UniProtKB - Q8N128 (F177A_HUMAN)

BLAST

>sp|Q8N128|F177A_HUMAN Protein FAM177A1 OS=Homo sapiens OX=9606 GN=FAM177A1 PE=1 SV=1
MDQEPVGGVERGEAVAASGAAAAAAFGESAGQMSNERGFENVELGVIGKKKKVPRRVIHF
VSGETMEEYSTDEDEVDGLEKKDVLPTVDPTKLTWGPYLWFYMLRAATSTLSVCDFLGEK
IASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPE
TVISSSFVNVNFEMEGDSEVIMESKQNPVSVPP

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History
Entry version 116 (07 Nov 2018)
Sequence version 1 (01 Oct 2002)
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Protein

Protein FAM177A1

Gene

FAM177A1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein FAM177A1
Gene namesⁱ	Name:FAM177A1 Synonyms:C14orf24
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000151327.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19829 FAM177A1
neXtProtⁱ	NX_Q8N128

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	283635
Open Targets More...OpenTargetsⁱ	ENSG00000151327
PharmGKBⁱ	PA162387378

Polymorphism and mutation databases

BioMutaⁱ	FAM177A1
DMDMⁱ	46395903

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000089885	1 – 213	Protein FAM177A1Add BLAST		213

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	70	PhosphoserineCombined sources	1
Modified residueⁱ	71	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q8N128
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N128
PaxDbⁱ	Q8N128
PeptideAtlas More...PeptideAtlasⁱ	Q8N128
PRIDEⁱ	Q8N128
ProteomicsDBⁱ	71528 71529 [Q8N128-2]

PTM databases

iPTMnetⁱ	Q8N128
PhosphoSitePlusⁱ	Q8N128
SwissPalmⁱ	Q8N128

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000151327 Expressed in 199 organ(s), highest expression level in testis
CleanExⁱ	HS_FAM177A1
ExpressionAtlasⁱ	Q8N128 baseline and differential
Genevisibleⁱ	Q8N128 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA053222 HPA055440

HPAⁱ

HPA053222
HPA055440

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	129627, 30 interactors
IntActⁱ	Q8N128, 8 interactors
STRINGⁱ	9606.ENSP00000280987

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N128
SMRⁱ	Q8N128
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	136 – 173	Sequence analysisAdd BLAST		38

Sequence similaritiesⁱ

Belongs to the FAM177 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IWRN Eukaryota ENOG41127S0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016736
HOGENOMⁱ	HOG000112451
HOVERGENⁱ	HBG051003
InParanoidⁱ	Q8N128
OMAⁱ	CEVIMES
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RQ2
PhylomeDBⁱ	Q8N128
TreeFamⁱ	TF326916

Family and domain databases

InterProⁱ	View protein in InterPro IPR028260 FAM177
PANTHERⁱ	PTHR31206 PTHR31206, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14774 FAM177, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8N128-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQEPVGGVE RGEAVAASGA AAAAAFGESA GQMSNERGFE NVELGVIGKK 
        60         70         80         90        100
KKVPRRVIHF VSGETMEEYS TDEDEVDGLE KKDVLPTVDP TKLTWGPYLW 
       110        120        130        140        150
FYMLRAATST LSVCDFLGEK IASVLGISTP KYQYAIDEYY RMKKEEEEEE 
       160        170        180        190        200
EENRMSEEAE KQYQQNKLQT DSIVQTDQPE TVISSSFVNV NFEMEGDSEV 
       210 
IMESKQNPVS VPP

Length:213

Mass (Da):23,757

Last modified:October 1, 2002 - v1

Checksum:ⁱ5AA0FE85489C4D78

Isoform 2 (identifier: Q8N128-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MEVGLPAITLFLTSASSPVVATTM

« Hide

        10         20         30         40         50
MEVGLPAITL FLTSASSPVV ATTMDQEPVG GVERGEAVAA SGAAAAAAFG 
        60         70         80         90        100
ESAGQMSNER GFENVELGVI GKKKKVPRRV IHFVSGETME EYSTDEDEVD 
       110        120        130        140        150
GLEKKDVLPT VDPTKLTWGP YLWFYMLRAA TSTLSVCDFL GEKIASVLGI 
       160        170        180        190        200
STPKYQYAID EYYRMKKEEE EEEEENRMSE EAEKQYQQNK LQTDSIVQTD 
       210        220        230 
QPETVISSSF VNVNFEMEGD SEVIMESKQN PVSVPP

Show »

Length:236

Mass (Da):26,045

Checksum:ⁱ86EF827D81A8EC50

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087X212	A0A087X212_HUMAN	Protein FAM177A1 Protein FAM177A1	FAM177A1	89	Annotation score:
G3V583	G3V583_HUMAN	Protein FAM177A1 Protein FAM177A1	FAM177A1	140	Annotation score:
G3V3Z5	G3V3Z5_HUMAN	Protein FAM177A1 Protein FAM177A1	FAM177A1	75	Annotation score:
H0YJX7	H0YJX7_HUMAN	Protein FAM177A1 Protein FAM177A1	FAM177A1	49	Annotation score:
R4GN97	R4GN97_HUMAN	Protein FAM177A1 Protein FAM177A1	FAM177A1	39	Annotation score:
H0YJC3	H0YJC3_HUMAN	Protein FAM177A1 Protein FAM177A1	FAM177A1	36	Annotation score:
A0A1Y8EH40	A0A1Y8EH40_HUMAN	Protein FAM177A1 Protein FAM177A1	FAM177A1	7	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	22	A → V in CAH18656 (PubMed:17974005).Curated	1
Sequence conflictⁱ	47	I → M in CAH18656 (PubMed:17974005).Curated	1
Sequence conflictⁱ	56	R → I in CAH18656 (PubMed:17974005).Curated	1
Sequence conflictⁱ	62	S → I in CAH18656 (PubMed:17974005).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_038223	1	M → MEVGLPAITLFLTSASSPVV ATTM in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK096173 mRNA Translation: BAC04716.1 CR749796 mRNA Translation: CAH18656.1 BC029559 mRNA Translation: AAH29559.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41944.1 [Q8N128-1] CCDS9653.2 [Q8N128-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001072987.1, NM_001079519.1 [Q8N128-1] NP_001275951.1, NM_001289022.1 [Q8N128-1] NP_775878.2, NM_173607.3 [Q8N128-2]
UniGeneⁱ	Hs.446357 Hs.745141

