UniProtKB - Q8N0Y2 (ZN444_HUMAN)
Protein
Zinc finger protein 444
Gene
ZNF444
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 179 – 201 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 207 – 229 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 250 – 272 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 278 – 300 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8N0Y2 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 444Alternative name(s): Endothelial zinc finger protein 2 Short name: EZF-2 Zinc finger and SCAN domain-containing protein 17 |
Gene namesi | Name:ZNF444 Synonyms:EZF2, ZSCAN17 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16052, ZNF444 |
MIMi | 607874, gene |
neXtProti | NX_Q8N0Y2 |
VEuPathDBi | HostDB:ENSG00000167685.14 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 55311 |
OpenTargetsi | ENSG00000167685 |
PharmGKBi | PA134984823 |
Miscellaneous databases
Pharosi | Q8N0Y2, Tdark |
Genetic variation databases
BioMutai | ZNF444 |
DMDMi | 38258800 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047593 | 1 – 327 | Zinc finger protein 444Add BLAST | 327 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Cross-linki | 8 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 18 | PhosphoserineCombined sources | 1 | |
Modified residuei | 104 | PhosphoserineCombined sources | 1 | |
Cross-linki | 190 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 235 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8N0Y2 |
jPOSTi | Q8N0Y2 |
MassIVEi | Q8N0Y2 |
MaxQBi | Q8N0Y2 |
PaxDbi | Q8N0Y2 |
PeptideAtlasi | Q8N0Y2 |
PRIDEi | Q8N0Y2 |
ProteomicsDBi | 71486 [Q8N0Y2-1] 71487 [Q8N0Y2-2] |
PTM databases
iPTMneti | Q8N0Y2 |
PhosphoSitePlusi | Q8N0Y2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167685, Expressed in cingulate cortex and 243 other tissues |
ExpressionAtlasi | Q8N0Y2, baseline and differential |
Genevisiblei | Q8N0Y2, HS |
Organism-specific databases
HPAi | ENSG00000167685, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsIsoform 2 [Q8N0Y2-2]
Protein-protein interaction databases
BioGRIDi | 120593, 47 interactors |
IntActi | Q8N0Y2, 64 interactors |
STRINGi | 9606.ENSP00000338860 |
Miscellaneous databases
RNActi | Q8N0Y2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 104 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 85 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 179 – 201 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 207 – 229 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 250 – 272 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 278 – 300 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162893 |
HOGENOMi | CLU_002678_49_3_1 |
InParanoidi | Q8N0Y2 |
OMAi | WRRFRHF |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8N0Y2 |
TreeFami | TF337369 |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N0Y2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEVAVPVKQE AEGLALDSPW HRFRRFHLGD APGPREALGL LRALCRDWLR
60 70 80 90 100
PEVHTKEQML ELLVLEQFLS ALPADTQAWV CSRQPQSGEE AVALLEELWG
110 120 130 140 150
PAASPDGSSA TRVPQDVTQG PGATGGKEDS GMIPLAGTAP GAEGPAPGDS
160 170 180 190 200
QAVRPYKQEP SSPPLAPGLP AFLAAPGTTS CPECGKTSLK PAHLLRHRQS
210 220 230 240 250
HSGEKPHACP ECGKAFRRKE HLRRHRDTHP GSPGSPGPAL RPLPAREKPH
260 270 280 290 300
ACCECGKTFY WREHLVRHRK THSGARPFAC WECGKGFGRR EHVLRHQRIH
310 320
GRAAASAQGA VAPGPDGGGP FPPWPLG
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EMV5 | K7EMV5_HUMAN | Zinc finger protein 444 | ZNF444 | 70 | Annotation score: | ||
K7EJ91 | K7EJ91_HUMAN | Zinc finger protein 444 | ZNF444 | 99 | Annotation score: | ||
K7EJH4 | K7EJH4_HUMAN | Zinc finger protein 444 | ZNF444 | 90 | Annotation score: | ||
K7ELZ3 | K7ELZ3_HUMAN | Zinc finger protein 444 | ZNF444 | 72 | Annotation score: | ||
K7ESL2 | K7ESL2_HUMAN | Zinc finger protein 444 | ZNF444 | 77 | Annotation score: | ||
