Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 444

Gene

ZNF444

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri179 – 201C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri207 – 229C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: GO_Central
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 444
Alternative name(s):
Endothelial zinc finger protein 2
Short name:
EZF-2
Zinc finger and SCAN domain-containing protein 17
Gene namesi
Name:ZNF444
Synonyms:EZF2, ZSCAN17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167685.14
HGNCiHGNC:16052 ZNF444
MIMi607874 gene
neXtProtiNX_Q8N0Y2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55311
OpenTargetsiENSG00000167685
PharmGKBiPA134984823

Polymorphism and mutation databases

BioMutaiZNF444
DMDMi38258800

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475931 – 327Zinc finger protein 444Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Cross-linki8Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei18PhosphoserineCombined sources1
Modified residuei104PhosphoserineCombined sources1
Cross-linki190Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei235PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8N0Y2
MaxQBiQ8N0Y2
PaxDbiQ8N0Y2
PeptideAtlasiQ8N0Y2
PRIDEiQ8N0Y2
ProteomicsDBi71486
71487 [Q8N0Y2-2]

PTM databases

iPTMnetiQ8N0Y2
PhosphoSitePlusiQ8N0Y2

Expressioni

Gene expression databases

BgeeiENSG00000167685 Expressed in 231 organ(s), highest expression level in cingulate cortex
CleanExiHS_ZNF444
ExpressionAtlasiQ8N0Y2 baseline and differential
GenevisibleiQ8N0Y2 HS

Organism-specific databases

HPAiHPA056895
HPA065203

Interactioni

Protein-protein interaction databases

BioGridi120593, 40 interactors
IntActiQ8N0Y2, 10 interactors
STRINGi9606.ENSP00000338860

Structurei

3D structure databases

ProteinModelPortaliQ8N0Y2
SMRiQ8N0Y2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 104SCAN boxPROSITE-ProRule annotationAdd BLAST85

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri179 – 201C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri207 – 229C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144000
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ8N0Y2
KOiK09230
OMAiACWQCGK
OrthoDBiEOG091G09O3
PhylomeDBiQ8N0Y2
TreeFamiTF337369

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N0Y2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVAVPVKQE AEGLALDSPW HRFRRFHLGD APGPREALGL LRALCRDWLR
60 70 80 90 100
PEVHTKEQML ELLVLEQFLS ALPADTQAWV CSRQPQSGEE AVALLEELWG
110 120 130 140 150
PAASPDGSSA TRVPQDVTQG PGATGGKEDS GMIPLAGTAP GAEGPAPGDS
160 170 180 190 200
QAVRPYKQEP SSPPLAPGLP AFLAAPGTTS CPECGKTSLK PAHLLRHRQS
210 220 230 240 250
HSGEKPHACP ECGKAFRRKE HLRRHRDTHP GSPGSPGPAL RPLPAREKPH
260 270 280 290 300
ACCECGKTFY WREHLVRHRK THSGARPFAC WECGKGFGRR EHVLRHQRIH
310 320
GRAAASAQGA VAPGPDGGGP FPPWPLG
Length:327
Mass (Da):35,204
Last modified:October 1, 2002 - v1
Checksum:iC7C812DC8FC6D706
GO
Isoform 2 (identifier: Q8N0Y2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-136: Missing.

Show »
Length:326
Mass (Da):35,133
Checksum:i4F3E49DD9F6182AF
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJH4K7EJH4_HUMAN
Zinc finger protein 444
ZNF444
90Annotation score:
K7EJ91K7EJ91_HUMAN
Zinc finger protein 444
ZNF444
99Annotation score:
K7ESL2K7ESL2_HUMAN
Zinc finger protein 444
ZNF444
77Annotation score:
K7EMV5K7EMV5_HUMAN
Zinc finger protein 444
ZNF444
70Annotation score:
K7ELZ3K7ELZ3_HUMAN
Zinc finger protein 444
ZNF444
72Annotation score:
K7EK55K7EK55_HUMAN
Zinc finger protein 444
ZNF444
44Annotation score:

