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Protein

Tetratricopeptide repeat protein 5

Gene

TTC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-HSA-6804760 Regulation of TP53 Activity through Methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 5
Short name:
TPR repeat protein 5
Alternative name(s):
Stress-responsive activator of p300
Short name:
Strap
Gene namesi
Name:TTC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000136319.11
HGNCiHGNC:19274 TTC5
neXtProtiNX_Q8N0Z6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi91875
OpenTargetsiENSG00000136319
PharmGKBiPA134919164

Polymorphism and mutation databases

BioMutaiTTC5
DMDMi229462802

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063811 – 440Tetratricopeptide repeat protein 5Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei203PhosphoserineBy similarity1
Modified residuei221PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N0Z6
MaxQBiQ8N0Z6
PaxDbiQ8N0Z6
PeptideAtlasiQ8N0Z6
PRIDEiQ8N0Z6
ProteomicsDBi71493

PTM databases

iPTMnetiQ8N0Z6
PhosphoSitePlusiQ8N0Z6

Expressioni

Gene expression databases

BgeeiENSG00000136319
CleanExiHS_TTC5
ExpressionAtlasiQ8N0Z6 baseline and differential
GenevisibleiQ8N0Z6 HS

Organism-specific databases

HPAiHPA045008
HPA054198

Interactioni

Subunit structurei

Interacts with JMY and p300/EP300.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124889, 38 interactors
IntActiQ8N0Z6, 12 interactors
MINTiQ8N0Z6
STRINGi9606.ENSP00000258821

Structurei

Secondary structure

1440
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi262 – 280Combined sources19
Helixi281 – 283Combined sources3
Helixi286 – 294Combined sources9
Helixi298 – 304Combined sources7
Helixi324 – 326Combined sources3
Beta strandi329 – 331Combined sources3
Beta strandi335 – 345Combined sources11
Beta strandi352 – 362Combined sources11
Beta strandi365 – 369Combined sources5
Beta strandi383 – 388Combined sources6
Beta strandi390 – 398Combined sources9
Beta strandi401 – 411Combined sources11
Helixi413 – 415Combined sources3

3D structure databases

ProteinModelPortaliQ8N0Z6
SMRiQ8N0Z6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N0Z6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 61TPR 1PROSITE-ProRule annotation1 PublicationAdd BLAST55
Repeati68 – 98TPR 2PROSITE-ProRule annotation1 PublicationAdd BLAST31
Repeati103 – 130TPR 3PROSITE-ProRule annotation1 PublicationAdd BLAST28
Repeati136 – 174TPR 4PROSITE-ProRule annotation1 PublicationAdd BLAST39
Repeati179 – 216TPR 5PROSITE-ProRule annotation1 PublicationAdd BLAST38
Repeati224 – 253TPR 6PROSITE-ProRule annotation1 PublicationAdd BLAST30

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IEK9 Eukaryota
ENOG410XP1F LUCA
GeneTreeiENSGT00390000006227
HOGENOMiHOG000006922
HOVERGENiHBG054388
InParanoidiQ8N0Z6
OMAiNMVQSWG
OrthoDBiEOG091G0ARR
PhylomeDBiQ8N0Z6
TreeFamiTF316804

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.40.50.550, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR032076 TTC5_OB
IPR038645 TTC5_OB_sf
PfamiView protein in Pfam
PF16669 TTC5_OB, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 2 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Q8N0Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMADEEEEVK PILQKLQELV DQLYSFRDCY FETHSVEDAG RKQQDVQKEM
60 70 80 90 100
EKTLQQMEEV VGSVQGKAQV LMLTGKALNV TPDYSPKAEE LLSKAVKLEP
110 120 130 140 150
ELVEAWNQLG EVYWKKGDVA AAHTCFSGAL THCRNKVSLQ NLSMVLRQLR
160 170 180 190 200
TDTEDEHSHH VMDSVRQAKL AVQMDVHDGR SWYILGNSYL SLYFSTGQNP
210 220 230 240 250
KISQQALSAY AQAEKVDRKA SSNPDLHLNR ATLHKYEESY GEALEGFSRA
260 270 280 290 300
AALDPAWPEP RQREQQLLEF LDRLTSLLES KGKVKTKKLQ SMLGSLRPAH
310 320 330 340 350
LGPCSDGHYQ SASGQKVTLE LKPLSTLQPG VNSGAVILGK VVFSLTTEEK
360 370 380 390 400
VPFTFGLVDS DGPCYAVMVY NIVQSWGVLI GDSVAIPEPN LRLHRIQHKG
410 420 430 440
KDYSFSSVRV ETPLLLVVNG KPQGSSSQAV ATVASRPQCE
Length:440
Mass (Da):48,928
Last modified:May 5, 2009 - v2
Checksum:iDB4505A217811BD0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03413114Q → H. Corresponds to variant dbSNP:rs34675160Ensembl.1
Natural variantiVAR_05529347Q → R2 PublicationsCorresponds to variant dbSNP:rs3742945Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074553 mRNA Translation: BAC11056.1
AL356019 Genomic DNA No translation available.
BC008647 mRNA Translation: AAH08647.1
BC030822 mRNA Translation: AAH30822.1
BC053538 mRNA Translation: AAH53538.1
CCDSiCCDS9546.1
RefSeqiNP_612385.2, NM_138376.2
UniGeneiHs.98553

Genome annotation databases

EnsembliENST00000258821; ENSP00000258821; ENSG00000136319
GeneIDi91875
KEGGihsa:91875
UCSCiuc001vwt.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTTC5_HUMAN
AccessioniPrimary (citable) accession number: Q8N0Z6
Secondary accession number(s): A8MQ18, Q96HF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 5, 2009
Last modified: June 20, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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