We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q8N0Y7 (PGAM4_HUMAN)
Protein
Probable phosphoglycerate mutase 4
Gene
PGAM4
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
This is the product of a processed gene created by retroposition from mRNA of an expressed gene. This gene seems to be expressed.
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 11 | Tele-phosphohistidine intermediateBy similarity | 1 | |
Binding sitei | 62 | SubstrateBy similarity | 1 | |
Active sitei | 89 | Proton donor/acceptorBy similarity | 1 | |
Binding sitei | 100 | SubstrateBy similarity | 1 | |
Sitei | 186 | Transition state stabilizerBy similarity | 1 |
GO - Molecular functioni
- bisphosphoglycerate mutase activity Source: UniProtKB-EC
- hydrolase activity Source: UniProtKB-KW
- phosphoglycerate mutase activity Source: UniProtKB
GO - Biological processi
- glycolytic process Source: UniProtKB
- positive regulation of flagellated sperm motility Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Isomerase |
Biological process | Glycolysis |
Enzyme and pathway databases
PathwayCommonsi | Q8N0Y7 |
SignaLinki | Q8N0Y7 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PGAM4 Synonyms:PGAM3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21731, PGAM4 |
MIMi | 300567, gene |
neXtProti | NX_Q8N0Y7 |
VEuPathDBi | HostDB:ENSG00000226784 |
Subcellular locationi
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- sperm principal piece Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 441531 |
OpenTargetsi | ENSG00000226784 |
PharmGKBi | PA142671183 |
Miscellaneous databases
Pharosi | Q8N0Y7, Tbio |
Genetic variation databases
BioMutai | PGAM4 |
DMDMi | 26006838 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000179832 | 1 – 254 | Probable phosphoglycerate mutase 4Add BLAST | 254 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 14 | PhosphoserineBy similarity | 1 | |
Modified residuei | 23 | PhosphoserineBy similarity | 1 | |
Modified residuei | 26 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 31 | PhosphoserineBy similarity | 1 | |
Modified residuei | 106 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 118 | PhosphoserineBy similarity | 1 | |
Modified residuei | 251 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 251 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 253 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 254 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8N0Y7 |
jPOSTi | Q8N0Y7 |
MassIVEi | Q8N0Y7 |
MaxQBi | Q8N0Y7 |
PaxDbi | Q8N0Y7 |
PeptideAtlasi | Q8N0Y7 |
PRIDEi | Q8N0Y7 |
ProteomicsDBi | 71490 |
PTM databases
DEPODi | PGAM4 |
GlyGeni | Q8N0Y7, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8N0Y7 |
PhosphoSitePlusi | Q8N0Y7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000226784, Expressed in temporal lobe and 71 other tissues |
Genevisiblei | Q8N0Y7, HS |
Organism-specific databases
HPAi | ENSG00000226784, Not detected |
Interactioni
Protein-protein interaction databases
BioGRIDi | 137555, 36 interactors |
IntActi | Q8N0Y7, 2 interactors |
STRINGi | 9606.ENSP00000412189 |
Miscellaneous databases
RNActi | Q8N0Y7, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 10 – 17 | Substrate bindingBy similarity | 8 | |
