UniProtKB - Q8N112 (LSME2_HUMAN)
Protein
Leucine-rich single-pass membrane protein 2
Gene
LSMEM2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich single-pass membrane protein 2 |
Gene namesi | Name:LSMEM2 Synonyms:C3orf45 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26781, LSMEM2 |
neXtProti | NX_Q8N112 |
VEuPathDBi | HostDB:ENSG00000179564.3 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 97 – 117 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 132228 |
PharmGKBi | PA143485322 |
Miscellaneous databases
Pharosi | Q8N112, Tdark |
Genetic variation databases
BioMutai | LSMEM2 |
DMDMi | 74728479 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000242663 | 1 – 164 | Leucine-rich single-pass membrane protein 2Add BLAST | 164 |
Proteomic databases
PaxDbi | Q8N112 |
PeptideAtlasi | Q8N112 |
PRIDEi | Q8N112 |
ProteomicsDBi | 71514 |
Expressioni
Gene expression databases
Bgeei | ENSG00000179564, Expressed in heart left ventricle and 106 other tissues |
Genevisiblei | Q8N112, HS |
Organism-specific databases
HPAi | ENSG00000179564, Group enriched (heart muscle, skeletal muscle, tongue) |
Interactioni
Binary interactionsi
Hide detailsQ8N112
Protein-protein interaction databases
BioGRIDi | 126313, 42 interactors |
IntActi | Q8N112, 19 interactors |
STRINGi | 9606.ENSP00000315081 |
Miscellaneous databases
RNActi | Q8N112, protein |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SABZ, Eukaryota |
GeneTreei | ENSGT00390000000577 |
HOGENOMi | CLU_137458_0_0_1 |
InParanoidi | Q8N112 |
OMAi | AHTLHTQ |
OrthoDBi | 1471751at2759 |
PhylomeDBi | Q8N112 |
TreeFami | TF338480 |
Family and domain databases
InterProi | View protein in InterPro IPR031674, DUF4714 |
PANTHERi | PTHR37333, PTHR37333, 1 hit |
Pfami | View protein in Pfam PF15833, DUF4714, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8N112-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPSLAPDCPL LAMPEETQED SVAPMMPSQR SRGPLAPNHV HEVCLHQVES
60 70 80 90 100
ISDLHSGAGT LRPYLTEEAR PWDELLGVLP PSLCAQAGCS PVYRRGGFLL
110 120 130 140 150
LLALLVLTCL VLALLAVYLS VLQSESLRIL AHTLRTQEET LLKLRLASLS
160
QLRRLNSSEA QAPS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK095927 mRNA Translation: BAC04652.1 U73167 Genomic DNA No translation available. BC028000 mRNA Translation: AAH28000.1 |
CCDSi | CCDS2814.1 |
RefSeqi | NP_001291314.1, NM_001304385.1 NP_694947.1, NM_153215.2 |
Genome annotation databases
Ensembli | ENST00000316436; ENSP00000315081; ENSG00000179564 |
GeneIDi | 132228 |
KEGGi | hsa:132228 |
UCSCi | uc003cyz.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK095927 mRNA Translation: BAC04652.1 U73167 Genomic DNA No translation available. BC028000 mRNA Translation: AAH28000.1 |
CCDSi | CCDS2814.1 |
RefSeqi | NP_001291314.1, NM_001304385.1 NP_694947.1, NM_153215.2 |
3D structure databases
SMRi | Q8N112 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126313, 42 interactors |
IntActi | Q8N112, 19 interactors |
STRINGi | 9606.ENSP00000315081 |
Genetic variation databases
BioMutai | LSMEM2 |
DMDMi | 74728479 |
Proteomic databases
PaxDbi | Q8N112 |
PeptideAtlasi | Q8N112 |
PRIDEi | Q8N112 |
ProteomicsDBi | 71514 |
Protocols and materials databases
Antibodypediai | 64735, 24 antibodies |
DNASUi | 132228 |
Genome annotation databases
Ensembli | ENST00000316436; ENSP00000315081; ENSG00000179564 |
GeneIDi | 132228 |
KEGGi | hsa:132228 |
UCSCi | uc003cyz.4, human |
Organism-specific databases
CTDi | 132228 |
DisGeNETi | 132228 |
GeneCardsi | LSMEM2 |
HGNCi | HGNC:26781, LSMEM2 |
HPAi | ENSG00000179564, Group enriched (heart muscle, skeletal muscle, tongue) |
neXtProti | NX_Q8N112 |
PharmGKBi | PA143485322 |
VEuPathDBi | HostDB:ENSG00000179564.3 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SABZ, Eukaryota |
GeneTreei | ENSGT00390000000577 |
HOGENOMi | CLU_137458_0_0_1 |
InParanoidi | Q8N112 |
OMAi | AHTLHTQ |
OrthoDBi | 1471751at2759 |
PhylomeDBi | Q8N112 |
TreeFami | TF338480 |
Enzyme and pathway databases
PathwayCommonsi | Q8N112 |
Miscellaneous databases
BioGRID-ORCSi | 132228, 3 hits in 868 CRISPR screens |
GenomeRNAii | 132228 |
Pharosi | Q8N112, Tdark |
PROi | PR:Q8N112 |
RNActi | Q8N112, protein |
Gene expression databases
Bgeei | ENSG00000179564, Expressed in heart left ventricle and 106 other tissues |
Genevisiblei | Q8N112, HS |
Family and domain databases
InterProi | View protein in InterPro IPR031674, DUF4714 |
PANTHERi | PTHR37333, PTHR37333, 1 hit |
Pfami | View protein in Pfam PF15833, DUF4714, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LSME2_HUMAN | |
Accessioni | Q8N112Primary (citable) accession number: Q8N112 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM