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Protein

Cytochrome P450 4X1

Gene

CYP4X1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi454Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Chemistry databases

SwissLipidsiSLP:000001715

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4X1 (EC:1.14.14.1)
Alternative name(s):
CYPIVX1
Gene namesi
Name:CYP4X1
ORF Names:UNQ1929/PRO4404
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000186377.7
HGNCiHGNC:20244 CYP4X1
MIMi614999 gene
neXtProtiNX_Q8N118

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186377
PharmGKBiPA134933184

Chemistry databases

ChEMBLiCHEMBL6048

Polymorphism and mutation databases

BioMutaiCYP4X1
DMDMi48428082

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518621 – 509Cytochrome P450 4X1Add BLAST509

Proteomic databases

EPDiQ8N118
MaxQBiQ8N118
PaxDbiQ8N118
PeptideAtlasiQ8N118
PRIDEiQ8N118
ProteomicsDBi71519

PTM databases

iPTMnetiQ8N118
PhosphoSitePlusiQ8N118
SwissPalmiQ8N118

Expressioni

Tissue specificityi

Expressed in brain, heart and kidney and, at lower levels, in skeletal muscle and liver. In the heart, very high level levels in aorta, but very levels in other heart regions.1 Publication

Gene expression databases

BgeeiENSG00000186377 Expressed in 191 organ(s), highest expression level in palpebral conjunctiva
CleanExiHS_CYP4X1
GenevisibleiQ8N118 HS

Organism-specific databases

HPAiHPA017661

Interactioni

Protein-protein interaction databases

BioGridi129254, 2 interactors
STRINGi9606.ENSP00000360968

Chemistry databases

BindingDBiQ8N118

Structurei

3D structure databases

ProteinModelPortaliQ8N118
SMRiQ8N118
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140829
HOGENOMiHOG000233833
HOVERGENiHBG000182
InParanoidiQ8N118
KOiK07428
OMAiYPCAFPC
OrthoDBiEOG091G06KN
PhylomeDBiQ8N118
TreeFamiTF105088

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N118-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEFSWLETRW ARPFYLAFVF CLALGLLQAI KLYLRRQRLL RDLRPFPAPP
60 70 80 90 100
THWFLGHQKF IQDDNMEKLE EIIEKYPRAF PFWIGPFQAF FCIYDPDYAK
110 120 130 140 150
TLLSRTDPKS QYLQKFSPPL LGKGLAALDG PKWFQHRRLL TPGFHFNILK
160 170 180 190 200
AYIEVMAHSV KMMLDKWEKI CSTQDTSVEV YEHINSMSLD IIMKCAFSKE
210 220 230 240 250
TNCQTNSTHD PYAKAIFELS KIIFHRLYSL LYHSDIIFKL SPQGYRFQKL
260 270 280 290 300
SRVLNQYTDT IIQERKKSLQ AGVKQDNTPK RKYQDFLDIV LSAKDESGSS
310 320 330 340 350
FSDIDVHSEV STFLLAGHDT LAASISWILY CLALNPEHQE RCREEVRGIL
360 370 380 390 400
GDGSSITWDQ LGEMSYTTMC IKETCRLIPA VPSISRDLSK PLTFPDGCTL
410 420 430 440 450
PAGITVVLSI WGLHHNPAVW KNPKVFDPLR FSQENSDQRH PYAYLPFSAG
460 470 480 490 500
SRNCIGQEFA MIELKVTIAL ILLHFRVTPD PTRPLTFPNH FILKPKNGMY

LHLKKLSEC
Length:509
Mass (Da):58,875
Last modified:October 1, 2002 - v1
Checksum:i702470A76E814278
GO
Isoform 2 (identifier: Q8N118-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: MEFSWLETRW...PTHWFLGHQK → MMWGGGLDLC...ICMTSSSSGL