Sequence cautioni

The sequence BAB84889 differs from that shown. Reason: Frameshift at position 99.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49L → P in BAA92028 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008798136Missing in isoform 2. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052955 mRNA Translation: BAC02698.1
AB052954 mRNA Translation: BAC02697.1
AL834130 mRNA Translation: CAD38847.1
AK074063 mRNA Translation: BAB84889.1 Frameshift.
AK001999 mRNA Translation: BAA92028.1
BC021282 mRNA Translation: AAH21282.1
CCDSiCCDS12939.1 [Q8N0Y2-1]
CCDS59426.1 [Q8N0Y2-2]
RefSeqiNP_001240721.1, NM_001253792.1 [Q8N0Y2-2]
NP_060807.2, NM_018337.3 [Q8N0Y2-1]
XP_005259091.1, XM_005259034.2 [Q8N0Y2-1]
XP_005259092.1, XM_005259035.1 [Q8N0Y2-1]
XP_005259093.1, XM_005259036.1 [Q8N0Y2-1]
XP_011525370.1, XM_011527068.1 [Q8N0Y2-1]
UniGeneiHs.24545
Hs.741890

Genome annotation databases

EnsembliENST00000337080; ENSP00000338860; ENSG00000167685 [Q8N0Y2-1]
ENST00000592949; ENSP00000468069; ENSG00000167685 [Q8N0Y2-2]
GeneIDi55311
KEGGihsa:55311
UCSCiuc002qmm.4 human [Q8N0Y2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052955 mRNA Translation: BAC02698.1
AB052954 mRNA Translation: BAC02697.1
AL834130 mRNA Translation: CAD38847.1
AK074063 mRNA Translation: BAB84889.1 Frameshift.
AK001999 mRNA Translation: BAA92028.1
BC021282 mRNA Translation: AAH21282.1
CCDSiCCDS12939.1 [Q8N0Y2-1]
CCDS59426.1 [Q8N0Y2-2]
RefSeqiNP_001240721.1, NM_001253792.1 [Q8N0Y2-2]
NP_060807.2, NM_018337.3 [Q8N0Y2-1]
XP_005259091.1, XM_005259034.2 [Q8N0Y2-1]
XP_005259092.1, XM_005259035.1 [Q8N0Y2-1]
XP_005259093.1, XM_005259036.1 [Q8N0Y2-1]
XP_011525370.1, XM_011527068.1 [Q8N0Y2-1]
UniGeneiHs.24545
Hs.741890

3D structure databases

ProteinModelPortaliQ8N0Y2
SMRiQ8N0Y2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120593, 40 interactors
IntActiQ8N0Y2, 10 interactors
STRINGi9606.ENSP00000338860

PTM databases

iPTMnetiQ8N0Y2
PhosphoSitePlusiQ8N0Y2

Polymorphism and mutation databases

BioMutaiZNF444
DMDMi38258800

Proteomic databases

EPDiQ8N0Y2
MaxQBiQ8N0Y2
PaxDbiQ8N0Y2
PeptideAtlasiQ8N0Y2
PRIDEiQ8N0Y2
ProteomicsDBi71486
71487 [Q8N0Y2-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337080; ENSP00000338860; ENSG00000167685 [Q8N0Y2-1]
ENST00000592949; ENSP00000468069; ENSG00000167685 [Q8N0Y2-2]
GeneIDi55311
KEGGihsa:55311
UCSCiuc002qmm.4 human [Q8N0Y2-1]

Organism-specific databases

CTDi55311
DisGeNETi55311
EuPathDBiHostDB:ENSG00000167685.14
GeneCardsiZNF444
HGNCiHGNC:16052 ZNF444
HPAiHPA056895
HPA065203
MIMi607874 gene
neXtProtiNX_Q8N0Y2
OpenTargetsiENSG00000167685
PharmGKBiPA134984823
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144000
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ8N0Y2
KOiK09230
OMAiACWQCGK
OrthoDBiEOG091G09O3
PhylomeDBiQ8N0Y2
TreeFamiTF337369

Miscellaneous databases

GenomeRNAii55311
PROiPR:Q8N0Y2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167685 Expressed in 231 organ(s), highest expression level in cingulate cortex
CleanExiHS_ZNF444
ExpressionAtlasiQ8N0Y2 baseline and differential
GenevisibleiQ8N0Y2 HS

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN444_HUMAN
AccessioniPrimary (citable) accession number: Q8N0Y2
Secondary accession number(s): Q8TEQ9, Q8WU35, Q9NUU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again