LSMEM2

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leucine-rich single-pass membrane protein 2
Gene namesⁱ	Name:LSMEM2 Synonyms:C3orf45
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179564.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26781 LSMEM2
neXtProtⁱ	NX_Q8N112

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	97 – 117	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA143485322

PharmGKBⁱ

PA143485322

Polymorphism and mutation databases

BioMutaⁱ	LSMEM2
DMDMⁱ	74728479

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000242663	1 – 164	Leucine-rich single-pass membrane protein 2Add BLAST		164

Proteomic databases

PaxDbⁱ	Q8N112
PeptideAtlas More...PeptideAtlasⁱ	Q8N112
PRIDEⁱ	Q8N112
ProteomicsDBⁱ	71514

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000179564 Expressed in 86 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_C3orf45
Genevisibleⁱ	Q8N112 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
EMP1	P54849	4	EBI-10264855,EBI-4319440
GIMAP5	Q96F15	5	EBI-10264855,EBI-6166686
LSMEM1	Q8N8F7	7	EBI-10264855,EBI-10200825

Protein-protein interaction databases

BioGridⁱ	126313, 26 interactors
IntActⁱ	Q8N112, 19 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N112
SMRⁱ	Q8N112
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IXEM Eukaryota ENOG411198B LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000577
HOGENOMⁱ	HOG000111365
InParanoidⁱ	Q8N112
OMAⁱ	MPEETQE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11FV
PhylomeDBⁱ	Q8N112
TreeFamⁱ	TF338480

Family and domain databases

InterProⁱ	View protein in InterPro IPR031674 DUF4714
PANTHERⁱ	PTHR37333 PTHR37333, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15833 DUF4714, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8N112-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPSLAPDCPL LAMPEETQED SVAPMMPSQR SRGPLAPNHV HEVCLHQVES 
        60         70         80         90        100
ISDLHSGAGT LRPYLTEEAR PWDELLGVLP PSLCAQAGCS PVYRRGGFLL 
       110        120        130        140        150
LLALLVLTCL VLALLAVYLS VLQSESLRIL AHTLRTQEET LLKLRLASLS 
       160 
QLRRLNSSEA QAPS

Length:164

Mass (Da):17,868

Last modified:October 1, 2002 - v1

Checksum:ⁱ809993458714252E

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK095927 mRNA Translation: BAC04652.1 U73167 Genomic DNA No translation available. BC028000 mRNA Translation: AAH28000.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2814.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001291314.1, NM_001304385.1 NP_694947.1, NM_153215.2
UniGeneⁱ	Hs.315177

Genome annotation databases

Ensemblⁱ	ENST00000316436; ENSP00000315081; ENSG00000179564
GeneIDⁱ	132228
KEGGⁱ	hsa:132228
UCSC genome browser More...UCSCⁱ	uc003cyz.4 human

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N112	Uncharacterized protein		Cebus capucinus imitator		164	UniRef50_Q8N112
Uncharacterized protein		AOTNA		164
Uncharacterized protein		CALJA		164
Leucine rich single-pass membrane protein 2		FELCA		168
Uncharacterized protein		TUPCH		150
+47

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK095927 mRNA Translation: BAC04652.1 U73167 Genomic DNA No translation available. BC028000 mRNA Translation: AAH28000.1
CCDSⁱ	CCDS2814.1
RefSeqⁱ	NP_001291314.1, NM_001304385.1 NP_694947.1, NM_153215.2
UniGeneⁱ	Hs.315177

3D structure databases

ProteinModelPortalⁱ	Q8N112
SMRⁱ	Q8N112
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126313, 26 interactors
IntActⁱ	Q8N112, 19 interactors

Polymorphism and mutation databases

BioMutaⁱ	LSMEM2
DMDMⁱ	74728479

Proteomic databases

PaxDbⁱ	Q8N112
PeptideAtlasⁱ	Q8N112
PRIDEⁱ	Q8N112
ProteomicsDBⁱ	71514

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	132228
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000316436; ENSP00000315081; ENSG00000179564
GeneIDⁱ	132228
KEGGⁱ	hsa:132228
UCSCⁱ	uc003cyz.4 human

Organism-specific databases

CTDⁱ	132228
EuPathDBⁱ	HostDB:ENSG00000179564.3
GeneCardsⁱ	LSMEM2
HGNCⁱ	HGNC:26781 LSMEM2
neXtProtⁱ	NX_Q8N112
PharmGKBⁱ	PA143485322
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IXEM Eukaryota ENOG411198B LUCA
GeneTreeⁱ	ENSGT00390000000577
HOGENOMⁱ	HOG000111365
InParanoidⁱ	Q8N112
OMAⁱ	MPEETQE
OrthoDBⁱ	EOG091G11FV
PhylomeDBⁱ	Q8N112
TreeFamⁱ	TF338480

Miscellaneous databases

GenomeRNAiⁱ	132228
Protein Ontology More...PROⁱ	PR:Q8N112

Gene expression databases

Bgeeⁱ	ENSG00000179564 Expressed in 86 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_C3orf45
Genevisibleⁱ	Q8N112 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR031674 DUF4714
PANTHERⁱ	PTHR37333 PTHR37333, 1 hit
Pfamⁱ	View protein in Pfam PF15833 DUF4714, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LSME2_HUMAN
Accessionⁱ	Q8N112Primary (citable) accession number: Q8N112
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
	Last sequence update:	October 1, 2002
	Last modified:	September 12, 2018
	This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N112 (LSME2_HUMAN)

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Leucine-rich single-pass membrane protein 2

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