Repeati256 – 298EAR 2PROSITE-ProRule annotationAdd BLAST43
Repeati302 – 349EAR 3PROSITE-ProRule annotationAdd BLAST48
Repeati351 – 394EAR 4PROSITE-ProRule annotationAdd BLAST44
Repeati396 – 439EAR 5PROSITE-ProRule annotationAdd BLAST44
Repeati441 – 483EAR 6PROSITE-ProRule annotationAdd BLAST43
Repeati487 – 532EAR 7PROSITE-ProRule annotationAdd BLAST46

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJHU Eukaryota
ENOG4111DWK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162018

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000286015

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N135

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHWFGGR

Database of Orthologous Groups

More...
OrthoDBi
365688at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N135

TreeFam database of animal gene trees

More...
TreeFami
TF333155

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR009039 EAR
IPR005492 EPTP
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03736 EPTP, 3 hits
PF13855 LRR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 3 hits
SM00082 LRRCT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50912 EAR, 7 hits
PS51450 LRR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N135-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGGAGILLLL LAGAGVVVAW RPPKGKCPLR CSCSKDSALC EGSPDLPVSF
60 70 80 90 100
SPTLLSLSLV RTGVTQLKAG SFLRIPSLHL LLFTSNSFSV IEDDAFAGLS
110 120 130 140 150
HLQYLFIEDN EIGSISKNAL RGLRSLTHLS LANNHLETLP RFLFRGLDTL
160 170 180 190 200
THVDLRGNPF QCDCRVLWLL QWMPTVNASV GTGACAGPAS LSHMQLHHLD
210 220 230 240 250
PKTFKCRAIE LSWFQTVGES ALSVEPFSYQ GEPHIVLAQP FAGRCLILSW
260 270 280 290 300
DYSLQRFRPE EELPAASVVS CKPLVLGPSL FVLAARLWGG SQLWARPSPG
310 320 330 340 350
LRLAPTQTLA PRRLLRPNDA ELLWLEGQPC FVVADASKAG STTLLCRDGP
360 370 380 390 400
GFYPHQSLHA WHRDTDAEAL ELDGRPHLLL ASASQRPVLF HWTGGRFERR
410 420 430 440 450
TDIPEAEDVY ATRHFQAGGD VFLCLTRYIG DSMVMRWDGS MFRLLQQLPS
460 470 480 490 500
RGAHVFQPLL IARDQLAILG SDFAFSQVLR LEPDKGLLEP LQELGPPALV
510 520 530
APRAFAHITM AGRRFLFAAC FKGPTQIYQH HEIDLSA
Length:537
Mass (Da):59,141
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47B920C809679926
GO
Isoform 2 (identifier: Q8N135-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-261: ELSWFQTVGE...YSLQRFRPEE → GGGLSRWGGR...CLPEPQFSHL
     262-537: Missing.

Show »
Length:261
Mass (Da):28,231
Checksum:i07AC514EF74512B6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MVC2A8MVC2_HUMAN
Leucine-rich repeat LGI family memb...
LGI4
494Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENQ0K7ENQ0_HUMAN
Leucine-rich repeat LGI family memb...
LGI4
378Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080055258R → P in AMCNMY. 1 PublicationCorresponds to variant dbSNP:rs755500591EnsemblClinVar.1
Natural variantiVAR_080056288 – 537Missing in AMCNMY. 1 PublicationAdd BLAST250
Natural variantiVAR_080057434V → D in AMCNMY. 1 PublicationCorresponds to variant dbSNP:rs1064797094EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009230210 – 261ELSWF…FRPEE → GGGLSRWGGRREIWGKGCQG QEARLTPCPAISRSGKTLSK QHCLPEPQFSHL in isoform 2. 2 PublicationsAdd BLAST52
Alternative sequenceiVSP_009231262 – 537Missing in isoform 2. 2 PublicationsAdd BLAST276

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF467954 mRNA Translation: AAM49552.1
AJ487959 mRNA Translation: CAD32306.1
AJ487519 mRNA Translation: CAD31787.1
AY358121 mRNA Translation: AAQ88488.1
BC087848 mRNA Translation: AAH87848.1
BC136694 mRNA Translation: AAI36695.1
BC136697 mRNA Translation: AAI36698.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12444.1 [Q8N135-1]

NCBI Reference Sequences

More...
RefSeqi
NP_644813.1, NM_139284.2 [Q8N135-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000310123; ENSP00000312273; ENSG00000153902 [Q8N135-1]
ENST00000591633; ENSP00000467784; ENSG00000153902 [Q8N135-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
163175

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:163175

UCSC genome browser

More...
UCSCi
uc002nxx.3 human [Q8N135-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467954 mRNA Translation: AAM49552.1
AJ487959 mRNA Translation: CAD32306.1
AJ487519 mRNA Translation: CAD31787.1
AY358121 mRNA Translation: AAQ88488.1
BC087848 mRNA Translation: AAH87848.1
BC136694 mRNA Translation: AAI36695.1
BC136697 mRNA Translation: AAI36698.1
CCDSiCCDS12444.1 [Q8N135-1]
RefSeqiNP_644813.1, NM_139284.2 [Q8N135-1]

3D structure databases

SMRiQ8N135
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127855, 1 interactor
STRINGi9606.ENSP00000312273

PTM databases

iPTMnetiQ8N135
PhosphoSitePlusiQ8N135

Polymorphism and mutation databases

BioMutaiLGI4
DMDMi32469741

Proteomic databases

MassIVEiQ8N135
PaxDbiQ8N135
PeptideAtlasiQ8N135
PRIDEiQ8N135
ProteomicsDBi71534 [Q8N135-1]
71535 [Q8N135-2]

Genome annotation databases

EnsembliENST00000310123; ENSP00000312273; ENSG00000153902 [Q8N135-1]
ENST00000591633; ENSP00000467784; ENSG00000153902 [Q8N135-2]
GeneIDi163175
KEGGihsa:163175
UCSCiuc002nxx.3 human [Q8N135-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
163175
DisGeNETi163175

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LGI4
HGNCiHGNC:18712 LGI4
HPAiHPA042116
HPA043556
MalaCardsiLGI4
MIMi608303 gene
617468 phenotype
neXtProtiNX_Q8N135
OpenTargetsiENSG00000153902
Orphaneti2680 Hypomyelination neuropathy-arthrogryposis syndrome
PharmGKBiPA38656

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJHU Eukaryota
ENOG4111DWK LUCA
GeneTreeiENSGT00940000162018
HOGENOMiHOG000286015
InParanoidiQ8N135
OMAiFHWFGGR
OrthoDBi365688at2759
PhylomeDBiQ8N135
TreeFamiTF333155

Enzyme and pathway databases

ReactomeiR-HSA-5682910 LGI-ADAM interactions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LGI4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
163175
PharosiQ8N135

Protein Ontology

More...
PROi
PR:Q8N135

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000153902 Expressed in 167 organ(s), highest expression level in tibial nerve
ExpressionAtlasiQ8N135 baseline and differential
GenevisibleiQ8N135 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR009039 EAR
IPR005492 EPTP
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF03736 EPTP, 3 hits
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS50912 EAR, 7 hits
PS51450 LRR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLGI4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N135
Secondary accession number(s): B2RN53, B9EGS7, Q5M8T1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: October 1, 2002
Last modified: October 16, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again