UniProtKB - Q8N128 (F177A_HUMAN)
Protein
Protein FAM177A1
Gene
FAM177A1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM177A1 |
Gene namesi | Name:FAM177A1 Synonyms:C14orf24 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19829, FAM177A1 |
neXtProti | NX_Q8N128 |
VEuPathDBi | HostDB:ENSG00000151327.12 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 283635 |
OpenTargetsi | ENSG00000151327 |
PharmGKBi | PA162387378 |
Miscellaneous databases
Pharosi | Q8N128, Tdark |
Genetic variation databases
BioMutai | FAM177A1 |
DMDMi | 46395903 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089885 | 1 – 213 | Protein FAM177A1Add BLAST | 213 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 70 | PhosphoserineCombined sources | 1 | |
Modified residuei | 71 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8N128 |
jPOSTi | Q8N128 |
MassIVEi | Q8N128 |
MaxQBi | Q8N128 |
PaxDbi | Q8N128 |
PeptideAtlasi | Q8N128 |
PRIDEi | Q8N128 |
ProteomicsDBi | 71528 [Q8N128-1] 71529 [Q8N128-2] |
PTM databases
iPTMneti | Q8N128 |
PhosphoSitePlusi | Q8N128 |
SwissPalmi | Q8N128 |
Expressioni
Gene expression databases
Bgeei | ENSG00000151327, Expressed in testis and 214 other tissues |
ExpressionAtlasi | Q8N128, baseline and differential |
Genevisiblei | Q8N128, HS |
Organism-specific databases
HPAi | ENSG00000151327, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsIsoform 2 [Q8N128-2]
Protein-protein interaction databases
BioGRIDi | 129627, 45 interactors |
IntActi | Q8N128, 35 interactors |
MINTi | Q8N128 |
STRINGi | 9606.ENSP00000280987 |
Miscellaneous databases
RNActi | Q8N128, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 136 – 173 | Sequence analysisAdd BLAST | 38 |
Sequence similaritiesi
Belongs to the FAM177 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502RYW3, Eukaryota |
GeneTreei | ENSGT00390000016736 |
HOGENOMi | CLU_081605_0_0_1 |
InParanoidi | Q8N128 |
OMAi | CDYMGER |
OrthoDBi | 1572938at2759 |
PhylomeDBi | Q8N128 |
TreeFami | TF326916 |
Family and domain databases
InterProi | View protein in InterPro IPR028260, FAM177 |
PANTHERi | PTHR31206, PTHR31206, 1 hit |
Pfami | View protein in Pfam PF14774, FAM177, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N128-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDQEPVGGVE RGEAVAASGA AAAAAFGESA GQMSNERGFE NVELGVIGKK
60 70 80 90 100
KKVPRRVIHF VSGETMEEYS TDEDEVDGLE KKDVLPTVDP TKLTWGPYLW
110 120 130 140 150
FYMLRAATST LSVCDFLGEK IASVLGISTP KYQYAIDEYY RMKKEEEEEE
160 170 180 190 200
EENRMSEEAE KQYQQNKLQT DSIVQTDQPE TVISSSFVNV NFEMEGDSEV
210
IMESKQNPVS VPP
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087X212 | A0A087X212_HUMAN | Protein FAM177A1 | FAM177A1 | 89 | Annotation score: | ||
G3V583 | G3V583_HUMAN | Protein FAM177A1 | FAM177A1 | 140 | Annotation score: | ||
G3V3Z5 | G3V3Z5_HUMAN | Protein FAM177A1 | FAM177A1 | 75 | Annotation score: | ||
H0YJC3 | H0YJC3_HUMAN | Protein FAM177A1 | FAM177A1 | 36 | Annotation score: | ||
R4GN97 | R4GN97_HUMAN | Protein FAM177A1 | FAM177A1 | 39 | Annotation score: | ||
H0YJX7 | H0YJX7_HUMAN | Protein FAM177A1 | FAM177A1 | 49 | Annotation score: | ||