Note: No experimental confirmation available.
Show »
Length:508
Mass (Da):57,901
Checksum:i8E66A23B0353DC06
GO
Isoform 3 (identifier: Q8N118-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Note: No experimental confirmation available.
Show »
Length:444
Mass (Da):50,944
Checksum:i8162580C640B5813
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192I → V in BAD18508 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0458891 – 65Missing in isoform 3. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_0458901 – 59MEFSW…LGHQK → MMWGGGLDLCPMPGQLKFPP CLSRCLLWEPPSLYLTQPTS SLAEPQALICMTSSSSGL in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040940 mRNA Translation: CAJ13826.1
AY358537 mRNA Translation: AAQ88901.1
AK091806 mRNA Translation: BAC03751.1
AK098065 mRNA Translation: BAC05226.1
AK131355 mRNA Translation: BAD18508.1
AL450996 Genomic DNA No translation available.
AL731892 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06882.1
CH471059 Genomic DNA Translation: EAX06883.1
CH471059 Genomic DNA Translation: EAX06884.1
BC028102 mRNA Translation: AAH28102.1
CCDSiCCDS544.1 [Q8N118-1]
RefSeqiNP_001307218.1, NM_001320289.1 [Q8N118-2]
NP_001307219.1, NM_001320290.1 [Q8N118-3]
NP_828847.1, NM_178033.1 [Q8N118-1]
UniGeneiHs.439760

Genome annotation databases

EnsembliENST00000371901; ENSP00000360968; ENSG00000186377 [Q8N118-1]
GeneIDi260293
KEGGihsa:260293
UCSCiuc001cqt.3 human [Q8N118-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040940 mRNA Translation: CAJ13826.1
AY358537 mRNA Translation: AAQ88901.1
AK091806 mRNA Translation: BAC03751.1
AK098065 mRNA Translation: BAC05226.1
AK131355 mRNA Translation: BAD18508.1
AL450996 Genomic DNA No translation available.
AL731892 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06882.1
CH471059 Genomic DNA Translation: EAX06883.1
CH471059 Genomic DNA Translation: EAX06884.1
BC028102 mRNA Translation: AAH28102.1
CCDSiCCDS544.1 [Q8N118-1]
RefSeqiNP_001307218.1, NM_001320289.1 [Q8N118-2]
NP_001307219.1, NM_001320290.1 [Q8N118-3]
NP_828847.1, NM_178033.1 [Q8N118-1]
UniGeneiHs.439760

3D structure databases

ProteinModelPortaliQ8N118
SMRiQ8N118
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129254, 2 interactors
STRINGi9606.ENSP00000360968

Chemistry databases

BindingDBiQ8N118
ChEMBLiCHEMBL6048
SwissLipidsiSLP:000001715

PTM databases

iPTMnetiQ8N118
PhosphoSitePlusiQ8N118
SwissPalmiQ8N118

Polymorphism and mutation databases

BioMutaiCYP4X1
DMDMi48428082

Proteomic databases

EPDiQ8N118
MaxQBiQ8N118
PaxDbiQ8N118
PeptideAtlasiQ8N118
PRIDEiQ8N118
ProteomicsDBi71519

Protocols and materials databases

DNASUi260293
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371901; ENSP00000360968; ENSG00000186377 [Q8N118-1]
GeneIDi260293
KEGGihsa:260293
UCSCiuc001cqt.3 human [Q8N118-1]

Organism-specific databases

CTDi260293
EuPathDBiHostDB:ENSG00000186377.7
GeneCardsiCYP4X1
HGNCiHGNC:20244 CYP4X1
HPAiHPA017661
MIMi614999 gene
neXtProtiNX_Q8N118
OpenTargetsiENSG00000186377
PharmGKBiPA134933184
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140829
HOGENOMiHOG000233833
HOVERGENiHBG000182
InParanoidiQ8N118
KOiK07428
OMAiYPCAFPC
OrthoDBiEOG091G06KN
PhylomeDBiQ8N118
TreeFamiTF105088

Miscellaneous databases

ChiTaRSiCYP4X1 human
GeneWikiiCYP4X1
GenomeRNAii260293
PROiPR:Q8N118
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186377 Expressed in 191 organ(s), highest expression level in palpebral conjunctiva
CleanExiHS_CYP4X1
GenevisibleiQ8N118 HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP4X1_HUMAN
AccessioniPrimary (citable) accession number: Q8N118
Secondary accession number(s): G3V1U1
, Q5VVE5, Q6ZN67, Q8NAZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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