UniProtKB - Q8N122 (RPTOR_HUMAN)
Regulatory-associated protein of mTOR
RPTOR
Functioni
GO - Molecular functioni
- 14-3-3 protein binding Source: UniProtKB
- protein-containing complex binding Source: UniProtKB
- protein kinase activator activity Source: WormBase
- protein kinase binding Source: UniProtKB
- protein-macromolecule adaptor activity Source: WormBase
- protein serine/threonine kinase inhibitor activity Source: WormBase
- RNA polymerase III type 1 promoter sequence-specific DNA binding Source: UniProtKB
- RNA polymerase III type 2 promoter sequence-specific DNA binding Source: UniProtKB
- RNA polymerase III type 3 promoter sequence-specific DNA binding Source: UniProtKB
- TFIIIC-class transcription factor complex binding Source: UniProtKB
GO - Biological processi
- cell cycle arrest Source: Reactome
- cellular response to amino acid stimulus Source: UniProtKB
- cellular response to leucine Source: CAFA
- cellular response to nutrient levels Source: UniProtKB
- cellular response to starvation Source: GO_Central
- positive regulation of cell growth Source: ParkinsonsUK-UCL
- positive regulation of endothelial cell proliferation Source: Ensembl
- positive regulation of G1/S transition of mitotic cell cycle Source: ParkinsonsUK-UCL
- positive regulation of peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
- positive regulation of peptidyl-threonine phosphorylation Source: ParkinsonsUK-UCL
- positive regulation of protein serine/threonine kinase activity Source: UniProtKB
- positive regulation of TOR signaling Source: UniProtKB
- positive regulation of transcription by RNA polymerase III Source: UniProtKB
- regulation of autophagy Source: GO_Central
- regulation of cell growth Source: UniProtKB
- regulation of cell size Source: UniProtKB
- regulation of cellular response to heat Source: Reactome
- regulation of macroautophagy Source: Reactome
- TORC1 signaling Source: WormBase
- TOR signaling Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | Q8N122 |
Reactomei | R-HSA-1632852, Macroautophagy R-HSA-165159, MTOR signalling R-HSA-166208, mTORC1-mediated signalling R-HSA-3371571, HSF1-dependent transactivation R-HSA-380972, Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-9639288, Amino acids regulate mTORC1 |
SABIO-RKi | Q8N122 |
SignaLinki | Q8N122 |
SIGNORi | Q8N122 |
Names & Taxonomyi
Protein namesi | Recommended name: Regulatory-associated protein of mTORShort name: Raptor Alternative name(s): p150 target of rapamycin (TOR)-scaffold protein |
Gene namesi | Name:RPTOR Synonyms:KIAA1303, RAPTOR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000141564.13 |
HGNCi | HGNC:30287, RPTOR |
MIMi | 607130, gene |
neXtProti | NX_Q8N122 |
Subcellular locationi
Lysosome
Other locations
- Cytoplasm
- Cytoplasmic granule 1 Publication
Note: Targeting to lysosomes depends on amino acid availability. In arsenite-stressed cells, accumulates in stress granules when associated with SPAG5 and association with lysosomes is drastically decreased.
