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Protein

Protein FAM177A1

Gene

FAM177A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM177A1
Gene namesi
Name:FAM177A1
Synonyms:C14orf24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000151327.12
HGNCiHGNC:19829 FAM177A1
neXtProtiNX_Q8N128

Pathology & Biotechi

Organism-specific databases

DisGeNETi283635
OpenTargetsiENSG00000151327
PharmGKBiPA162387378

Polymorphism and mutation databases

BioMutaiFAM177A1
DMDMi46395903

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000898851 – 213Protein FAM177A1Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei70PhosphoserineCombined sources1
Modified residuei71PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8N128
MaxQBiQ8N128
PaxDbiQ8N128
PeptideAtlasiQ8N128
PRIDEiQ8N128
ProteomicsDBi71528
71529 [Q8N128-2]

PTM databases

iPTMnetiQ8N128
PhosphoSitePlusiQ8N128
SwissPalmiQ8N128

Expressioni

Gene expression databases

BgeeiENSG00000151327 Expressed in 199 organ(s), highest expression level in testis
CleanExiHS_FAM177A1
ExpressionAtlasiQ8N128 baseline and differential
GenevisibleiQ8N128 HS

Organism-specific databases

HPAiHPA053222
HPA055440

Interactioni

Protein-protein interaction databases

BioGridi129627, 30 interactors
IntActiQ8N128, 8 interactors
STRINGi9606.ENSP00000280987

Structurei

3D structure databases

ProteinModelPortaliQ8N128
SMRiQ8N128
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili136 – 173Sequence analysisAdd BLAST38

Sequence similaritiesi

Belongs to the FAM177 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IWRN Eukaryota
ENOG41127S0 LUCA
GeneTreeiENSGT00390000016736
HOGENOMiHOG000112451
HOVERGENiHBG051003
InParanoidiQ8N128
OMAiCEVIMES
OrthoDBiEOG091G0RQ2
PhylomeDBiQ8N128
TreeFamiTF326916

Family and domain databases

InterProiView protein in InterPro
IPR028260 FAM177
PANTHERiPTHR31206 PTHR31206, 1 hit
PfamiView protein in Pfam
PF14774 FAM177, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N128-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDQEPVGGVE RGEAVAASGA AAAAAFGESA GQMSNERGFE NVELGVIGKK
60 70 80 90 100
KKVPRRVIHF VSGETMEEYS TDEDEVDGLE KKDVLPTVDP TKLTWGPYLW
110 120 130 140 150
FYMLRAATST LSVCDFLGEK IASVLGISTP KYQYAIDEYY RMKKEEEEEE
160 170 180 190 200
EENRMSEEAE KQYQQNKLQT DSIVQTDQPE TVISSSFVNV NFEMEGDSEV
210
IMESKQNPVS VPP
Length:213
Mass (Da):23,757
Last modified:October 1, 2002 - v1
Checksum:i5AA0FE85489C4D78
GO
Isoform 2 (identifier: Q8N128-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEVGLPAITLFLTSASSPVVATTM

Show »
Length:236
Mass (Da):26,045
Checksum:i86EF827D81A8EC50
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X212A0A087X212_HUMAN
Protein FAM177A1
FAM177A1
89Annotation score:
G3V583G3V583_HUMAN
Protein FAM177A1
FAM177A1
140Annotation score:
G3V3Z5G3V3Z5_HUMAN
Protein FAM177A1
FAM177A1
75Annotation score:
H0YJX7H0YJX7_HUMAN
Protein FAM177A1
FAM177A1
49Annotation score:
R4GN97R4GN97_HUMAN
Protein FAM177A1
FAM177A1
39Annotation score:
H0YJC3H0YJC3_HUMAN
Protein FAM177A1
FAM177A1
36Annotation score:
A0A1Y8EH40A0A1Y8EH40_HUMAN
Protein FAM177A1
FAM177A1
7Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22A → V in CAH18656 (PubMed:17974005).Curated1
Sequence conflicti47I → M in CAH18656 (PubMed:17974005).Curated1
Sequence conflicti56R → I in CAH18656 (PubMed:17974005).Curated1
Sequence conflicti62S → I in CAH18656 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0382231M → MEVGLPAITLFLTSASSPVV ATTM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096173 mRNA Translation: BAC04716.1
CR749796 mRNA Translation: CAH18656.1
BC029559 mRNA Translation: AAH29559.1
CCDSiCCDS41944.1 [Q8N128-1]
CCDS9653.2 [Q8N128-2]
RefSeqiNP_001072987.1, NM_001079519.1 [Q8N128-1]
NP_001275951.1, NM_001289022.1 [Q8N128-1]
NP_775878.2, NM_173607.3 [Q8N128-2]
UniGeneiHs.446357
Hs.745141

