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Protein

Probable phosphoglycerate mutase 4

Gene

PGAM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

This is the product of a processed gene created by retroposition from mRNA of an expressed gene. This gene seems to be expressed.

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.By similarity
3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11Tele-phosphohistidine intermediateBy similarity1
Binding sitei62SubstrateBy similarity1
Active sitei89Proton donor/acceptorBy similarity1
Binding sitei100SubstrateBy similarity1
Sitei186Transition state stabilizerBy similarity1

GO - Molecular functioni

GO - Biological processi

  • gluconeogenesis Source: GO_Central
  • glycolytic process Source: UniProtKB
  • positive regulation of flagellated sperm motility Source: UniProtKB
  • regulation of pentose-phosphate shunt Source: GO_Central

Keywordsi

Molecular functionHydrolase, Isomerase
Biological processGlycolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoglycerate mutase 4 (EC:5.4.2.11By similarity, EC:5.4.2.4By similarity)
Gene namesi
Name:PGAM4
Synonyms:PGAM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000226784.2
HGNCiHGNC:21731 PGAM4
MIMi300567 gene
neXtProtiNX_Q8N0Y7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi441531
OpenTargetsiENSG00000226784
PharmGKBiPA142671183

Polymorphism and mutation databases

BioMutaiPGAM4
DMDMi26006838

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001798321 – 254Probable phosphoglycerate mutase 4Add BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei26PhosphotyrosineBy similarity1
Modified residuei31PhosphoserineBy similarity1
Modified residuei106N6-acetyllysineBy similarity1
Modified residuei118PhosphoserineBy similarity1
Modified residuei251N6-acetyllysine; alternateBy similarity1
Modified residuei251N6-succinyllysine; alternateBy similarity1
Modified residuei253N6-acetyllysineBy similarity1
Modified residuei254N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8N0Y7
MaxQBiQ8N0Y7
PaxDbiQ8N0Y7
PeptideAtlasiQ8N0Y7
PRIDEiQ8N0Y7
ProteomicsDBi71490

PTM databases

DEPODiQ8N0Y7
iPTMnetiQ8N0Y7
PhosphoSitePlusiQ8N0Y7

Expressioni

Gene expression databases

BgeeiENSG00000226784
CleanExiHS_PGAM4
GenevisibleiQ8N0Y7 HS

Organism-specific databases

HPAiHPA042528
HPA060483

Interactioni

Protein-protein interaction databases

BioGridi137555, 2 interactors
IntActiQ8N0Y7, 1 interactor
STRINGi9606.ENSP00000412189

Structurei

3D structure databases

ProteinModelPortaliQ8N0Y7
SMRiQ8N0Y7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 17Substrate bindingBy similarity8
Regioni23 – 24Substrate bindingBy similarity2
Regioni89 – 92Substrate bindingBy similarity4
Regioni116 – 117Substrate bindingBy similarity2
Regioni187 – 188Substrate bindingBy similarity2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi122 – 131Pro-rich10

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0235 Eukaryota
COG0588 LUCA
GeneTreeiENSGT00390000016700
HOGENOMiHOG000221682
HOVERGENiHBG027528
InParanoidiQ8N0Y7
KOiK01834
OrthoDBiEOG091G0GIS
PhylomeDBiQ8N0Y7
TreeFamiTF300007

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
HAMAPiMF_01039 PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR005952 Phosphogly_mut1
PANTHERiPTHR11931 PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300 His_Phos_1, 2 hits
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR01258 pgm_1, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N0Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAYKLVLIR HGESTWNLEN RFSCWYDADL SPAGHEEAKR GGQALRDAGY
60 70 80 90 100
EFDICLTSVQ KRVIRTLWTV LDAIDQMWLP VVRTWRLNER HYGGLTGLNK
110 120 130 140 150
AETAAKHGEA QVKIWRRSYD VPPPPMEPDH PFYSNISKDR RYADLTEDQL
160 170 180 190 200
PSYESPKDTI ARALPFWNEE IVPQIKEGKR VLIAAHGNSL QGIAKHVEGL
210 220 230 240 250
SEEAIMELNL PTGIPIVYEL DKNLKPIKPM QFLGDEETVC KAIEAVAAQG

KAKK
Length:254
Mass (Da):28,777
Last modified:October 1, 2002 - v1
Checksum:iBB589CDEAAC2E706
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01435540R → C1 PublicationCorresponds to variant dbSNP:rs782408548Ensembl.1
Natural variantiVAR_01435690R → Q1 PublicationCorresponds to variant dbSNP:rs5959129Ensembl.1
Natural variantiVAR_014357175I → T1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465731 Genomic DNA Translation: AAM27282.1
AF465732 Genomic DNA Translation: AAM27283.1
AF465733 Genomic DNA Translation: AAM27284.1
AF465734 Genomic DNA Translation: AAM27285.1
AF465735 Genomic DNA Translation: AAM27286.1
AF465736 Genomic DNA Translation: AAM27287.1
AF465737 Genomic DNA Translation: AAM27288.1
AF465738 Genomic DNA Translation: AAM27289.1
AF465739 Genomic DNA Translation: AAM27290.1
AF465740 Genomic DNA Translation: AAM27291.1
AF465741 Genomic DNA Translation: AAM27292.1
AF465742 Genomic DNA Translation: AAM27293.1
AF465743 Genomic DNA Translation: AAM27294.1
AF465744 Genomic DNA Translation: AAM27295.1
AF465745 Genomic DNA Translation: AAM27296.1
DQ120647 Genomic DNA Translation: ABB92432.1
AL772330 Genomic DNA No translation available.
CCDSiCCDS35338.1
RefSeqiNP_001025062.1, NM_001029891.2
UniGeneiHs.632822

Genome annotation databases

EnsembliENST00000458128; ENSP00000412189; ENSG00000226784
GeneIDi441531
KEGGihsa:441531
UCSCiuc004ecy.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPGAM4_HUMAN
AccessioniPrimary (citable) accession number: Q8N0Y7
Secondary accession number(s): Q5JPN2
, Q8NI24, Q8NI25, Q8NI26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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