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UniProtKB - Q8N130 (NPT2C_HUMAN)

Entry version 146 (25 May 2022)
Sequence version 2 (30 Nov 2010)
Previous versions | rss
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Protein

Sodium-dependent phosphate transport protein 2C

Gene

SLC34A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx.

Miscellaneous

A 2:1 stoichiometry to Na+/Pi is observed at pH 7.4.

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=79 µM for phosphate1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N130

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-427589, Type II Na+/Pi cotransporters
R-HSA-5619097, Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q8N130

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8N130

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.58.1.3, the phosphate:na(+) symporter (pnas) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium-dependent phosphate transport protein 2C
Short name:
Sodium-phosphate transport protein 2C
Alternative name(s):
Na(+)-dependent phosphate cotransporter 2C
Sodium/inorganic phosphate cotransporter IIC
Sodium/phosphate cotransporter 2C
Short name:
Na(+)/Pi cotransporter 2C
Short name:
NaPi-2c
Solute carrier family 34 member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC34A3
Synonyms:NPT2C, NPTIIC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20305, SLC34A3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609826, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N130

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198569

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 76CytoplasmicSequence analysisAdd BLAST76
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei77 – 97Helical; Name=M1Sequence analysisAdd BLAST21
Topological domaini98 – 111ExtracellularSequence analysisAdd BLAST14
Transmembranei112 – 132Helical; Name=M2Sequence analysisAdd BLAST21
Topological domaini133 – 188CytoplasmicSequence analysisAdd BLAST56
Transmembranei189 – 209Helical; Name=M3Sequence analysisAdd BLAST21
Topological domaini210 – 322ExtracellularSequence analysisAdd BLAST113
Transmembranei323 – 343Helical; Name=M4Sequence analysisAdd BLAST21
Topological domaini344 – 367CytoplasmicSequence analysisAdd BLAST24
Transmembranei368 – 388Helical; Name=M5Sequence analysisAdd BLAST21
Topological domaini389 – 445ExtracellularSequence analysisAdd BLAST57
Transmembranei446 – 466Helical; Name=M6Sequence analysisAdd BLAST21
Topological domaini467 – 485CytoplasmicSequence analysisAdd BLAST19
Transmembranei486 – 506Helical; Name=M7Sequence analysisAdd BLAST21
Topological domaini507 – 510ExtracellularSequence analysis4
Transmembranei511 – 531Helical; Name=M8Sequence analysisAdd BLAST21
Topological domaini532 – 599CytoplasmicSequence analysisAdd BLAST68

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAutosomal recessive form of hypophosphatemia characterized by reduced renal phosphate reabsorption and rickets. Increased serum levels of 1,25-dihydroxyvitamin D lead to increase in urinary calcium excretion.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025707138S → F in HHRH. 1 PublicationCorresponds to variant dbSNP:rs141734934EnsemblClinVar.1
Natural variantiVAR_025709192S → L in HHRH. 2 PublicationsCorresponds to variant dbSNP:rs199690076EnsemblClinVar.1
Natural variantiVAR_025710196G → R in HHRH. 1 PublicationCorresponds to variant dbSNP:rs121918237EnsemblClinVar.1
Natural variantiVAR_025713353R → L in HHRH. 1 PublicationCorresponds to variant dbSNP:rs121918234EnsemblClinVar.1
Natural variantiVAR_025714413A → E in HHRH. 1 PublicationCorresponds to variant dbSNP:rs121918235EnsemblClinVar.1
Natural variantiVAR_025715468R → W in HHRH. 1 PublicationCorresponds to variant dbSNP:rs121918238EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		142680

MalaCards human disease database

More...MalaCardsi		SLC34A3
MIMi241530, phenotype

Open Targets

More...OpenTargetsi		ENSG00000198569

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		157215, Hereditary hypophosphatemic rickets with hypercalciuria

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134930298

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N130, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4295900

Drug and drug target database

More...DrugBanki		DB11348, Calcium Phosphate
DB14481, Calcium phosphate dihydrate
DB14502, Sodium phosphate, dibasic
DB09449, Sodium phosphate, monobasic
DB14503, Sodium phosphate, monobasic, unspecified form

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC34A3

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104149

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000686171 – 599Sodium-dependent phosphate transport protein 2CAdd BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi276 ↔ 309By similarity
Glycosylationi286N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N130

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N130

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N130

PeptideAtlas

More...PeptideAtlasi		Q8N130

PRoteomics IDEntifications database

More...PRIDEi		Q8N130

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71531

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8N130, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N130