Genome annotation databases

EnsembliENST00000280987; ENSP00000280987; ENSG00000151327 [Q8N128-2]
ENST00000382406; ENSP00000371843; ENSG00000151327 [Q8N128-1]
ENST00000396472; ENSP00000379734; ENSG00000151327 [Q8N128-1]
GeneIDi283635
KEGGihsa:283635
UCSCiuc001wsp.4 human [Q8N128-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096173 mRNA Translation: BAC04716.1
CR749796 mRNA Translation: CAH18656.1
BC029559 mRNA Translation: AAH29559.1
CCDSiCCDS41944.1 [Q8N128-1]
CCDS9653.2 [Q8N128-2]
RefSeqiNP_001072987.1, NM_001079519.1 [Q8N128-1]
NP_001275951.1, NM_001289022.1 [Q8N128-1]
NP_775878.2, NM_173607.3 [Q8N128-2]
UniGeneiHs.446357
Hs.745141

3D structure databases

ProteinModelPortaliQ8N128
SMRiQ8N128
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129627, 30 interactors
IntActiQ8N128, 8 interactors
STRINGi9606.ENSP00000280987

PTM databases

iPTMnetiQ8N128
PhosphoSitePlusiQ8N128
SwissPalmiQ8N128

Polymorphism and mutation databases

BioMutaiFAM177A1
DMDMi46395903

Proteomic databases

EPDiQ8N128
MaxQBiQ8N128
PaxDbiQ8N128
PeptideAtlasiQ8N128
PRIDEiQ8N128
ProteomicsDBi71528
71529 [Q8N128-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280987; ENSP00000280987; ENSG00000151327 [Q8N128-2]
ENST00000382406; ENSP00000371843; ENSG00000151327 [Q8N128-1]
ENST00000396472; ENSP00000379734; ENSG00000151327 [Q8N128-1]
GeneIDi283635
KEGGihsa:283635
UCSCiuc001wsp.4 human [Q8N128-1]

Organism-specific databases

CTDi283635
DisGeNETi283635
EuPathDBiHostDB:ENSG00000151327.12
GeneCardsiFAM177A1
H-InvDBiHIX0011596
HGNCiHGNC:19829 FAM177A1
HPAiHPA053222
HPA055440
neXtProtiNX_Q8N128
OpenTargetsiENSG00000151327
PharmGKBiPA162387378
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWRN Eukaryota
ENOG41127S0 LUCA
GeneTreeiENSGT00390000016736
HOGENOMiHOG000112451
HOVERGENiHBG051003
InParanoidiQ8N128
OMAiCEVIMES
OrthoDBiEOG091G0RQ2
PhylomeDBiQ8N128
TreeFamiTF326916

Miscellaneous databases

ChiTaRSiFAM177A1 human
GenomeRNAii283635
PROiPR:Q8N128

Gene expression databases

BgeeiENSG00000151327 Expressed in 199 organ(s), highest expression level in testis
CleanExiHS_FAM177A1
ExpressionAtlasiQ8N128 baseline and differential
GenevisibleiQ8N128 HS

Family and domain databases

InterProiView protein in InterPro
IPR028260 FAM177
PANTHERiPTHR31206 PTHR31206, 1 hit
PfamiView protein in Pfam
PF14774 FAM177, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF177A_HUMAN
AccessioniPrimary (citable) accession number: Q8N128
Secondary accession number(s): Q68CT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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