A0A1Y8EH40 | A0A1Y8EH40_HUMAN | Protein FAM177A1 | FAM177A1 | 7 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 22 | A → V in CAH18656 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 47 | I → M in CAH18656 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 56 | R → I in CAH18656 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 62 | S → I in CAH18656 (PubMed:17974005).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038223 | 1 | M → MEVGLPAITLFLTSASSPVV ATTM in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096173 mRNA Translation: BAC04716.1 CR749796 mRNA Translation: CAH18656.1 BC029559 mRNA Translation: AAH29559.1 |
CCDSi | CCDS41944.1 [Q8N128-1] CCDS9653.2 [Q8N128-2] |
RefSeqi | NP_001072987.1, NM_001079519.1 [Q8N128-1] NP_001275951.1, NM_001289022.1 [Q8N128-1] NP_775878.2, NM_173607.3 [Q8N128-2] |
Genome annotation databases
Ensembli | ENST00000280987; ENSP00000280987; ENSG00000151327 [Q8N128-2] ENST00000382406; ENSP00000371843; ENSG00000151327 [Q8N128-1] ENST00000396472; ENSP00000379734; ENSG00000151327 [Q8N128-1] |
GeneIDi | 283635 |
KEGGi | hsa:283635 |
UCSCi | uc001wsp.4, human [Q8N128-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096173 mRNA Translation: BAC04716.1 CR749796 mRNA Translation: CAH18656.1 BC029559 mRNA Translation: AAH29559.1 |
CCDSi | CCDS41944.1 [Q8N128-1] CCDS9653.2 [Q8N128-2] |
RefSeqi | NP_001072987.1, NM_001079519.1 [Q8N128-1] NP_001275951.1, NM_001289022.1 [Q8N128-1] NP_775878.2, NM_173607.3 [Q8N128-2] |
3D structure databases
SMRi | Q8N128 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129627, 45 interactors |
IntActi | Q8N128, 35 interactors |
MINTi | Q8N128 |
STRINGi | 9606.ENSP00000280987 |
PTM databases
iPTMneti | Q8N128 |
PhosphoSitePlusi | Q8N128 |
SwissPalmi | Q8N128 |
Genetic variation databases
BioMutai | FAM177A1 |
DMDMi | 46395903 |
Proteomic databases
EPDi | Q8N128 |
jPOSTi | Q8N128 |
MassIVEi | Q8N128 |
MaxQBi | Q8N128 |
PaxDbi | Q8N128 |
PeptideAtlasi | Q8N128 |
PRIDEi | Q8N128 |
ProteomicsDBi | 71528 [Q8N128-1] 71529 [Q8N128-2] |
Protocols and materials databases
Antibodypediai | 23180, 39 antibodies |
Genome annotation databases
Ensembli | ENST00000280987; ENSP00000280987; ENSG00000151327 [Q8N128-2] ENST00000382406; ENSP00000371843; ENSG00000151327 [Q8N128-1] ENST00000396472; ENSP00000379734; ENSG00000151327 [Q8N128-1] |
GeneIDi | 283635 |
KEGGi | hsa:283635 |
UCSCi | uc001wsp.4, human [Q8N128-1] |
Organism-specific databases
CTDi | 283635 |
DisGeNETi | 283635 |
GeneCardsi | FAM177A1 |
HGNCi | HGNC:19829, FAM177A1 |
HPAi | ENSG00000151327, Low tissue specificity |
neXtProti | NX_Q8N128 |
OpenTargetsi | ENSG00000151327 |
PharmGKBi | PA162387378 |
VEuPathDBi | HostDB:ENSG00000151327.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RYW3, Eukaryota |
GeneTreei | ENSGT00390000016736 |
HOGENOMi | CLU_081605_0_0_1 |
InParanoidi | Q8N128 |
OMAi | CDYMGER |
OrthoDBi | 1572938at2759 |
PhylomeDBi | Q8N128 |
TreeFami | TF326916 |
Enzyme and pathway databases
PathwayCommonsi | Q8N128 |
Miscellaneous databases
BioGRID-ORCSi | 283635, 11 hits in 878 CRISPR screens |
ChiTaRSi | FAM177A1, human |
GenomeRNAii | 283635 |
Pharosi | Q8N128, Tdark |
PROi | PR:Q8N128 |
RNActi | Q8N128, protein |
Gene expression databases
Bgeei | ENSG00000151327, Expressed in testis and 214 other tissues |
ExpressionAtlasi | Q8N128, baseline and differential |
Genevisiblei | Q8N128, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028260, FAM177 |
PANTHERi | PTHR31206, PTHR31206, 1 hit |
Pfami | View protein in Pfam PF14774, FAM177, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F177A_HUMAN | |
Accessioni | Q8N128Primary (citable) accession number: Q8N128 Secondary accession number(s): Q68CT2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families