Cytosol
- cytosol Source: HPA
Lysosome
- lysosomal membrane Source: UniProtKB
- lysosome Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
Other locations
- cytoplasm Source: UniProtKB
- cytoplasmic stress granule Source: UniProtKB
- dendrite Source: Ensembl
- neuronal cell body Source: Ensembl
- TORC1 complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, LysosomePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 722 | S → A: Abolishes AMPK-mediated phosphorylation; when associated with A-792. 1 Publication | 1 | |
Mutagenesisi | 792 | S → A: Abolishes AMPK-mediated phosphorylation; when associated with A-722. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 57521 |
OpenTargetsi | ENSG00000141564 |
PharmGKBi | PA165432629 |
Miscellaneous databases
Pharosi | Q8N122, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3120040 |
Polymorphism and mutation databases
BioMutai | RPTOR |
DMDMi | 46577501 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051200 | 1 – 1335 | Regulatory-associated protein of mTORAdd BLAST | 1335 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 696 | Phosphoserine; by MAPK8Combined sources2 Publications | 1 | |
Modified residuei | 706 | Phosphothreonine; by MAPK82 Publications | 1 | |
Modified residuei | 719 | Phosphoserine; by RPS6KA1Combined sources1 Publication | 1 | |
Modified residuei | 721 | Phosphoserine; by RPS6KA11 Publication | 1 | |
Modified residuei | 722 | Phosphoserine; by AMPK and RPS6KA1Combined sources2 Publications | 1 | |
Modified residuei | 738 | PhosphoserineCombined sources | 1 | |
Modified residuei | 792 | Phosphoserine; by AMPK1 Publication | 1 | |
Modified residuei | 855 | Phosphoserine1 Publication | 1 | |
Modified residuei | 859 | Phosphoserine; by MTORCombined sources1 Publication | 1 | |
Modified residuei | 863 | Phosphoserine; by MAPK8 and MTORCombined sources2 Publications | 1 | |
Modified residuei | 865 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 877 | PhosphoserineCombined sources1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8N122 |
jPOSTi | Q8N122 |
MassIVEi | Q8N122 |
MaxQBi | Q8N122 |
PaxDbi | Q8N122 |
PeptideAtlasi | Q8N122 |
PRIDEi | Q8N122 |
ProteomicsDBi | 27504 71521 [Q8N122-1] 71522 [Q8N122-2] |
PTM databases
iPTMneti | Q8N122 |
MetOSitei | Q8N122 |
PhosphoSitePlusi | Q8N122 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000141564, Expressed in frontal cortex and 175 other tissues |
ExpressionAtlasi | Q8N122, baseline and differential |
Genevisiblei | Q8N122, HS |
Organism-specific databases
HPAi | ENSG00000141564, Low tissue specificity |
Interactioni
Subunit structurei
Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR (PubMed:12150925, PubMed:12408816, PubMed:17386266, PubMed:25940091). mTORC1 binds to and is inhibited by FKBP12-rapamycin (PubMed:12408816, PubMed:15066126). Binds directly to 4EBP1 and RPS6KB1 independently of its association with MTOR (PubMed:12150925, PubMed:12150926). Binds preferentially to poorly or non-phosphorylated forms of EIF4EBP1, and this binding is critical to the ability of MTOR to catalyze phosphorylation (PubMed:12747827).
Forms a complex with MTOR under both leucine-rich and -poor conditions.
Interacts with ULK1 in a nutrient-dependent manner; the interaction is reduced during starvation (PubMed:19211835).
Interacts (when phosphorylated by AMPK) with 14-3-3 protein, leading to inhibition of its activity (PubMed:18439900).
Interacts with SPAG5; SPAG5 competes with MTOR for RPTOR-binding, resulting in decreased mTORC1 formation.
Interacts with WAC; WAC positively regulates MTOR activity by promoting the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex which leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014).
Interacts with G3BP1. The complex formed with G3BP1 AND SPAG5 is increased by oxidative stress (PubMed:23953116).
Interacts with HTR6 (PubMed:23027611).
Interacts with PIH1D1 (PubMed:24036451).
Interacts with LARP1 (PubMed:25940091).
Interacts with BRAT1 (PubMed:25657994).
Interacts with SIK3 (PubMed:30232230).