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N130

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198569, Expressed in adult mammalian kidney and 85 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N130, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198569, Tissue enhanced (intestine, kidney)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126771, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q8N130, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000442397

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q8N130

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N130, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8N130

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC34A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTG0, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183177

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_025063_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N130

Identification of Orthologs from Complete Genome Data

More...OMAi		HDAIPVM

Database of Orthologous Groups

More...OrthoDBi		976094at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N130

TreeFam database of animal gene trees

More...TreeFami		TF313981

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003841, Na/Pi_transpt
IPR029850, Na/Pi_transpt_2C

The PANTHER Classification System

More...PANTHERi		PTHR10010, PTHR10010, 1 hit
PTHR10010:SF35, PTHR10010:SF35, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02690, Na_Pi_cotrans, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01013, 2a58, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8N130-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSSLPGSQV PHPTLDAVDL VEKTLRNEGT SSSAPVLEEG DTDPWTLPQL 
        60         70         80         90        100
KDTSQPWKEL RVAGRLRRVA GSVLKACGLL GSLYFFICSL DVLSSAFQLL 
       110        120        130        140        150
GSKVAGDIFK DNVVLSNPVA GLVIGVLVTA LVQSSSTSSS IVVSMVAAKL 
       160        170        180        190        200
LTVRVSVPII MGVNVGTSIT STLVSMAQSG DRDEFQRAFS GSAVHGIFNW 
       210        220        230        240        250
LTVLVLLPLE SATALLERLS ELALGAASLT PRAQAPDILK VLTKPLTHLI 
       260        270        280        290        300
VQLDSDMIMS SATGNATNSS LIKHWCGTTG QPTQENSSCG AFGPCTEKNS 
       310        320        330        340        350
TAPADRLPCR HLFAGTELTD LAVGCILLAG SLLVLCGCLV LIVKLLNSVL 
       360        370        380        390        400
RGRVAQVVRT VINADFPFPL GWLGGYLAVL AGAGLTFALQ SSSVFTAAVV 
       410        420        430        440        450
PLMGVGVISL DRAYPLLLGS NIGTTTTALL AALASPADRM LSALQVALIH 
       460        470        480        490        500
FFFNLAGILL WYLVPALRLP IPLARHFGVV TARYRWVAGV YLLLGFLLLP 
       510        520        530        540        550
LAAFGLSLAG GMELAAVGGP LVGLVLLVIL VTVLQRRRPA WLPVRLRSWA 
       560        570        580        590 
WLPVWLHSLE PWDRLVTRCC PCNVCSPPKA TTKEAYCYEN PEILASQQL
Length:599
Mass (Da):63,550
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3747DE33D0A53E95
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A669KB46A0A669KB46_HUMAN
Sodium-dependent phosphate transpor...
SLC34A3
144Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KB63A0A669KB63_HUMAN
Sodium-dependent phosphate transpor...
SLC34A3
353Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02570667R → H1 PublicationCorresponds to variant dbSNP:rs34372115EnsemblClinVar.1
Natural variantiVAR_025707138S → F in HHRH. 1 PublicationCorresponds to variant dbSNP:rs141734934EnsemblClinVar.1
Natural variantiVAR_025708180G → A1 PublicationCorresponds to variant dbSNP:rs35643193EnsemblClinVar.1
Natural variantiVAR_025709192S → L in HHRH. 2 PublicationsCorresponds to variant dbSNP:rs199690076EnsemblClinVar.1
Natural variantiVAR_025710196G → R in HHRH. 1 PublicationCorresponds to variant dbSNP:rs121918237EnsemblClinVar.1
Natural variantiVAR_025711237D → N1 PublicationCorresponds to variant dbSNP:rs145877051EnsemblClinVar.1
Natural variantiVAR_025712337G → S1 PublicationCorresponds to variant dbSNP:rs35699762EnsemblClinVar.1
Natural variantiVAR_025713353R → L in HHRH. 1 PublicationCorresponds to variant dbSNP:rs121918234EnsemblClinVar.1
Natural variantiVAR_025714413A → E in HHRH. 1 PublicationCorresponds to variant dbSNP:rs121918235EnsemblClinVar.1
Natural variantiVAR_025715468R → W in HHRH. 1 PublicationCorresponds to variant dbSNP:rs121918238EnsemblClinVar.1
Natural variantiVAR_025716513E → V4 PublicationsCorresponds to variant dbSNP:rs28542318EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB055000 mRNA Translation: BAB83242.1
AK095999 mRNA Translation: BAC04667.1
BX255925 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7038.1

