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UniProtKB - Q8N114 (SHSA5_HUMAN)
Protein
Protein shisa-5
Gene
SHISA5
Organism
Homo sapiens (Human)
Status
Functioni
Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis.
1 PublicationGO - Molecular functioni
- WW domain binding Source: UniProtKB
GO - Biological processi
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q8N114 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
SignaLinki | Q8N114 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein shisa-5Alternative name(s): Putative NF-kappa-B-activating protein 120 Scotin |
Gene namesi | Name:SHISA5 Synonyms:SCOTIN ORF Names:PSEC0133 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30376, SHISA5 |
MIMi | 607290, gene |
neXtProti | NX_Q8N114 |
VEuPathDBi | HostDB:ENSG00000164054 |
Subcellular locationi
Nucleus
- Nucleus membrane 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum lumen Source: Reactome
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 29 – 105 | ExtracellularSequence analysisAdd BLAST | 77 | |
Transmembranei | 106 – 126 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 127 – 240 | CytoplasmicSequence analysisAdd BLAST | 114 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 51246 |
OpenTargetsi | ENSG00000164054 |
PharmGKBi | PA162403295 |
Miscellaneous databases
Pharosi | Q8N114, Tbio |
Genetic variation databases
BioMutai | SHISA5 |
DMDMi | 74714697 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000312878 | 29 – 240 | Protein shisa-5Add BLAST | 212 |
Proteomic databases
jPOSTi | Q8N114 |
MassIVEi | Q8N114 |
PaxDbi | Q8N114 |
PeptideAtlasi | Q8N114 |
PRIDEi | Q8N114 |
ProteomicsDBi | 30355 71515 [Q8N114-1] 71516 [Q8N114-2] 71517 [Q8N114-3] |
PTM databases
GlyGeni | Q8N114, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8N114 |
PhosphoSitePlusi | Q8N114 |
Expressioni
Inductioni
Induced in a p53/TP53-dependent manner in response to cellular stress.1 Publication
Gene expression databases
Bgeei | ENSG00000164054, Expressed in prostate gland and 218 other tissues |
ExpressionAtlasi | Q8N114, baseline and differential |
Genevisiblei | Q8N114, HS |
Organism-specific databases
HPAi | ENSG00000164054, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with PDCD6; PDCD6 can stabilze SHISA5.
1 PublicationBinary interactionsi
Q8N114
With | #Exp. | IntAct |
---|---|---|
WWOX [Q9NZC7] | 2 | EBI-2115556,EBI-4320739 |
Pdcd6 [P12815] from Mus musculus. | 5 | EBI-2115556,EBI-309164 |
Isoform 3 [Q8N114-3]
GO - Molecular functioni
- WW domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 119403, 11 interactors |
ELMi | Q8N114 |
IntActi | Q8N114, 10 interactors |
STRINGi | 9606.ENSP00000296444 |
Miscellaneous databases
RNActi | Q8N114, protein |
Structurei
Family & Domainsi
Domaini
The proline-rich region is required for endoplasmic reticulum localization.1 Publication
Sequence similaritiesi
Belongs to the shisa family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S2Y4, Eukaryota |
GeneTreei | ENSGT00390000008296 |
HOGENOMi | CLU_093192_1_0_1 |
InParanoidi | Q8N114 |
OMAi | YKMCRKP |
OrthoDBi | 1267386at2759 |
PhylomeDBi | Q8N114 |
TreeFami | TF332572 |
Family and domain databases
InterProi | View protein in InterPro IPR026910, Shisa |
PANTHERi | PTHR31395, PTHR31395, 1 hit |
Pfami | View protein in Pfam PF13908, Shisa, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N114-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTAPVPAPRI LLPLLLLLLL TPPPGARGEV CMASRGLSLF PESCPDFCCG
60 70 80 90 100
TCDDQYCCSD VLKKFVWSEE RCAVPEASVP ASVEPVEQLG SALRFRPGYN
110 120 130 140 150
DPMSGFGATL AVGLTIFVLS VVTIIICFTC SCCCLYKTCR RPRPVVTTTT
160 170 180 190 200
STTVVHAPYP QPPSVPPSYP GPSYQGYHTM PPQPGMPAAP YPMQYPPPYP
210 220 230 240
AQPMGPPAYH ETLAGGAAAP YPASQPPYNP AYMDAPKAAL
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8WFD9 | F8WFD9_HUMAN | Protein shisa-5 | SHISA5 | 123 | Annotation score: | ||
C9IZ46 | C9IZ46_HUMAN | Protein shisa-5 | SHISA5 | 112 | Annotation score: | ||
A0A087WZK8 | A0A087WZK8_HUMAN | Protein shisa-5 | SHISA5 | 170 | Annotation score: | ||
