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Protein

Leucine-rich single-pass membrane protein 2

Gene

LSMEM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich single-pass membrane protein 2
Gene namesi
Name:LSMEM2
Synonyms:C3orf45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000179564.3
HGNCiHGNC:26781 LSMEM2
neXtProtiNX_Q8N112

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485322

Polymorphism and mutation databases

BioMutaiLSMEM2
DMDMi74728479

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002426631 – 164Leucine-rich single-pass membrane protein 2Add BLAST164

Proteomic databases

PaxDbiQ8N112
PeptideAtlasiQ8N112
PRIDEiQ8N112
ProteomicsDBi71514

Expressioni

Gene expression databases

BgeeiENSG00000179564 Expressed in 86 organ(s), highest expression level in heart left ventricle
CleanExiHS_C3orf45
GenevisibleiQ8N112 HS

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi126313, 26 interactors
IntActiQ8N112, 19 interactors

Structurei

3D structure databases

ProteinModelPortaliQ8N112
SMRiQ8N112
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXEM Eukaryota
ENOG411198B LUCA
GeneTreeiENSGT00390000000577
HOGENOMiHOG000111365
InParanoidiQ8N112
OMAiMPEETQE
OrthoDBiEOG091G11FV
PhylomeDBiQ8N112
TreeFamiTF338480

Family and domain databases

InterProiView protein in InterPro
IPR031674 DUF4714
PANTHERiPTHR37333 PTHR37333, 1 hit
PfamiView protein in Pfam
PF15833 DUF4714, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N112-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSLAPDCPL LAMPEETQED SVAPMMPSQR SRGPLAPNHV HEVCLHQVES
60 70 80 90 100
ISDLHSGAGT LRPYLTEEAR PWDELLGVLP PSLCAQAGCS PVYRRGGFLL
110 120 130 140 150
LLALLVLTCL VLALLAVYLS VLQSESLRIL AHTLRTQEET LLKLRLASLS
160
QLRRLNSSEA QAPS
Length:164
Mass (Da):17,868
Last modified:October 1, 2002 - v1
Checksum:i809993458714252E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095927 mRNA Translation: BAC04652.1
U73167 Genomic DNA No translation available.
BC028000 mRNA Translation: AAH28000.1
CCDSiCCDS2814.1
RefSeqiNP_001291314.1, NM_001304385.1
NP_694947.1, NM_153215.2
UniGeneiHs.315177

Genome annotation databases

EnsembliENST00000316436; ENSP00000315081; ENSG00000179564
GeneIDi132228
KEGGihsa:132228
UCSCiuc003cyz.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095927 mRNA Translation: BAC04652.1
U73167 Genomic DNA No translation available.
BC028000 mRNA Translation: AAH28000.1
CCDSiCCDS2814.1
RefSeqiNP_001291314.1, NM_001304385.1
NP_694947.1, NM_153215.2
UniGeneiHs.315177

3D structure databases

ProteinModelPortaliQ8N112
SMRiQ8N112
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126313, 26 interactors
IntActiQ8N112, 19 interactors

Polymorphism and mutation databases

BioMutaiLSMEM2
DMDMi74728479

Proteomic databases

PaxDbiQ8N112
PeptideAtlasiQ8N112
PRIDEiQ8N112
ProteomicsDBi71514

Protocols and materials databases

DNASUi132228
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316436; ENSP00000315081; ENSG00000179564
GeneIDi132228
KEGGihsa:132228
UCSCiuc003cyz.4 human

Organism-specific databases

CTDi132228
EuPathDBiHostDB:ENSG00000179564.3
GeneCardsiLSMEM2
HGNCiHGNC:26781 LSMEM2
neXtProtiNX_Q8N112
PharmGKBiPA143485322
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXEM Eukaryota
ENOG411198B LUCA
GeneTreeiENSGT00390000000577
HOGENOMiHOG000111365
InParanoidiQ8N112
OMAiMPEETQE
OrthoDBiEOG091G11FV
PhylomeDBiQ8N112
TreeFamiTF338480

Miscellaneous databases

GenomeRNAii132228
PROiPR:Q8N112

Gene expression databases

BgeeiENSG00000179564 Expressed in 86 organ(s), highest expression level in heart left ventricle
CleanExiHS_C3orf45
GenevisibleiQ8N112 HS

Family and domain databases

InterProiView protein in InterPro
IPR031674 DUF4714
PANTHERiPTHR37333 PTHR37333, 1 hit
PfamiView protein in Pfam
PF15833 DUF4714, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLSME2_HUMAN
AccessioniPrimary (citable) accession number: Q8N112
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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