14 Publications(Microbial infection) Interacts with vaccinia virus protein F17; this interaction dysregulates mTOR.
1 PublicationBinary interactionsi
Hide detailsQ8N122
GO - Molecular functioni
- 14-3-3 protein binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- TFIIIC-class transcription factor complex binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 121582, 265 interactors |
ComplexPortali | CPX-503, mTORC1 complex |
CORUMi | Q8N122 |
DIPi | DIP-39482N |
ELMi | Q8N122 |
IntActi | Q8N122, 67 interactors |
MINTi | Q8N122 |
STRINGi | 9606.ENSP00000307272 |
Miscellaneous databases
RNActi | Q8N122, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8N122 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 1020 – 1061 | WD 1Add BLAST | 42 | |
Repeati | 1065 – 1106 | WD 2Add BLAST | 42 | |
Repeati | 1121 – 1160 | WD 3Add BLAST | 40 | |
Repeati | 1164 – 1203 | WD 4Add BLAST | 40 | |
Repeati | 1209 – 1249 | WD 5Add BLAST | 41 | |
Repeati | 1251 – 1291 | WD 6Add BLAST | 41 | |
Repeati | 1299 – 1335 | WD 7Add BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 881 – 887 | Poly-Ser | 7 |
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG1517, Eukaryota |
GeneTreei | ENSGT00640000091541 |
HOGENOMi | CLU_061814_0_0_1 |
InParanoidi | Q8N122 |
OMAi | HQFEDHL |
PhylomeDBi | Q8N122 |
TreeFami | TF105729 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000357, HEAT IPR004083, Raptor IPR029347, Raptor_N IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR12848, PTHR12848, 1 hit |
Pfami | View protein in Pfam PF02985, HEAT, 1 hit PF14538, Raptor_N, 1 hit PF00400, WD40, 1 hit |
SMARTi | View protein in SMART SM01302, Raptor_N, 1 hit SM00320, WD40, 7 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50294, WD_REPEATS_REGION, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESEMLQSPL LGLGEEDEAD LTDWNLPLAF MKKRHCEKIE GSKSLAQSWR
60 70 80 90 100
MKDRMKTVSV ALVLCLNVGV DPPDVVKTTP CARLECWIDP LSMGPQKALE
110 120 130 140 150
TIGANLQKQY ENWQPRARYK QSLDPTVDEV KKLCTSLRRN AKEERVLFHY
160 170 180 190 200
NGHGVPRPTV NGEVWVFNKN YTQYIPLSIY DLQTWMGSPS IFVYDCSNAG
210 220 230 240 250
LIVKSFKQFA LQREQELEVA AINPNHPLAQ MPLPPSMKNC IQLAACEATE
260 270 280 290 300
LLPMIPDLPA DLFTSCLTTP IKIALRWFCM QKCVSLVPGV TLDLIEKIPG
310 320 330 340 350
RLNDRRTPLG ELNWIFTAIT DTIAWNVLPR DLFQKLFRQD LLVASLFRNF
360 370 380 390 400
LLAERIMRSY NCTPVSSPRL PPTYMHAMWQ AWDLAVDICL SQLPTIIEEG
410 420 430 440 450
TAFRHSPFFA EQLTAFQVWL TMGVENRNPP EQLPIVLQVL LSQVHRLRAL
460 470 480 490 500
DLLGRFLDLG PWAVSLALSV GIFPYVLKLL QSSARELRPL LVFIWAKILA
510 520 530 540 550
VDSSCQADLV KDNGHKYFLS VLADPYMPAE HRTMTAFILA VIVNSYHTGQ
560 570 580 590 600
EACLQGNLIA ICLEQLNDPH PLLRQWVAIC LGRIWQNFDS ARWCGVRDSA
610 620 630 640 650
HEKLYSLLSD PIPEVRCAAV FALGTFVGNS AERTDHSTTI DHNVAMMLAQ
660 670 680 690 700
LVSDGSPMVR KELVVALSHL VVQYESNFCT VALQFIEEEK NYALPSPATT
710 720 730 740 750
EGGSLTPVRD SPCTPRLRSV SSYGNIRAVA TARSLNKSLQ NLSLTEESGG
760 770 780 790 800
AVAFSPGNLS TSSSASSTLG SPENEEHILS FETIDKMRRA SSYSSLNSLI
810 820 830 840 850
GVSFNSVYTQ IWRVLLHLAA DPYPEVSDVA MKVLNSIAYK ATVNARPQRV
860 870 880 890 900
LDTSSLTQSA PASPTNKGVH IHQAGGSPPA SSTSSSSLTN DVAKQPVSRD
910 920 930 940 950
LPSGRPGTTG PAGAQYTPHS HQFPRTRKMF DKGPEQTADD ADDAAGHKSF
