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UniProtKB - Q8N114 (SHSA5_HUMAN)

Entry version 135 (23 Feb 2022)
Sequence version 1 (01 Oct 2002)
Previous versions | rss
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Protein

Protein shisa-5

Gene

SHISA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N114

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275, Post-translational protein phosphorylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8N114

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein shisa-5
Alternative name(s):
Putative NF-kappa-B-activating protein 120
Scotin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SHISA5
Synonyms:SCOTIN
ORF Names:PSEC0133
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30376, SHISA5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607290, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N114

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000164054

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 105ExtracellularSequence analysisAdd BLAST77
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 240CytoplasmicSequence analysisAdd BLAST114

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		51246

Open Targets

More...OpenTargetsi		ENSG00000164054

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162403295

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N114, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SHISA5

Domain mapping of disease mutations (DMDM)

More...DMDMi		74714697

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031287829 – 240Protein shisa-5Add BLAST212

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N114

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N114

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N114

PeptideAtlas

More...PeptideAtlasi		Q8N114

PRoteomics IDEntifications database

More...PRIDEi		Q8N114

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		30355
71515 [Q8N114-1]
71516 [Q8N114-2]
71517 [Q8N114-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8N114, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N114

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N114

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced in a p53/TP53-dependent manner in response to cellular stress.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000164054, Expressed in prostate gland and 218 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N114, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N114, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000164054, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PDCD6; PDCD6 can stabilze SHISA5.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119403, 11 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q8N114

Protein interaction database and analysis system

More...IntActi		Q8N114, 10 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000296444

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N114, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The proline-rich region is required for endoplasmic reticulum localization.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the shisa family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S2Y4, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008296

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_093192_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N114

Identification of Orthologs from Complete Genome Data

More...OMAi		YKMCRKP

Database of Orthologous Groups

More...OrthoDBi		1267386at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N114

TreeFam database of animal gene trees

More...TreeFami		TF332572

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026910, Shisa

The PANTHER Classification System

More...PANTHERi		PTHR31395, PTHR31395, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13908, Shisa, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N114-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAPVPAPRI LLPLLLLLLL TPPPGARGEV CMASRGLSLF PESCPDFCCG 
        60         70         80         90        100
TCDDQYCCSD VLKKFVWSEE RCAVPEASVP ASVEPVEQLG SALRFRPGYN 
       110        120        130        140        150
DPMSGFGATL AVGLTIFVLS VVTIIICFTC SCCCLYKTCR RPRPVVTTTT 
       160        170        180        190        200
STTVVHAPYP QPPSVPPSYP GPSYQGYHTM PPQPGMPAAP YPMQYPPPYP 
       210        220        230        240
AQPMGPPAYH ETLAGGAAAP YPASQPPYNP AYMDAPKAAL
Length:240
Mass (Da):25,582
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C4A8E7A2AD8E272
GO
Isoform 2 (identifier: Q8N114-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:209
Mass (Da):22,367
Checksum:i523A68BE70B836AF
GO
Isoform 3 (identifier: Q8N114-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.
     104-104: S → M

Show »
Length:137
Mass (Da):14,502
Checksum:i7DB8894F341443AD
GO
Isoform 4 (identifier: Q8N114-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.
     104-104: S → M
     216-240: GAAAPYPASQPPYNPAYMDAPKAAL → ECPCQL

Show »
Length:118
Mass (Da):12,661
Checksum:i028379F596023F38
GO
Isoform 5 (identifier: Q8N114-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-77: Missing.

Show »
Length:233
Mass (Da):24,855
Checksum:i8302434F0F5AF946
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WFD9F8WFD9_HUMAN
Protein shisa-5
SHISA5
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IZ46C9IZ46_HUMAN
Protein shisa-5
SHISA5
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZK8A0A087WZK8_HUMAN
Protein shisa-5
SHISA5
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDS1F8WDS1_HUMAN
Protein shisa-5
SHISA5
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCE2F8WCE2_HUMAN
Protein shisa-5
SHISA5
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2R0H7C2R0_HUMAN
Protein shisa-5
SHISA5
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054031216G → R. Corresponds to variant dbSNP:rs35750010Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0299531 – 103Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST103
Alternative sequenceiVSP_0299541 – 31Missing in isoform 2. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_05571271 – 77Missing in isoform 5. Curated7
Alternative sequenceiVSP_029955104S → M in isoform 3 and isoform 4. 3 Publications1
Alternative sequenceiVSP_029956216 – 240GAAAP…PKAAL → ECPCQL in isoform 4. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF520698 mRNA Translation: AAM74232.1
AH011688 Genomic DNA Translation: AAM74235.1
AB097007 mRNA Translation: BAC77360.1
AK056328 mRNA Translation: BAB71152.1
AK075441 mRNA Translation: BAC11623.1
AK124652 mRNA Translation: BAG54061.1
AL117413 mRNA Translation: CAH10718.1
AL832568 mRNA Translation: CAH10587.1
AC104448 Genomic DNA No translation available.
AC134772 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64885.1
CH471055 Genomic DNA Translation: EAW64887.1
BC001463 mRNA Translation: AAH01463.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2770.1 [Q8N114-1]
CCDS63621.1 [Q8N114-3]
CCDS63622.1 [Q8N114-2]
CCDS63623.1 [Q8N114-5]