Regioni | 23 – 24 | Substrate bindingBy similarity | 2 | |
Regioni | 89 – 92 | Substrate bindingBy similarity | 4 | |
Regioni | 116 – 117 | Substrate bindingBy similarity | 2 | |
Regioni | 187 – 188 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0235, Eukaryota |
GeneTreei | ENSGT00950000182926 |
HOGENOMi | CLU_033323_1_1_1 |
InParanoidi | Q8N0Y7 |
OMAi | DHDYYAI |
PhylomeDBi | Q8N0Y7 |
TreeFami | TF300007 |
Family and domain databases
CDDi | cd07067, HP_PGM_like, 1 hit |
Gene3Di | 3.40.50.1240, 1 hit |
HAMAPi | MF_01039, PGAM_GpmA, 1 hit |
InterProi | View protein in InterPro IPR013078, His_Pase_superF_clade-1 IPR029033, His_PPase_superfam IPR001345, PG/BPGM_mutase_AS IPR005952, Phosphogly_mut1 |
PANTHERi | PTHR11931, PTHR11931, 1 hit |
Pfami | View protein in Pfam PF00300, His_Phos_1, 2 hits |
SMARTi | View protein in SMART SM00855, PGAM, 1 hit |
SUPFAMi | SSF53254, SSF53254, 1 hit |
TIGRFAMsi | TIGR01258, pgm_1, 1 hit |
PROSITEi | View protein in PROSITE PS00175, PG_MUTASE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8N0Y7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAYKLVLIR HGESTWNLEN RFSCWYDADL SPAGHEEAKR GGQALRDAGY
60 70 80 90 100
EFDICLTSVQ KRVIRTLWTV LDAIDQMWLP VVRTWRLNER HYGGLTGLNK
110 120 130 140 150
AETAAKHGEA QVKIWRRSYD VPPPPMEPDH PFYSNISKDR RYADLTEDQL
160 170 180 190 200
PSYESPKDTI ARALPFWNEE IVPQIKEGKR VLIAAHGNSL QGIAKHVEGL
210 220 230 240 250
SEEAIMELNL PTGIPIVYEL DKNLKPIKPM QFLGDEETVC KAIEAVAAQG
KAKK
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014355 | 40 | R → C1 PublicationCorresponds to variant dbSNP:rs782408548Ensembl. | 1 | |
Natural variantiVAR_014356 | 90 | R → Q1 PublicationCorresponds to variant dbSNP:rs5959129Ensembl. | 1 | |
Natural variantiVAR_014357 | 175 | I → T1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF465731 Genomic DNA Translation: AAM27282.1 AF465732 Genomic DNA Translation: AAM27283.1 AF465733 Genomic DNA Translation: AAM27284.1 AF465734 Genomic DNA Translation: AAM27285.1 AF465735 Genomic DNA Translation: AAM27286.1 AF465736 Genomic DNA Translation: AAM27287.1 AF465737 Genomic DNA Translation: AAM27288.1 AF465738 Genomic DNA Translation: AAM27289.1 AF465739 Genomic DNA Translation: AAM27290.1 AF465740 Genomic DNA Translation: AAM27291.1 AF465741 Genomic DNA Translation: AAM27292.1 AF465742 Genomic DNA Translation: AAM27293.1 AF465743 Genomic DNA Translation: AAM27294.1 AF465744 Genomic DNA Translation: AAM27295.1 AF465745 Genomic DNA Translation: AAM27296.1 DQ120647 Genomic DNA Translation: ABB92432.1 AL772330 Genomic DNA No translation available. |
CCDSi | CCDS35338.1 |
RefSeqi | NP_001025062.1, NM_001029891.2 |
Genome annotation databases
Ensembli | ENST00000458128.3; ENSP00000412189.1; ENSG00000226784.3 |
GeneIDi | 441531 |
KEGGi | hsa:441531 |
MANE-Selecti | ENST00000458128.3; ENSP00000412189.1; NM_001029891.3; NP_001025062.1 |