F8WDS1 | F8WDS1_HUMAN | Protein shisa-5 | SHISA5 | 44 | Annotation score: | ||
F8WCE2 | F8WCE2_HUMAN | Protein shisa-5 | SHISA5 | 61 | Annotation score: | ||
H7C2R0 | H7C2R0_HUMAN | Protein shisa-5 | SHISA5 | 47 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054031 | 216 | G → R. Corresponds to variant dbSNP:rs35750010Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029953 | 1 – 103 | Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST | 103 | |
Alternative sequenceiVSP_029954 | 1 – 31 | Missing in isoform 2. 1 PublicationAdd BLAST | 31 | |
Alternative sequenceiVSP_055712 | 71 – 77 | Missing in isoform 5. Curated | 7 | |
Alternative sequenceiVSP_029955 | 104 | S → M in isoform 3 and isoform 4. 3 Publications | 1 | |
Alternative sequenceiVSP_029956 | 216 – 240 | GAAAP…PKAAL → ECPCQL in isoform 4. 1 PublicationAdd BLAST | 25 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000296444; ENSP00000296444; ENSG00000164054 ENST00000426002; ENSP00000390388; ENSG00000164054 [Q8N114-3] ENST00000442747; ENSP00000408223; ENSG00000164054 [Q8N114-2] ENST00000443308; ENSP00000395373; ENSG00000164054 [Q8N114-5] ENST00000444115; ENSP00000407957; ENSG00000164054 [Q8N114-2] ENST00000619810; ENSP00000484992; ENSG00000164054 [Q8N114-2] |
GeneIDi | 51246 |
KEGGi | hsa:51246 |
MANE-Selecti | ENST00000296444.7; ENSP00000296444.2; NM_016479.6; NP_057563.3 |
UCSCi | uc003ctm.4, human [Q8N114-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119403, 11 interactors |
ELMi | Q8N114 |
IntActi | Q8N114, 10 interactors |
STRINGi | 9606.ENSP00000296444 |
PTM databases
GlyGeni | Q8N114, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8N114 |
PhosphoSitePlusi | Q8N114 |
Genetic variation databases
BioMutai | SHISA5 |
DMDMi | 74714697 |
Proteomic databases
jPOSTi | Q8N114 |
MassIVEi | Q8N114 |
PaxDbi | Q8N114 |
PeptideAtlasi | Q8N114 |
PRIDEi | Q8N114 |
ProteomicsDBi | 30355 71515 [Q8N114-1] 71516 [Q8N114-2] 71517 [Q8N114-3] |
Protocols and materials databases
Antibodypediai | 30112, 137 antibodies from 18 providers |
DNASUi | 51246 |
Genome annotation databases
Ensembli | ENST00000296444; ENSP00000296444; ENSG00000164054 ENST00000426002; ENSP00000390388; ENSG00000164054 [Q8N114-3] ENST00000442747; ENSP00000408223; ENSG00000164054 [Q8N114-2] ENST00000443308; ENSP00000395373; ENSG00000164054 [Q8N114-5] ENST00000444115; ENSP00000407957; ENSG00000164054 [Q8N114-2] ENST00000619810; ENSP00000484992; ENSG00000164054 [Q8N114-2] |
GeneIDi | 51246 |
KEGGi | hsa:51246 |
MANE-Selecti | ENST00000296444.7; ENSP00000296444.2; NM_016479.6; NP_057563.3 |
UCSCi | uc003ctm.4, human [Q8N114-1] |
Organism-specific databases
CTDi | 51246 |
DisGeNETi | 51246 |
GeneCardsi | SHISA5 |
HGNCi | HGNC:30376, SHISA5 |
HPAi | ENSG00000164054, Low tissue specificity |
MIMi | 607290, gene |
neXtProti | NX_Q8N114 |
OpenTargetsi | ENSG00000164054 |
PharmGKBi | PA162403295 |
VEuPathDBi | HostDB:ENSG00000164054 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S2Y4, Eukaryota |
GeneTreei | ENSGT00390000008296 |
HOGENOMi | CLU_093192_1_0_1 |
InParanoidi | Q8N114 |
OMAi | YKMCRKP |
OrthoDBi | 1267386at2759 |
PhylomeDBi | Q8N114 |
TreeFami | TF332572 |
Enzyme and pathway databases
PathwayCommonsi | Q8N114 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
SignaLinki | Q8N114 |
Miscellaneous databases
BioGRID-ORCSi | 51246, 8 hits in 1050 CRISPR screens |
ChiTaRSi | SHISA5, human |
GenomeRNAii | 51246 |
Pharosi | Q8N114, Tbio |
PROi | PR:Q8N114 |
RNActi | Q8N114, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164054, Expressed in prostate gland and 218 other tissues |
ExpressionAtlasi | Q8N114, baseline and differential |
Genevisiblei | Q8N114, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026910, Shisa |
PANTHERi | PTHR31395, PTHR31395, 1 hit |
Pfami | View protein in Pfam PF13908, Shisa, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SHSA5_HUMAN | |
Accessioni | Q8N114Primary (citable) accession number: Q8N114 Secondary accession number(s): B3KW99 Q9BV58 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families