NCBI Reference Sequences

More...RefSeqi		NP_001258994.1, NM_001272065.1 [Q8N114-5]
NP_001258995.1, NM_001272066.1 [Q8N114-2]
NP_001258996.1, NM_001272067.1 [Q8N114-2]
NP_001258997.1, NM_001272068.1 [Q8N114-2]
NP_001259011.1, NM_001272082.1 [Q8N114-3]
NP_001259012.1, NM_001272083.1 [Q8N114-4]
NP_057563.3, NM_016479.4 [Q8N114-1]
XP_005265262.1, XM_005265205.1 [Q8N114-2]
XP_006713251.1, XM_006713188.2 [Q8N114-2]
XP_011532098.1, XM_011533796.1 [Q8N114-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000296444; ENSP00000296444; ENSG00000164054
ENST00000426002; ENSP00000390388; ENSG00000164054 [Q8N114-3]
ENST00000442747; ENSP00000408223; ENSG00000164054 [Q8N114-2]
ENST00000443308; ENSP00000395373; ENSG00000164054 [Q8N114-5]
ENST00000444115; ENSP00000407957; ENSG00000164054 [Q8N114-2]
ENST00000619810; ENSP00000484992; ENSG00000164054 [Q8N114-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51246

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51246

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000296444.7; ENSP00000296444.2; NM_016479.6; NP_057563.3

UCSC genome browser

More...UCSCi		uc003ctm.4, human [Q8N114-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520698 mRNA Translation: AAM74232.1
AH011688 Genomic DNA Translation: AAM74235.1
AB097007 mRNA Translation: BAC77360.1
AK056328 mRNA Translation: BAB71152.1
AK075441 mRNA Translation: BAC11623.1
AK124652 mRNA Translation: BAG54061.1
AL117413 mRNA Translation: CAH10718.1
AL832568 mRNA Translation: CAH10587.1
AC104448 Genomic DNA No translation available.
AC134772 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64885.1
CH471055 Genomic DNA Translation: EAW64887.1
BC001463 mRNA Translation: AAH01463.2
CCDSiCCDS2770.1 [Q8N114-1]
CCDS63621.1 [Q8N114-3]
CCDS63622.1 [Q8N114-2]
CCDS63623.1 [Q8N114-5]
RefSeqiNP_001258994.1, NM_001272065.1 [Q8N114-5]
NP_001258995.1, NM_001272066.1 [Q8N114-2]
NP_001258996.1, NM_001272067.1 [Q8N114-2]
NP_001258997.1, NM_001272068.1 [Q8N114-2]
NP_001259011.1, NM_001272082.1 [Q8N114-3]
NP_001259012.1, NM_001272083.1 [Q8N114-4]
NP_057563.3, NM_016479.4 [Q8N114-1]
XP_005265262.1, XM_005265205.1 [Q8N114-2]
XP_006713251.1, XM_006713188.2 [Q8N114-2]
XP_011532098.1, XM_011533796.1 [Q8N114-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi119403, 11 interactors
ELMiQ8N114
IntActiQ8N114, 10 interactors
STRINGi9606.ENSP00000296444

PTM databases

GlyGeniQ8N114, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ8N114
PhosphoSitePlusiQ8N114

Genetic variation databases

BioMutaiSHISA5
DMDMi74714697

Proteomic databases

jPOSTiQ8N114
MassIVEiQ8N114
PaxDbiQ8N114
PeptideAtlasiQ8N114
PRIDEiQ8N114
ProteomicsDBi30355
71515 [Q8N114-1]
71516 [Q8N114-2]
71517 [Q8N114-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30112, 137 antibodies from 18 providers

The DNASU plasmid repository

More...DNASUi		51246

Genome annotation databases

EnsembliENST00000296444; ENSP00000296444; ENSG00000164054
ENST00000426002; ENSP00000390388; ENSG00000164054 [Q8N114-3]
ENST00000442747; ENSP00000408223; ENSG00000164054 [Q8N114-2]
ENST00000443308; ENSP00000395373; ENSG00000164054 [Q8N114-5]
ENST00000444115; ENSP00000407957; ENSG00000164054 [Q8N114-2]
ENST00000619810; ENSP00000484992; ENSG00000164054 [Q8N114-2]
GeneIDi51246
KEGGihsa:51246
MANE-SelectiENST00000296444.7; ENSP00000296444.2; NM_016479.6; NP_057563.3
UCSCiuc003ctm.4, human [Q8N114-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51246
DisGeNETi51246

GeneCards: human genes, protein and diseases

More...GeneCardsi		SHISA5
HGNCiHGNC:30376, SHISA5
HPAiENSG00000164054, Low tissue specificity
MIMi607290, gene
neXtProtiNX_Q8N114
OpenTargetsiENSG00000164054
PharmGKBiPA162403295
VEuPathDBiHostDB:ENSG00000164054

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S2Y4, Eukaryota
GeneTreeiENSGT00390000008296
HOGENOMiCLU_093192_1_0_1
InParanoidiQ8N114
OMAiYKMCRKP
OrthoDBi1267386at2759
PhylomeDBiQ8N114
TreeFamiTF332572

Enzyme and pathway databases

PathwayCommonsiQ8N114
ReactomeiR-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275, Post-translational protein phosphorylation
SignaLinkiQ8N114

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51246, 8 hits in 1050 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SHISA5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51246
PharosiQ8N114, Tbio

Protein Ontology

More...PROi		PR:Q8N114
RNActiQ8N114, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000164054, Expressed in prostate gland and 218 other tissues
ExpressionAtlasiQ8N114, baseline and differential
GenevisibleiQ8N114, HS

Family and domain databases

InterProiView protein in InterPro
IPR026910, Shisa
PANTHERiPTHR31395, PTHR31395, 1 hit
PfamiView protein in Pfam
PF13908, Shisa, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHSA5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N114
Secondary accession number(s): B3KW99
, F8W9N8, Q69YY9, Q7Z433, Q8NHL9, Q96MW8, Q9BV58
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2002
Last modified: February 23, 2022
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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