UCSCi | uc004ecy.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF465731 Genomic DNA Translation: AAM27282.1 AF465732 Genomic DNA Translation: AAM27283.1 AF465733 Genomic DNA Translation: AAM27284.1 AF465734 Genomic DNA Translation: AAM27285.1 AF465735 Genomic DNA Translation: AAM27286.1 AF465736 Genomic DNA Translation: AAM27287.1 AF465737 Genomic DNA Translation: AAM27288.1 AF465738 Genomic DNA Translation: AAM27289.1 AF465739 Genomic DNA Translation: AAM27290.1 AF465740 Genomic DNA Translation: AAM27291.1 AF465741 Genomic DNA Translation: AAM27292.1 AF465742 Genomic DNA Translation: AAM27293.1 AF465743 Genomic DNA Translation: AAM27294.1 AF465744 Genomic DNA Translation: AAM27295.1 AF465745 Genomic DNA Translation: AAM27296.1 DQ120647 Genomic DNA Translation: ABB92432.1 AL772330 Genomic DNA No translation available. |
CCDSi | CCDS35338.1 |
RefSeqi | NP_001025062.1, NM_001029891.2 |
3D structure databases
AlphaFoldDBi | Q8N0Y7 |
SMRi | Q8N0Y7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 137555, 36 interactors |
IntActi | Q8N0Y7, 2 interactors |
STRINGi | 9606.ENSP00000412189 |
PTM databases
DEPODi | PGAM4 |
GlyGeni | Q8N0Y7, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8N0Y7 |
PhosphoSitePlusi | Q8N0Y7 |
Genetic variation databases
BioMutai | PGAM4 |
DMDMi | 26006838 |
Proteomic databases
EPDi | Q8N0Y7 |
jPOSTi | Q8N0Y7 |
MassIVEi | Q8N0Y7 |
MaxQBi | Q8N0Y7 |
PaxDbi | Q8N0Y7 |
PeptideAtlasi | Q8N0Y7 |
PRIDEi | Q8N0Y7 |
ProteomicsDBi | 71490 |
Protocols and materials databases
Antibodypediai | 67001, 99 antibodies from 14 providers |
DNASUi | 441531 |
Genome annotation databases
Ensembli | ENST00000458128.3; ENSP00000412189.1; ENSG00000226784.3 |
GeneIDi | 441531 |
KEGGi | hsa:441531 |
MANE-Selecti | ENST00000458128.3; ENSP00000412189.1; NM_001029891.3; NP_001025062.1 |
UCSCi | uc004ecy.2, human |
Organism-specific databases
CTDi | 441531 |
DisGeNETi | 441531 |
GeneCardsi | PGAM4 |
HGNCi | HGNC:21731, PGAM4 |
HPAi | ENSG00000226784, Not detected |
MIMi | 300567, gene |
neXtProti | NX_Q8N0Y7 |
OpenTargetsi | ENSG00000226784 |
PharmGKBi | PA142671183 |
VEuPathDBi | HostDB:ENSG00000226784 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0235, Eukaryota |
GeneTreei | ENSGT00950000182926 |
HOGENOMi | CLU_033323_1_1_1 |
InParanoidi | Q8N0Y7 |
OMAi | DHDYYAI |
PhylomeDBi | Q8N0Y7 |
TreeFami | TF300007 |
Enzyme and pathway databases
PathwayCommonsi | Q8N0Y7 |
SignaLinki | Q8N0Y7 |
Miscellaneous databases
BioGRID-ORCSi | 441531, 315 hits in 626 CRISPR screens |
GenomeRNAii | 441531 |
Pharosi | Q8N0Y7, Tbio |
PROi | PR:Q8N0Y7 |
RNActi | Q8N0Y7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000226784, Expressed in temporal lobe and 71 other tissues |
Genevisiblei | Q8N0Y7, HS |
Family and domain databases
CDDi | cd07067, HP_PGM_like, 1 hit |
Gene3Di | 3.40.50.1240, 1 hit |
HAMAPi | MF_01039, PGAM_GpmA, 1 hit |
InterProi | View protein in InterPro IPR013078, His_Pase_superF_clade-1 IPR029033, His_PPase_superfam IPR001345, PG/BPGM_mutase_AS IPR005952, Phosphogly_mut1 |
PANTHERi | PTHR11931, PTHR11931, 1 hit |
Pfami | View protein in Pfam PF00300, His_Phos_1, 2 hits |
SMARTi | View protein in SMART SM00855, PGAM, 1 hit |
SUPFAMi | SSF53254, SSF53254, 1 hit |
TIGRFAMsi | TIGR01258, pgm_1, 1 hit |
PROSITEi | View protein in PROSITE PS00175, PG_MUTASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PGAM4_HUMAN | |
Accessioni | Q8N0Y7Primary (citable) accession number: Q8N0Y7 Secondary accession number(s): Q5JPN2 Q8NI26 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2002 |
Last sequence update: | October 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families