K7EK55 | K7EK55_HUMAN | Zinc finger protein 444 | ZNF444 | 44 | Annotation score: |
Sequence cautioni
The sequence BAB84889 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 49 | L → P in BAA92028 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008798 | 136 | Missing in isoform 2. 3 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB052955 mRNA Translation: BAC02698.1 AB052954 mRNA Translation: BAC02697.1 AL834130 mRNA Translation: CAD38847.1 AK074063 mRNA Translation: BAB84889.1 Frameshift. AK001999 mRNA Translation: BAA92028.1 BC021282 mRNA Translation: AAH21282.1 |
CCDSi | CCDS12939.1 [Q8N0Y2-1] CCDS59426.1 [Q8N0Y2-2] |
RefSeqi | NP_001240721.1, NM_001253792.1 [Q8N0Y2-2] NP_060807.2, NM_018337.3 [Q8N0Y2-1] XP_005259091.1, XM_005259034.2 [Q8N0Y2-1] XP_005259092.1, XM_005259035.1 [Q8N0Y2-1] XP_005259093.1, XM_005259036.1 [Q8N0Y2-1] XP_011525370.1, XM_011527068.1 [Q8N0Y2-1] |
Genome annotation databases
Ensembli | ENST00000337080; ENSP00000338860; ENSG00000167685 [Q8N0Y2-1] ENST00000592949; ENSP00000468069; ENSG00000167685 [Q8N0Y2-2] |
GeneIDi | 55311 |
KEGGi | hsa:55311 |
UCSCi | uc002qmm.4, human [Q8N0Y2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB052955 mRNA Translation: BAC02698.1 AB052954 mRNA Translation: BAC02697.1 AL834130 mRNA Translation: CAD38847.1 AK074063 mRNA Translation: BAB84889.1 Frameshift. AK001999 mRNA Translation: BAA92028.1 BC021282 mRNA Translation: AAH21282.1 |
CCDSi | CCDS12939.1 [Q8N0Y2-1] CCDS59426.1 [Q8N0Y2-2] |
RefSeqi | NP_001240721.1, NM_001253792.1 [Q8N0Y2-2] NP_060807.2, NM_018337.3 [Q8N0Y2-1] XP_005259091.1, XM_005259034.2 [Q8N0Y2-1] XP_005259092.1, XM_005259035.1 [Q8N0Y2-1] XP_005259093.1, XM_005259036.1 [Q8N0Y2-1] XP_011525370.1, XM_011527068.1 [Q8N0Y2-1] |
3D structure databases
SMRi | Q8N0Y2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120593, 47 interactors |
IntActi | Q8N0Y2, 64 interactors |
STRINGi | 9606.ENSP00000338860 |
PTM databases
iPTMneti | Q8N0Y2 |
PhosphoSitePlusi | Q8N0Y2 |
Genetic variation databases
BioMutai | ZNF444 |
DMDMi | 38258800 |
Proteomic databases
EPDi | Q8N0Y2 |
jPOSTi | Q8N0Y2 |
MassIVEi | Q8N0Y2 |
MaxQBi | Q8N0Y2 |
PaxDbi | Q8N0Y2 |
PeptideAtlasi | Q8N0Y2 |
PRIDEi | Q8N0Y2 |
ProteomicsDBi | 71486 [Q8N0Y2-1] 71487 [Q8N0Y2-2] |
Protocols and materials databases
Antibodypediai | 19607, 81 antibodies |
Genome annotation databases
Ensembli | ENST00000337080; ENSP00000338860; ENSG00000167685 [Q8N0Y2-1] ENST00000592949; ENSP00000468069; ENSG00000167685 [Q8N0Y2-2] |
GeneIDi | 55311 |
KEGGi | hsa:55311 |
UCSCi | uc002qmm.4, human [Q8N0Y2-1] |
Organism-specific databases
CTDi | 55311 |
DisGeNETi | 55311 |
GeneCardsi | ZNF444 |
HGNCi | HGNC:16052, ZNF444 |
HPAi | ENSG00000167685, Low tissue specificity |
MIMi | 607874, gene |
neXtProti | NX_Q8N0Y2 |
OpenTargetsi | ENSG00000167685 |
PharmGKBi | PA134984823 |
VEuPathDBi | HostDB:ENSG00000167685.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162893 |
HOGENOMi | CLU_002678_49_3_1 |
InParanoidi | Q8N0Y2 |
OMAi | WRRFRHF |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8N0Y2 |
TreeFami | TF337369 |
Enzyme and pathway databases
PathwayCommonsi | Q8N0Y2 |
Miscellaneous databases
BioGRID-ORCSi | 55311, 5 hits in 1014 CRISPR screens |
ChiTaRSi | ZNF444, human |
GenomeRNAii | 55311 |
Pharosi | Q8N0Y2, Tdark |
PROi | PR:Q8N0Y2 |
RNActi | Q8N0Y2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167685, Expressed in cingulate cortex and 243 other tissues |
ExpressionAtlasi | Q8N0Y2, baseline and differential |
Genevisiblei | Q8N0Y2, HS |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN444_HUMAN | |
Accessioni | Q8N0Y2Primary (citable) accession number: Q8N0Y2 Secondary accession number(s): Q8TEQ9, Q8WU35, Q9NUU1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 7, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families