NCBI Reference Sequences

More...RefSeqi		NP_001170787.1, NM_001177316.1
NP_001170788.1, NM_001177317.1
NP_543153.1, NM_080877.2
XP_016869781.1, XM_017014292.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361134.2; ENSP00000355353.2; ENSG00000198569.10
ENST00000538474.5; ENSP00000442397.1; ENSG00000198569.10
ENST00000673835.1; ENSP00000501114.1; ENSG00000198569.10

Database of genes from NCBI RefSeq genomes

More...GeneIDi		142680

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:142680

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000673835.1; ENSP00000501114.1; NM_001177316.2; NP_001170787.2

UCSC genome browser

More...UCSCi		uc004cmf.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055000 mRNA Translation: BAB83242.1
AK095999 mRNA Translation: BAC04667.1
BX255925 Genomic DNA No translation available.
CCDSiCCDS7038.1
RefSeqiNP_001170787.1, NM_001177316.1
NP_001170788.1, NM_001177317.1
NP_543153.1, NM_080877.2
XP_016869781.1, XM_017014292.1

3D structure databases

AlphaFoldDBiQ8N130
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi126771, 7 interactors
IntActiQ8N130, 5 interactors
STRINGi9606.ENSP00000442397

Chemistry databases

BindingDBiQ8N130
ChEMBLiCHEMBL4295900
DrugBankiDB11348, Calcium Phosphate
DB14481, Calcium phosphate dihydrate
DB14502, Sodium phosphate, dibasic
DB09449, Sodium phosphate, monobasic
DB14503, Sodium phosphate, monobasic, unspecified form

Protein family/group databases

TCDBi2.A.58.1.3, the phosphate:na(+) symporter (pnas) family

PTM databases

GlyGeniQ8N130, 4 sites
iPTMnetiQ8N130
PhosphoSitePlusiQ8N130

Genetic variation databases

BioMutaiSLC34A3
DMDMi313104149

Proteomic databases

EPDiQ8N130
MassIVEiQ8N130
PaxDbiQ8N130
PeptideAtlasiQ8N130
PRIDEiQ8N130
ProteomicsDBi71531

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18978, 129 antibodies from 21 providers

The DNASU plasmid repository

More...DNASUi		142680

Genome annotation databases

EnsembliENST00000361134.2; ENSP00000355353.2; ENSG00000198569.10
ENST00000538474.5; ENSP00000442397.1; ENSG00000198569.10
ENST00000673835.1; ENSP00000501114.1; ENSG00000198569.10
GeneIDi142680
KEGGihsa:142680
MANE-SelectiENST00000673835.1; ENSP00000501114.1; NM_001177316.2; NP_001170787.2
UCSCiuc004cmf.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		142680
DisGeNETi142680

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC34A3
HGNCiHGNC:20305, SLC34A3
HPAiENSG00000198569, Tissue enhanced (intestine, kidney)
MalaCardsiSLC34A3
MIMi241530, phenotype
609826, gene
neXtProtiNX_Q8N130
OpenTargetsiENSG00000198569
Orphaneti157215, Hereditary hypophosphatemic rickets with hypercalciuria
PharmGKBiPA134930298
VEuPathDBiHostDB:ENSG00000198569

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QTG0, Eukaryota
GeneTreeiENSGT00950000183177
HOGENOMiCLU_025063_0_0_1
InParanoidiQ8N130
OMAiHDAIPVM
OrthoDBi976094at2759
PhylomeDBiQ8N130
TreeFamiTF313981

Enzyme and pathway databases

PathwayCommonsiQ8N130
ReactomeiR-HSA-427589, Type II Na+/Pi cotransporters
R-HSA-5619097, Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)
SABIO-RKiQ8N130
SignaLinkiQ8N130

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		142680, 14 hits in 1069 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SLC34A3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		142680
PharosiQ8N130, Tbio

Protein Ontology

More...PROi		PR:Q8N130
RNActiQ8N130, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198569, Expressed in adult mammalian kidney and 85 other tissues
GenevisibleiQ8N130, HS

Family and domain databases

InterProiView protein in InterPro
IPR003841, Na/Pi_transpt
IPR029850, Na/Pi_transpt_2C
PANTHERiPTHR10010, PTHR10010, 1 hit
PTHR10010:SF35, PTHR10010:SF35, 1 hit
PfamiView protein in Pfam
PF02690, Na_Pi_cotrans, 2 hits
TIGRFAMsiTIGR01013, 2a58, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNPT2C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N130
Secondary accession number(s): A2BFA1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 30, 2010
Last modified: May 25, 2022
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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