Genome annotation databases

Ensemblⁱ	ENST00000280987; ENSP00000280987; ENSG00000151327 [Q8N128-2] ENST00000382406; ENSP00000371843; ENSG00000151327 [Q8N128-1] ENST00000396472; ENSP00000379734; ENSG00000151327 [Q8N128-1]
GeneIDⁱ	283635
KEGGⁱ	hsa:283635
UCSC genome browser More...UCSCⁱ	uc001wsp.4 human [Q8N128-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q8N128	Isoform 2 of Protein FAM177A1		HUMAN		236	UniRef100_Q8N128
Protein FAM177A1 (Fragment)		HUMAN		140
Protein FAM177A1 (Fragment)		HUMAN		75

Protein	Similar proteins		Species	Score	Length	Source
Q8N128	Protein FAM177A1		BOVIN		212	UniRef90_Q8N128
Isoform 2 of Protein FAM177A1		HUMAN		236
Protein FAM177A1 isoform 1		CALJA		236
protein FAM177A1 isoform X1		TURTR		236
protein FAM177A1 isoform X1		PHYCD		236
+37

Protein	Similar proteins		Species	Score	Length	Source
Q8N128	Protein FAM177A1		BOVIN		212	UniRef50_Q8N128
Isoform 2 of Protein FAM177A1		HUMAN		236
Signal recognition particle 54		SAIBB		236
protein FAM177A1 isoform X1		Yangtze finless porpoise		236
protein FAM177A1 isoform X1		PHYCD		236
+256

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK096173 mRNA Translation: BAC04716.1 CR749796 mRNA Translation: CAH18656.1 BC029559 mRNA Translation: AAH29559.1
CCDSⁱ	CCDS41944.1 [Q8N128-1] CCDS9653.2 [Q8N128-2]
RefSeqⁱ	NP_001072987.1, NM_001079519.1 [Q8N128-1] NP_001275951.1, NM_001289022.1 [Q8N128-1] NP_775878.2, NM_173607.3 [Q8N128-2]
UniGeneⁱ	Hs.446357 Hs.745141

3D structure databases

ProteinModelPortalⁱ	Q8N128
SMRⁱ	Q8N128
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129627, 30 interactors
IntActⁱ	Q8N128, 8 interactors
STRINGⁱ	9606.ENSP00000280987

PTM databases

iPTMnetⁱ	Q8N128
PhosphoSitePlusⁱ	Q8N128
SwissPalmⁱ	Q8N128

Polymorphism and mutation databases

BioMutaⁱ	FAM177A1
DMDMⁱ	46395903

Proteomic databases

EPDⁱ	Q8N128
MaxQBⁱ	Q8N128
PaxDbⁱ	Q8N128
PeptideAtlasⁱ	Q8N128
PRIDEⁱ	Q8N128
ProteomicsDBⁱ	71528 71529 [Q8N128-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000280987; ENSP00000280987; ENSG00000151327 [Q8N128-2] ENST00000382406; ENSP00000371843; ENSG00000151327 [Q8N128-1] ENST00000396472; ENSP00000379734; ENSG00000151327 [Q8N128-1]
GeneIDⁱ	283635
KEGGⁱ	hsa:283635
UCSCⁱ	uc001wsp.4 human [Q8N128-1]

Organism-specific databases

CTDⁱ	283635
DisGeNETⁱ	283635
EuPathDBⁱ	HostDB:ENSG00000151327.12
GeneCardsⁱ	FAM177A1
H-InvDBⁱ	HIX0011596
HGNCⁱ	HGNC:19829 FAM177A1
HPAⁱ	HPA053222 HPA055440
neXtProtⁱ	NX_Q8N128
OpenTargetsⁱ	ENSG00000151327
PharmGKBⁱ	PA162387378
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IWRN Eukaryota ENOG41127S0 LUCA
GeneTreeⁱ	ENSGT00390000016736
HOGENOMⁱ	HOG000112451
HOVERGENⁱ	HBG051003
InParanoidⁱ	Q8N128
OMAⁱ	CEVIMES
OrthoDBⁱ	EOG091G0RQ2
PhylomeDBⁱ	Q8N128
TreeFamⁱ	TF326916

Miscellaneous databases

ChiTaRSⁱ	FAM177A1 human
GenomeRNAiⁱ	283635
Protein Ontology More...PROⁱ	PR:Q8N128

Gene expression databases

Bgeeⁱ	ENSG00000151327 Expressed in 199 organ(s), highest expression level in testis
CleanExⁱ	HS_FAM177A1
ExpressionAtlasⁱ	Q8N128 baseline and differential
Genevisibleⁱ	Q8N128 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR028260 FAM177
PANTHERⁱ	PTHR31206 PTHR31206, 1 hit
Pfamⁱ	View protein in Pfam PF14774 FAM177, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F177A_HUMAN
Accessionⁱ	Q8N128Primary (citable) accession number: Q8N128 Secondary accession number(s): Q68CT2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N128 (F177A_HUMAN)

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Protein FAM177A1

FAM177A1

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