960 970 980 990 1000
ISATVQTGFC DWSARYFAQP VMKIPEEHDL ESQIRKEREW RFLRNSRVRR
1010 1020 1030 1040 1050
QAQQVIQKGI TRLDDQIFLN RNPGVPSVVK FHPFTPCIAV ADKDSICFWD
1060 1070 1080 1090 1100
WEKGEKLDYF HNGNPRYTRV TAMEYLNGQD CSLLLTATDD GAIRVWKNFA
1110 1120 1130 1140 1150
DLEKNPEMVT AWQGLSDMLP TTRGAGMVVD WEQETGLLMS SGDVRIVRIW
1160 1170 1180 1190 1200
DTDREMKVQD IPTGADSCVT SLSCDSHRSL IVAGLGDGSI RVYDRRMALS
1210 1220 1230 1240 1250
ECRVMTYREH TAWVVKASLQ KRPDGHIVSV SVNGDVRIFD PRMPESVNVL
1260 1270 1280 1290 1300
QIVKGLTALD IHPQADLIAC GSVNQFTAIY NSSGELINNI KYYDGFMGQR
1310 1320 1330
VGAISCLAFH PHWPHLAVGS NDYYISVYSV EKRVR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L436 | I3L436_HUMAN | Regulatory-associated protein of mT... | RPTOR | 235 | Annotation score: | ||
I3L2I3 | I3L2I3_HUMAN | Regulatory-associated protein of mT... | RPTOR | 95 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 217 – 218 | LE → RQ in BAA92541 (PubMed:10718198).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010174 | 380 – 1335 | Missing in isoform 2. 1 PublicationAdd BLAST | 956 | |
Alternative sequenceiVSP_054042 | 504 – 661 | Missing in isoform 3. 1 PublicationAdd BLAST | 158 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY090663 mRNA Translation: AAM09075.1 AB082951 mRNA Translation: BAC06490.1 AC016245 Genomic DNA No translation available. AC109327 Genomic DNA No translation available. AC127496 Genomic DNA No translation available. AC133012 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89618.1 BC025180 mRNA Translation: AAH25180.1 BC033258 mRNA Translation: AAH33258.1 BC064515 mRNA Translation: AAH64515.1 BC136652 mRNA Translation: AAI36653.1 BC136654 mRNA Translation: AAI36655.1 AB037724 mRNA Translation: BAA92541.1 GQ183898 mRNA Translation: ACS44766.1 |
CCDSi | CCDS11773.1 [Q8N122-1] CCDS54175.1 [Q8N122-3] |
RefSeqi | NP_001156506.1, NM_001163034.1 [Q8N122-3] NP_065812.1, NM_020761.2 [Q8N122-1] |
Genome annotation databases
Ensembli | ENST00000306801; ENSP00000307272; ENSG00000141564 [Q8N122-1] ENST00000544334; ENSP00000442479; ENSG00000141564 [Q8N122-3] ENST00000570891; ENSP00000460136; ENSG00000141564 [Q8N122-2] |
GeneIDi | 57521 |
KEGGi | hsa:57521 |
UCSCi | uc002jys.5, human [Q8N122-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY090663 mRNA Translation: AAM09075.1 AB082951 mRNA Translation: BAC06490.1 AC016245 Genomic DNA No translation available. AC109327 Genomic DNA No translation available. AC127496 Genomic DNA No translation available. AC133012 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89618.1 BC025180 mRNA Translation: AAH25180.1 BC033258 mRNA Translation: AAH33258.1 BC064515 mRNA Translation: AAH64515.1 BC136652 mRNA Translation: AAI36653.1 BC136654 mRNA Translation: AAI36655.1 AB037724 mRNA Translation: BAA92541.1 GQ183898 mRNA Translation: ACS44766.1 |
CCDSi | CCDS11773.1 [Q8N122-1] CCDS54175.1 [Q8N122-3] |
RefSeqi | NP_001156506.1, NM_001163034.1 [Q8N122-3] NP_065812.1, NM_020761.2 [Q8N122-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5H64 | electron microscopy | 4.40 | B/b | 1-1335 | [»] | |
6BCU | electron microscopy | 3.43 | W/Y | 2-1335 | [»] | |
6BCX | electron microscopy | 3.00 | W/Y | 2-1335 | [»] | |
6SB0 | electron microscopy | 5.50 | N/Y | 1-1335 | [»] | |
6SB2 | electron microscopy | 6.20 | N/Y | 1-1335 | [»] | |
6U62 | electron microscopy | 3.18 | A | 1-1335 | [»] | |
SMRi | Q8N122 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121582, 265 interactors |
ComplexPortali | CPX-503, mTORC1 complex |
CORUMi | Q8N122 |
DIPi | DIP-39482N |
ELMi | Q8N122 |
IntActi | Q8N122, 67 interactors |
MINTi | Q8N122 |
STRINGi | 9606.ENSP00000307272 |
Chemistry databases
ChEMBLi | CHEMBL3120040 |
PTM databases
iPTMneti | Q8N122 |
MetOSitei | Q8N122 |
PhosphoSitePlusi | Q8N122 |
Polymorphism and mutation databases
BioMutai | RPTOR |
DMDMi | 46577501 |
Proteomic databases
EPDi | Q8N122 |
jPOSTi | Q8N122 |
MassIVEi | Q8N122 |
MaxQBi | Q8N122 |
PaxDbi | Q8N122 |
PeptideAtlasi | Q8N122 |
PRIDEi | Q8N122 |
ProteomicsDBi | 27504 71521 [Q8N122-1] 71522 [Q8N122-2] |
Protocols and materials databases
Antibodypediai | 4616, 591 antibodies |
CPTCi | Q8N122, 2 antibodies |
DNASUi | 57521 |
Genome annotation databases
Ensembli | ENST00000306801; ENSP00000307272; ENSG00000141564 [Q8N122-1] ENST00000544334; ENSP00000442479; ENSG00000141564 [Q8N122-3] ENST00000570891; ENSP00000460136; ENSG00000141564 [Q8N122-2] |
GeneIDi | 57521 |
KEGGi | hsa:57521 |
UCSCi | uc002jys.5, human [Q8N122-1] |
Organism-specific databases
CTDi | 57521 |
DisGeNETi | 57521 |
EuPathDBi | HostDB:ENSG00000141564.13 |
GeneCardsi | RPTOR |
HGNCi | HGNC:30287, RPTOR |
HPAi | ENSG00000141564, Low tissue specificity |
MIMi | 607130, gene |
neXtProti | NX_Q8N122 |
OpenTargetsi | ENSG00000141564 |
PharmGKBi | PA165432629 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1517, Eukaryota |
GeneTreei | ENSGT00640000091541 |
HOGENOMi | CLU_061814_0_0_1 |
InParanoidi | Q8N122 |
OMAi | HQFEDHL |
PhylomeDBi | Q8N122 |
TreeFami | TF105729 |
Enzyme and pathway databases
PathwayCommonsi | Q8N122 |
Reactomei | R-HSA-1632852, Macroautophagy R-HSA-165159, MTOR signalling R-HSA-166208, mTORC1-mediated signalling R-HSA-3371571, HSF1-dependent transactivation R-HSA-380972, Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-9639288, Amino acids regulate mTORC1 |
SABIO-RKi | Q8N122 |
SignaLinki | Q8N122 |
SIGNORi | Q8N122 |
Miscellaneous databases
BioGRID-ORCSi | 57521, 596 hits in 854 CRISPR screens |
ChiTaRSi | RPTOR, human |
GeneWikii | RPTOR |
GenomeRNAii | 57521 |
Pharosi | Q8N122, Tbio |
PROi | PR:Q8N122 |
RNActi | Q8N122, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000141564, Expressed in frontal cortex and 175 other tissues |
ExpressionAtlasi | Q8N122, baseline and differential |
Genevisiblei | Q8N122, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000357, HEAT IPR004083, Raptor IPR029347, Raptor_N IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR12848, PTHR12848, 1 hit |
Pfami | View protein in Pfam PF02985, HEAT, 1 hit PF14538, Raptor_N, 1 hit PF00400, WD40, 1 hit |
SMARTi | View protein in SMART SM01302, Raptor_N, 1 hit SM00320, WD40, 7 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPTOR_HUMAN | |
Accessioni | Q8N122Primary (citable) accession number: Q8N122 Secondary accession number(s): B2RN36 Q9P2P3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 185 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM